Autonomic Neuroscience-Basic & Clinical最新文献

{"title":"Interoception in Parkinson's disease: A narrative review and framework for translational research","authors":"Katherine Longardner ,&nbsp;Senegal Alfred Mabry ,&nbsp;Gloria Chen ,&nbsp;Roy Freeman ,&nbsp;Sahib S. Khalsa ,&nbsp;Paul Beach","doi":"10.1016/j.autneu.2025.103258","DOIUrl":"10.1016/j.autneu.2025.103258","url":null,"abstract":"<div><div>Parkinson's disease (PD) is the second most common, and the fastest growing, neurodegenerative disease worldwide. Non-motor manifestations, particularly autonomic nervous system dysfunction, are common throughout the disease course, in some cases preceding motor symptom onset by years, and are often more disabling and harder to treat than motor symptoms and contribute significantly to disability. An understudied consequence of autonomic and visceral dysfunction in PD is <em>interoception</em>, the neural processing of internal organ system signals. Interoceptive processes form a foundational body-brain interface, mediating basic homeostatic reflexes and complex physiologic and behavioral adaptive responses to internal perturbations. Emerging evidence exists that interoception is impaired in some individuals with PD, potentially explaining why those who have objective evidence of autonomic dysfunction do not always report typical symptoms. Failure to recognize these impairments may lead to missed opportunities for early intervention, particularly in addressing ‘silent’ autonomic disturbances (e.g., orthostatic hypotension leading to sudden falls, dysphagia leading to aspiration pneumonia). In this narrative review, we synthesize current findings on the neuroanatomical networks underlying interoception, examine clinical manifestations of interoceptive dysfunction across multiple organ systems in PD, and identify key gaps in knowledge. We propose a translational research framework to enhance early detection, symptom management, and intervention strategies for PD. This framework integrates cognitive, mood, and autonomic dysfunctions with clinical factors (disease stage, duration, motor subtype, levodopa status) to understand interoceptive dysfunction within a translational model. This approach highlights novel opportunities for personalized care and improved therapeutic interventions in PD.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103258"},"PeriodicalIF":3.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-mediated modulation of autonomic nervous system and inflammatory response in sleep-deprived individuals: A narrative reviews of implications for cardiovascular health","authors":"Riki Edo Saputro ,&nbsp;Chun-Chung Chou ,&nbsp;Yi-Yuan Lin ,&nbsp;Takashi Tarumi ,&nbsp;Yi-Hung Liao","doi":"10.1016/j.autneu.2025.103256","DOIUrl":"10.1016/j.autneu.2025.103256","url":null,"abstract":"<div><div>Sleep deprivation is a growing concern in cardiovascular risk, causing physiological disruptions like autonomic dysregulation and inflammation. Recent research indicates that sleep deprivation increases sympathetic nervous activity while decreasing parasympathetic activity, leading to increased blood pressure, impaired endothelial function, and heightened inflammation. Exercise has emerged as a non-pharmacological approach to increase cardiovascular health. However, the impact of exercise on sleep deprivation-induced changes in autonomic activity and inflammation remains unclear. To explore this, we reviewed studies investigating the effects of acute exercise on autonomic regulation and inflammatory markers following sleep deprivation. We conducted a narrative review of the literature. PubMed/MEDLINE, Google Scholar, and Web of Science (WOS) searched the articles between May 2022 and April 2023. The papers had to: [1] focus on recent studies between 2000 and 2023; [2] consist of sleep deprivation participants; [3] be published in English. Acute moderate- to high-intensity exercise after sleep deprivation may reduce parasympathetic activity, trigger pro-inflammatory cytokines, and delay recovery to normal levels. In contrast, regular exercise routines may mitigate the adverse effects of sleep deprivation on autonomic regulation and reduce systemic inflammation. Sleep deprivation can lead to autonomic imbalance, increased blood pressure, and increased inflammatory responses, which are further amplified by acute exercise, increasing the cardiovascular burden. When sleep deprivation occurs, exercise intensity and timing should be carefully chosen to avoid adverse cardiovascular health risks.