Autonomic Neuroscience-Basic & Clinical最新文献

{"title":"Sympathetic transduction to blood pressure following three days in hypobaric hypoxia: Influence of nocturnal periodic breathing","authors":"James P. Fisher ,&nbsp;Johanna Roche ,&nbsp;Amanda G. Duffy ,&nbsp;Abubaker Ibrahim ,&nbsp;Rachel Turner ,&nbsp;Giovanni Vinetti ,&nbsp;Matteo Cesari ,&nbsp;Michael Furian ,&nbsp;Ambra Stefani ,&nbsp;Hannes Gatterer ,&nbsp;Birgit Högl ,&nbsp;Christoph Siebenmann","doi":"10.1016/j.autneu.2026.103386","DOIUrl":"10.1016/j.autneu.2026.103386","url":null,"abstract":"<div><div>We investigated whether three days of hypoxic exposure in a hypobaric chamber, and the associated nocturnal periodic breathing (nPB), reduce sympathetic nerve activity (MSNA) transduction to blood pressure (BP). While hypoxia did not affect MSNA transduction to BP, larger drops in BP occurred following cardiac cycles without sympathetic bursts, suggesting increased reliance on sympathetic vasoconstrictor support for beat-to-beat BP. Prevention of nPB by inspiratory carbon dioxide administration did not affect MSNA transduction to BP in hypoxia.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"264 ","pages":"Article 103386"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability as a non-invasive biomarker of autonomic dysfunction in amyotrophic lateral sclerosis: A systematic review and meta-analysis","authors":"Alfa Zamrotin Malaniale Maidi ,&nbsp;Reema Priyanka Suram ,&nbsp;Yasemin Deniz ,&nbsp;Sun-Joung Leigh An ,&nbsp;Yonggeun Hong","doi":"10.1016/j.autneu.2026.103393","DOIUrl":"10.1016/j.autneu.2026.103393","url":null,"abstract":"<div><h3>Objective</h3><div>This study assessed heart rate variability (HRV) alterations in amyotrophic lateral sclerosis (ALS) patients compared to healthy control groups using both frequency-domain and time-domain HRV parameters.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted using studies retrieved from PubMed, Embase, Web of Science, and Cochrane Library databases up to November 13, 2024. Fourteen studies were included in the qualitative synthesis and eight in the quantitative analysis.</div></div><div><h3>Results</h3><div>ALS patients exhibited significantly reduced Low Frequency (LF) and High Frequency (HF) HRV parameters compared to healthy controls (<em>p</em> &lt; 0.001 and <em>p</em> = 0.02, respectively). Time-domain parameters also showed significant reductions: RMSSD (p &lt; 0.001), SDNN (p &lt; 0.001), and pNN50% (<em>p</em> = 0.01). Despite an overall decrease in HRV, the LF/HF ratio did not show a statistically significant difference (<em>p</em> = 0.12).</div></div><div><h3>Conclusion</h3><div>Patients with ALS demonstrate autonomic dysfunction, evidenced by significant reductions in key time-domain (RMSSD, SDNN, pNN50%) and frequency-domain (LF, HF) parameters, suggesting impaired parasympathetic modulation. HRV may serve as a valuable, non-invasive biomarker for the early detection and management of cardiorespiratory complications in ALS.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"264 ","pages":"Article 103393"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From lab to life: Wearables, real-world data, and the future of autonomic research","authors":"Julien Rimok ,&nbsp;Kelly A. Larkin-Kaiser","doi":"10.1016/j.autneu.2025.103377","DOIUrl":"10.1016/j.autneu.2025.103377","url":null,"abstract":"<div><div>Traditional methods for assessing autonomic nervous system (ANS) function are constrained by conventional clinical settings, limited timeframes, and exclusionary protocols. These limitations prevent the accurate capture of dynamic physiological fluctuations, particularly in underserved populations and those with complex or rare autonomic disorders. This paper outlines how wearable technologies and mobile health (mHealth) platforms are redefining the landscape of ANS research. By enabling continuous, real-world monitoring and integrating multimodal data, including comprehensive physiological and behavioral signals, patient-reported outcomes, these tools offer unprecedented opportunities for personalization, decentralized and pragmatic clinical trial designs, and enable early detection and intervention. We examine the evolution of wearable sensors, the role of artificial intelligence in translating raw data into clinically actionable insights, and the economic and equity implications of digital-first research. With regulatory momentum growing and real-world evidence gaining traction, the convergence of wearable technology and autonomic science signals not just a methodological shift, but a fundamental redefinition of how, where, and for whom clinical science is conducted.