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Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells TBZPy光动力治疗可调节HeLa细胞中PI3K/AKT和内质网应激相关的PERK/eIF2α通路
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028056
Yifan Li, Jing Zhang, Yi-Ming Fan, H. Xiao, Kexin Kang, Yali Zhou, Zhiwen Zhang, Yumin Li, Muzhou Teng
{"title":"Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells","authors":"Yifan Li, Jing Zhang, Yi-Ming Fan, H. Xiao, Kexin Kang, Yali Zhou, Zhiwen Zhang, Yumin Li, Muzhou Teng","doi":"10.32604/biocell.2023.028056","DOIUrl":"https://doi.org/10.32604/biocell.2023.028056","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73176412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs) 一种新的ROR2突变导致ROR2功能丧失并抑制骨髓间充质干细胞(BMSCs)的成骨分化能力。
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028851
Wen-Qi Chen, Xiao Chu, Yang Zeng, Yousheng Yan, Yipeng Wang, Donglan Sun, Dong-Liang Zhang, Jing Zhang, Kai Yang
{"title":"A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs)","authors":"Wen-Qi Chen, Xiao Chu, Yang Zeng, Yousheng Yan, Yipeng Wang, Donglan Sun, Dong-Liang Zhang, Jing Zhang, Kai Yang","doi":"10.32604/biocell.2023.028851","DOIUrl":"https://doi.org/10.32604/biocell.2023.028851","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75444460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The correlation of miRNA expression and tumor mutational burden in uterine corpus endometrial carcinoma 子宫内膜癌中miRNA表达与肿瘤突变负荷的相关性研究
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027346
Yanya Chen, Hongyuan Wu, Ruisi Zhou, Heling Dong, Xuefang Zhang, Xuewei Wu, Wenshan Chen, Yanting You, Yifen Wu
{"title":"The correlation of miRNA expression and tumor mutational burden in uterine corpus endometrial carcinoma","authors":"Yanya Chen, Hongyuan Wu, Ruisi Zhou, Heling Dong, Xuefang Zhang, Xuewei Wu, Wenshan Chen, Yanting You, Yifen Wu","doi":"10.32604/biocell.2023.027346","DOIUrl":"https://doi.org/10.32604/biocell.2023.027346","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75656527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.: A review 余甘子代谢物的植物化学及民族药性质研究进展
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.022065
Vijay Kumar, Praveen C. Ramamurthy, Simranjeet Singh, Daljeet Singh Dhanjal, Parul Parihar, D. Bhatia, R. Prasad, Joginder Singh
{"title":"Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.: A review","authors":"Vijay Kumar, Praveen C. Ramamurthy, Simranjeet Singh, Daljeet Singh Dhanjal, Parul Parihar, D. Bhatia, R. Prasad, Joginder Singh","doi":"10.32604/biocell.2023.022065","DOIUrl":"https://doi.org/10.32604/biocell.2023.022065","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74860181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Characteristics and expression of the TCP transcription factors family in Allium senescens reveal its potential roles in drought stress responses 衰老葱TCP转录因子家族的特征及其表达揭示了其在干旱胁迫响应中的潜在作用
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026930
Xiaohong Fu, Jie Zhao, D. Cao, Chengxing He, Ziyi Wang, Yibei Jiang, Jianfeng Liu, Guixi Liu
{"title":"Characteristics and expression of the TCP transcription factors family in Allium senescens reveal its potential roles in drought stress responses","authors":"Xiaohong Fu, Jie Zhao, D. Cao, Chengxing He, Ziyi Wang, Yibei Jiang, Jianfeng Liu, Guixi Liu","doi":"10.32604/biocell.2023.026930","DOIUrl":"https://doi.org/10.32604/biocell.2023.026930","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88980060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Inhibition of H2O2-induced TM3 cell apoptosis by oxidative stress by lentinan functionalized selenium nanoparticles through JAK2/STAT-3 and P53 pathways 香菇多糖功能化硒纳米粒子通过JAK2/STAT-3和P53途径抑制h2o2氧化应激诱导的TM3细胞凋亡
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027971
Miaomiao Li, Z. Zheng, Junyi Ke, Jieyi Luo, Fan Jiang, Yan-xia Qu, B. Zhu, Yinghua Li, Liandong Zuo
{"title":"Inhibition of H2O2-induced TM3 cell apoptosis by oxidative stress by lentinan functionalized selenium nanoparticles through JAK2/STAT-3 and P53 pathways","authors":"Miaomiao Li, Z. Zheng, Junyi Ke, Jieyi Luo, Fan Jiang, Yan-xia Qu, B. Zhu, Yinghua Li, Liandong Zuo","doi":"10.32604/biocell.2023.027971","DOIUrl":"https://doi.org/10.32604/biocell.2023.027971","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83351544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible therapeutic role of short-chain fatty acids from skin commensal bacteria in UVB-induced skin carcinogenesis 来自皮肤共生菌的短链脂肪酸在uvb诱导的皮肤癌发生中的可能治疗作用
4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030383
PAVITHRA SUBRAMANI, RAUNAK KUMAR DAS
