Autonomic Neuroscience-Basic & Clinical最新文献

{"title":"Inspiratory muscle training enhances cardiac autonomic response to orthostatic stress in patients with Parkinson's disease: a preliminary study","authors":"Felipe Castro Ferreira ,&nbsp;Michelle Cristina Salabert Vaz Padilha ,&nbsp;Pedro Paulo da Silva Soares ,&nbsp;Marco Antônio Araujo-Leite ,&nbsp;Gabriel Dias Rodrigues","doi":"10.1016/j.autneu.2025.103334","DOIUrl":"10.1016/j.autneu.2025.103334","url":null,"abstract":"<div><div>In this pilot study, eight patients with Parkinson's disease (PD) and eight age-matched healthy controls completed a 5-week home-based inspiratory muscle training (IMT) program. Maximal inspiratory pressure and heart rate variability during sitting (SIT) and orthostatic stress were assessed before and after IMT. Both groups exhibited better maximal inspiratory pressure and vagal modulation of the heart in the SIT position post-IMT. However, only patients with PD showed enhanced cardiac autonomic modulation during orthostatic stress. These findings suggest that IMT may improve the cardiac autonomic response to orthostatic stress in patients with PD, warranting further investigation.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"261 ","pages":"Article 103334"},"PeriodicalIF":3.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise and the autonomic nervous system: New insights and future directions.","authors":"James P Fisher, Lauro C Vianna","doi":"10.1016/j.autneu.2025.103333","DOIUrl":"https://doi.org/10.1016/j.autneu.2025.103333","url":null,"abstract":"","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":" ","pages":"103333"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedle-assisted iontophoretic transdermal administration of adrenergic antagonists does not modulate palmar sweating induced by static exercise in healthy young adults","authors":"Hui Wang ,&nbsp;Kaito Tamura ,&nbsp;Shoma Oshima ,&nbsp;Shotaro Yokoyama ,&nbsp;Yumi Okamoto ,&nbsp;Junto Otsuka ,&nbsp;Hanano Kato ,&nbsp;Hirofumi Yamashita ,&nbsp;Ying-Shu Quan ,&nbsp;Tatsuro Amano","doi":"10.1016/j.autneu.2025.103321","DOIUrl":"10.1016/j.autneu.2025.103321","url":null,"abstract":"<div><div>Palmar sweating is primarily evoked by psychological and physical (e.g., exercise) stress, while the peripheral control of this response remains uncertain. We investigated whether the transdermal administration of adrenergic antagonists modulates palmar sweating induced by isometric knee extension (IKE) exercise. In a climate chamber (28 °C and 40 % relative humidity), 15 healthy young adult males completed IKE exercises at maximal (5 s maximum voluntary contraction, MVC) and submaximal (50 % MVC to exhaustion) effort, before and after the transdermal iontophoretic administration of bretylium (noradrenergic sympathetic nerve inhibitor), terazosin (α-adrenergic receptor antagonist), propranolol (β-adrenergic receptor antagonist), or NaCl (control) to the palm pretreated with solid microneedles to enhance skin permeability. The efficacy of terazosin and propranolol on the palm was assessed by administering α- and β-adrenergic agonists (phenylephrine and salbutamol combined with aminophylline, respectively) in follow-up studies, whereas bretylium efficacy was verified by evaluating cold-induced palmar cutaneous vasoconstriction. Compared with exercise before drug administrations, neither bretylium, terazosin, propranolol, nor NaCl affected sweating induced by both IKE exercises (all <em>P</em> ≥ 0.600, interaction and treatment effect). In the follow-up study, the successful α-adrenergic receptor blockade was confirmed by attenuated phenylephrine-induced sweating (<em>P</em> = 0.001). Unexpectedly, the administration of propranolol increased salbutamol-induced palmar sweating (<em>P</em> = 0.008), leaving the efficacy of β-adrenergic receptor blockade uncertain. The bretylium administration effectively abolished cold-induced cutaneous vasoconstriction (<em>P</em> = 0.006). In conclusion, this study demonstrates that transdermal administration of bretylium, terazosin, and propranolol does not alter palmar sweating induced by IKE exercise, implying the absence of adrenergic modulation.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"261 ","pages":"Article 103321"},"PeriodicalIF":3.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetric projection attractor reconstruction: Transcutaneous auricular vagus nerve stimulation for visually induced motion sickness","authors":"Emmanuel Molefi ,&nbsp;Ian McLoughlin ,&nbsp;Ramaswamy Palaniappan","doi":"10.1016/j.autneu.2025.103318","DOIUrl":"10.1016/j.autneu.2025.103318","url":null,"abstract":"<div><div>Motion sickness is an enigma that has plagued humans for millennia – and could be exacerbated by automated vehicles and virtual reality. Here, we examined the neuromodulatory effects of transcutaneous auricular vagus nerve stimulation (taVNS) – a non-invasive brain stimulation tool – on autonomic function in response to motion sickness-induced nausea. We conducted a crossover randomized controlled study of healthy participants (<em>n</em> = 29) administered with active taVNS and sham, concurrent with visually-induced motion sickness during electrocardiogram (ECG) acquisition. Using symmetric projection attractor reconstruction (SPAR), a recent mathematical tool that computes images (“attractors”) of morphology and variability of any approximately periodic signals, we show that taVNS induces a significant reduction in measures derived from these attractor image data, compared to sham. Notably, we found that a taVNS-evoked decrease in peak theta density showed a marked correlation with improvements in motion-induced nausea symptom severity. Furthermore, the use of machine learning revealed differential discriminatory power of taVNS response with an area under the receiver operating characteristic curve (AUC) of 0.81. Taken together, these findings provide novel insights into taVNS for motion-induced nausea; and additionally suggest that ECG SPAR-based features may be important for evaluating taVNS therapy response — with implications for adaptive taVNS.