光遗传学调节心脏自主神经系统

IF 3.2 4区医学 Q2 NEUROSCIENCES

Autonomic Neuroscience-Basic & Clinical Pub Date : 2024-07-17 DOI:10.1016/j.autneu.2024.103199

Ramon A. Hernández-Domínguez , Jorge F. Herrera-Orozco , Guadalupe E. Salazar-Calderón , María Chávez-Canales , Manlio F. Márquez , Felipe González-Álvarez , Armando Totomoch-Serra , Tania Reyes-Cruz , Finn Lip , José J. Aceves-Buendía

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引用次数: 0

摘要

以下是对光遗传学基本原理的叙述性回顾。它侧重于通过改变不同疾病的病理生理特征来操纵自律神经系统的优势和限制因素。虽然这项技术的使用目前还处于实验阶段，但我们将讨论已经实施的改进措施，并确定必要的措施，以便在控制心脏自律神经系统方面实现潜在的临床前转化。

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Optogenetic modulation of cardiac autonomic nervous system

The following is a narrative review of the fundamentals of optogenetics. It focuses on the advantages and constraints of manipulating the autonomic nervous system by modifying the pathophysiological characteristics that arise in different diseases. Although the use of this technique is currently experimental, we will discuss improvements that have been implemented and identify the necessary measures for potential preclinical translation in the control of the cardiac autonomic nervous system.

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来源期刊

Autonomic Neuroscience-Basic & Clinical 医学-神经科学

CiteScore

5.80

自引率

7.40%

发文量

审稿时长

66 days

期刊介绍： This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.