Clinical Neuropathology最新文献

Application of carbonic anhydrase IX in sporadic hemangioblastoma of the central nervous system and hemangioblastoma associated with von Hippel-Lindau disease. 碳酸酐酶 IX 在中枢神经系统散发性血管母细胞瘤和与 von Hippel-Lindau 病相关的血管母细胞瘤中的应用。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-10-02 DOI: 10.5414/NP301620

Xue Chen, Xiaoxiang Gao, Jiaqi Bo, Haixia Bi, Haoyang Zhang, Yuting Liu, Jie Yu, Xianghua Yi, Fei Wang, Suxia Zhang, Yu Zeng

{"title":"Application of carbonic anhydrase IX in sporadic hemangioblastoma of the central nervous system and hemangioblastoma associated with von Hippel-Lindau disease.","authors":"Xue Chen, Xiaoxiang Gao, Jiaqi Bo, Haixia Bi, Haoyang Zhang, Yuting Liu, Jie Yu, Xianghua Yi, Fei Wang, Suxia Zhang, Yu Zeng","doi":"10.5414/NP301620","DOIUrl":"10.5414/NP301620","url":null,"abstract":"Objective: This research aims to examine the expression of carbonic anhydrase IX (CAIX) protein in hemangioblastoma of the central nervous system and its potential application in pathological diagnosis and differential diagnosis.Materials and methods: Immunohistochemistry was used to identify the expression of CAIX and the α-inhibin protein. The sensitivity and specificity of CAIX and α-inhibin for identifying hemangioblastoma of the central nervous system were compared. In addition, 86 patients with meningiomas were gathered to detect CAIX protein expression. Hemangioblastoma and angiomatous, microcystic the two subtypes of meningiomas, were compared for CAIX and EMA protein expression.Results: In hemangioblastoma, there were significant differences in the median positive percentage and staining intensity of CAIX and α-inhibin (p < 0.05). There was no discernible difference in the expression of the CAIX protein between sporadic hemangioblastoma of the central nervous system and those linked to von Hippel‒Lindau disease. In comparison to angiomatous and microcystic meningiomas, the positive rate of CAIX in hemangioblastomas was substantially greater (p < 0.001). The expression of EMA in microcystic meningioma (6/6) and angiomatous meningioma (17/17) was significantly different from hemangioblastoma (0/30) (p < 0.0001).Conclusion: Hemangioblastoma might be diagnosed with high specificity and sensitivity through CAIX immunohistochemistry. The combination of CAIX with EMA is useful for the diagnosis and differential diagnosis of hemangioblastoma.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retracing RAS signaling by correlating protein expression in different subtypes of neurofibromatosis 1-associated nerve sheath tumors. 通过关联神经纤维瘤病 1 相关神经鞘瘤不同亚型中的蛋白质表达，重新追踪 RAS 信号转导。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-07-01 DOI: 10.5414/NP301624

Christian Hagel, Louisa K N Nörnberg, Reinhard E Friedrich

{"title":"Retracing RAS signaling by correlating protein expression in different subtypes of neurofibromatosis 1-associated nerve sheath tumors.","authors":"Christian Hagel, Louisa K N Nörnberg, Reinhard E Friedrich","doi":"10.5414/NP301624","DOIUrl":"10.5414/NP301624","url":null,"abstract":"Aims: Expression patterns of key proteins involved in RAS signaling and connected pathways were determined and correlated to possibly provide information for therapeutic application of RAS inhibitors in neurofibromatosis type 1 (NF1)-associated peripheral nerve sheath tumors (PNST).Materials and methods: Clinical variables (age, sex), histological parameters (cell density, mitoses), and expression of immunohistochemically evaluated ligand and receptor proteins (neuregulin 1 (NRG1), ErbB2, ErbB3), RAS pathway proteins (mTor, Rho, phosphorylated MEK), transcription factors (Pax7, Sox9), and proliferation marker Ki-67, were correlated in cutaneous (CNF, n = 136), diffuse (DNF, n = 123)/diffuse plexiform (DPNF, n = 113), and plexiform neurofibroma (PNF, n = 126), and in malignant PNST (MPNST, n = 22).Results: In CNF, NRG1 correlated with Ki-67 and Pax7. Further, mTOR correlated with ErbB3, Sox9, Pax7, and Ki-67. In DNF/DPNF, expression of NRG1 correlated with pMEK and Pax7. mTOR correlated with pMEK, Sox9, and Pax7. Noteworthy, pMEK was weakly expressed in some DNF but not in DPNF. ErbB3 correlated with mTor and Ki-67. Furthermore, Rho correlated with Pax7 and Ki-67. In PNF, ErbB3 expression was associated with Sox9, mTOR, pMEK, and Pax7 as well as mTOR with Sox9 and Pax7, Rho with pMEK and Pax7, and pMEK with Pax7 and Sox9. In MPNST, only few correlations were observed, ErbB2 correlated with Ki-67, and Rho with pMEK.Conclusion: Signaling networks of the RAS pathway could be retraced by correlation analysis of protein expression in subgroups of NF1 associated benign PNST. In regard to treatment of PNST, MEK inhibitors, which are presently evaluated for PNF, may possibly also be effective to some extent in DNF.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma. 评估 ST6Gal1 在人类胶质瘤中的表达和临床病理意义。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-07-01 DOI: 10.5414/NP301631

