Clinical Neuropathology最新文献_第5页

Spindle cell oncocytoma reclassified from amelanotic melanocytoma of the sellar region. 鞍区无色素黑素细胞瘤的梭形细胞癌重新分类。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-09-01 DOI: 10.5414/NP301550

Marta Kisiel, Kesava K V Reddy, John Provias, Anthony C Whitton, Jian-Qiang Lu

引用次数: 0

Expression of Ras signaling pathway proteins and developmental factors in peripheral nerve sheath tumors of patients with neurofibromatosis type 1. 1型神经纤维瘤病患者周围神经鞘肿瘤中Ras信号通路蛋白及发育因子的表达

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-07-01 DOI: 10.5414/NP301554

Christian Hagel, Louisa K N Nörnberg, Reinhard E Friedrich

{"title":"Expression of Ras signaling pathway proteins and developmental factors in peripheral nerve sheath tumors of patients with neurofibromatosis type 1.","authors":"Christian Hagel, Louisa K N Nörnberg, Reinhard E Friedrich","doi":"10.5414/NP301554","DOIUrl":"https://doi.org/10.5414/NP301554","url":null,"abstract":"Purpose: To characterize expression of factors relevant for Ras signaling and developmental factors in a large series of peripheral nerve sheath tumors (PNST) obtained from patients with neurofibromatosis type 1 (NF1).Materials and methods: Tissue micro-array technique was applied to study 520 PNST of 385 NF1 patients by immunohistochemistry for mTor, Rho, phosphorylated MEK, Pax7, Sox9, and periaxin expression. PNST comprised cutaneous neurofibroma (CNF) (n = 114), diffuse neurofibroma (DNF) (n = 109), diffuse plexiform neurofibroma (DPNF) (n = 108), plexiform neurofibroma (PNF) (n = 110), and malignant PNST (MPNST) (n = 22).Results: All proteins examined showed highest expression levels/highest frequency of expression in MPNST. Benign PNF with potential for malignant dedifferentiation expressed mTor, phosphorylated MEK, Sox9, and periaxin significantly higher/more frequently than other benign neurofibroma subtypes.Conclusion: In NF1-associated PNST, expression of proteins involved in Ras-signaling and development is upregulated not only in MPNST, but also in benign PNF with the potential for malignant dedifferentiation. The differences in protein expression may provide clues for understanding the therapeutic effects of substances applied for reduction of PNST in NF1.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 4","pages":"150-160"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Neuropathology 4-2023. 临床神经病理学4-2023。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-07-01 DOI: 10.5414/NPP42129

Christian Mawrin

引用次数: 0

Molecular imaging of gliomas. 胶质瘤的分子影像学。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-07-01 DOI: 10.5414/NP301535

Marie-Christin Metz, Benedikt Wiestler

{"title":"Molecular imaging of gliomas.","authors":"Marie-Christin Metz, Benedikt Wiestler","doi":"10.5414/NP301535","DOIUrl":"https://doi.org/10.5414/NP301535","url":null,"abstract":"Molecular characterization has become a key diagnostic tool for the classification and grading of primary brain tumors. Molecular markers, such as isocitrate dehydrogenase (IDH) mutation status, 1p/19q codeletion, methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter, or CDKN2A/B homozygous deletion discriminate different tumor entities and grades, and play a crucial role for treatment response and prognosis. In recent years, magnetic resonance imaging (MRI), whose main functions has been to detect a tumor, to provide spatial information for neurosurgical and radiotherapy planning, and to monitor treatment response, has shown potential in assessing molecular features of gliomas from image-based biomarkers. As an outstanding example, numerous studies have proven that the T2/FLAIR mismatch sign can identify IDH-mutant, 1p/19q non-codeleted astrocytomas with a specificity of up to 100%. For other purposes, multiparametric MRI, often coupled with machine learning methods, seems to achieve the highest accuracy in predicting molecular markers. Relevant future applications might be anticipating changes in the molecular composition of gliomas and providing useful information about the cellular and genetic heterogeneity of gliomas, especially in the non-resected tumor parts.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 4","pages":"131-139"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9681851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary CNS EBV-positive post-transplant lymphoproliferative disorder with polymorphic and classic Hodgkin lymphoma features: A case report and literature review. 原发性中枢神经系统ebv阳性移植后淋巴增生性疾病伴多形和经典霍奇金淋巴瘤特征:1例报告并文献复习。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-07-01 DOI: 10.5414/NP301526

