IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.024948

Qian Zhang, Minger Zhen, Peng Li, X. Chi, Yifei Zhang

引用次数: 0

Molecular mechanisms and cellular process in signal transduction pathway related to air pollutants in obstructive lung diseases: A mini-review 阻塞性肺疾病中空气污染物信号转导通路的分子机制和细胞过程综述

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028975

A. Jang

{"title":"Molecular mechanisms and cellular process in signal transduction pathway related to air pollutants in obstructive lung diseases: A mini-review","authors":"A. Jang","doi":"10.32604/biocell.2023.028975","DOIUrl":"https://doi.org/10.32604/biocell.2023.028975","url":null,"abstract":"Exposure to air pollutants such as PM10, PM2.5, PM0.1, O3, CO, NO2, and SO2, and biological pollutants are important factors causing the evolution and furtherance of obstructive lung diseases (OLD), including asthma and chronic obstructive pulmonary disease (COPD). Asthma is the most frequent chronic inflammatory airway disease, characterized by breathlessness, wheezing, chest tightness, and cough, together with the presence of exaggerated expiratory airflow fluctuation that varies over time. COPD is a heterogeneous lung condition characterized by chronic respiratory symptoms such as dyspnea, cough, expectoration, and/or exacerbations due to abnormalities of the airways and/or alveoli that cause persistent, often progressive, airflow obstruction. Understanding the molecular mechanisms and cellular processes based on the development of OLD on exposure to air pollutants will provide insights into the solution of pathogenesis, prevention, and treatment of these conditions. The molecular mechanisms and cellular process involved in signal transduction pathway plays a role in the binding of extracellular signaling molecules and ligands to receptors placed on the cell surface or on the inner side cell that trigger inflammation that occurs, especially when something important enters the cell to bring into a cascade response. This binding then alters the cell metabolism, shape, and gene expression in the airway. This review aimed to reveal the effect of air pollutants on the molecular mechanisms and cellular processes involved in the signal transduction pathways in OLD.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"24 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85678412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of docosahexaenoic acid or arachidonic acid supplementation on the behavior of cardiomyocytes derived from human pluripotent stem cells 补充二十二碳六烯酸或花生四烯酸对人多能干细胞衍生的心肌细胞行为的影响

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028186

引用次数: 0

The microRNA pathway activation in insect cell model upon Autographa californica multiple nucleopolyhedrovirus infection 加州签名虫多核多角体病毒感染昆虫细胞模型中microRNA通路的激活

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026182

Qiaojing Jia, Yu V. Fu

引用次数: 0

PSTCNN: Explainable COVID-19 diagnosis using PSO-guided self-tuning CNN. PSTCNN：使用 PSO 引导的自调整 CNN 进行可解释的 COVID-19 诊断。

IF 0.8 4区生物学

Biocell Pub Date : 2023-01-01 Epub Date: 2022-11-18 DOI: 10.32604/biocell.2021.0xxx

Wei Wang, Yanrong Pei, Shui-Hua Wang, Juan Manuel Gorrz, Yu-Dong Zhang

{"title":"PSTCNN: Explainable COVID-19 diagnosis using PSO-guided self-tuning CNN.","authors":"Wei Wang, Yanrong Pei, Shui-Hua Wang, Juan Manuel Gorrz, Yu-Dong Zhang","doi":"10.32604/biocell.2021.0xxx","DOIUrl":"10.32604/biocell.2021.0xxx","url":null,"abstract":"<p><p>Since 2019, the coronavirus disease-19 (COVID-19) has been spreading rapidly worldwide, posing an unignorable threat to the global economy and human health. It is a disease caused by severe acute respiratory syndrome coronavirus 2, a single-stranded RNA virus of the genus Betacoronavirus. This virus is highly infectious and relies on its angiotensin-converting enzyme 2-receptor to enter cells. With the increase in the number of confirmed COVID-19 diagnoses, the difficulty of diagnosis due to the lack of global healthcare resources becomes increasingly apparent. Deep learning-based computer-aided diagnosis models with high generalisability can effectively alleviate this pressure. Hyperparameter tuning is essential in training such models and significantly impacts their final performance and training speed. However, traditional hyperparameter tuning methods are usually time-consuming and unstable. To solve this issue, we introduce Particle Swarm Optimisation to build a PSO-guided Self-Tuning Convolution Neural Network (PSTCNN), allowing the model to tune hyperparameters automatically. Therefore, the proposed approach can reduce human involvement. Also, the optimisation algorithm can select the combination of hyperparameters in a targeted manner, thus stably achieving a solution closer to the global optimum. Experimentally, the PSTCNN can obtain quite excellent results, with a sensitivity of 93.65%±1.86%, a specificity of 94.32%±2.07%, a precision of 94.30%±2.04%, an accuracy of 93.99%±1.78%, an F1-score of 93.97%±1.78%, Matthews Correlation Coefficient of 87.99%±3.56%, and Fowlkes-Mallows Index of 93.97%±1.78%. Our experiments demonstrate that compared to traditional methods, hyperparameter tuning of the model using an optimisation algorithm is faster and more effective.</p>","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"47 2","pages":"373-384"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613982/pdf/EMS158588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10517202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells TBZPy光动力治疗可调节HeLa细胞中PI3K/AKT和内质网应激相关的PERK/eIF2α通路

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028056

Yifan Li, Jing Zhang, Yi-Ming Fan, H. Xiao, Kexin Kang, Yali Zhou, Zhiwen Zhang, Yumin Li, Muzhou Teng

引用次数: 0

Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.: A review 余甘子代谢物的植物化学及民族药性质研究进展

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.022065

Vijay Kumar, Praveen C. Ramamurthy, Simranjeet Singh, Daljeet Singh Dhanjal, Parul Parihar, D. Bhatia, R. Prasad, Joginder Singh

引用次数: 1

SW-Net: A novel few-shot learning approach for disease subtype prediction SW-Net:一种用于疾病亚型预测的新颖的少量学习方法