Ying Zhou, Yutong Wu, Dacuan Shen, Qimin Wang, Aline M Thomas, Shen Li, Feng Shi, Eric Wing-Fai Lam, Huamin Qin

{"title":"Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma.","authors":"Ying Zhou, Yutong Wu, Dacuan Shen, Qimin Wang, Aline M Thomas, Shen Li, Feng Shi, Eric Wing-Fai Lam, Huamin Qin","doi":"10.5414/NP301631","DOIUrl":"10.5414/NP301631","url":null,"abstract":"Glioma is the most common brain tumor, accounting for a large majority of cancer-related deaths. β-galactoside α2, 6 sialyltranferase 1 (ST6Gal1), the primary enzyme responsible for the conjugation of α2, 6 sialic acids to protein and lipid targets, is strongly associated with the occurrence and development of several brain tumor types. Still, the expression, targets, and functions of ST6Gal1 in glioma patients remain undetermined. As sialylation of the Ig-like cell adhesion family molecules have prominent roles in the latter's regulation in other biological contexts, we screened for members that have potential to be regulated by ST6Gal1 in silico and examined co-expressed protein modules using data derived from the Cancer Genome Atlas (TCGA) database, and we identified neural cell adhesion molecule (NCAM1) as a major ST6Gal1-interacting target. Bioinformatic binding analysis confirmed the interaction of ST6Gal1 and NCAM1. Immunohistochemistry was then used to evaluate post-operative samples from 156 patients with gliomas. ST6Gal1 and NCAM1 were co-expressed in gliomas, and their expression correlated significantly (p = 0.002) by univariate analysis. Our study also found that the expression levels of both ST6Gal1 and NCAM1 corresponded negatively with glioma grade, isocitrate dehydrogenase (IDH) mutation, and proliferation index (Ki67). Consistently, Kaplan-Meier survival curves showed that lower ST6Gal1 and NCAM1 protein levels are linked to unfavorable outcomes in glioma patients (p = 0.018 and p < 0.001, respectively). Our data indicate that ST6Gal1 may participate in the inhibition of oncogenesis and malignant progression via interacting with and targeting NCAM1 in glioma, thus presenting a novel strategy for intervention.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JCV granule cell neuronopathy: A rare case manifestation. JCV颗粒细胞神经元病：一种罕见的病例表现。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-07-01 DOI: 10.5414/NP301639

Rumela Nayak, Shilpa Rao, Nirmala Subramanian

引用次数: 0

Clinical Neuropathology 4-2024. 临床神经病理学 4-2024.

