Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes.

IF 2.3 3区 医学 Q3 CLINICAL NEUROLOGY
Marjorie Metzger, Stefan Dukic, Roisin McMackin, Eileen Giglia, Matthew Mitchell, Saroj Bista, Emmet Costello, Colm Peelo, Yasmine Tadjine, Vladyslav Sirenko, Lara McManus, Teresa Buxo, Antonio Fasano, Rangariroyashe Chipika, Marta Pinto-Grau, Christina Schuster, Mark Heverin, Amina Coffey, Michael Broderick, Parameswaran M Iyer, Kieran Mohr, Brighid Gavin, Niall Pender, Peter Bede, Muthuraman Muthuraman, Orla Hardiman, Bahman Nasseroleslami
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引用次数: 0

Abstract

Amyotrophic lateral sclerosis (ALS) is characterised primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% of cases. We have shown previously that resting-state EEG captures dysfunction in motor and cognitive networks in ALS. However, the longitudinal development of these dysfunctional patterns, especially in networks linked with cognitive-behavioural functions, remains unclear. Longitudinal studies on non-motor changes in ALS are essential to further develop our understanding of disease progression, improve care and enhance the evaluation of new treatments. To address this gap, we examined 124 ALS individuals with 128-channel resting-state EEG recordings, categorised by cognitive impairment (ALSci, n = 25), behavioural impairment (ALSbi, n = 58), or non-impaired (ALSncbi, n = 53), with 12 participants meeting the criteria for both ALSci and ALSbi. Using linear mixed-effects models, we characterised the general and phenotype-specific longitudinal changes in brain network, and their association with cognitive performance, behaviour changes, fine motor symptoms, and survival. Our findings revealed a significant decline in [Formula: see text]-band spectral power over time in the temporal region along with increased [Formula: see text]-band power in the fronto-temporal region in the ALS group. ALSncbi participants showed widespread β-band synchrony decrease, while ALSci participants exhibited increased co-modulation correlated with verbal fluency decline. Longitudinal network-level changes were specific of ALS subgroups and correlated with motor, cognitive, and behavioural decline, as well as with survival. Spectral EEG measures can longitudinally track abnormal network patterns, serving as a candidate stratification tool for clinical trials and personalised treatments in ALS.

反映 ALS 认知表型中功能性网络中断的脑电图测量的不同纵向变化。
肌萎缩性脊髓侧索硬化症(ALS)的主要特征是运动系统变性,高达 50% 的病例有认知和行为改变的临床证据。我们之前已经证明,静息态脑电图能捕捉到 ALS 运动和认知网络的功能障碍。然而,这些功能障碍模式的纵向发展,尤其是与认知行为功能相关的网络的纵向发展仍不清楚。对 ALS 非运动变化的纵向研究对于进一步了解疾病进展、改善护理和加强对新疗法的评估至关重要。为了填补这一空白,我们研究了 124 名 ALS 患者的 128 通道静息态脑电图记录,按照认知障碍(ALSci,n = 25)、行为障碍(ALSbi,n = 58)或无障碍(ALSncbi,n = 53)进行分类,其中有 12 人同时符合 ALSci 和 ALSbi 的标准。利用线性混合效应模型,我们描述了大脑网络的一般和表型特异性纵向变化,以及它们与认知能力、行为变化、精细运动症状和存活率之间的关系。我们的研究结果表明,随着时间的推移,ALS 组颞叶区域的[公式:见正文]频谱功率明显下降,而前颞叶区域的[公式:见正文]频谱功率则有所上升。ALSncbi 参与者表现出广泛的 β 波段同步性下降,而 ALSci 参与者则表现出与言语流利性下降相关的共调制增加。纵向网络水平变化是 ALS 亚组的特异性特征,与运动、认知和行为能力下降以及存活率相关。频谱脑电图测量可纵向追踪异常网络模式,可作为 ALS 临床试验和个性化治疗的候选分层工具。
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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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