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"264 ","pages":"Article 103377"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous HRV fluctuations are linked to functional changes in resting state brain activation in younger and older adults","authors":"Christian Rominger ,&nbsp;Karl Koschutnig ,&nbsp;Andreas Fink ,&nbsp;Andreas R. Schwerdtfeger","doi":"10.1016/j.autneu.2026.103389","DOIUrl":"10.1016/j.autneu.2026.103389","url":null,"abstract":"<div><div>The vagus nerve connects the brain and the heart, allowing communication between the body and the mind. Studies have strengthened the meaning of the brain to control heart rate variability (HRV), however, brain research has largely overlooked the effects of age on the association between phasic changes in HRV and resting state functional brain connectivity. To close this gap, we studied a large open data set of 69 old and 134 young participants with two consecutive fMRI resting state scans in combination with the corresponding physiological HRV data assessed via photoplethysmography (PPG). We quantified spontaneous HRV changes from one resting state to the other and studied the unique information about the relationship between changes in functional coupling between brain areas and spontaneous HRV changes. Using a fc-MVPA, we identified functional brain coupling patterns associated with changes in HRV within brain networks, including the anterior cingulate cortex (ACC), the cerebellum, the brainstem, and the temporal lobe. These patterns were not significantly different between the two age groups – indicating age invariance of brain heart communication. Post hoc seed-to-voxel analyses indicated a stronger functional coupling of these identified clusters with brain regions such as the insula, the opercular cortex, the superior frontal gyrus, and the cerebellum when HRV increased. This pattern of findings is in accordance with prominent theories and provides further insights into the neural mechanisms underlying brain-heart communication.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"264 ","pages":"Article 103389"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of FIB-4 with orthostatic hypotension in Parkinson's disease","authors":"Wen Zhou ,&nbsp;Tianfang Zeng ,&nbsp;Duan Liu ,&nbsp;Ruijuan Pang ,&nbsp;Liang Gong","doi":"10.1016/j.autneu.2026.103390","DOIUrl":"10.1016/j.autneu.2026.103390","url":null,"abstract":"<div><h3>Background</h3><div>Orthostatic hypotension (OH) is a common complication in Parkinson's disease (PD) patients, significantly impacting their quality of life. Recent evidence suggests a potential link between liver fibrosis, indicated by the Fibrosis-4 (FIB-4) index, and autonomic dysfunction. However, its relationship with OH in PD remains unexplored.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis was conducted using data from 1268 PD patients. The FIB-4 index was calculated based on age, AST, ALT, and platelet count. The association between FIB-4 and OH was assessed using multivariate logistic regression, with further curve fitting and subgroup analyses to test robustness.</div></div><div><h3>Results</h3><div>The FIB-4 index was significantly associated with OH. For each 0.2-unit increase in FIB-4, the odds ratio (OR) for OH was 1.11 (95% CI: 1.05–1.17, <em>p</em> &lt; 0.001). Tertile analysis showed ORs of 2.05 (95% CI: 1.27–3.31, <em>p</em> = 0.003) for T2 and 2.61 (95% CI: 1.64–4.17, <em>p</em> &lt; 0.001) for T3, compared to T1. Curve fitting indicated a linear relationship, with no evidence of non-linearity. Sensitivity and subgroup analyses confirmed robustness.</div></div><div><h3>Conclusions</h3><div>Higher FIB-4 index values are independently associated with an increased risk of OH in PD patients, suggesting that liver fibrosis may contribute to OH development. Further longitudinal studies are needed to explore the underlying mechanisms.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"264 ","pages":"Article 103390"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of immediate sacral neuromodulation on bladder in rats with spinal cord hemisection-induced neurogenic bladder","authors":"Zikai Li ,&nbsp;Qinghua Zhu ,&nbsp;Yanping Zhang ,&nbsp;Wen Zhu ,&nbsp;Lei Lv ,&nbsp;Yan Zhang ,&nbsp;Chuanyu Wang ,&nbsp;Yongkun Zeng ,&nbsp;Shuo Xu ,&nbsp;Jianguo Wen ,&nbsp;Qingwei Wang","doi":"10.1016/j.autneu.2026.103391","DOIUrl":"10.1016/j.autneu.2026.103391","url":null,"abstract":"<div><h3>Objectives</h3><div>To establish a novel spinal cord hemisection-induced neurogenic bladder (SCHNB) rat model combined with sacral neuromodulation (SNM) and evaluate the immediate effects of SNM on bladder function and morphology in SCHNB.