Autonomic Neuroscience-Basic & Clinical最新文献

{"title":"The influence of sleep on autonomic nervous system regulation in women across the lifespan","authors":"Jeremy A. Bigalke,&nbsp;Jason R. Carter","doi":"10.1016/j.autneu.2025.103275","DOIUrl":"10.1016/j.autneu.2025.103275","url":null,"abstract":"<div><div>Sleep and autonomic regulation are closely related processes which incur significant influence on health and wellbeing in women across the lifespan. Aging in women is associated with increases in cardiovascular risk through greater sympathetic predominance compared to premenopausal women, as well as reductions in sleep quality and quantity. Women remain an understudied population with regards to sleep, autonomic function, and cardiovascular risk. Understanding the interplay between sleep and autonomic function across the lifespan of women is crucial to improve subsequent lifelong health outcomes. The present review integrates knowledge that has accrued regarding experimental sleep deprivation, restriction, and chronic sleep disturbance and their respective impacts on autonomic regulation at various life stages in women. The review focuses on high-fidelity measures of sympathetic regulation (i.e., microneurography), as aging in women is associated with a disproportionate increase in sympathetic activity compared to men. Evidence summarized within this review delineates a significant impact of sleep processes on autonomic function in women across the lifespan. However, there remain substantial gaps in our knowledge of this interplay between sleep processes and autonomic regulation of cardiovascular control in women. There is a need for further research efforts to disentangle the complexity associated with sleep and autonomic regulation in women at all life stages. Efforts in this area will improve our understanding of women's health and factors such as sleep and sleep disturbance which precipitate lifelong health and chronic cardiovascular risk.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"260 ","pages":"Article 103275"},"PeriodicalIF":3.2,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic control of blood pressure in women: The roles of hypertension and aging","authors":"John D. Akins,&nbsp;Takuro Washio,&nbsp;Qi Fu","doi":"10.1016/j.autneu.2025.103274","DOIUrl":"10.1016/j.autneu.2025.103274","url":null,"abstract":"<div><div>Hypertension remains a leading cause of cardiovascular morbidity and mortality worldwide, with implications in women's health across the lifespan. Of note, autonomic nervous system imbalances have been linked to the development of hypertension and are present with natural aging and various conditions unique to women (e.g., menopause, hypertensive disorders of pregnancy, polycystic ovary syndrome). As such, this article reviews the critical changes in the sympathetic and parasympathetic nervous systems that occur in women and may contribute to the development of hypertension. Special focus is paid to the regulating pathways across the baroreflex arc, including baroreflex sensitivity, efferent sympathetic outflow, and peripheral sympathetic transduction, at rest and during various physiological stressors. To this point, aging women experience increasing sympathetic outflow, blunted sympathetic transduction, and reduced cardiovagal baroreflex sensitivity, which may be further potentiated by the presence of hypertension. Additionally, this review applies some clinical perspective to the physiological findings in order to identify potential therapeutic pathways. The information gathered in this review has important implications for future research into women's autonomic blood pressure regulation and its impact on the genesis of hypertension.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"260 ","pages":"Article 103274"},"PeriodicalIF":3.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonic mucosal TRPA1 expression profiles in irritable bowel syndrome and its correlation to symptom severity: An exploratory study","authors":"Sylvester R. Groen ,&nbsp;Daniel Keszthelyi ,&nbsp;Ellen Wilms ,&nbsp;Justin Huig ,&nbsp;Pan Xu ,&nbsp;Montserrat Elizalde ,&nbsp;Lisa Vork ,&nbsp;Daisy M.A.E. Jonkers ,&nbsp;Zsuzsanna Helyes ,&nbsp;Ad A.M. Masclee ,&nbsp;Zsa Zsa R.M. Weerts","doi":"10.1016/j.autneu.2025.103273","DOIUrl":"10.1016/j.autneu.2025.103273","url":null,"abstract":"<div><h3>Introduction</h3><div>Visceral hypersensitivity is a hallmark of irritable bowel syndrome (IBS). A putative involvement of the Transient Receptor Potential Ankyrin-1 (TRPA1) cation channel has been suggested by several animal studies. Main objective of this study is to assess location-specific TRPA1 expression in the colonic mucosa and its correlation with symptom severity in IBS patients.