Brain Topography最新文献

{"title":"Neuronal Control of Posture in Blind Individuals.","authors":"I Helmich, R Gemmerich","doi":"10.1007/s10548-024-01041-7","DOIUrl":"10.1007/s10548-024-01041-7","url":null,"abstract":"<p><p>The control of posture is guided by the integration of sensory information. Because blind individuals cannot apply visual information to control posture as sighted individuals do they must compensate by the remaining senses. We therefore hypothesize that blind individuals alter their brain activation in the sensorimotor cortex during postural control to compensate for balance control without vision by the increased integration of somatosensory information. Ten blind and ten sighted (matched) individuals controlled posture during conditions with (I) eyes closed / open, and (II) stable / unstable surface conditions. Postural sway was recorded by applying a pressure distribution measuring plate. Brain activation was collected by functional Near InfraRed Spectroscopy (fNIRS) above motor-sensory cortices of the right and left hemispheres. Blind individuals showed significantly increased postural sway when balancing with open eyes on an unstable surface and when compared to sighted individuals. Whereas blind individuals showed significantly increased brain activation when balancing with open eyes on stable and unstable surface conditions, sighted individuals increased their brain oxygenation only during closed eyes and unstable surface conditions. Overall conditions, blind individuals presented significantly increased brain activation in two channels of the left and right hemispheric motor-sensory cortex when compared to sighted individuals. We therefore conclude that sighted individuals increase their brain oxygenation in the sensorimotor cortex during postural control tasks that demand sensory integration processes. Blind individuals are characterized by increased brain activation overall conditions indicating additional sensory integration during postural control. Thus, the sensorimotor cortex of blind individuals adapts to control posture without vision.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"783-795"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophenomenological Investigation of Mindfulness Meditation \"Cessation\" Experiences Using EEG Network Analysis in an Intensively Sampled Adept Meditator.","authors":"Remko van Lutterveld, Avijit Chowdhury, Daniel M Ingram, Matthew D Sacchet","doi":"10.1007/s10548-024-01052-4","DOIUrl":"10.1007/s10548-024-01052-4","url":null,"abstract":"<p><p>Mindfulness meditation is a contemplative practice that is informed by Buddhism. It has been proven effective for improving mental and physical health in clinical and non-clinical contexts. To date, mainstream dialogue and scientific research on mindfulness has focused primarily on short-term mindfulness training and applications of mindfulness for reducing stress. Understanding advanced mindfulness practice has important implications for mental health and general wellbeing. According to Theravada Buddhist meditation, a \"cessation\" event is a dramatic experience of profound clarity and equanimity that involves a complete discontinuation in experience, and is evidence of mastery of mindfulness meditation. Thirty-seven cessation events were captured in a single intensively sampled advanced meditator (over 6,000 h of retreat mindfulness meditation training) while recording electroencephalography (EEG) in 29 sessions between November 12, 2019 and March 11, 2020. Functional connectivity and network integration were assessed from 40 s prior to cessations to 40 s after cessations. From 21 s prior to cessations there was a linear decrease in large-scale functional interactions at the whole-brain level in the alpha band. In the 40 s following cessations these interactions linearly returned to prior levels. No modulation of network integration was observed. The decrease in whole-brain functional connectivity was underlain by frontal to left temporal and to more posterior decreases in connectivity, while the increase was underlain by wide-spread increases in connectivity. These results provide neuroscientific evidence of large-scale modulation of brain activity related to cessation events that provides a foundation for future studies of advanced meditation.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"849-858"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Cortical Activity during a Finger Tap in People with Stroke.","authors":"Priya Balasubramanian, Roxanne P De Leon, Dylan B Snyder, Scott A Beardsley, Allison S Hyngstrom, Brian D Schmit","doi":"10.1007/s10548-024-01049-z","DOIUrl":"10.1007/s10548-024-01049-z","url":null,"abstract":"<p><p>This study describes electroencephalography (EEG) measurements during a simple finger movement in people with stroke to understand how temporal patterns of cortical activation and network connectivity align with prolonged muscle contraction at the end of a task. We investigated changes in the EEG temporal patterns in the beta band (13-26 Hz) of people with chronic stroke (N = 10, 7 F/3 M) and controls (N = 10, 7 F/3 