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Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): A case report with surgical and neuropathological differential diagnosis. 多形性低级别幼年神经上皮肿瘤（PLNTY）：手术和神经病理学鉴别诊断病例报告。
IF 0.8 4区 医学
Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NP301609
Ozgur Orhan, Halit Anil Eray, Baran Can Alpergin, Murat Zaimoglu, Omer Mert Ozpiskin, Nermin Aras, Aylin Heper, Umit Eroglu
{"title":"Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): A case report with surgical and neuropathological differential diagnosis.","authors":"Ozgur Orhan, Halit Anil Eray, Baran Can Alpergin, Murat Zaimoglu, Omer Mert Ozpiskin, Nermin Aras, Aylin Heper, Umit Eroglu","doi":"10.5414/NP301609","DOIUrl":"10.5414/NP301609","url":null,"abstract":"<p><strong>Background: </strong>Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a rare entity of low-grade neuroepithelial tumors that primarily affects children and young adults. This distinct type of tumor presents unique challenges in diagnosis and management. With its relatively recent identification, researchers and clinicians are striving to understand the characteristics, behavior, and optimal treatment strategies. The symptoms are primarily related to seizures. However, PLNTY can be asymptomatic in some cases.</p><p><strong>Materials and methods: </strong>This is a single-center case report study and a literature review paper. We reviewed a case treated and diagnosed at the Ankara University Faculty of Medicine, Department of Neurosurgery. The demographic data, clinical follow-ups, laboratory, and radiological data of the patients were assessed.</p><p><strong>Results: </strong>We present a 32-year-old male patient who has undergone gross total surgical excision with strict clinical follow-up. Clinical course as well as surgical data of the patient were observed and analyzed.</p><p><strong>Conclusion: </strong>On imaging, morphologic resembling and indistinctive clinical course can be nonspecific, contributing to diagnostic uncertainties. This case report was written with the notion that rare diagnoses present an opportunity to understand the progression and patho-oncological factors that can pave the way for better treatment.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"83-91"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic hypereosinophilic syndrome presenting with stroke. 出现中风的特发性高嗜酸性粒细胞综合征。
IF 0.8 4区 医学
Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NP301613
Neeraj Singla, Anuj Prabhakar, Nupur Pradhan, Sreejesh Sreedharanunni, Manupdesh Singh Sachdeva, Harbir Singh Kohli, Kirti Gupta
{"title":"Idiopathic hypereosinophilic syndrome presenting with stroke.","authors":"Neeraj Singla, Anuj Prabhakar, Nupur Pradhan, Sreejesh Sreedharanunni, Manupdesh Singh Sachdeva, Harbir Singh Kohli, Kirti Gupta","doi":"10.5414/NP301613","DOIUrl":"10.5414/NP301613","url":null,"abstract":"<p><p>Hypereosinophilic syndrome (HES) is characterized by eosinophilia associated with organ damage. The disorder has substantial clinical heterogeneity and a highly variable prognosis. This report describes an interesting autopsy case of a 62-year-old lady presenting with itching and stroke-like symptoms. She was diagnosed with an \"idiopathic\" variant of HES after a thorough exclusion of all known causes. Despite adequate measures, she deteriorated rapidly. At autopsy, acute cerebral infarcts were identified in multiple vascular territories including infarcts in watershed areas. Additionally, her heart showed classic pathological features of eosinophilic myocarditis spanning all three stages.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"92-97"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Neuropathology 3-2024. 临床神经病理学 3-2024.
IF 0.8 4区 医学
Clinical Neuropathology Pub Date : 2024-05-01 DOI: 10.5414/NPP43073
Christian Mawrin
{"title":"Clinical Neuropathology 3-2024.","authors":"Christian Mawrin","doi":"10.5414/NPP43073","DOIUrl":"10.5414/NPP43073","url":null,"abstract":"","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"73"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated embryonal rhabdomyosarcoma of the anterior petrous bone in a young child: Focusing on the intra-operative diagnosis and differentials. 一名幼童前枕骨的孤立性胚胎性横纹肌肉瘤：聚焦术中诊断和鉴别。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NP301586
Ipsita Panda, Murali Krishna Bethanbhatla, Kirti Gupta, Pravin Salunke
{"title":"Isolated embryonal rhabdomyosarcoma of the anterior petrous bone in a young child: Focusing on the intra-operative diagnosis and differentials.","authors":"Ipsita Panda, Murali Krishna Bethanbhatla, Kirti Gupta, Pravin Salunke","doi":"10.5414/NP301586","DOIUrl":"10.5414/NP301586","url":null,"abstract":"<p><strong>Objective: </strong>Rhabdomyosarcoma is a common soft tissue tumor, but isolated involvement of anterior portion of petrous bone is exceedingly rare. Here, we present a case of embryonal rhabdomyosarcoma involving the anterior petrous without involvement of the mastoid and middle ear.</p><p><strong>Patient: </strong>A 6-year-old boy presented with a progressive right side lower motor neuron facial paresis for 1-month duration along with headache and recurrent vomiting episodes. Radiology showed a contrast-enhancing lesion involving the right petrous apex. He underwent craniotomy and excision of the lesion. Based on the frozen section, a diagnosis of rhabdomyosarcoma was rendered, and gross total resection could be achieved. Postoperative course was uneventful.</p><p><strong>Conclusion: </strong>Isolated petrous bone involvement of embryonal rhabdomyosarcoma is a rare presentation. Intra-operative frozen section plays a key role in decision making regarding the extent of excision. Hence, a prompt and accurate diagnosis is essential in managing these cases.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"48-52"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intratumoral histological and molecular heterogeneity in an adult diffuse glioma. 成人弥漫性胶质瘤的瘤内组织学和分子异质性。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NP301598
