Biopreservation and Biobanking最新文献

{"title":"Strategic Planning as a Community Effort: Surveying the Perspectives of Members of the German Biobank Alliance.","authors":"Corinna Klingler, Johanna Schiller, Verena Huth, Ronny Baber, Romy Kirsten, Cornelia Specht","doi":"10.1177/19475535251366754","DOIUrl":"10.1177/19475535251366754","url":null,"abstract":"<p><p><b><i>Background:</i></b> The German Biobank Node (GBN) coordinates the national network of academic biobanks in Germany; the German Biobank Alliance (GBA). At the beginning of 2025, the GBA consisted of 42 biobanks. With an upcoming strategic reorientation, the GBN/GBA was interested in understanding the perspectives of their community to ensure that strategic decisions were aligned with their needs and interests. <b><i>Materials and Methods:</i></b> An online survey with a cross-sectional design was conducted with the GBA community, targeting mostly first-line management of GBA biobanks. The invitation to the survey was sent via an internal GBA mailing list. It addressed primarily satisfaction with GBN/GBA services, organization of and collaboration within GBN/GBA, and expectations/wishes for the future. Responses were analyzed using descriptive statistics and qualitative content analysis. <b><i>Results:</i></b> Participants generally considered being part of GBA to be important to very important. They emphasized the opportunity to network and exchange with colleagues as particularly helpful, but also training opportunities and quality management (QM) tools provided. In terms of organization, they found that the benefits of cooperating within GBA largely outweighed efforts and that opportunities to participate in processes were adequate. However, they also identified areas for improvement, for example, in the provision of information on how to join or establish working groups. In terms of relevant future topics, participants identified lobbying, networking within and outside GBA, training, and QM as particularly important priorities for GBN/GBA, as well as securing funding and strengthening local cooperation for individual biobanks. <b><i>Discussion:</i></b> The findings have informed the strategic development of GBN/GBA, with QM, education, and networking being the top future priorities. In terms of networking, the GBN/GBA has emphasized the importance of making the perspective of the community heard in other national networks. How to address sustainable funding remains an open question.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience of Biobanks in Latin America During the COVID-19 Pandemic: Lessons from Costa Rica.","authors":"Michael Zuñiga, Daniela Mora, Bernal Cortes, Viviana Loria, Amada Aparicio, Alejandro Calderon, Daniela Ugalde-Araya, Karine Sargsyan, Carolina Porras, Rolando Herrero, Denis Marino","doi":"10.1177/19475535251369966","DOIUrl":"10.1177/19475535251369966","url":null,"abstract":"<p><p>Global measures and restrictions implemented to control the COVID-19 pandemic had a significant impact and created challenges in regular business, commerce, and scientific activities, including biobank operations. The challenges were exacerbated by a dependence on imported supplies and reagents from countries such as the United States, China, and within Europe, as well as restrictions on exporting biological samples. The pandemic has highlighted the pressing need for regional autonomy in biobanking activities. This article aims to enhance the capacity of biobanks to respond effectively to future crises. Recognizing the importance of adaptability and resilience, our study highlights the specific strategies employed by a large biobank in Costa Rica to ensure the continuity of operations during unprecedented times. During the COVID-19 pandemic, biobanking operations encountered a number of critical challenges, which led to the identification, implementation, and integration of targeted mitigation strategies into our contingency framework. Five challenges were identified and subsequently addressed: disruptions and shortfalls in the supply of essential material, continuity of daily biobank operations, storage capacity constraints coupled with export limitations, difficulties associated with consent procedures, and complications surrounding personnel testing. These lessons underscore the critical importance of contingency planning, digitization of biobanking workflows, and increased regional collaboration to strengthen the autonomy and resilience of biobanks in the face of future crises.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Biospecimens as a Biobank Output for Biomedical Research-A Report from the ISBER Annual Meeting 2024 Annual Meeting Roundtable Discussions.","authors":"Anusha Hettiaratchi, Rajeev Singh, Cassandra Griffin, Deb Kerr, Susan D'Silva, Bindu Madala, Kate Merlin, Marta Castelhano, Birendra Kumar Yadav, Hanh Vu, Jajah Fachiroh, Tatsuaki Tsuruyama, Bushra Allah Rakha, Nida Jawaid, Javeria Aijaz, Wayne Ng","doi":"10.1177/19475535251375881","DOIUrl":"https://doi.org/10.1177/19475535251375881","url":null,"abstract":"<p><p>Despite widespread recognition of the need to increase sample utilization, the utilization rate of collected biospecimens for research is still low. In recent years, funders have shifted priorities towards supporting biobanks/collections with high utilization. Given the imperative to upscale sample utilization, a roundtable was held to discuss the considerations for maximizing and measuring the utilization of biospecimens and the output models that biobanks can employ to ensure greater impact and directly attributable advancements in medical science. The discussion revealed that most represented biobanks measure utilization of biospecimen but the measures vary broadly. Attendees agreed that the need to maximize utilization of collected biospecimens for research could be reinforced by a harmonized approach to increasing visibility, facilitating accessibility, and measuring subsequent outputs. The roundtable concluded with calls to action for the creation of biospecimen finding platforms and increased efforts towards the promotion of biobanking to the public.