Autonomic Neuroscience-Basic & Clinical最新文献

{"title":"Neural networks involved in nausea in adult humans: A systematic review","authors":"C. Varangot-Reille ,&nbsp;G.J. Sanger ,&nbsp;P.L.R. Andrews ,&nbsp;A. Herranz-Gomez ,&nbsp;L. Suso-Martí ,&nbsp;J. de la Nava ,&nbsp;F. Cuenca-Martínez","doi":"10.1016/j.autneu.2022.103059","DOIUrl":"10.1016/j.autneu.2022.103059","url":null,"abstract":"<div><p><span>Nausea is a common clinical symptom, poorly managed with anti-emetic drugs. To identify potential brain regions which may be therapeutic targets we systematically reviewed brain imaging in subjects reporting nausea. The </span>systematic review<span> followed PRISMA statements with methodological quality (MINORS) and risk of bias (ROBINS-I) assessed. Irrespective of the nauseagenic stimulus the common (but not only) cortical structures activated were the inferior frontal gyrus (IFG), the anterior cingulate cortex<span><span> (ACC) and the anterior insula (AIns) with some evidence for lateralization (Left-IFG, Right-AIns, Right-ACC). Basal ganglia<span> structures (e.g., putamen) were also consistently activated. Inactivation was rarely reported but occurred mainly in the cerebellum<span> and occipital lobe. During nausea, </span></span></span>functional connectivity<span> increased, mainly between the posterior and mid- cingulate cortex. Limitations include, a paucity of studies and stimuli, subject demographics, inconsistent definition and measurement of nausea. Structures implicated in nausea are discussed in the context of knowledge of central pathways for interoception, emotion and autonomic control. Comparisons are made between nausea and other aversive sensations as multimodal aversive conscious experiences.</span></span></span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"245 ","pages":"Article 103059"},"PeriodicalIF":2.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABAergic leptin receptor-expressing neurons in the dorsomedial hypothalamus project to brown adipose tissue-related neurons in the paraventricular nucleus of mice","authors":"Yanyan Jiang ,&nbsp;Kavon Rezai-Zadeh ,&nbsp;Lucie D. Desmoulins ,&nbsp;Heike Muenzberg ,&nbsp;Andrei V. Derbenev ,&nbsp;Andrea Zsombok","doi":"10.1016/j.autneu.2022.103058","DOIUrl":"10.1016/j.autneu.2022.103058","url":null,"abstract":"<div><p><span><span><span>Brown adipose tissue (BAT) contributes to energy </span>homeostasis<span><span> via nonshivering thermogenesis. The BAT is densely innervated by the </span>sympathetic nervous system (SNS) and activity of pre-autonomic neurons modulates the sympathetic outflow. Leptin, an </span></span>adipocyte<span> hormone, alters energy homeostasis and thermogenesis of BAT via several neuronal circuits; however, the cellular effects of leptin on interscapular BAT (iBAT)-related neurons in the </span></span>hypothalamus<span> remain to be determined. In this study, we used pseudorabies virus<span><span> (PRV) to identify iBAT-related neurons in the paraventricular nucleus (PVN) of the hypothalamus and test the hypothesis that iBAT-related PVN neurons are modulated by leptin. Inoculation of iBAT with PRV in leptin receptor reporter mice (Lepr:EGFP) demonstrated that a population of iBAT-related PVN neurons expresses Lepr receptors. Our electrophysiological findings revealed that leptin application caused hyperpolarization in some of iBAT-related PVN neurons. Bath application of leptin also modulated excitatory and inhibitory </span>neurotransmission<span> to most of iBAT-related PVN neurons. Using channel rhodopsin assisted circuit mapping we found that GABAergic and glutamatergic Lepr-expressing neurons in the dorsomedial hypothalamus/dorsal hypothalamic area (dDMH/DHA) project to PVN neurons; however, connected iBAT-related PVN neurons receive exclusively inhibitory signals from Lepr-expressing dDMH/DHA neurons.</span></span></span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"245 ","pages":"Article 103058"},"PeriodicalIF":2.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring mechanisms of blood pressure regulation in response to device-guided and non-device-guided slow breathing: A mini review","authors":"Harika Pingali,&nbsp;Stacy D. Hunter","doi":"10.1016/j.autneu.2022.103050","DOIUrl":"10.1016/j.autneu.2022.103050","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension is a widespread disease that, if persistent, increases the risks of coronary heart disease mortality and morbidity. Slow breathing is a recommended blood pressure-lowering strategy though the mechanisms mediating its effects are unknown.</p></div><div><h3>Objective</h3><p>This review aims to evaluate autonomic and vascular function as potential mediators driving BP adaptive responses with slow breathing.