Martin Mulligan, Richard Flavin, Alan Beausang

{"title":"Primary CNS EBV-positive post-transplant lymphoproliferative disorder with polymorphic and classic Hodgkin lymphoma features: A case report and literature review.","authors":"Martin Mulligan, Richard Flavin, Alan Beausang","doi":"10.5414/NP301526","DOIUrl":"https://doi.org/10.5414/NP301526","url":null,"abstract":"Post-transplant lymphoproliferative disorders (PTLD) are typically Epstein-Barr virus (EBV)-associated lymphoid or plasmacytic proliferations that occur when immunosuppressed after transplantation. Only 2 cases of primary central nervous system (PCNS) classic Hodgkin lymphoma PTLD and 1 case of PCNS Hodgkin lymphoma-like PTLD have been previously reported. A 59-year-old male presented with malaise, headaches, and dizziness; neuroimaging revealed a 1.7-cm right cerebellar mass and a 0.6-cm right frontal mass. Microscopic examination demonstrated a perivascular and parenchymal polymorphous infiltrate composed of lymphocytes (CD3-positive T cells and CD20-positive B cells), plasma cells, and macrophages. Focally, macrophages had a spindled morphology with a fascicular arrangement amounting to poorly formed granulomata. Mitoses were seen. Scattered large atypical cells were visualized with irregular hyperchromatic nuclei, reminiscent of lacunar cells, mononuclear Hodgkin and binucleate Reed-Sternberg (RS) cells. EBV in situ highlighted a significant number of small lymphoid cells as well as many large atypical forms. Large atypical cells were seen to co-express CD15 and CD30. To our knowledge, this is the first such case with hybrid polymorphic PTLD and classic Hodgkin lymphoma features and the first such case to arise following liver transplantation. This case highlights the histological and immunophenotypic spectrum of these lymphoid proliferations and the resulting challenges in diagnosis and definitive subtyping.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 4","pages":"161-167"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of pannexin1 in lung cancer brain metastasis and immune microenvironment. pannexin1在肺癌脑转移及免疫微环境中的表达。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-07-01 DOI: 10.5414/NP301501

Rober Abdo, Abdulaziz Bholat, Linda Jackson-Boeters, Danielle Johnston, Silvia Penuela, Qi Zhang

{"title":"Expression of pannexin1 in lung cancer brain metastasis and immune microenvironment.","authors":"Rober Abdo, Abdulaziz Bholat, Linda Jackson-Boeters, Danielle Johnston, Silvia Penuela, Qi Zhang","doi":"10.5414/NP301501","DOIUrl":"https://doi.org/10.5414/NP301501","url":null,"abstract":"Brain metastases are the most common central nervous system malignancy, and the leading cause of cancer-related deaths. Non-small cell lung carcinomas (NSCLC) comprise the most common cell of origin. Immunotherapy, particularly checkpoint inhibitors, has emerged as the standard of care for many patients with advanced lung cancer. Pannexin1 (PANX1) is a transmembrane glycoprotein that forms large-pore channels and has been reported to promote cancer metastasis. However, the roles of PANX1 in lung cancer brain metastases and tumor immune microenvironment have not been characterized. 42 patient-matched formalin-fixed paraffin-embedded tissue samples from lung carcinomas and the subsequent brain metastases were constructed into three tissue microarrays (TMAs). PANX1 and markers of tumor-infiltrating immune cells (CD3, CD4, CD8, CD68, and TMEM119) were assessed using immunohistochemistry and digital image analysis. The expression of PANX1 was significantly higher in brain metastases than in their paired primary lung carcinoma. The high levels of PANX1 in lung carcinoma cells in the brain inversely correlated with infiltration of peripheral blood-derived macrophages. Our findings highlight the role of PANX1 in the progression of metastatic NSCLC, and the potential therapeutic approach of targeting PANX1 enhances the efficacy of immune checkpoint inhibitors in brain metastasis.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 4","pages":"140-149"},"PeriodicalIF":1.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain biopsy in neurological disease of unknown etiology: A single-center 12-year retrospective analysis. 病因不明的神经系统疾病的脑活检:一项12年单中心回顾性分析。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-05-01 DOI: 10.5414/NP301517