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> Treat \"Biobank\" and \"Biorepository\" as Synonyms, and Watch \"Biobank\" Win the Race.","authors":"Jonas J Astrin, Emma Snapes, Daniel Catchpoole, Clare M Allocca, Fay Betsou","doi":"10.1177/19475535251369203","DOIUrl":"https://doi.org/10.1177/19475535251369203","url":null,"abstract":"","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> The Use of the Terms Biorepository and Biobank as Working Definition for the Virtual Biorepository System: Reply from the Authors.","authors":"May Chu, Judith Giri, Amy Price, Zoe Steinberg","doi":"10.1177/19475535251372858","DOIUrl":"https://doi.org/10.1177/19475535251372858","url":null,"abstract":"","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and Outlook from the First Ethical, Legal, and Social Implication Symposium of the BBMRI-ERIC Academy at International Agency for Research on Cancer/World Health Organization.","authors":"Michaela Th Mayrhofer, Marialuisa Lavitrano, Zisis Kozlakidis","doi":"10.1177/19475535251370637","DOIUrl":"10.1177/19475535251370637","url":null,"abstract":"<p><p>The first Biobanking and BioMolecular resources Research Infrastructure-Academy Ethical, Legal, and Social Implications (ELSI)'s Symposium, held in June 2024 at IARC/WHO in Lyon, explored ethical, legal, and societal dimensions of biobanking and biomedical research through interdisciplinary perspectives. Over eight thematic sessions, the event addressed diverse topics including data privacy, artificial intelligence ethics, regulatory compliance, genomics, and public participation, showcasing contributions from global experts and young researchers. The symposium emphasized the importance of balancing research innovation with societal and ethical considerations, offering insights into trust-building, gender-sensitive approaches, and cross-border collaboration. Marking a milestone for ELSI-focused discourse, the symposium laid the groundwork for ongoing engagement, with the next meeting planned for 2025 in Bilbao.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Based Quality Control of Cell Lines.","authors":"Svetlana Gramatiuk, Igor A Kryvoruchko, Yulia V Ivanova, Emily Hubbard, Maria Noebauer-Babenko, Karine Sargsyan","doi":"10.1177/19475535251367317","DOIUrl":"https://doi.org/10.1177/19475535251367317","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> This study is part of the broader Stem Line project Mito-Cell-UAB073, specifically focusing on \"Stem Cell Lines-Quality Control,\" and aims to innovate in the field of Quality Control (QC) through a unique, artificial intelligence (AI)-powered model known as Life Cell AI UAB. This model utilizes deep learning algorithms and computer vision, allowing it to make accurate viability assessments of cell and stem cell lines based solely on static images captured through standard optical microscopes. <b><i>Aim:</i></b> The aim of this study was to develop and validate an AI-driven, image-based model that reliably predicts cell line viability. <b><i>Methods:</i></b> Our methodology involved training the Life Cell AI UAB model on single static images of cell lines using advanced computer vision and deep learning techniques. Performance evaluation was conducted on three independent blind test sets sourced from various biotechnology laboratories, allowing for assessment across diverse environments. <b><i>Results:</i></b> The Life Cell AI UAB model achieved a sensitivity of 82.1% in identifying viable cell lines and a specificity of 67.5% for non-viable lines across the test sets. Each blind test set exhibited a weighted accuracy above 63%, with a combined accuracy of 64.3%. Notably, predictions showed a clear distinction between correctly and incorrectly classified cells. The model outperformed traditional QC methods by improving accuracy in binary classification tasks by 21.9% (<i>p</i> = 0.042) and demonstrated a 42.0% enhancement over conventional Standard Operation Procedure (SOP) procedures (<i>p</i> = 0.026). <b><i>Conclusion:</i></b> The Life Cell AI UAB model represents a notable advancement in biobanking QC, offering a precise, standardized, and non-invasive method for assessing cell line viability. This model has the potential to streamline QC processes across laboratories, minimizing the need for time-lapse imaging and promoting uniformity in QC practices for both cell and stem cells.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The College of American Pathologists Biorepository Accreditation Program: Results from the First 10 Years.","authors":"Nalin Leelatian, Joan H Rose, Sarah Cliff, Richard C Davis, Helena Ellis, Jing Di, Basal Kashlan, Nilsa C Ramirez, Jim Vaught, Erik Zmuda, Shannon J McCall, Rebecca C Obeng","doi":"10.1177/19475535251365758","DOIUrl":"https://doi.org/10.1177/19475535251365758","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The College of American Pathologists (CAP) Biorepository Accreditation Program (BAP) was established in 2012 with the goal of providing standardized requirements that ensure high quality for procuring, processing, storing, distributing, and computerizing information of biospecimens for scientific investigations. CAP BAP was the first biorepository accreditation program, and, since the program started in 2012, the world's second biorepository accreditation standard was issued by the International Organization for Standardization (ISO) as ISO 20387 in 2018. CAP BAP serves as an interface between several programs and draws best