</div></div><div><h3>Materials and methods</h3><div>Female Sprague-Dawley rats were randomly assigned to three groups: control, SCHNB, and SCHNB + SNM groups. Rats in control group underwent only T9–T10 laminectomy, SCHNB group received right T9–T10 spinal cord hemisection and electrode implantation without electrical stimulation, SCHNB + SNM group underwent the same procedure as SCHNB group but also received daily 3-hours SNM beginning on postoperative day 1 for 3 weeks. All rats subsequently underwent motor function assessment, bladder ultrasonography and cystography, cystometric testing, and histological analysis of spinal cord and bladder tissues.</div></div><div><h3>Results</h3><div>Ultrasonography revealed significantly increased post void residual in SCHNB group compared to control and SCHNB + SNM groups. Bladder weight in SCHNB group was significantly higher than in control and SCHNB + SNM groups. Cystometric analysis showed a shorter voiding contraction interval in SCHNB + SNM group than control group but longer than SCHNB group. During bladder filling, SCHNB group exhibited multiple uninhibited detrusor contractions, SCHNB + SNM group showed fewer uninhibited contractions and a lower maximum pressure. Histological examination revealed that compared to control and SCHNB + SNM groups, SCHNB group displayed disorganized bladder mucosal epithelium, disrupted and loosened lamina propria, tissue edema, and increased fibrosis.</div></div><div><h3>Conclusions</h3><div>This model of SCHNB combined with SNM provides a new experimental platform for SNM research. Immediate SNM effectively inhibited bladder overactivity and partially improved functional and structural abnormalities of the bladder.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"264 ","pages":"Article 103391"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable ANS monitoring in real life: A critical review of context-sensitive interpretation and implications for psychophysiology","authors":"Greg J. Norman ,&nbsp;Eric Morgan ,&nbsp;Sabina Raja ,&nbsp;Gary G. Berntson","doi":"10.1016/j.autneu.2025.103364","DOIUrl":"10.1016/j.autneu.2025.103364","url":null,"abstract":"<div><div>Wearable autonomic sensors are rapidly expanding the reach of psychophysiological research into real-world environments. These tools hold clear promise for advancing our understanding of how autonomic nervous system (ANS) function relates to emotion, stress, health, and disease. However, interpreting wearable ANS signals outside the laboratory presents unique conceptual and methodological challenges. In this critical review, we outline the theoretical foundations of ANS flexibility and context-sensitivity, summarize the technical capabilities and limitations of current wearable ANS devices, and highlight the critical role of contextual information—ranging from behavioral state to social environment—in shaping the meaning of ambulatory physiological data. We emphasize that ANS signals cannot be meaningfully interpreted in isolation and that understanding their relevance for health and behavior depends on careful consideration of both physiological and situational context. Finally, we discuss key challenges and future directions for wearable ANS monitoring, including improving signal quality, advancing data interpretation through context-aware modeling, and addressing privacy and ethical concerns. Together, these efforts are essential for realizing the potential of wearable ANS sensors to support both scientific discovery and clinical application.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"263 ","pages":"Article 103364"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant tempol reverses autonomic dysregulation and neurogenic hypertension in acid-sensing ion channel 2 deficient mice","authors":"Rasna Sabharwal ,&nbsp;Francois M. Abboud ,&nbsp;Mark W. Chapleau","doi":"10.1016/j.autneu.2025.103376","DOIUrl":"10.1016/j.autneu.2025.103376","url":null,"abstract":"<div><div>Acid-Sensing Ion Channel 2 (ASIC2) has been implicated in mechanosensation. We reported previously that ASIC2 is highly expressed in aortic baroreceptor neurons and contributes to baroreceptor mechanotransduction; and that ASIC2 deficient mice exhibit decreased baroreflex sensitivity (BRS), sympathovagal imbalance and neurogenic hypertension. Oxidative stress is widely considered an important contributor to hypertension. The major goal of this study was to determine if treatment of ASIC2^−/− mice with the antioxidant tempol attenuates baroreflex/autonomic dysfunction and hypertension. Blood pressure (BP), heart rate (HR) and locomotor activity were measured by telemetry in