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103256"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic reactivity to emotional stress in women with major depressive disorder","authors":"Aaron S. Autler ,&nbsp;Ashley M. Darling ,&nbsp;Rachel J. Skow ,&nbsp;Benjamin E. Young ,&nbsp;Paul J. Fadel ,&nbsp;Erika F.H. Saunders ,&nbsp;Jody L. Greaney","doi":"10.1016/j.autneu.2025.103257","DOIUrl":"10.1016/j.autneu.2025.103257","url":null,"abstract":"<div><div>Young women, who suffer from major depressive disorder (MDD) at twice the rate as young men, are particularly vulnerable to cardiovascular events triggered by emotional stress, an association that may be partially explained by excessive sympathetic activation. However, no studies have directly measured sympathetic activity during acute emotional stress in young women with MDD. We hypothesized that the muscle sympathetic nerve activity (MSNA) response to acute emotional stress would be greater in young women with MDD (18–30 yrs) compared to healthy non-depressed young women. MSNA (peroneal microneurography) and beat-to-beat blood pressure (BP; finger photoplethysmography) were measured at rest and during acute emotional stress evoked by viewing negative images selected from the International Affective Picture System in 17 healthy young women and in 30 young women with MDD of mild-to-moderate severity (unmedicated). There were no group differences in either the peak increase in MSNA (Δ0.1 ± 2.9 healthy vs. Δ2.0 ± 4.9 bursts/min MDD; <em>p</em> = 0.45) or the peak increase in mean arterial pressure (Δ0.6 ± 3.5 healthy vs. Δ1.4 ± 2.1 mmHg MDD; <em>p</em> = 0.67) in response to viewing negative images. However, in young women with MDD, MSNA reactivity to viewing negative images was positively related to current depressive symptom severity (<em>r</em> = 0.49; <em>p</em> = 0.04). Although these data indicate only minor MSNA responses to viewing negative images, they also highlight that sympathetic-cardiovascular reactivity to an acute, passive emotional stress stimulus is not exaggerated in young women with MDD. However, more severe current depressive symptoms may amplify emotional stress-induced sympathetic activation, thereby increasing cardiovascular risk.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103257"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of isometric handgrip and post-exercise circulatory occlusion on muscle sympathetic nerve activity: A systematic review and meta-analysis","authors":"Lauren E. Maier ,&nbsp;Sarah E. Meyer ,&nbsp;Andy Deprato ,&nbsp;Stephen Busch ,&nbsp;Allison Sivak ,&nbsp;Margie H. Davenport ,&nbsp;Craig D. Steinback","doi":"10.1016/j.autneu.2025.103251","DOIUrl":"10.1016/j.autneu.2025.103251","url":null,"abstract":"<div><div>This systematic review and meta-analysis was conducted to identify a ‘normative’ sympathetic response to isometric handgrip and post-exercise circulatory occlusion. Structured searches of databases were performed until June 2024. We included all primary studies (other than systematic reviews and meta-analyses), and inclusion criteria were: population (all populations); intervention (isometric handgrip and post-exercise circulatory occlusion); comparator (baseline); and outcome (MSNA). One-hundred fifty-eight studies (n = 3551) were included. Burst frequency was elevated during handgrip (n = 1853; MD, 12.19bursts/min; 95 % CI, 11.09, 13.28; I² = 94 %; p &lt; 0.00001) and during PECO (n = 948; MD, 11.42bursts/min; 95 % CI, 10.10, 12.75; I² = 65 %; p &lt; 0.00001). A similar pattern was observed for burst incidence in handgrip (n = 1074; MD, 8.50bursts/100 hbs; 95 % CI, 7.07, 9.93; I2 = 39 %; p &lt; 0.00001) and PECO (n = 560; MD, 14.87bursts/100 hbs; 95 % CI, 12.65, 17.10; I2 = 43 %; p &lt; 0.00001). Subgroup analyses indicated a larger response in burst frequency and incidence during handgrip exercise in healthy individuals compared to individuals with cardiovascular diseases or other conditions (p &lt; 0.05). A similar response in burst frequency to PECO was observed with subgroup differences between healthy individuals and individuals with cardiovascular diseases and other conditions (p &lt; 0.00001). MSNA is elevated during handgrip exercise across a range of handgrip protocols, populations, and co-interventions. Increases in MSNA during PECO supports the role of the metaboreflex separate to the exercise pressor reflex. A blunted sympathetic response to handgrip and PECO in individuals with cardiovascular diseases contradicts the current understanding of general sympathetic hyperactivity in these populations.