M), during and after a cued movement of the index finger. We quantified the change in beta band EEG power relative to baseline as activation at each electrode and the change in task-based phase-locking value (tbPLV) and beta band task-based coherence (tbCoh) relative to baseline coherence as connectivity between EEG electrodes. Finger movements were associated with a decrease in beta power (event related desynchronization (ERD)) followed by an increase in beta power (event related resynchronization (ERS)). The ERS in the post task period was lower in the stroke group (7%), compared to controls (44%) (p < 0.001) and the transition from ERD to ERS was delayed in the stroke group (1.43 s) compared to controls (0.90 s) in the C3 electrode (p = 0.007). In the same post movement period, the stroke group maintained a heightened tbPLV (p = 0.030 for time to baseline of the C3:Fz electrode pair) and did not show the decrease in connectivity in electrode pair C3:Fz that was observed in controls (tbPLV: p = 0.006; tbCoh: p = 0.023). Our results suggest that delays in cortical deactivation patterns following movement coupled with changes in the time course of connectivity between the sensorimotor and frontal cortices in the stroke group might explain clinical observations of prolonged muscle activation in people with stroke. This prolonged activation might be attributed to the combination of cortical reorganization and changes to sensory feedback post-stroke.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"907-920"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Single and Paired Phonemes Using 7T Functional MRI.","authors":"Maria Araújo Vitória, Francisco Guerreiro Fernandes, Max van den Boom, Nick Ramsey, Mathijs Raemaekers","doi":"10.1007/s10548-024-01034-6","DOIUrl":"10.1007/s10548-024-01034-6","url":null,"abstract":"<p><p>Several studies have shown that mouth movements related to the pronunciation of individual phonemes are represented in the sensorimotor cortex. This would theoretically allow for brain computer interfaces that are capable of decoding continuous speech by training classifiers based on the activity in the sensorimotor cortex related to the production of individual phonemes. To address this, we investigated the decodability of trials with individual and paired phonemes (pronounced consecutively with one second interval) using activity in the sensorimotor cortex. Fifteen participants pronounced 3 different phonemes and 3 combinations of two of the same phonemes in a 7T functional MRI experiment. We confirmed that support vector machine (SVM) classification of single and paired phonemes was possible. Importantly, by combining classifiers trained on single phonemes, we were able to classify paired phonemes with an accuracy of 53% (33% chance level), demonstrating that activity of isolated phonemes is present and distinguishable in combined phonemes. A SVM searchlight analysis showed that the phoneme representations are widely distributed in the ventral sensorimotor cortex. These findings provide insights about the neural representations of single and paired phonemes. Furthermore, it supports the notion that speech BCI may be feasible based on machine learning algorithms trained on individual phonemes using intracranial electrode grids.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"731-747"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An MRI Study of Morphology, Asymmetry, and Sex Differences of Inferior Precentral Sulcus.","authors":"Xinran Zhao, Yu Wang, Xiaokang Wu, Shuwei Liu","doi":"10.1007/s10548-024-01035-5","DOIUrl":"10.1007/s10548-024-01035-5","url":null,"abstract":"<p><p>Numerous studies utilizing magnetic resonance imaging (MRI) have observed sex and interhemispheric disparities in sulcal morphology, which could potentially underpin certain functional disparities in the human brain. Most of the existing research examines the precentral sulcus comprehensively, with a rare focus on its subsections. To explore the morphology, asymmetry, and sex disparities within the inferior precentral sulcus (IPCS), we acquired 3.0T magnetic resonance images from 92 right-handed Chinese adolescents. Brainvisa was used to reconstruct the IPCS structure and calculate its mean depth (MD). Based on the morphological patterns of IPCS, it was categorized into five distinct types. Additionally, we analyzed four different types of spatial relationships between IPCS and inferior frontal sulcus (IFS). There was a statistically significant sex disparity in the MD of IPCS, primarily observed in the right hemisphere. Females exhibited significantly greater asymmetry in the MD of IPCS compared to males. No statistically significant sex or hemispheric variations were identified in sulcal patterns. Our findings expand the comprehension of inconsistencies in sulcal structure, while also delivering an anatomical foundation for the study of related regions' function.