conscious, control C57BL/6 and ASIC2^−/− male mice, before and after administration of tempol in drinking water (1 mM) for two weeks. Cardiac sympathetic tone, mean arterial BP and BP variability were higher, and cardiac vagal tone and BRS were lower in ASIC2^−/− mice, compared with controls (<em>P</em> &lt; 0.05). Oxidative stress measured by mRNA expression of NADPH oxidase subunits (Nox2, Nox4, p22phox) and dihydroethidium (DHE) fluorescence was increased significantly (<em>P</em> &lt; 0.05) in ASIC2^−/− mice in a tissue-specific manner (sympathetic and nodose ganglia &gt; &gt; brain stem &gt; &gt; skeletal muscle, with no change in aorta). Treatment with tempol strongly attenuated DHE fluorescence and restored autonomic regulation and BP to control levels in ASIC2^−/− mice, while not affecting these phenotypes in control mice. We conclude: (1) oxidative stress in ASIC2^−/− mice is prominent in the autonomic nervous system but not present in aorta; and (2) the antioxidant tempol reverses decreased BRS, sympathovagal imbalance and hypertension in ASIC2^−/− mice; effects that are associated with decreased oxidative stress.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"263 ","pages":"Article 103376"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in muscle sympathetic nerve activity between patients with orthostatic hypertension and those with orthostatic normotensive hypertension","authors":"Tadayuki Hirai ,&nbsp;Hisayoshi Murai ,&nbsp;Hiroyuki Sugimoto ,&nbsp;Yusuke Mukai ,&nbsp;Hideki Tokuhisa ,&nbsp;Tatsunori Ikeda ,&nbsp;Daisuke Kobayashi ,&nbsp;Shigeo Takata ,&nbsp;Kenji Sakata ,&nbsp;Soichiro Usui ,&nbsp;Masayuki Takamura","doi":"10.1016/j.autneu.2025.103366","DOIUrl":"10.1016/j.autneu.2025.103366","url":null,"abstract":"<div><div>Orthostatic hypertension (OrthoHT), an excessive pressor response to standing, increases cardiovascular risk; however, its relationship with sympathetic nerve activity is poorly understood. This study aimed to assess differences in muscle sympathetic nerve activity (MSNA) between patients with OrthoHT and those with orthostatic normotensive hypertension. We measured resting MSNA in seven patients with OrthoHT and 11 matched controls. The OrthoHT group exhibited significantly elevated MSNA burst frequency (38.4 ± 12.2 vs. 28.3 ± 5.7 bursts/min, <em>P</em> &lt; 0.05) and burst incidence (61.1 ± 21.3 vs. 44.6 ± 11.1 bursts/100 heartbeats, P &lt; 0.05). In conclusion, OrthoHT is strongly associated with sympathetic hyperactivity at rest, suggesting that this may be a key physiological mechanism contributing to the increased cardiovascular risk observed in these patients.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"263 ","pages":"Article 103366"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The orthostatic tolerance of service personnel of the Household Division of the British Army","authors":"Iain Parsons ,&nbsp;Michael Stacey ,&nbsp;Nick Gall ,&nbsp;David Woods","doi":"10.1016/j.autneu.2025.103374","DOIUrl":"10.1016/j.autneu.2025.103374","url":null,"abstract":"<div><div>Reflex syncope is common among UK Armed Forces (UKAF) personnel in the Household Division, particularly during ceremonial duties involving prolonged orthostatic stress. This study aimed to (1) assess orthostatic tolerance (OT) using head-up tilt combined with lower body negative pressure (HUT/LBNP), (2) evaluate the retrospective diagnostic accuracy of HUT/LBNP based on syncope trigger, and (3) examine test repeatability. Seventy-three service personnel were categorized into ORTHOSTATIC (27 %), NON-ORTHOSTATIC (16 %), or CONTROL (56 %) groups based on prior syncopal history. OT was measured to presyncope using a standardized HUT/LBNP protocol with continuous cardiovascular monitoring. Repeatability was assessed in a subset of 17 participants one week apart. Mean OT across participants was 32 ± 12 min. The ability of HUT/LBNP-derived OT to identify prior reflex syncope yielded an AUC of 0.75 (<em>p</em> = 0.0003), improving to 0.85 (<em>p</em> &lt; 0.0001) in the ORTHOSTATIC group but was non-significant in NON-ORTHOSTATIC participants (<em>p</em> = 0.44). HUT/LBNP demonstrated high repeatability (bias: 1.1 ± 4.2 min; 3 ± 11 %). UKAF personnel with orthostatic-mediated syncope had significantly lower OT compared to both non-fainters and those with non-orthostatic syncope. HUT/LBNP is a reproducible tool that can discriminate between syncope subtypes and may be useful in monitoring intervention efficacy and guiding management in high-risk occupational settings.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"263 ","pages":"Article 103374"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}