健康和疾病中的肾脏截流。

IF 3.2 4区 医学 Q2 NEUROSCIENCES
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引用次数: 0

摘要

最近,美国食品及药物管理局(FDA)批准了基于导管的肾神经支配治疗高血压。传统上,肾神经支配的抗高血压作用归因于消融传出的交感神经。近年来,传入感觉性肾神经在血压调节中的作用受到越来越多的关注。此外,肾传入神经去神经化与交感神经系统活动减少有关。这表明,肾脏以外器官交感神经驱动力的降低可能是导管肾脏去神经化临床试验中观察到的非肾脏有益效应的原因。在这篇综述中,我们将概述肾传入神经在肾功能调节以及肾脏和非肾脏病理生理发展中的作用。我们还将介绍肾传入神经的中枢投射,以说明消融和激活肾传入神经后的反应。最后,我们将讨论肾脏作为感知器官的新作用。我们将描述肾脏在调节相互感知敏感性方面的潜在作用,并在此背景下推测肾功能改变可能带来的病理后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Renal interoception in health and disease

Catheter based renal denervation has recently been FDA approved for the treatment of hypertension. Traditionally, the anti-hypertensive effects of renal denervation have been attributed to the ablation of the efferent sympathetic renal nerves. In recent years the role of the afferent sensory renal nerves in the regulation of blood pressure has received increased attention. In addition, afferent renal denervation is associated with reductions in sympathetic nervous system activity. This suggests that reductions in sympathetic drive to organs other than the kidney may contribute to the non-renal beneficial effects observed in clinical trials of catheter based renal denervation. In this review we will provide an overview of the role of the afferent renal nerves in the regulation of renal function and the development of pathophysiologies, both renal and non-renal. We will also describe the central projections of the afferent renal nerves, to give context to the responses seen following their ablation and activation. Finally, we will discuss the emerging role of the kidney as an interoceptive organ. We will describe the potential role of the kidney in the regulation of interoceptive sensitivity and in this context, speculate on the possible pathological consequences of altered renal function.

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来源期刊
CiteScore
5.80
自引率
7.40%
发文量
83
审稿时长
66 days
期刊介绍: This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.
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