</div></div><div><h3>Methods</h3><div>Biopsies were obtained from the sigmoid of 30 IBS patients (Rome III; median age 39.0 years, 80 % female) and 23 healthy controls (median age 22.7 years, 43.5 % female). Additional biopsies of the proximal colon were obtained in 24 IBS patients. TRPA1 expression levels were measured in duplicate by quantitative reverse-transcriptase–polymerase-chain-reaction, normalized to GAPDH, and assessed as relative mRNA values using the −2^ΔCt method. In IBS patients, symptoms were assessed and correlated with TRPA1 expression.</div></div><div><h3>Results</h3><div>Relative TRPA1 expression in the sigmoid was significantly higher in IBS patients compared to healthy controls (<em>P</em> &lt; 0.001). Within IBS patients TRPA1 expression of sigmoid biopsies was significantly higher compared to proximal colon samples (<em>p</em> &lt; 0.001). No significant correlation was found between TRPA1 expression in sigmoid or proximal colon samples and the symptom severity (abdominal discomfort, abdominal pain and bloating).</div></div><div><h3>Conclusion</h3><div>These findings suggest a potential role for the TRPA1 related pathway as a target for IBS treatment in the future. Since there was no correlation found in the current exploratory study between TRPA1 expression and symptom severity, further research towards the clinical relevance of the increased TRPA1 expression in IBS-patients along with its location-specific expression is warranted.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103273"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthostatic cardiovascular responses to postural sway and discreet counterpressure maneuvers","authors":"E.L. Williams ,&nbsp;J. Lando ,&nbsp;V.-E.M. Lucci ,&nbsp;B.C.D. Hockin ,&nbsp;K. Elabd ,&nbsp;S.N. Robinovitch ,&nbsp;I.T. Parsons ,&nbsp;V.E. Claydon","doi":"10.1016/j.autneu.2025.103271","DOIUrl":"10.1016/j.autneu.2025.103271","url":null,"abstract":"<div><div>Counterpressure maneuvers (CPM) are movements used to delay or abort syncope, but may have practical barriers to use. We recently showed exaggerated postural sway produces protective responses against syncope. Accordingly, we aimed to evaluate a series of discreet, accessible movements as novel preventative CPM.</div><div>We tested 26 healthy adults (12 female) aged 28.9 ± 1.2 years. Participants performed a baseline stand (BL), followed by three randomized CPM trials (exaggerated anteroposterior sway, AP; toe clenching, TC; gluteal muscle clenching, GC). Non-invasive beat-to-beat systolic arterial pressure (SAP), heart rate, stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR), mean middle cerebral artery blood velocity (mMCAv), and total path length moved (TPL) were measured. Muscularity was assessed using bioelectrical impedance.</div><div>All discreet CPM augmented orthostatic SV (<em>p</em> &lt; 0.001) and CO (<em>p</em> &lt; 0.001), while reducing TPR (<em>p</em> &lt; 0.001). SAP increased during AP (<em>p</em> &lt; 0.001) and GC (<em>p</em> &lt; 0.001), but not TC. GC responses were unstable, with increased standard deviation of SAP (<em>p</em> = 0.002) and SV (<em>p</em> = 0.022) that may predispose syncope. Only AP improved mMCAv (<em>p</em> = 0.005) and sympathovagal balance (<em>p</em> &lt; 0.001). Responses were largest in those with greater initial cardiovascular instability (<em>p</em> &lt; 0.003), larger leg muscle mass (<em>p</em> &lt; 0.02), and where TPL was greater (<em>p</em> &lt; 0.002).</div><div>These novel CPM hold clinical potential for the prevention of orthostatic syncope and presyncope, while addressing real-world patient-reported barriers to CPM. Exaggerated AP sway was most robust and stable at improving orthostatic hemodynamics in healthy controls, with reduced reliance on sympathetic baroreflex-mediated vasoconstriction during enhanced muscle pumping activity. Accordingly, AP shows the most promise as a simple and discrete CPM.