Trishhani Yogaretnam, Josephine Heffernan, Rosa Leung, Ciara Heeney, Andrea Walsh, Seamus Looby, John Caird, Francesca M Brett
{"title":"Intratumoral histological and molecular heterogeneity in an adult diffuse glioma.","authors":"Trishhani Yogaretnam, Josephine Heffernan, Rosa Leung, Ciara Heeney, Andrea Walsh, Seamus Looby, John Caird, Francesca M Brett","doi":"10.5414/NP301598","DOIUrl":"10.5414/NP301598","url":null,"abstract":"<p><p>Adult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance imaging (MRI), on this admission, showed a mass lesion in the left frontal operculum with poorly identified margins and right-sided midline shift. Sampling from the left temporal lobe showed an IDH-mutant, ATRX-mutant astrocytoma, which appeared grade 4 in the enhancing anterior portion and grade 2 in the left temporal lobe. Methylation analysis confirmed this heterogeneity. In summary, this is an excellent example of tumor heterogeneity both histologically and by molecular analysis. It is probable, given the clinical history of presentation 2 years prior, that this tumor originated as a low-grade glioma and subsequently evolved.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"60-64"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamma-delta T-cell lymphoma of the central nervous system: A case report and review of the literature. 中枢神经系统γ-δT细胞淋巴瘤：病例报告和文献综述。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NP301596
Alexa T Andre, Meagan Chambers, Daniel E Sabath
{"title":"Gamma-delta T-cell lymphoma of the central nervous system: A case report and review of the literature.","authors":"Alexa T Andre, Meagan Chambers, Daniel E Sabath","doi":"10.5414/NP301596","DOIUrl":"10.5414/NP301596","url":null,"abstract":"<p><p>Primary T-cell lymphoma (TCL) of the central nervous system (CNS) is a rare and potentially aggressive entity. We describe a case of TCL presenting in the basal ganglia with γδ receptor expression and a remarkably aggressive clinical course. To the best of our knowledge, this is the fifth reported case of γδ TCL presenting in the CNS. We review existing literature, including the previously reported cases of γδ TCL of the CNS. In our case, a 69-year-old male presented with acute onset dysarthria and right-sided weakness, with initial imaging concerning for stroke. Repeat imaging demonstrated a 2.6-cm mass in the left basal ganglia-corona radiata. Pathologic examination of a stereotactic biopsy revealed TCL with γδ receptor phenotype. The patient suffered rapid clinical decline and passed away within 6 weeks of initial diagnosis. This represents an important differential diagnosis and sheds light on the potentially poor prognosis conferred by γδ TCL of the CNS.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"53-59"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Neuropathology 2-2024. 临床神经病理学 2-2024。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NPP43041
Christian Mawrin
{"title":"Clinical Neuropathology 2-2024.","authors":"Christian Mawrin","doi":"10.5414/NPP43041","DOIUrl":"10.5414/NPP43041","url":null,"abstract":"","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"41-42"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olfactory groove schwannoma: Common pathology in an uncommon location. 嗅沟分裂瘤：不常见部位的常见病理。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NP301605
Akhil Sunil, Sumit Thakar, Sanjay Honavalli Murali, Nayana Nagappa Sriramanakoppa, Saritha Aryan
{"title":"Olfactory groove schwannoma: Common pathology in an uncommon location.","authors":"Akhil Sunil, Sumit Thakar, Sanjay Honavalli Murali, Nayana Nagappa Sriramanakoppa, Saritha Aryan","doi":"10.5414/NP301605","DOIUrl":"10.5414/NP301605","url":null,"abstract":"","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"65-68"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry. 被误诊为转移性肾细胞癌的内淋巴囊肿瘤：形态学和免疫组化的陷阱。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-03-01 DOI: 10.5414/NP301603
Wenjia Sun, Manxiang Wang, Junqiu Yue
{"title":"Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry.","authors":"Wenjia Sun, Manxiang Wang, Junqiu Yue","doi":"10.5414/NP301603","DOIUrl":"10.5414/NP301603","url":null,"abstract":"<p><p>Endolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confirming the absence of renal neoplasm to rule out the possibility of metastasis are critical for obtaining an accurate final diagnosis.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"43-47"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SWI/SNF-deficient tumors of the central nervous system: An update. 中枢神经系统SWI/ snf缺陷肿瘤:最新进展。
IF 1.1 4区 医学
Clinical Neuropathology Pub Date : 2024-01-01 DOI: 10.5414/NP301594
Martin Hasselblatt, Marcel Kool, Michael C Frühwald
{"title":"SWI/SNF-deficient tumors of the central nervous system: An update.","authors":"Martin Hasselblatt, Marcel Kool, Michael C Frühwald","doi":"10.5414/NP301594","DOIUrl":"10.5414/NP301594","url":null,"abstract":"<p><p>Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system characterized by biallelic inactivation of SWI/SNF chromatin remodeling complex members SMARCB1/INI1 or (rarely) SMARCA4/BRG1. Most high-grade central nervous system lesions showing loss of nuclear SMARCB1 or SMARCA4 protein expression can indeed be categorized as AT/RT. However, some high-grade lesions have been identified, whose clinical and/or molecular features justify separation from AT/RT. Furthermore, other recently described tumor types such as desmoplastic myxoid tumor, SMARCB1-mutant, and low-grade diffusely infiltrative tumor, SMARCB1-mutant, may even manifest as low-grade lesions. Here, we review recent developments in the definition of the molecular landscape of AT/RT and give an update on other rare high- and low-grade SWI/SNF-deficient central nervous system tumors.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"2-9"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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