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"261 ","pages":"Article 103318"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crosstalk between bladder-cardiovascular autonomic nervous system in synucleinopathies","authors":"Ryuji Sakakibara ,&nbsp;Tomoyuki Uchiyama ,&nbsp;Tatsuya Yamamoto","doi":"10.1016/j.autneu.2025.103320","DOIUrl":"10.1016/j.autneu.2025.103320","url":null,"abstract":"<div><h3>Objective</h3><div>Parkinson's disease (PD) and multiple system atrophy (MSA) are major neurogenerative diseases characterized pathologically by abnormal alpha-synuclein aggregation, called synucleinopathy. PD and MSA are clinically characterized by motor disorder and autonomic dysfunction (particularly lower urinary tract dysfunction, LUTD and orthostatic hypotension, OH). However, few literatures are available concerning mutual interaction between bladder-cardiovascular autonomic disorders in PD or MSA.</div></div><div><h3>Method</h3><div>A narrative review including the past 10-year PubMed research papers on this topic. We also included dementia with Lewy bodies (DLB) that shares pathology with PD.</div></div><div><h3>Results</h3><div>The LUTD in MSA is more severe than that in PD for large post-void residual (PVR) or urinary retention. These LUTDs presumably reflect the different nervous system pathologies. Of particular importance is that MSA may presents with LUTD alone initially, and some PD or MSA presents with OH alone (called pure autonomic failure, PAF); needs early diagnosis and management. For treating autonomic dysfunction in PD or MSA, mutual interactions between bladder-cardiovascular are worth considering, particularly when we prescribe urology drugs (alpha blockers might worsen OH) or cardiology drugs (antihypertensive drugs might worsen OH, and drugs to treat OH might worsen PVR). Care should also be taken for micturition syncope. This care improves individual's quality of life in PD or MSA; it can also prevent emergency hospitalizations, and early institutionalization.</div></div><div><h3>Conclusions</h3><div>This review summarizes the pathophysiology and practical management of (mutual) bladder-cardiovascular autonomic disorders in individuals with PD or MSA.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"261 ","pages":"Article 103320"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral nerve electrical stimulation (SNES) ameliorates bladder dysfunction and detrusor fibrosis in early-stage spinal cord injury: A randomized controlled experimental study in rats","authors":"Lingyan Wang,&nbsp;Junhua Li,&nbsp;Chenhao Tang,&nbsp;Chen Song,&nbsp;Yanbin Wang","doi":"10.1016/j.autneu.2025.103322","DOIUrl":"10.1016/j.autneu.2025.103322","url":null,"abstract":"<div><div>This study evaluated the therapeutic effects of sacral nerve electrical stimulation (SNES) targeting the L6-S1 spinal nerves on neurogenic bladder dysfunction following spinal cord injury (SCI). Using a randomized controlled design, 80 female Sprague-Dawley rats were divided into four groups: sham surgery, complete T9 spinal cord transection (SCI model), SCI with electrode implantation only (control), and SCI with active SNES (3–5 Hz, 3–5 V daily for 4 weeks). Bladder function was assessed through urodynamics, while detrusor fibrosis was examined using histological and ultrastructural analyses.</div><div>The SCI model group demonstrated significant urodynamic impairments compared to sham controls, including increased leak point pressure (43.15 ± 1.37 vs 25.52 ± 1.29 cmH₂O) and decreased bladder capacity (1.52 ± 0.21 vs 4.21 ± 0.72 mL) and compliance (0.21 ± 0.14 vs 0.42 ± 0.26 mL/cmH₂O; all <em>P</em> &lt; 0.01). SNES treatment substantially reversed these abnormalities (P &lt; 0.01 vs SCI group), restoring parameters to near-normal levels. Histological examination revealed that SNES significantly reduced collagen deposition (types I and III) in detrusor muscle compared to untreated SCI animals (<em>P</em> &lt; 0.05). Transmission electron microscopy showed preserved mitochondrial structure in SNES-treated animals, contrasting with the cellular vacuolization observed in SCI controls.</div><div>These results demonstrate that early intervention with SNES at the L6-S1 level can effectively mitigate both functional and structural bladder impairments following SCI. The treatment improved urodynamic parameters while reducing fibrotic changes in detrusor muscle, suggesting its potential as a species-specific neuromodulation strategy for neurogenic bladder. This study provides experimental evidence supporting further investigation of sacral-level neuromodulation for SCI-related bladder dysfunction.