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"260 ","pages":"Article 103271"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular and sympathetic neural responses during acute vagus nerve stimulation and subsequent static handgrip exercise in healthy adults","authors":"Takuro Washio ,&nbsp;John D. Akins ,&nbsp;Sarah L. Hissen ,&nbsp;Anna K. Geib ,&nbsp;Skyler A. Robles ,&nbsp;Qi Fu","doi":"10.1016/j.autneu.2025.103270","DOIUrl":"10.1016/j.autneu.2025.103270","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to investigate cardiovascular and sympathetic neural responses during acute cervical non-invasive vagus nerve stimulation (nVNS) and subsequent static handgrip (SHG) exercise with post-exercise circulatory occlusion (PECO) in healthy humans.</div></div><div><h3>Methods</h3><div>Ten healthy adults (5 men and 5 women, 33 ± 9 [standard deviation] yrs) participated in this double-blinded, randomized, crossover study. Each participant was studied twice on two separate days, with approximately 4 weeks apart: once during the actual cervical nVNS and once during sham stimulation for 4 min each. Mean arterial pressure (MAP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were measured during nVNS and sham stimulation. In addition, participants performed SHG at 40 % of maximal voluntary contraction until fatigue, followed by 2-min PECO to isolate muscle metaboreflex activation before and after each stimulation.</div></div><div><h3>Results</h3><div>During both nVNS and sham stimulation, HR decreased (△−4 ± 4 and △−4 ± 5 bpm; both <em>P</em> &lt; 0.001), and MSNA increased (△4 ± 6 and △2 ± 3 bursts/min; both P &lt; 0.001) in all participants, although MAP remained unchanged (<em>P</em> = 0.312). However, these responses did not differ between nVNS and sham stimulation (all <em>P</em> &gt; 0.05). Additionally, there were no differences in cardiovascular and MSNA responses to fatiguing SHG and PECO between stimulations (all <em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Compared to the sham condition, cervical nVNS had no significant impact on cardiovascular variables and MSNA during acute stimulation, nor on the responses to SHG or PECO. These findings suggest that cervical nVNS has no or minimal acute effect on sympathetic neural (re)activity in healthy adults.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103270"},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the exercise pressor reflex in heart failure: A multi-step failure","authors":"Danilo Iannetta ,&nbsp;Fabio Giuseppe Laginestra ,&nbsp;D. Walter Wray ,&nbsp;Markus Amann","doi":"10.1016/j.autneu.2025.103269","DOIUrl":"10.1016/j.autneu.2025.103269","url":null,"abstract":"<div><div>The contribution of neural feedback originating from exercising limb muscles to the cardiovascular response to exercise was first recognized nearly 100 years ago. Today, it is well established that this influence is initiated by the activation of group III and IV sensory neurons with terminal endings located within contracting skeletal muscle. During exercise, these sensory neurons project feedback related to intramuscular mechanical and metabolic perturbations to medullary neural circuits which reflexively evoke decreases in parasympathetic and increases in sympathetic nervous system activity with the purpose of optimizing central and peripheral hemodynamics. Considerable evidence from animal and human studies suggests that the function of this regulatory control system, known as the exercise pressor reflex (EPR), is abnormal in heart failure and exaggerates sympatho-excitation which impairs the hemodynamic response to exercise and contributes to the functional limitations characterizing these patients. This review briefly introduces the key determinants of EPR control in health and covers the impact of heart failure on the integrity of each of its components and overall function. These include the sensitivity of group III/IV muscle afferents, afferent signal transmission in the spinal cord, and the central integration and processing of sensory feedback within the brainstem. Importantly, although most data relevant for this review come from studies in HFrEF, the limited HFpEF-specific insights are included when available. While arguably not part of the EPR, we also discuss the impact of heart failure on the exercise-induced increase of intramuscular stimuli of group III/IV muscle afferents and end-organ responsiveness to sympathetic/neurochemical stimulation.