</p></div><div><h3>Methods</h3><p>We searched EBSCO host, Web of Science, Cochrane Central Register of Controlled Trials, and PubMed using key words for optimized search results.</p></div><div><h3>Results</h3><p><span>Nineteen studies were included in this review (11 device-guided; 8 non-device-guided breathing). Though some studies showed increased vagally mediated components of heart rate variability<span> during slow breathing, results from acute and long-term studies were incongruent. Increases in baroreflex<span> sensitivity (BRS) following a single device-guided slow breathing bout were noted in normotensive and hypertensive adults. Long-term (4 weeks to 3 months) effects of slow breathing on BRS were absent. Device-guided breathing resulted in immediate reductions in muscle sympathetic nerve activity<span> (MSNA) in normo- and hyper-tensive adults though results from long-term studies yielded inconsistent findings. Non-device-guided slow breathing posed acute and chronic effects on vascular function with reductions in arterial stiffness in adults with </span></span></span></span>type I diabetes<span> and increases in microvascular endothelial function<span> in adults with irritable bowel syndrome<span>. Non-device guided breathing also reduced pro-inflammatory cytokines in healthy and hypertensive adults in acute and chronic studies. No adverse effects or non-adherence to treatment were noted in these trials.</span></span></span></p></div><div><h3>Conclusion</h3><p>Device-guided slow breathing is a feasible and effective modality in improving BRS, HRV, and arterial stiffness though its long-term effects are obscure. Though less evidence exists supporting the efficacy of non-device-guided slow breathing, acute and chronic studies demonstrate improvements in vascular function and inflammatory cytokines. More studies are needed to further explore the long-term effects of slow breathing in general and non-device-guided breathing in particular.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103050"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of proteins for synaptic release in nerve endings associated with the trachealis muscle of rats","authors":"Hisae Moriai ,&nbsp;Takuya Yokoyama ,&nbsp;Sayed Sharif Abdali ,&nbsp;Nobuaki Nakamuta ,&nbsp;Yoshio Yamamoto","doi":"10.1016/j.autneu.2022.103042","DOIUrl":"10.1016/j.autneu.2022.103042","url":null,"abstract":"<div><p><span><span>The immunohistochemical localization of proteins for synaptic release was examined in smooth muscle-associated sensory nerve endings<span> using whole-mount preparations of the rat trachea. Plant-like smooth muscle-associated nerve endings with </span></span>immunoreactivity for Na</span>⁺-K⁺-ATPase, α₃<span>-subunit were identified in the trachealis muscle<span><span>. VGLUT1, synapsin1, t-SNARE proteins (SNAP25 and syntaxin1), v-SNARE proteins (VAMP1 and VAMP2), and a presynaptic active zone-related protein (piccolo) were detected in the terminal parts of these endings. These results suggest that smooth muscle-associated nerve endings secrete </span>glutamate<span><span> to modulate sensorimotor functions in the </span>lung deflation reflex.</span></span></span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103042"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral contraceptive use and menstrual cycle influence acute cerebrovascular response to standing","authors":"C. Barranca ,&nbsp;T.J. Pereira ,&nbsp;H. Edgell","doi":"10.1016/j.autneu.2022.103054","DOIUrl":"10.1016/j.autneu.2022.103054","url":null,"abstract":"<div><h3>Purpose</h3><p><span>To determine if the menstrual cycle<span> and oral contraceptives (OC) influence responses to acute </span></span>orthostatic stress<span> and if these factors are clinically relevant to the diagnosis of initial orthostatic hypotension (iOH).</span></p></div><div><h3>Methods</h3><p>Young, healthy women were recruited, including OC users (n = 12) and non-users (NOC; n = 9). Women were tested during the low hormone (LH; placebo<span> pills; days 2–5 natural cycle) and high hormone (HH; active dose; days 18–24 natural cycle) menstrual phases. Changes in mean arterial pressure, cardiac output, heart rate, the 30:15 heart rate ratio and cerebrovascular resistance indices within 30 s of standing were examined.</span></p></div><div><h3>Results</h3><p><span><span>There were no effects of OC or menstrual cycle on hemodynamic responses during standing (all p&gt;0.05). In the LH phase, OC users had a greater fall in mean </span>middle cerebral artery blood velocity (MCA</span>_V) compared to NOC (p&lt;0.05). However, this was reversed in the HH phase, where OC users had a reduced fall in mean MCA_V (p&lt;0.05). Interestingly, 8 women (OC and NOC) had drops in systolic/diastolic blood pressure meeting the criteria for iOH, and 7 of those 8 women displayed this drop in a single phase of the menstrual cycle.