practices from renowned organizations. This elective program is based on a peer-inspection model to ensure that the inspectors have proper expertise and to promote educational efforts through information sharing. On-site inspections occur every 2 years, like other CAP Accreditation Programs, with an interim self-inspection in the off year. The program compliance is assessed based on CAP Accreditation Checklists, which are regularly revised. <b><i>Objective:</i></b> This article reviews the accomplishments of the first 10 years of the CAP Biorepository Accreditation Program. <b><i>Results:</i></b> As of December 2024, 104 biorepositories are CAP BAP accredited, which increased from 53 accredited biorepositories in 2018. Accreditation of 10 additional biorepositories is underway. A total of 88 inspections were completed between January 2017 and December 2022; 16 were initial inspections and 72 were reinspections. Deficiencies, defined as insufficient or lack of evidence of compliance with a checklist item, were mainly related to equipment/instrumentation (24%), quality management (15%), safety (14%), information technology (13%), personnel (13%), specimen handling and quality control (9%), facilities (6%), and regulatory (6%) issues. The proportion of deficiencies between categories was like the first 5 years. <b><i>Conclusion:</i></b> The increased number of accredited biorepositories, in both academic and commercial settings, highlights the continued success of the program and its applicability to maintaining high standards for biorepositories.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Biospecimen Management: A Roadmap for Integrated Sample Traceability in the Era of Global Research.","authors":"Sion Israel Sion, Trinh Nguyen-Phan, Mélissa Fortin, Anne-Marie Mes-Masson, Kaiwen Zhang","doi":"10.1177/19475535251366364","DOIUrl":"https://doi.org/10.1177/19475535251366364","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Advancements in biomedical research depend on the quality and availability of biological samples. Despite their sophisticated storage capabilities, biobanks face significant challenges in sample management, with stored specimens often remaining unused and researchers struggling to access the required samples. <b><i>Objectives:</i></b> To analyze the challenges in biospecimen access and traceability, evaluate existing solutions, and propose a framework for integrated sample management in global research collaboration. <b><i>Methods:</i></b> A scoping review was conducted across PubMed, Scopus, and Web of Science databases, supplemented by grey literature (2004-2024). The analysis included an examination of Biobank Information Management Systems and an evaluation of sample management systems, tracking technologies, and governance frameworks. <b><i>Results:</i></b> The analysis revealed fragmented management systems, with at least 38 different biobanking software solutions offering limited interoperability. Proprietary systems and vendor lock-ins create significant barriers to data sharing. Sample tracking shows the evolution from manual to digital systems; however, cross-institutional tracking remains challenging. Reproducibility issues account for significant challenges in research, whereas inefficient resource utilization persists, with 67% of biobanks citing underutilization as a major concern. <b><i>Conclusions:</i></b> Addressing biobank sample access and traceability requires a shift from an institution-centric to an ecosystem-wide approach. Its success depends on integrating technological solutions such as Blockchain, the Internet of Things, and artificial intelligence with governance frameworks while ensuring alignment with stakeholder needs. Future developments should focus on implementing integrated traceability systems that support transparent and accountable sample management across the global research ecosystem.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing HIV and Cancer Research: Implementing an AIDS and Cancer Specimen Resource in Latin America.","authors":"Larissa L S Scholte, Evandro S Mello, Karim Yaqub Ibrahim, Miyuki Uno, Vanesse Maria da Costa, Ellen Sayuri Miazima, Camila Motta Venchiarutti Moniz, Giullia Dias de Souza, Larissa Oliveira Amorim, Isabela Cristina de Souza, Kris Oliveira, Roger Chammas, Kristina Bowles, Lipsa Das, Anna E Coghill, Lisa Rimsza, Aluisio Segurado, Jeffrey M Bethony","doi":"10.1177/19475535251363861","DOIUrl":"https://doi.org/10.1177/19475535251363861","url":null,"abstract":"<p><p>The AIDS and Cancer Specimen Resource (ACSR) has developed a global biorepository network to support research on AIDS-defining and non-AIDS-defining cancers. This article details the establishment of a dedicated HIV-associated cancer biorepository in São Paulo, Brazil, a region with a high burden of these malignancies. The repository addresses the need for high-quality, well-annotated biospecimens from Latin American (LATAM) populations to support research on cancer pathogenesis in people with HIV (PWH), viral reservoirs, and clinical outcomes. It systematically collects and links biospecimens with demographic and clinical data, providing a resource for investigators. Developed with international ethics, community engagement, and regulatory standards, the biorepository is modeled after similar efforts in low- and middle-income countries. This article outlines its implementation, including sample acquisition, infrastructure, inventory management, data governance, and research collaboration. By expanding access to biospecimens, the ACSR supports research that can improve outcomes for PWH and cancer, while strengthening research capacity in the LATAM region.</p>","PeriodicalId":55358,"journal":{"name":"Biopreservation and Biobanking","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}