4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029986

GAOZHONG LI, FUXIN LI, NING WEI, QING JIA

{"title":"Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer","authors":"GAOZHONG LI, FUXIN LI, NING WEI, QING JIA","doi":"10.32604/biocell.2023.029986","DOIUrl":"https://doi.org/10.32604/biocell.2023.029986","url":null,"abstract":"Background: This study was aimed at identifying natural killer (NK) cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer (GC) prognosis. Methods: We obtained NK cell-related genes from various databases, followed by Cox regression analysis and molecular typing to identify prognostic genes. Various immune algorithms and enrichment analyses were used to investigate the mutations, immune status, and pathway variations among different genotypes. The key prognostic genes were assessed using the least absolute shrinkage and selection operator (Lasso) regression analysis and univariate Cox regression analysis. Thereafter, the risk score (RS) prognosis model was constructed based on the selected important prognostic genes. A Receiver Operating Characteristics (ROC) curve was plotted for analyzing the robustness of the model. Subsequently, the decision and calibration curves were used for assessing the reliability and prediction accuracy of the proposed model. The ‘pRRophetic’ R software package was utilized for predicting the half-maximal inhibitory concentration (IC50) of immunotherapy and chemotherapy drugs. Results: We screened 21 prognostic genes and three molecular subtypes and found that the C1 subtype had the worst prognosis. Further, the pathways promoting tumor proliferation, such as epithelial-mesenchymal transition were significantly up-regulated. The results also showed that the macrophages in the M2 stage were significantly infiltrated in the C1 subtype, and there was significant overexpression in the C1 subtype, accompanied by a severe inflammatory reaction. The C1 was highly sensitive to drugs like 5-fluorouracil and paclitaxel. The ROC, calibration curve, and decision curve showed that the risk model was robust and strongly reliable. Conclusion: Overall, our proposed NK cell-related RS model can be used as a more accurate prediction index for GC patients, providing a valuable contribution to personalized medicine.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135755386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy 结直肠癌的癌症相关成纤维细胞:液体活检和靶向治疗的转化前景

4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030541

ELYN AMIELA SALLEH, YEONG YEH LEE, ANDEE DZULKARNAEN ZAKARIA, NUR ASYILLA CHE JALIL, MARAHAINI MUSA

{"title":"Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy","authors":"ELYN AMIELA SALLEH, YEONG YEH LEE, ANDEE DZULKARNAEN ZAKARIA, NUR ASYILLA CHE JALIL, MARAHAINI MUSA","doi":"10.32604/biocell.2023.030541","DOIUrl":"https://doi.org/10.32604/biocell.2023.030541","url":null,"abstract":"Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient prognosis and enables the detection of cancer through liquid biopsy. Liquid biopsy is gaining traction as it is non-invasive, allows frequent and easy sampling, and shows concordance to tissue biopsy analysis. In addition, CAF-targeted therapy is currently being studied extensively to be used as one of the treatment avenues for CRC. Various mechanisms of CAF-targeted therapy have been reported, including blocking the signaling pathways involving CAFs and cancer cells, thus abolishing the CAF-tumor cell crosstalk and subsequently hindering tumorigenesis. These translational applications of cCAFs and utilization of CAFs as key targets for CRC therapy, although still in the early phases of development, will potentially improve CRC patient management in the future.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135506333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microRNA pathway activation in insect cell model upon Autographa californica multiple nucleopolyhedrovirus infection 加州签名虫多核多角体病毒感染昆虫细胞模型中microRNA通路的激活

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026182

Qiaojing Jia, Yu V. Fu

引用次数: 0

Vitamin D attenuates TGF-β1-induced lung fibroblast proliferation and migration through repression of RasGRP3 维生素D通过抑制RasGRP3减弱TGF-β1诱导的肺成纤维细胞增殖和迁移

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027763

Guanqiong Hu, Ri-hong Huang, Luelue Lu, Qinshi Pan, Xiaoxin Chen

引用次数: 0

Correlations among core species corresponding to the clinical staging of periodontitis 牙周炎临床分期相关核心菌种的相关性

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.024948

Qian Zhang, Minger Zhen, Peng Li, X. Chi, Yifei Zhang

引用次数: 0

Initial steps on the analysis of the underlying pharmacological mechanisms of Wendan decoction on sudden deafness using network pharmacology and molecular docking 网络药理学与分子对接初步分析文胆汤治疗突发性耳聋的潜在药理机制

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029333

S. Ye, Yufeng Zhang, Ting Liu, Congzheng Wang, Zheng Yan, Wandong She, Haibing Hua

引用次数: 0

Ginsenoside Rg1 protects against ischemia-induced neuron damage by regulating the rno-miRNA-27a-3p/PPARγ axis 人参皂苷Rg1通过调节rna - mirna -27a-3p/PPARγ轴来保护缺血诱导的神经元损伤

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028016

Yue Guan, Tingting Zhang, Jianan Yu, Jia-wei Liu, Wenyuan Li, Yu Zheng, Jiale Wang, Yueh-Feng Liu, F. Zhai

引用次数: 0

Cloning of and analysis of cadmium resistant in 耐镉品种的克隆与分析

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029106

Zhenghong Feng, Bing Gao, Yu Gao, Jianhui Wu

引用次数: 0

Therapeutic targets and signal transduction mechanisms of medicinal plant formula Gancao Xiexin decoction against ulcerative colitis: A network pharmacological study 中药复方甘草泻心汤治疗溃疡性结肠炎的靶点及信号转导机制:网络药理学研究

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028381

Chenhao Shi, Maohong Hua, Guanhua Xu

引用次数: 0

Molecular mechanisms and cellular process in signal transduction pathway related to air pollutants in obstructive lung diseases: A mini-review 阻塞性肺疾病中空气污染物信号转导通路的分子机制和细胞过程综述

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028975

A. Jang

{"title":"Molecular mechanisms and cellular process in signal transduction pathway related to air pollutants in obstructive lung diseases: A mini-review","authors":"A. Jang","doi":"10.32604/biocell.2023.028975","DOIUrl":"https://doi.org/10.32604/biocell.2023.028975","url":null,"abstract":"Exposure to air pollutants such as PM10, PM2.5, PM0.1, O3, CO, NO2, and SO2, and biological pollutants are important factors causing the evolution and furtherance of obstructive lung diseases (OLD), including asthma and chronic obstructive pulmonary disease (COPD). Asthma is the most frequent chronic inflammatory airway disease, characterized by breathlessness, wheezing, chest tightness, and cough, together with the presence of exaggerated expiratory airflow fluctuation that varies over time. COPD is a heterogeneous lung condition characterized by chronic respiratory symptoms such as dyspnea, cough, expectoration, and/or exacerbations due to abnormalities of the airways and/or alveoli that cause persistent, often progressive, airflow obstruction. Understanding the molecular mechanisms and cellular processes based on the development of OLD on exposure to air pollutants will provide insights into the solution of pathogenesis, prevention, and treatment of these conditions. The molecular mechanisms and cellular process involved in signal transduction pathway plays a role in the binding of extracellular signaling molecules and ligands to receptors placed on the cell surface or on the inner side cell that trigger inflammation that occurs, especially when something important enters the cell to bring into a cascade response. This binding then alters the cell metabolism, shape, and gene expression in the airway. This review aimed to reveal the effect of air pollutants on the molecular mechanisms and cellular processes involved in the signal transduction pathways in OLD.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85678412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocell最新文献