</p></div><div><h3>Conclusion</h3><p>Our results indicate that chronic versus acute OC use (i.e., long-term use observed via LH phase versus short-term use observed via HH phase) have opposing effects on cerebral blood velocity during standing. Further, our results highlight that multiple assessments across the cycle may be necessary to accurately diagnose iOH, as most women met the diagnostic criteria during a single menstrual phase.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103054"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10791444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between heart rate variability and cerebral autoregulation in septic patients","authors":"Armin Alvaro Quispe-Cornejo ,&nbsp;Ilaria Alice Crippa ,&nbsp;Péter Bakos ,&nbsp;Andrea Dominguez-Faure ,&nbsp;Jacques Creteur ,&nbsp;Fabio Silvio Taccone","doi":"10.1016/j.autneu.2022.103051","DOIUrl":"10.1016/j.autneu.2022.103051","url":null,"abstract":"<div><h3>Background</h3><p><span>Heart rate variability (HRV) may provide an estimation of the autonomous </span>nervous system<span> (ANS) integrity in critically ill patients. Disturbances of cerebral autoregulation<span> (CAR) may share common pathways of ANS dysfunction.</span></span></p></div><div><h3>Aim</h3><p>To explore whether changes in HRV and CAR index correlate in critically ill septic patients.</p></div><div><h3>Methods</h3><p><span><span>Prospectively collected data on septic adult (&gt; 18 years) patients admitted into a mixed Intensive Care between February 2016 and August 2019 with a recorded transcranial doppler CAR assessment. CAR was assessed calculating the Pearson's correlation coefficient (i.e. mean flow index, Mxa) between the left </span>middle cerebral artery<span> flow velocity (FV), insonated with a 2-MHz probe, and invasive blood pressure (BP) signal, both recorded simultaneously through a Doppler Box (DWL, Germany). MATLAB software was used for CAR assessment using a validated script; a Mxa &gt;0.3 was considered as impaired CAR. HRV was assessed during the same time period using a specific software (Kubios HRV 3.2.0) and analyzed in both time-domain and frequency domain methods</span></span><em>.</em> Correlation between HRV-derived variables and Mxa were assessed using the Spearman's coefficient.</p></div><div><h3>Results</h3><p>A total of 141 septic patients was studied; median Mxa was 0.35 [0.13–0.60], with 77 (54.6 %) patients having an impaired CAR. Mxa had a significant although weak correlation with HRV time domain (SDNN, <em>r</em> = 0.17, <em>p</em> = 0.04; RMSSD, <em>r</em> = 0.18, <em>p</em> = 0.03; NN50, <em>r</em> = 0.23, <em>p</em> = 0.006; pNN50, r = 0.23, <em>p</em> = 0.007), frequency domain (FFT-HF, <em>r</em> = 0.21; <em>p</em> = 0.01; AR-HF, <em>r</em> = 0.19; <em>p</em> = 0.02), and non-linear domain (SD1, <em>r</em> = 0.18, <em>p</em> = 0.03) parameters. Impaired CAR patients had also all of these HRV-derived parameters higher than those with intact CAR.</p></div><div><h3>Conclusions</h3><p>In this exploratory study, a potential association of ANS dysfunction and impaired CAR during sepsis was observed.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103051"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10854846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies","authors":"Iris Knoop ,&nbsp;Federica Picariello ,&nbsp;Emma Jenkinson ,&nbsp;Nicholas Gall ,&nbsp;Claudia Chisari ,&nbsp;Rona Moss-Morris","doi":"10.1016/j.autneu.2022.103052","DOIUrl":"10.1016/j.autneu.2022.103052","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background and objective&lt;/h3&gt;&lt;p&gt;Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic health condition affecting mostly women of childbearing age, and significantly impacting their health and quality of life. It is currently poorly understood with no approved licensed treatments. The aim of this systematic review was to contextualize the symptom burden of POTS, and review factors associated with this burden that may guide future treatments. The specific questions were (1) How does symptom burden in POTS compare to the burden in other long term conditions (LTCs), (2) Which factors are associated with POTS symptom burden, and (3) Which interventions show promise in reducing symptom burden in POTS.