Andrew Lockhart, Josephine Heffernan, Ann Kennedy, Andrea Walsh, Ciara Heeney, Rosa Cheung, Rachel Howley, Jane Cryan, Alan Beausang, Michael Farrell, Francesca Brett

{"title":"Brain biopsy in neurological disease of unknown etiology: A single-center 12-year retrospective analysis.","authors":"Andrew Lockhart, Josephine Heffernan, Ann Kennedy, Andrea Walsh, Ciara Heeney, Rosa Cheung, Rachel Howley, Jane Cryan, Alan Beausang, Michael Farrell, Francesca Brett","doi":"10.5414/NP301517","DOIUrl":"https://doi.org/10.5414/NP301517","url":null,"abstract":"There are no international guidelines for brain biopsy in neurological disease of unknown etiology, yet most practicing neurologists will encounter difficult cases in which biopsy is considered. This patient cohort is heterogenous, and it is unclear in which circumstances biopsy is most useful. We performed an audit of brain biopsies reviewed in our neuropathology department from 2010 to 2021. Of 9,488 biopsies, 331 biopsies undertaken for an undiagnosed neurological disease were identified. Where documented, the commonest symptoms were hemorrhage, encephalopathy, and dementia. 29% of biopsies were non-diagnostic. The most common clinically relevant findings on biopsy were infection, cerebral amyloid angiopathy with or without angiitis, and demyelination. Rarer conditions included CNS vasculitis, non-infectious encephalitis, and Creutzfeldt Jakob Disease. We highlight the value of brain biopsy in the workup of cryptogenic neurological disease despite recent advances in less invasive diagnostics.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 3","pages":"93-99"},"PeriodicalIF":1.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clasmatodendrosis: Brief review of an underreported neuropathological finding. 类齿突病:一个未被报道的神经病理发现的简要回顾。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-05-01 DOI: 10.5414/NP301496

Sumit Das

引用次数: 0

Clinical Neuropathology 3-2023. 临床神经病理学3-2023。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-05-01 DOI: 10.5414/NPP42085

Christian Mawrin

引用次数: 0

What neuropathology teaches us about autoimmune encephalitides, autoimmune epilepsies, and encephalomyelitides. 神经病理学告诉我们关于自身免疫性脑炎、自身免疫性癫痫和脑脊髓炎的知识。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-05-01 DOI: 10.5414/NP301536

Christian G Bien, Jan Bauer

{"title":"What neuropathology teaches us about autoimmune encephalitides, autoimmune epilepsies, and encephalomyelitides.","authors":"Christian G Bien, Jan Bauer","doi":"10.5414/NP301536","DOIUrl":"https://doi.org/10.5414/NP301536","url":null,"abstract":"Delineation of the autoimmune encephalitides with antibodies against neural surface antigens (anti-N-Methyl-D-aspartate, anti-leucine-rich glioma-inactivated protein 1, and others), autoimmune-associated epilepsies (Rasmussen encephalitis, paraneoplastic encephalitides, temporal lobe epilepsy with antibodies against glutamic acid decarboxylase), and encephalomyelitides with glial antibodies (neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody disease) has been a major advance in neurology. But how do these inflammatory diseases \"work\"? What kind of interaction between elements of the immune system and brain cells leads to these conditions? The only direct way of answering these questions is to investigate affected brain tissue by neuropathological techniques. They provide morphological and, in part, temporal information on the elements and localization of the disease process. Molecular techniques broaden and support these data. Brain tissue becomes available through autopsies and brain biopsies, obtained for diagnostic or therapeutic interventions. The limitations of neuropathological pathogenic research are discussed. Finally, representative neuropathological findings in autoimmune encephalitides and related conditions are summarized.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 3","pages":"87-92"},"PeriodicalIF":1.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9441593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0