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103269"},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal nerve afferents drive preferential renal sympathoexcitation in response to acute renal ischemia/reperfusion in rats","authors":"A.C. Marreiros ,&nbsp;M.I.O. Milanez ,&nbsp;R.S. Carvalhal ,&nbsp;E.E. Nishi ,&nbsp;D.D. Santos ,&nbsp;C.D. Gil ,&nbsp;R. Lantyer ,&nbsp;M.M. Knuepfer ,&nbsp;C.T. Bergamaschi ,&nbsp;R.R. Campos","doi":"10.1016/j.autneu.2025.103268","DOIUrl":"10.1016/j.autneu.2025.103268","url":null,"abstract":"<div><div>Renal nerve activity is composed of afferent (sensory) and efferent (sympathetic) nerve activity. Ischemia/reperfusion (IR) of the kidney increases renal sympathetic nerve activity (rSNA) and depresses renal function. As the role of renal afferent fibers in acute renal IR is unclear, we tested the hypothesis that renal IR increases rSNA triggered by renal afferent nerves responding to acute ischemia. Two experimental series were performed in adult male Wistar rats. IR was induced by total obstruction of blood flow to the left kidney by clamping the renal artery for 60 min and reperfusion for 120 min. We recorded MAP, HR, rSNA, and splanchnic sympathetic vasomotor activity (sSNA) in 8 normal IR rats and 6 left kidney deafferented IR rats (IR ARD). Renal deafferentation was performed using capsaicin administration to the left renal nerve 2 weeks before the experiments. Blood samples were collected before ischemia and at the end of reperfusion for total and differential leukocyte counts. Renal ischemia significantly increased rSNA 23 % (20 min: 0,07 ± 0,04mVs <em>P</em> &lt; 0.05) but not sSNA. The increase in rSNA was triggered by activation of renal afferent fibers, since IR significantly reduced rSNA in the IR ARD group maximal decrease in frequency 22 % (180 min: −62 ± 29Δspikes/s) and in amplitude 41 % (−0,29 ± 0, 12mVs, <em>P</em> &lt; 0.05) and induced hypotension and bradycardia. However, no significant difference was observed between groups in blood leukocyte profile, but a significant reduction in renal IL-6 was found in IR ARD, suggesting a reduction in renal inflammation in deafferented IR rats. The results show that renal afferent nerves trigger a preferential increase in rSNA and inflammation in the kidney during acute IR.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103268"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoception in Parkinson's disease: A narrative review and framework for translational research","authors":"Katherine Longardner ,&nbsp;Senegal Alfred Mabry ,&nbsp;Gloria Chen ,&nbsp;Roy Freeman ,&nbsp;Sahib S. Khalsa ,&nbsp;Paul Beach","doi":"10.1016/j.autneu.2025.103258","DOIUrl":"10.1016/j.autneu.2025.103258","url":null,"abstract":"<div><div>Parkinson's disease (PD) is the second most common, and the fastest growing, neurodegenerative disease worldwide. Non-motor manifestations, particularly autonomic nervous system dysfunction, are common throughout the disease course, in some cases preceding motor symptom onset by years, and are often more disabling and harder to treat than motor symptoms and contribute significantly to disability. An understudied consequence of autonomic and visceral dysfunction in PD is <em>interoception</em>, the neural processing of internal organ system signals. Interoceptive processes form a foundational body-brain interface, mediating basic homeostatic reflexes and complex physiologic and behavioral adaptive responses to internal perturbations. Emerging evidence exists that interoception is impaired in some individuals with PD, potentially explaining why those who have objective evidence of autonomic dysfunction do not always report typical symptoms. Failure to recognize these impairments may lead to missed opportunities for early intervention, particularly in addressing ‘silent’ autonomic disturbances (e.g., orthostatic hypotension leading to sudden falls, dysphagia leading to aspiration pneumonia). In this narrative review, we synthesize current findings on the neuroanatomical networks underlying interoception, examine clinical manifestations of interoceptive dysfunction across multiple organ systems in PD, and identify key gaps in knowledge. We propose a translational research framework to enhance early detection, symptom management, and intervention strategies for PD. This framework integrates cognitive, mood, and autonomic dysfunctions with clinical factors (disease stage, duration, motor subtype, levodopa status) to understand interoceptive dysfunction within a translational model. This approach highlights novel opportunities for personalized care and improved therapeutic interventions in PD.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103258"},"PeriodicalIF":3.