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"259 ","pages":"Article 103251"},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes and prognostic significance of autonomic cardiac regulation during ageing","authors":"Elisa Karhumaa,&nbsp;Antti Vuoti,&nbsp;Antti M. Kiviniemi,&nbsp;M. Juhani Junttila,&nbsp;Mikko P. Tulppo,&nbsp;Heikki V. Huikuri,&nbsp;Olavi H. Ukkola,&nbsp;Juha S. Perkiömäki","doi":"10.1016/j.autneu.2025.103255","DOIUrl":"10.1016/j.autneu.2025.103255","url":null,"abstract":"<div><h3>Background</h3><div>Data on the changes of heart rate variability (HRV) and their prognostic significance during ageing are limited.</div></div><div><h3>Methods</h3><div>HRV analyzes were done from standardized 45-min ECG recordings, which consisted of 15 min recordings in lying down, sitting positions and during walking. We used time domain-, frequency domain- and non-linear methods to estimate HRV. The baseline ECG recordings were done in 1991–1993 (<em>n</em> = 783) and follow up recordings were done in 2013–2014 (<em>n</em> = 466). Endpoints were reviewed in 2021.</div></div><div><h3>Results</h3><div>During a mean follow-up of 22.1 ± 0.7 years, high-, low- and very-low-frequency powers (HF, LF, VLF), standard deviation of RR intervals (SDNN), the short-term fractal-like scaling exponent analyzed by the detrended fluctuation analysis (DFA1) and approximate entropy (ApEn) decreased statistically significantly (<em>p</em>-values from &lt;0.05 to &lt;0.001). Larger decrease of VLF(ln) and LF(ln) predicted total and cardiovascular (CV) mortality in the multivariate model (<em>p</em>-values from &lt;0.05 to &lt;0.001). Baseline natural logarithm of LF (LF(ln)) dichotomized and DFA1 had the strongest prognostic value on total and CV-mortality in multivariate analysis after adjustments with relevant clinical characteristics. Also, lower values of baseline ApEn retained their predictive power for total mortality and decreased ratio of LF to HF (LF/HF) for CV-mortality after adjustments.</div></div><div><h3>Conclusions</h3><div>Almost all the HRV parameters decreased during ageing. Larger decrease of VLF(ln) and LF(ln) predicted total and CV-mortality after adjustments indicating that larger attenuation in cardiac autonomic regulation during ageing yields prognostic information. Of the baseline HRV parameters LF(ln) dichotomized and DFA1 had the strongest prognostic value on total and CV-mortality.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"258 ","pages":"Article 103255"},"PeriodicalIF":3.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monotherapy with tolterodine or mirabegron is insufficient for ameliorating cyclophosphamide-induced bladder overactivity in rats","authors":"Håvard Fjelltveit ,&nbsp;Thomas Carlsson ,&nbsp;Fernando Perez ,&nbsp;Ozgu Aydogdu ,&nbsp;Bhavik Patel ,&nbsp;Michael Winder","doi":"10.1016/j.autneu.2025.103253","DOIUrl":"10.1016/j.autneu.2025.103253","url":null,"abstract":"<div><div>Monotherapy continues to be the most common pharmacological treatment option for patients with overactive bladder (OAB), despite evidence indicating that it may have inferior efficacy compared to combination therapy. This seems to be especially true for patients with concomitant cystitis. The current study examined the effects of monotherapy with either the antimuscarinic tolterodine or the β3 agonist mirabegron on bladder overactivity induced by bladder inflammation. Further, the possible involvement of nitric oxide (NO) was studied. For this purpose, rats were pretreated with either drug for 10 days. Bladder inflammation was induced by intraperitoneal injection with cyclophosphamide, with saline serving as control. Micturition parameters were assessed in a metabolic cage. Meanwhile, urine samples were collected and further analysed for NO content. After 16 h, the animals were euthanized, and their bladders