Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas.

IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY
Georgi Galev, Maximillian A Weigelt, Richard A Prayson
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引用次数: 0

Abstract

Tumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histologically, the lesion showed a glioblastoma, IDH-wildtype, WHO grade 4, associated with a metastatic adenocarcinoma (positive for estrogen receptor, progesterone receptor, and mammaglobin), suggesting a breast primary. The patient passed away 5 months after surgery. Involvement of glioblastoma by TTM is especially rare; only 1 case of TTM to glioblastoma is thus far reported in the English literature. The mechanism by which TTM occurs is poorly understood. TTM may be the first presentation of an occult malignancy and warrants thorough clinical, laboratory, and imaging investigation.

腺癌向胶质母细胞瘤的肿瘤间转移——肿瘤向胶质瘤转移的文献综述。
肿瘤间转移(TTM)是一个肿瘤转移到另一个肿瘤的过程。这是一种极为罕见的现象,尤其是在中枢神经系统,它最常见于作为受体的脑膜瘤。在此,我们报告了一例75岁女性腺癌向胶质母细胞瘤的肿瘤间转移。该患者8年前有高级别乳腺原位导管癌病史,曾接受肿块切除术和放疗。她表现为左额顶骨肿块。组织学上,病变显示为胶质母细胞瘤,IDH野生型,世界卫生组织4级,与转移性腺癌相关(雌激素受体、孕酮受体和乳腺珠蛋白阳性),提示乳腺原发性。病人在手术后5个月去世。TTM累及胶质母细胞瘤的情况尤其罕见;迄今为止,在英国文献中仅报道了1例TTM致胶质母细胞瘤的病例。TTM发生的机制尚不清楚。TTM可能是隐匿性恶性肿瘤的首次表现,需要进行彻底的临床、实验室和影像学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Neuropathology
Clinical Neuropathology 医学-病理学
CiteScore
1.60
自引率
0.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.
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