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"261 ","pages":"Article 103322"},"PeriodicalIF":3.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic Neuroscience: Basic to Clinical (AN:BC): A new relationship with the SPARC portal","authors":"Julian F.R. Paton ,&nbsp;Peter Hunter ,&nbsp;David Nickerson","doi":"10.1016/j.autneu.2025.103319","DOIUrl":"10.1016/j.autneu.2025.103319","url":null,"abstract":"","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"260 ","pages":"Article 103319"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms underpinning peripheral chemoreceptor modulation of hypertension","authors":"Xin Shen,&nbsp;Julian F.R. Paton","doi":"10.1016/j.autneu.2025.103317","DOIUrl":"10.1016/j.autneu.2025.103317","url":null,"abstract":"<div><div>On its activation, the carotid body (CB) provides one of the greatest stimulants to raise cardiovascular sympathetic activity. Through proof of principle studies the CB has been shown to be a major driver of the heightened sympathetic activity associated with several cardiometabolic diseases. Understanding the mechanisms of hypoxia and cellular transduction as well as inter-cellular signalling within the CB becomes crucial for identification of novel interventions to quench CB hyperactivity in disease. In this review, we summarise the mechanisms of hypoxia but also emphasise that the CB is more than an oxygen sensor which is acutely tuned to the regulation of both oxygen and glucose with feedback from blood-borne hormones regulating metabolism. This feature opens new druggable targets to restrain CB activity as well as the possibility to consider this organ as a nodal point for regulating autonomic dysfunction underpinning the metabolic syndrome.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"261 ","pages":"Article 103317"},"PeriodicalIF":3.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding neurogenic urogenital dysfunction and the clinical application of the EAN/EFAS/INUS NEUROGED guidelines","authors":"Ivan Adamec ,&nbsp;Magdalena Krbot Skorić ,&nbsp;Luka Crnošija ,&nbsp;Alessandra Fanciulli ,&nbsp;Jalesh Panicker ,&nbsp;Tamara B. Kaplan ,&nbsp;Mario Habek","doi":"10.1016/j.autneu.2025.103314","DOIUrl":"10.1016/j.autneu.2025.103314","url":null,"abstract":"<div><div>Neurogenic urogenital dysfunction encompasses various urinary and sexual issues resulting from neurological disorders, which significantly impact patients' quality of life. To address these challenges, the European Academy of Neurology (EAN), in collaboration with the European Federation of Autonomic Societies (EFAS) and the International Neuro-Urology Society (INUS), developed the NEUROGED guidelines. These guidelines aim to provide neurologists with evidence-based recommendations for managing neurogenic bladder and sexual dysfunctions. The task force comprised 37 members from 17 countries across four continents, highlighting a comprehensive and collaborative effort. The committee has established evidence-based recommendations for 11 key questions, consensus-based recommendations for eight questions, and good practice statements for 19, addressing the complexities of managing neurogenic urogenital dysfunction. This review seeks to enhance understanding of the NEUROGED guidelines through two sections. The first section examines the neuroanatomy, pathophysiology, and clinical presentation of lower urinary tract symptoms (LUTS) and sexual dysfunction (SD), establishing a basis for the guidelines. The second section explores the impact of the NEUROGED guidelines on the investigation and management of urogenital symptoms, addressing their implementation and potential barriers in clinical practice.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"260 ","pages":"Article 103314"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between cardiac autonomic function and cognition across the adult female lifespan","authors":"Alicia Duval ,&nbsp;Blaine Ditto","doi":"10.1016/j.autneu.2025.103316","DOIUrl":"10.1016/j.autneu.2025.103316","url":null,"abstract":"<div><div>A growing body of evidence highlights the direct involvement of the autonomic nervous system on cognitive processes. Vagal-mediated heart rate variability (vmHRV), a measure of cardiac autonomic control, has been linked to cognitive outcomes in both healthy and clinical populations. However, few studies have directly examined this relationship in females. Understanding the interplay between vmHRV and cognitive functioning in females is important for elucidating sex-specific mechanisms contributing to cognitive trajectories across the female lifespan. The present review synthesizes the literature examining vmHRV and cognition in females at different transitional life phases, including the menstrual cycle, menopausal transition, and postmenopausal period, and considers the implications of polycystic ovary syndrome. The evidence summarized describes fluctuations in vmHRV and cognitive function across the female adult lifespan; however, notable gaps in the literature are identified. Further research is needed to better understand these complex interactions and to guide the development of targeted strategies to support female cognitive health with advancing age.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"260 ","pages":"Article 103316"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}