IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025865

Yu-Han Ji, Yong Liang, Ziyi Yang, Ning Ai

引用次数: 0

PSTCNN: Explainable COVID-19 diagnosis using PSO-guided self-tuning CNN. PSTCNN：使用 PSO 引导的自调整 CNN 进行可解释的 COVID-19 诊断。

IF 0.8 4区生物学

Biocell Pub Date : 2023-01-01 Epub Date: 2022-11-18 DOI: 10.32604/biocell.2021.0xxx

Wei Wang, Yanrong Pei, Shui-Hua Wang, Juan Manuel Gorrz, Yu-Dong Zhang

{"title":"PSTCNN: Explainable COVID-19 diagnosis using PSO-guided self-tuning CNN.","authors":"Wei Wang, Yanrong Pei, Shui-Hua Wang, Juan Manuel Gorrz, Yu-Dong Zhang","doi":"10.32604/biocell.2021.0xxx","DOIUrl":"10.32604/biocell.2021.0xxx","url":null,"abstract":"Since 2019, the coronavirus disease-19 (COVID-19) has been spreading rapidly worldwide, posing an unignorable threat to the global economy and human health. It is a disease caused by severe acute respiratory syndrome coronavirus 2, a single-stranded RNA virus of the genus Betacoronavirus. This virus is highly infectious and relies on its angiotensin-converting enzyme 2-receptor to enter cells. With the increase in the number of confirmed COVID-19 diagnoses, the difficulty of diagnosis due to the lack of global healthcare resources becomes increasingly apparent. Deep learning-based computer-aided diagnosis models with high generalisability can effectively alleviate this pressure. Hyperparameter tuning is essential in training such models and significantly impacts their final performance and training speed. However, traditional hyperparameter tuning methods are usually time-consuming and unstable. To solve this issue, we introduce Particle Swarm Optimisation to build a PSO-guided Self-Tuning Convolution Neural Network (PSTCNN), allowing the model to tune hyperparameters automatically. Therefore, the proposed approach can reduce human involvement. Also, the optimisation algorithm can select the combination of hyperparameters in a targeted manner, thus stably achieving a solution closer to the global optimum. Experimentally, the PSTCNN can obtain quite excellent results, with a sensitivity of 93.65%±1.86%, a specificity of 94.32%±2.07%, a precision of 94.30%±2.04%, an accuracy of 93.99%±1.78%, an F1-score of 93.97%±1.78%, Matthews Correlation Coefficient of 87.99%±3.56%, and Fowlkes-Mallows Index of 93.97%±1.78%. Our experiments demonstrate that compared to traditional methods, hyperparameter tuning of the model using an optimisation algorithm is faster and more effective.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"47 2","pages":"373-384"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613982/pdf/EMS158588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10517202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.: A review 余甘子代谢物的植物化学及民族药性质研究进展

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.022065

Vijay Kumar, Praveen C. Ramamurthy, Simranjeet Singh, Daljeet Singh Dhanjal, Parul Parihar, D. Bhatia, R. Prasad, Joginder Singh

引用次数: 1

A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs) 一种新的ROR2突变导致ROR2功能丧失并抑制骨髓间充质干细胞(BMSCs)的成骨分化能力。

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028851

Wen-Qi Chen, Xiao Chu, Yang Zeng, Yousheng Yan, Yipeng Wang, Donglan Sun, Dong-Liang Zhang, Jing Zhang, Kai Yang

引用次数: 0

The correlation of miRNA expression and tumor mutational burden in uterine corpus endometrial carcinoma 子宫内膜癌中miRNA表达与肿瘤突变负荷的相关性研究

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027346

Yanya Chen, Hongyuan Wu, Ruisi Zhou, Heling Dong, Xuefang Zhang, Xuewei Wu, Wenshan Chen, Yanting You, Yifen Wu

引用次数: 0

SPP1 and the risk score model to improve the survival prediction of patients with hepatocellular carcinoma based on multiple algorithms and back propagation neural networks SPP1和基于多算法和反向传播神经网络的风险评分模型提高肝癌患者的生存预测