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-mediated modulation of autonomic nervous system and inflammatory response in sleep-deprived individuals: A narrative reviews of implications for cardiovascular health","authors":"Riki Edo Saputro ,&nbsp;Chun-Chung Chou ,&nbsp;Yi-Yuan Lin ,&nbsp;Takashi Tarumi ,&nbsp;Yi-Hung Liao","doi":"10.1016/j.autneu.2025.103256","DOIUrl":"10.1016/j.autneu.2025.103256","url":null,"abstract":"<div><div>Sleep deprivation is a growing concern in cardiovascular risk, causing physiological disruptions like autonomic dysregulation and inflammation. Recent research indicates that sleep deprivation increases sympathetic nervous activity while decreasing parasympathetic activity, leading to increased blood pressure, impaired endothelial function, and heightened inflammation. Exercise has emerged as a non-pharmacological approach to increase cardiovascular health. However, the impact of exercise on sleep deprivation-induced changes in autonomic activity and inflammation remains unclear. To explore this, we reviewed studies investigating the effects of acute exercise on autonomic regulation and inflammatory markers following sleep deprivation. We conducted a narrative review of the literature. PubMed/MEDLINE, Google Scholar, and Web of Science (WOS) searched the articles between May 2022 and April 2023. The papers had to: [1] focus on recent studies between 2000 and 2023; [2] consist of sleep deprivation participants; [3] be published in English. Acute moderate- to high-intensity exercise after sleep deprivation may reduce parasympathetic activity, trigger pro-inflammatory cytokines, and delay recovery to normal levels. In contrast, regular exercise routines may mitigate the adverse effects of sleep deprivation on autonomic regulation and reduce systemic inflammation. Sleep deprivation can lead to autonomic imbalance, increased blood pressure, and increased inflammatory responses, which are further amplified by acute exercise, increasing the cardiovascular burden. When sleep deprivation occurs, exercise intensity and timing should be carefully chosen to avoid adverse cardiovascular health risks.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103256"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic reactivity to emotional stress in women with major depressive disorder","authors":"Aaron S. Autler ,&nbsp;Ashley M. Darling ,&nbsp;Rachel J. Skow ,&nbsp;Benjamin E. Young ,&nbsp;Paul J. Fadel ,&nbsp;Erika F.H. Saunders ,&nbsp;Jody L. Greaney","doi":"10.1016/j.autneu.2025.103257","DOIUrl":"10.1016/j.autneu.2025.103257","url":null,"abstract":"<div><div>Young women, who suffer from major depressive disorder (MDD) at twice the rate as young men, are particularly vulnerable to cardiovascular events triggered by emotional stress, an association that may be partially explained by excessive sympathetic activation. However, no studies have directly measured sympathetic activity during acute emotional stress in young women with MDD. We hypothesized that the muscle sympathetic nerve activity (MSNA) response to acute emotional stress would be greater in young women with MDD (18–30 yrs) compared to healthy non-depressed young women. MSNA (peroneal microneurography) and beat-to-beat blood pressure (BP; finger photoplethysmography) were measured at rest and during acute emotional stress evoked by viewing negative images selected from the International Affective Picture System in 17 healthy young women and in 30 young women with MDD of mild-to-moderate severity (unmedicated). There were no group differences in either the peak increase in MSNA (Δ0.1 ± 2.9 healthy vs. Δ2.0 ± 4.9 bursts/min MDD; <em>p</em> = 0.45) or the peak increase in mean arterial pressure (Δ0.6 ± 3.5 healthy vs. Δ1.4 ± 2.1 mmHg MDD; <em>p</em> = 0.67) in response to viewing negative images. However, in young women with MDD, MSNA reactivity to viewing negative images was positively related to current depressive symptom severity (<em>r</em> = 0.49; <em>p</em> = 0.04). Although these data indicate only minor MSNA responses to viewing negative images, they also highlight that sympathetic-cardiovascular reactivity to an acute, passive emotional stress stimulus is not exaggerated in young women with MDD. However, more severe current depressive symptoms may amplify emotional stress-induced sympathetic activation, thereby increasing cardiovascular risk.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103257"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}