{"title":"Possible therapeutic role of short-chain fatty acids from skin commensal bacteria in UVB-induced skin carcinogenesis","authors":"PAVITHRA SUBRAMANI, RAUNAK KUMAR DAS","doi":"10.32604/biocell.2023.030383","DOIUrl":"https://doi.org/10.32604/biocell.2023.030383","url":null,"abstract":"Solar ultraviolet B (UVB) radiation is a major skin cancer-causing agent. Initiation, promotion, and progression are the diverse phases of UVB-induced carcinogenesis. Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways: thymine dimer formation, DNA damage, oxidative stress, inflammatory responses, and altered cell signaling, eventually resulting in tumor formation. The increased skin cancer rates urge researchers to develop more efficient drugs, but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues, which have been reported recently. The current review focuses on the relationship between microbes and cancer. Human skin acts as a barrier against the external environment and serves as a protective shield for its inhabitant microbiota, collectively called skin microbes. The gut microbiome plays a vital role in cancer therapy. Production of short-chain fatty acids (SCFAs) such as butyrate, acetate, and propionate by intestinal microbes has anti-cancer properties against various cancer cell lines. Yet, the knowledge of SCFAs produced by skin microbes remains yet to be elucidated exhaustively. In this review, we strive to summarize the findings of studies performed to date regarding the anti-cancer properties of SCFA against various cancer cell lines and provide insight into future directions in the skin microbiome field.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135504584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HOXB8 contributed to oxaliplatin chemo-resistance in colon cancer cells by activating STAT3 HOXB8通过激活STAT3参与结肠癌细胞对奥沙利铂的耐药
4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030147
LIANLI NI, YUN YU, HAN LIN, WEISHAN ZHUGE, LU TAO, YIWEI SHEN, RI CUI, SHAOTANG LI
{"title":"HOXB8 contributed to oxaliplatin chemo-resistance in colon cancer cells by activating STAT3","authors":"LIANLI NI, YUN YU, HAN LIN, WEISHAN ZHUGE, LU TAO, YIWEI SHEN, RI CUI, SHAOTANG LI","doi":"10.32604/biocell.2023.030147","DOIUrl":"https://doi.org/10.32604/biocell.2023.030147","url":null,"abstract":"<b>Background:</b> Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. <b>Methods:</b> The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC cells. The protein and mRNA levels were evaluated by western blot and real-time reverse transcription-polymerase chain reaction. <b>Results:</b> HOXB8 expression was upregulated in OXA-resistant HCT116 cells (HCT116/OXA) compared to its level in the parent HCT116 cells. Knockdown of HOXB8 significantly inhibited CRC cell growth by suppressing the signal transducer and activator of transcription 3 (STAT3) pathway. HOXB8 knockdown also potentiated cytotoxicity of OXA in CRC cells. Inversely, HOXB8 overexpression attenuated OXA-induced growth inhibition of HCT116 cells and RKO cells by activating STAT3 signaling. HOXB8 knockdown effectively inhibited HCT116/OXA cell viability regardless of OXA treatment by suppressing STAT3 signaling. <b>Conclusions:</b> These results shed light on the important functions of HOXB8 in OXA-resistant CRC and suggested that targeting HOXB8 might be an effective therapeutic strategy for select OXA-resistant CRC patients.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CPT1A in cancer: Tumorigenic roles and therapeutic implications CPT1A在癌症中的致瘤作用和治疗意义
4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027677
SHENGJIE SONG, ZHIZHOU SHI
{"title":"CPT1A in cancer: Tumorigenic roles and therapeutic implications","authors":"SHENGJIE SONG, ZHIZHOU SHI","doi":"10.32604/biocell.2023.027677","DOIUrl":"https://doi.org/10.32604/biocell.2023.027677","url":null,"abstract":"Metabolic reprogramming frequently occurs in the majority of cancers, wherein fatty acid oxidation (FAO) is usually induced and serves as a compensatory mechanism to improve energy consumption. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO and is widely involved in tumor growth, metastasis, and chemo-/radio-resistance. This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis, including in proliferation and tumor growth, invasion and metastasis, and the tumor microenvironment. Importantly, CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target, especially for the treatment of drug- and radiation-resistant tumors. In summary, CPT1A plays remarkable roles in promoting cancer progression and is a potential anticancer therapeutic target.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation 长链非编码RNA-ATB通过ZNF217升高抑制miR- 200c，诱导曲妥珠单抗耐药，并加重胃癌进展
4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029860
JIAZHUANG LI, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU
{"title":"Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation","authors":"JIAZHUANG LI, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU","doi":"10.32604/biocell.2023.029860","DOIUrl":"https://doi.org/10.32604/biocell.2023.029860","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135556221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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