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"748-763"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Chronic Pain on Use-Dependent Plasticity: Corticomotor Excitability and Motor Representation in Musicians With and Without Pain.","authors":"Anna M Zamorano, Enrico De Martino, Ainhoa Insausti-Delgado, Peter Vuust, Herta Flor, Thomas Graven-Nielsen","doi":"10.1007/s10548-023-01031-1","DOIUrl":"10.1007/s10548-023-01031-1","url":null,"abstract":"<p><p>Long-term musical training induces adaptive changes in the functional representation of the motor cortex. It is unknown if the maladaptive plasticity associated with chronic pain, frequently affecting trained musicians, may alter the use-dependent plasticity in the motor cortex. This study investigated the interaction between adaptive and maladaptive plasticity in the motor pathways, in particular how chronic pain influences long-term use-dependent plasticity. Using transcranial magnetic stimulation (TMS), corticospinal excitability was assessed by measuring the amplitude of the motor-evoked potential (MEP), area of the motor map, volume, and center of gravity of the first dorsal interosseous muscle in 19 pain-free musicians, 17 upper limb/neck pain chronic pain musicians, and 19 pain-free non-musicians as controls. Motor map volume and MEP amplitude were smaller for both pain-free and chronic pain musicians compared to pain-free controls (P < 0.011). No significant differences were found between musicians with and without chronic pain. These findings confirm that long-term musical training can lead to focalized and specialized functional organization of the primary motor cortex. Moreover, the adaptive use-dependent plasticity acquired through fine-motor skill acquisition is not significantly compromised by the maladaptive plasticity typically associated with chronic pain, highlighting the potential of long-term sensorimotor training to counteract the effects of chronic pain in the motor system.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"874-880"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Delta and Theta Power Density in Sickle Cell Disease Individuals with Chronic Pain Secondary to Hip Osteonecrosis: A Resting-State Eeg Study.","authors":"Tiago S Lopes, Jamille E Santana, Wellington S Silva, Francisco J Fraga, Pedro Montoya, Katia N Sá, Larissa C Lopes, Rita Lucena, Yossi Zana, Abrahão F Baptista","doi":"10.1007/s10548-023-01027-x","DOIUrl":"10.1007/s10548-023-01027-x","url":null,"abstract":"<p><strong>Purpose: </strong>Identify the presence of a dysfunctional electroencephalographic (EEG) pattern in individuals with sickle cell disease (SCD) and hip osteonecrosis, and assess its potential associations with depression, anxiety, pain severity, and serum levels of brain-derived neurotrophic factor (BDNF).</p><p><strong>Methods: </strong>In this cross-sectional investigation, 24 SCD patients with hip osteonecrosis and chronic pain were matched by age and sex with 19 healthy controls. Resting-state EEG data were recorded using 32 electrodes for both groups. Power spectral density (PSD) and peak alpha frequency (PAF) were computed for each electrode across Delta, Theta, Alpha, and Beta frequency bands. Current Source Density (CSD) measures were performed utilizing the built-in Statistical nonparametric Mapping Method of the LORETA-KEY software.</p><p><strong>Results: </strong>Our findings demonstrated that SCD individuals exhibited higher PSD in delta and theta frequency bands when compared to healthy controls. Moreover, SCD individuals displayed increased CSD in delta and theta frequencies, coupled with decreased CSD in the alpha frequency within brain regions linked to pain processing, motor function, emotion, and attention. In comparison to the control group, depression symptoms, and pain intensity during hip abduction were positively correlated with PSD and CSD in the delta frequency within the parietal region. Depression symptoms also exhibited a positive association with PSD and CSD in the theta frequency within the same region, while serum BDNF levels showed a negative correlation with CSD in the alpha frequency within the left insula.</p><p><strong>Conclusion: </strong>This study indicates that individuals with SCD experiencing hip osteonecrosis and chronic pain manifest a dysfunctional EEG pattern characterized by the persistence of low-frequency PSD during a resting state. This dysfunctional EEG pattern may be linked to clinical and biochemical outcomes, including depression symptoms, pain severity during movement, and serum BDNF levels.