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Databases and data treatment&lt;/h3&gt;&lt;p&gt;Electronic databases (CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science, APA PsycArticles, OpenGrey) were searched from inception to January 2022 for observational studies reporting on the association between any biological, psychological or social factors and symptom burden, and randomized controlled trials reporting on interventions for symptom burden in adults with POTS. Two reviewers independently conducted eligibility screening, data extraction and quality assessment. A narrative synthesis was undertaken.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results/Conclusion&lt;/h3&gt;&lt;p&gt;5159 entries were screened for eligibility. Twenty-nine studies were included (1372 participants with POTS of a total sample size of 2314, 17 High-, 12 Medium-quality), seventeen were observational and twelve were randomized controlled experimental and intervention trials. Overall methodological quality of the evidence was medium-high but heterogeneity was high and sample sizes modest, allowing moderately robust conclusions. Orthostatic symptom burden was higher in POTS than other LTCs. Serum activity against adrenergic α1 receptors, physical functioning, depression, catastrophizing, prolonged cognitive stress testing and anxiety were significantly associated with symptom burden in medium-high quality studies. Preliminary medium-high quality evidence from predominantly proof-of-concept (&lt;em&gt;n&lt;/em&gt; = 11) studies and one 3-month 2 × 2 factorial design trial suggest that compression garments, propranolol, pyridostigmine, desmopressin, and bisoprolol may hold promise in reducing symptom burden. Directions for future research include investigating associated factors over time, the development of complex interventions which address both biological and psychosocial factors associated with symptom burden, and effectiveness trials of these interventions.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Significance&lt;/h3&gt;&lt;p&gt;POTS symptom burden is high, particularly in relation to orthostatic intolerance when compared to other long-term conditions (LTCs). Despite this burden, there are no effectiveness randomized controlled trials of treatment to reduce symptoms in POTS. This review provides a starting point to understanding researched biological and psychosocial factor","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103052"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9300813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"By trying different approaches (and transparent reporting)! Response to: How to approach baseline imbalance in cross-randomised studies?","authors":"Julian Koenig ,&nbsp;Michael Kaess","doi":"10.1016/j.autneu.2022.103055","DOIUrl":"10.1016/j.autneu.2022.103055","url":null,"abstract":"","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103055"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10791432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to approach baseline imbalance in cross-randomised studies?","authors":"Ali Gholamrezaei ,&nbsp;Hassan Jafari","doi":"10.1016/j.autneu.2022.103020","DOIUrl":"10.1016/j.autneu.2022.103020","url":null,"abstract":"","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103020"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10791433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The multiple roles of dopamine receptor activation in the modulation of gastrointestinal motility and mucosal function","authors":"Rosa Serio ,&nbsp;Maria Grazia Zizzo","doi":"10.1016/j.autneu.2022.103041","DOIUrl":"10.1016/j.autneu.2022.103041","url":null,"abstract":"<div><p><span><span>Dopamine (DA) is a catecholamine regulatory molecule with potential role in physiology and </span>physiopathology<span> of the intestinal tract. Various cellular sources of DA have been indicated as enteric neurons, immune cells, intestinal flora and </span></span>gastrointestinal epithelium<span><span>. Moreover, DA is produced by nutritional tyrosine. All the five DA receptors<span><span><span>, actually described, are present throughout the gut. Current knowledge of DA in this area is reviewed, focusing on gastrointestinal function<span> in health and during inflammation. Research on animal models and humans are reported. A major obstacle to understanding the physiologic and/or pharmacological roles of enteric DA is represented by the multiplicity of receptors involved in the responses together with many signalling pathways related to each </span></span>receptor subtype<span>. It is mandatory to map precisely the distributions of DA receptors, to determine the relevance of a receptor in a specific location in order to explore novel therapies directed to </span></span>dopaminergic targets that may be useful in the control of </span></span>intestinal inflammation.</span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"244 ","pages":"Article 103041"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}