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-07-01 DOI: 10.5414/NPP43103

Christian Mawrin

引用次数: 0

Hypertrophy of the inferior olivary nucleus in corticobasal degeneration: A neuropathological study. 皮质基底层变性的下橄榄核肥大：神经病理学研究

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NP301616

Daisuke Tahara, Nao Tahara, Akio Akagi, Yuichi Riku, Jun Sone, Hiroaki Miyahara, Atsushi Nagai, Mari Yoshida, Yasushi Iwasaki

{"title":"Hypertrophy of the inferior olivary nucleus in corticobasal degeneration: A neuropathological study.","authors":"Daisuke Tahara, Nao Tahara, Akio Akagi, Yuichi Riku, Jun Sone, Hiroaki Miyahara, Atsushi Nagai, Mari Yoshida, Yasushi Iwasaki","doi":"10.5414/NP301616","DOIUrl":"10.5414/NP301616","url":null,"abstract":"Aims: Corticobasal degeneration (CBD) is a rare neurodegenerative disorder. The status of the inferior olivary nucleus (ION) in CBD has been inadequately investigated. In this study, we conducted a pathological investigation of the ION in CBD.Materials and methods: We reviewed the data of Japanese patients with pathologically confirmed CBD who underwent consecutive autopsies between 1985 and 2020 at our institute. We retrospectively examined clinical data from medical records and clinicopathological conferences and semi-quantitatively assessed the ION, central tegmental tract, superior cerebellar peduncle, and dentate nucleus.Results: Of the 32 patients included, 14 (43.8%) had hypertrophy of the ION (HION), of whom 6 showed laterality. In the 14 HION cases, with or without laterality, except in 1 unevaluable case, atrophy/myelin pallor of the central tegmental tract was observed on the same side as the hypertrophy. Ten patients with HION, with or without laterality, had atrophy/myelin pallor of the superior cerebellar peduncle on the contralateral side to the hypertrophy.Conclusion: The ION presents with hypertrophic changes in CBD. The lesion is a primary degeneration in CBD and is related to the degeneration of the Guillain-Mollaret triangle. This finding contributes to the elucidation of the specific pathological characteristics of CBD.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): A case report with surgical and neuropathological differential diagnosis. 多形性低级别幼年神经上皮肿瘤（PLNTY）：手术和神经病理学鉴别诊断病例报告。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NP301609

Ozgur Orhan, Halit Anil Eray, Baran Can Alpergin, Murat Zaimoglu, Omer Mert Ozpiskin, Nermin Aras, Aylin Heper, Umit Eroglu

{"title":"Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): A case report with surgical and neuropathological differential diagnosis.","authors":"Ozgur Orhan, Halit Anil Eray, Baran Can Alpergin, Murat Zaimoglu, Omer Mert Ozpiskin, Nermin Aras, Aylin Heper, Umit Eroglu","doi":"10.5414/NP301609","DOIUrl":"10.5414/NP301609","url":null,"abstract":"Background: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a rare entity of low-grade neuroepithelial tumors that primarily affects children and young adults. This distinct type of tumor presents unique challenges in diagnosis and management. With its relatively recent identification, researchers and clinicians are striving to understand the characteristics, behavior, and optimal treatment strategies. The symptoms are primarily related to seizures. However, PLNTY can be asymptomatic in some cases.Materials and methods: This is a single-center case report study and a literature review paper. We reviewed a case treated and diagnosed at the Ankara University Faculty of Medicine, Department of Neurosurgery. The demographic data, clinical follow-ups, laboratory, and radiological data of the patients were assessed.Results: We present a 32-year-old male patient who has undergone gross total surgical excision with strict clinical follow-up. Clinical course as well as surgical data of the patient were observed and analyzed.Conclusion: On imaging, morphologic resembling and indistinctive clinical course can be nonspecific, contributing to diagnostic uncertainties. This case report was written with the notion that rare diagnoses present an opportunity to understand the progression and patho-oncological factors that can pave the way for better treatment.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic hypereosinophilic syndrome presenting with stroke. 出现中风的特发性高嗜酸性粒细胞综合征。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NP301613

Neeraj Singla, Anuj Prabhakar, Nupur Pradhan, Sreejesh Sreedharanunni, Manupdesh Singh Sachdeva, Harbir Singh Kohli, Kirti Gupta

引用次数: 0

Clinical Neuropathology 3-2024. 临床神经病理学 3-2024.

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NPP43073

Christian Mawrin

引用次数: 0

Isolated embryonal rhabdomyosarcoma of the anterior petrous bone in a young child: Focusing on the intra-operative diagnosis and differentials. 一名幼童前枕骨的孤立性胚胎性横纹肌肉瘤：聚焦术中诊断和鉴别。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NP301586

Ipsita Panda, Murali Krishna Bethanbhatla, Kirti Gupta, Pravin Salunke

引用次数: 0