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"859-873"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Context Modulates Perceived Fairness in Altruistic Punishment: Neural Signatures from ERPs and EEG Oscillations.","authors":"Lei Yang, Yuan Gao, Lihong Ao, He Wang, Shuhang Zhou, Yingjie Liu","doi":"10.1007/s10548-024-01039-1","DOIUrl":"10.1007/s10548-024-01039-1","url":null,"abstract":"<p><p>Social norms and altruistic punitive behaviours are both based on the integration of information from multiple contexts. Individual behavioural performance can be altered by loss and gain contexts, which produce different mental states and subjective perceptions. In this study, we used event-related potential and time-frequency techniques to examine performance on a third-party punishment task and to explore the neural mechanisms underlying context-dependent differences in punishment decisions. The results indicated that individuals were more likely to reject unfairness in the context of loss (vs. gain) and to increase punishment as unfairness increased. In contrast, fairness appeared to cause an early increase in cognitive control signal enhancement, as indicated by the P2 amplitude and theta oscillations, and a later increase in emotional and motivational salience during decision-making in gain vs. loss contexts, as indicated by the medial frontal negativity and beta oscillations. In summary, individuals were more willing to sanction violations of social norms in the loss context than in the gain context and rejecting unfair losses induced more equity-related cognitive conflict than accepting unfair gains, highlighting the importance of context (i.e., gain vs. loss) in equity-related social decision-making processes.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"764-782"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Effect of Multichannel tDCS Protocol in Patients with Central Cortex Epilepsies Associated with Epilepsia Partialis Continua.","authors":"M Daoud, C Durelle, A Fierain, El Youssef N, F Wendling, G Ruffini, P Benquet, F Bartolomei","doi":"10.1007/s10548-024-01045-3","DOIUrl":"10.1007/s10548-024-01045-3","url":null,"abstract":"<p><p>Epilepsia partialis continua (EPC) is a rare type of focal motor status epilepticus that causes continuous muscle jerking in a specific part of the body. Experiencing this type of seizure, along with other seizure types, such as focal motor seizures and focal to bilateral tonic-clonic seizures, can result in a disabling situation. Non-invasive brain stimulation methods like transcranial direct current stimulation (tDCS) show promise in reducing seizure frequency (SF) when medications are ineffective. However, research on tDCS for EPC and related seizures is limited. We evaluated personalized multichannel tDCS in drug-resistant EPC of diverse etiologies for long-term clinical efficacy We report three EPC patients undergoing a long-term protocol of multichannel tDCS. The patients received several cycles (11, 9, and 3) of five consecutive days of stimulation at 2 mA for 2 × 20 min, targeting the epileptogenic zone (EZ), including the central motor cortex with cathodal electrodes. The primary measurement was SF changes. In three cases, EPC was due to Rasmussen's Encephalitis (case 1), focal cortical dysplasia (case 2), or remained unknown (case 3). tDCS cycles were administered over 6 to 22 months. The outcomes comprised a reduction of at least 75% in seizure frequency for two patients, and in one case, a complete cessation of severe motor seizures. However, tDCS had no substantial impact on the continuous myoclonus characterizing EPC. No serious side effects were reported. Long-term application of tDCS cycles is well tolerated and can lead to a considerable reduction in disabling seizures in patients with various forms of epilepsy with EPC.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":" ","pages":"897-906"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Effects of Repetitive Paired-Pulse Transcranial Magnetic Stimulation on Visuomotor Training Using TMS-EEG","authors":"Ryoki Sasaki, Brodie J. Hand, Wei-Yeh Liao, John G. Semmler, George M. Opie","doi":"10.1007/s10548-024-01071-1","DOIUrl":"https://doi.org/10.1007/s10548-024-01071-1","url":null,"abstract":"<p>I-wave periodicity repetitive paired-pulse transcranial magnetic stimulation (iTMS) can modify acquisition of a novel motor skill, but the associated neurophysiological effects remain unclear. The current study therefore used combined TMS-electroencephalography (TMS-EEG) to investigate the neurophysiological effects of iTMS on subsequent visuomotor training (VT). Sixteen young adults (26.1 ± 5.1 years) participated in three sessions including real iTMS and VT (iTMS + VT), control iTMS and VT (iTMS_{<i>Control</i>} + VT), or iTMS alone. Motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs) were measured before and after iTMS, and again after VT, to assess neuroplastic changes. Irrespective of the intervention, MEP amplitude was not changed after iTMS or VT. Motor skill was improved compared with baseline, but no differences were found between stimulus conditions. In contrast, the P30 peak was altered by VT when preceded by control iTMS (<i>P</i> &lt; 0.05), but this effect was not apparent when VT was preceded by iTMS or following iTMS alone (all <i>P</i> &gt; 0.15). In contrast to expectations, iTMS was unable to modulate MEP amplitude or influence motor learning. Despite this, changes in P30 amplitude suggested that motor learning was associated with altered cortical reactivity. Furthermore, this effect was abolished by priming with iTMS, suggesting an influence of priming that failed to impact learning.</p>","PeriodicalId":55329,"journal":{"name":"Brain Topography","volume":"40 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141782291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}