were excised and examined immunohistochemically for signs of inflammation. Cyclophosphamide treatment led to bladder overactivity and obvious signs of inflammation. Neither treatment with tolterodine nor mirabegron could significantly alleviate the induced overactivity or the observed inflammation. Further, while induction of inflammation led to a significant increase in NO production, neither drug seemed to act by further enhancing its production. On the contrary, treatment with either tolterodine or mirabegron significantly decreased NO production in cyclophosphamide treated rats. Considering previous findings showing significant improvement by combination therapy, the current study indirectly implies this as the superior treatment option. Further studies are needed to verify the involvement, or lack thereof, of NO in the mechanism of action of drugs used to treat OAB.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"258 ","pages":"Article 103253"},"PeriodicalIF":3.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertonic saline solution evokes cardiovascular recovery in hemorrhagic rats dependent on GABA A and β-adrenergic transmission in the subfornical organ","authors":"Amanda Barbosa Coelho da Silva ,&nbsp;Stefanne Madalena Marques ,&nbsp;James O. Fajemiroye ,&nbsp;Eduardo Colombari ,&nbsp;Carlos Henrique Xavier ,&nbsp;Marcos Luiz Ferreira-Neto ,&nbsp;Lara Marques Naves ,&nbsp;Gustavo Rodrigues Pedrino","doi":"10.1016/j.autneu.2025.103252","DOIUrl":"10.1016/j.autneu.2025.103252","url":null,"abstract":"<div><h3>Background</h3><div>Studies have reported the use of a hypertonic saline solution (HSS) for the treatment of hypotensive hemorrhage (HH). Despite the established role of central mechanisms in the cardiovascular recovery induced by HSS during HH, the involvement of the Subfornical Organ (SFO) in these responses remains to be elucidated. The present study evaluated the role of SFO and adrenergic neurotransmission in the nucleus in the cardiovascular responses to HSS infusion in hemorrhagic rats.</div></div><div><h3>Methods</h3><div>Mean arterial pressure (MAP), heart rate (HR), and aortic vascular resistance (AVR) were recorded in Wistar rats. HH was performed through blood withdrawal until a MAP of 60 mmHg was attained. Nanoinjections of saline (NaCl; 0.15 M; control group; <em>n</em> = 7), muscimol (4 mM; GABAergic agonist; muscimol group; <em>n</em> = 7), or propranolol (10 mM; non-selective β-adrenergic blocker; propranolol group; n = 7) in SFO were performed 10 min after the onset of blood withdrawal, followed by HSS infusion (NaCl; 3 M; 1.8 ml∙kg⁻¹) 20 min after the beginning of HH.</div></div><div><h3>Results</h3><div>Hypotension, bradycardia, and aortic vasoconstriction were observed in all groups During HH. Sodium overload reestablished MAP and HR while maintaining aortic vasoconstriction in the control group. Activation of GABA A receptors or β-adrenergic receptor blockade in the SFO prevents HSS-induced recovery of MAP and HR. In addition, maintenance of aortic vasoconstriction induced by HSS infusion was abolished by SFO inhibition.</div></div><div><h3>Conclusions</h3><div>The results suggest that the integrity of SFO neurons and β-adrenergic neurotransmission are essential for cardiovascular recovery promoted by sodium overload in hemorrhagic rats.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"258 ","pages":"Article 103252"},"PeriodicalIF":3.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Vagal Nerve Activity During Exercise: New insights and future directions","authors":"Julia Shanks,&nbsp;Rohit Ramchandra","doi":"10.1016/j.autneu.2025.103254","DOIUrl":"10.1016/j.autneu.2025.103254","url":null,"abstract":"<div><div>A new paradigm is emerging in which cardiac vagal nerve activity is maintained and increases during exercise. This paradigm challenges decades of studies that have quoted a withdrawal of cardiac vagal activity during exercise. Here, we outline the existing evidence for increased cardiac vagal activity. We also explain why previous indirect methods used to measure vagal activity might have indirectly led to incorrect conclusions about the role of the cardiac vagus during exercise. We will review evidence that vagal control of the sinoatrial node and the ventricles differs and how vagal neurotransmitters other than acetylcholine may regulate cardiac function during exercise. We will also suggest future directions for research to uncover how the cardiac vagus influences cardiac function and the mechanisms behind the increase in cardiac vagal nerve activity during exercise.