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025957

Wenli Zeng, Feng Ling, Kainuo Dang, Qing-xia Chi

引用次数: 0

HOXB8 contributed to oxaliplatin chemo-resistance in colon cancer cells by activating STAT3 HOXB8通过激活STAT3参与结肠癌细胞对奥沙利铂的耐药

4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030147

LIANLI NI, YUN YU, HAN LIN, WEISHAN ZHUGE, LU TAO, YIWEI SHEN, RI CUI, SHAOTANG LI

{"title":"HOXB8 contributed to oxaliplatin chemo-resistance in colon cancer cells by activating STAT3","authors":"LIANLI NI, YUN YU, HAN LIN, WEISHAN ZHUGE, LU TAO, YIWEI SHEN, RI CUI, SHAOTANG LI","doi":"10.32604/biocell.2023.030147","DOIUrl":"https://doi.org/10.32604/biocell.2023.030147","url":null,"abstract":"Background: Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. Methods: The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC cells. The protein and mRNA levels were evaluated by western blot and real-time reverse transcription-polymerase chain reaction. Results: HOXB8 expression was upregulated in OXA-resistant HCT116 cells (HCT116/OXA) compared to its level in the parent HCT116 cells. Knockdown of HOXB8 significantly inhibited CRC cell growth by suppressing the signal transducer and activator of transcription 3 (STAT3) pathway. HOXB8 knockdown also potentiated cytotoxicity of OXA in CRC cells. Inversely, HOXB8 overexpression attenuated OXA-induced growth inhibition of HCT116 cells and RKO cells by activating STAT3 signaling. HOXB8 knockdown effectively inhibited HCT116/OXA cell viability regardless of OXA treatment by suppressing STAT3 signaling. Conclusions: These results shed light on the important functions of HOXB8 in OXA-resistant CRC and suggested that targeting HOXB8 might be an effective therapeutic strategy for select OXA-resistant CRC patients.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible therapeutic role of short-chain fatty acids from skin commensal bacteria in UVB-induced skin carcinogenesis 来自皮肤共生菌的短链脂肪酸在uvb诱导的皮肤癌发生中的可能治疗作用

4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030383

PAVITHRA SUBRAMANI, RAUNAK KUMAR DAS

{"title":"Possible therapeutic role of short-chain fatty acids from skin commensal bacteria in UVB-induced skin carcinogenesis","authors":"PAVITHRA SUBRAMANI, RAUNAK KUMAR DAS","doi":"10.32604/biocell.2023.030383","DOIUrl":"https://doi.org/10.32604/biocell.2023.030383","url":null,"abstract":"Solar ultraviolet B (UVB) radiation is a major skin cancer-causing agent. Initiation, promotion, and progression are the diverse phases of UVB-induced carcinogenesis. Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways: thymine dimer formation, DNA damage, oxidative stress, inflammatory responses, and altered cell signaling, eventually resulting in tumor formation. The increased skin cancer rates urge researchers to develop more efficient drugs, but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues, which have been reported recently. The current review focuses on the relationship between microbes and cancer. Human skin acts as a barrier against the external environment and serves as a protective shield for its inhabitant microbiota, collectively called skin microbes. The gut microbiome plays a vital role in cancer therapy. Production of short-chain fatty acids (SCFAs) such as butyrate, acetate, and propionate by intestinal microbes has anti-cancer properties against various cancer cell lines. Yet, the knowledge of SCFAs produced by skin microbes remains yet to be elucidated exhaustively. In this review, we strive to summarize the findings of studies performed to date regarding the anti-cancer properties of SCFA against various cancer cell lines and provide insight into future directions in the skin microbiome field.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135504584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CPT1A in cancer: Tumorigenic roles and therapeutic implications CPT1A在癌症中的致瘤作用和治疗意义

4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027677

SHENGJIE SONG, ZHIZHOU SHI

引用次数: 0

Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation 长链非编码RNA-ATB通过ZNF217升高抑制miR- 200c，诱导曲妥珠单抗耐药，并加重胃癌进展

4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029860

JIAZHUANG LI, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

引用次数: 0

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