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"258 ","pages":"Article 103254"},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-individual variability in muscle sympathetic nerve activity at rest and during exercise: Disconnection with blood pressure","authors":"André L. Teixeira,&nbsp;Philip J. Millar","doi":"10.1016/j.autneu.2025.103250","DOIUrl":"10.1016/j.autneu.2025.103250","url":null,"abstract":"<div><div>Microneurographic recordings of muscle sympathetic nerve activity (MSNA) have provided fundamental insight into sympathetic discharge patterns at rest and during exercise in health and disease. A key feature of MSNA recordings at rest is a large inter-individual variability, even among healthy adults. The physiological consequences of inter-individual variability in MSNA are commonly discussed as being associated with the regulation of resting blood pressure. However, available evidence from large cross-sectional analyses demonstrate a near absence of an association between resting MSNA and blood pressure. Less appreciated, MSNA also exhibits inter-individual variability in response to stress, such as exercise. Again, the consequences of variability in MSNA are unclear and can be dissociated from the blood pressure response, particularly at low-to-moderate intensity muscle contractions for short durations (≤2 min). In this brief review, we summarize several examples of how inter-individual variability in MSNA is unrelated to blood pressure control at rest and during exercise and discuss potential mechanisms responsible for this observation, and key methodological considerations for future study design and interpretation. Additionally, we highlight several unanswered questions that could pave the way for future investigations in the field.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"258 ","pages":"Article 103250"},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional knock out of Acid Sensing Ion Channel 3 prevents the exaggerated exercise pressor reflex in rats exercising on a treadmill","authors":"Gail D. Thomas ,&nbsp;Shannon P. Higgins ,&nbsp;Matthew J. Kuczmarski ,&nbsp;Guillaume P. Ducrocq ,&nbsp;Laura Anselmi ,&nbsp;Victor Ruiz-Velasco ,&nbsp;Marc P. Kaufman","doi":"10.1016/j.autneu.2025.103249","DOIUrl":"10.1016/j.autneu.2025.103249","url":null,"abstract":"<div><div>We have compared the cardiovascular responses to treadmill exercise between wild-type (WT) Wistar Kyoto rats with their ASIC3 knock out (KO) counterparts both before and after their femoral arteries were bilaterally ligated. The rats were instrumented with radiotelemetry devices to measure arterial blood pressure and ran at a treadmill speed of 15–20 m/min. We found no difference in the pressor and cardioaccelerator responses to exercise between the WT and the ASIC3 KO rats when their femoral arteries were freely perfused. In contrast, the WT rats, but not the ASIC3 KO rats, displayed significantly larger peak and integrated pressor responses to treadmill exercise after both femoral arteries were ligated for 3 days. We also examined the effect of bilaterally injecting APETx2 into the substance of the gastrocnemius muscles on the cardiovascular responses to treadmill exercise in both the WT and the ASIC3 KO rats. We found that APETx2, an ASIC3 antagonist, attenuated the integrated pressor responses to exercise in the WT rats, after but not before the femoral arteries were ligated. Injection of APETx2 into the gastrocnemius muscles had no effect on the responses to exercise in the ASIC3 KO rats regardless of whether their femoral arteries were freely perfused or ligated. Our findings in conscious rats exercising on a treadmill extend our previous findings in reduced preparations in which we reported that ASIC3 “receptors” presumably on the intramuscular endings of group IV afferents play an important role in evoking the exaggerated component of the exercise pressor reflex induced by ischemia.</div></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"258 ","pages":"Article 103249"},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}