Clinical Neuropathology最新文献_第6页

Prognostic significance of PD-1, CTLA-4, CD4, and CD8 expression in olfactory neuroblastoma. PD-1、CTLA-4、CD4和CD8表达在嗅神经母细胞瘤中的预后意义。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-03-01 DOI: 10.5414/NP301519

Linlin Wu, Hui Liu, Honggang Liu

{"title":"Prognostic significance of PD-1, CTLA-4, CD4, and CD8 expression in olfactory neuroblastoma.","authors":"Linlin Wu, Hui Liu, Honggang Liu","doi":"10.5414/NP301519","DOIUrl":"https://doi.org/10.5414/NP301519","url":null,"abstract":"There are limited data regarding immune surveillance mechanisms in olfactory neuroblastoma. We investigated the expression of programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), CD4, and CD8 in olfactory neuroblastoma to identify potential therapeutic targets. Immunohistochemistry was used to detect PD-1 and CTLA-4 and measure the numbers of CD4+ and CD8+ T cells in 56 patients with olfactory neuroblastoma. The relationships between these molecules in tumor microenvironment, clinicopathological features, and survival were analyzed. The prevalence of PD-1 in Kadish C stage was 24.14%, significantly greater than in Kadish A and B stage. CD4+ T-cell and CD8+ T-cell levels correlated with higher Hyams histological grade and Kadish stage. In addition, PD-1 was related positively with CTLA-4, CD4+ T cells, and CD8+ T cells in olfactory neuroblastoma. Univariate survival analysis showed that higher PD-1 positivity, CD8+ T cells, and Hyams grade correlated with worse clinical outcome. Multivariate analysis showed that the expression of PD-1 was an independent parameter for poor prognosis. In conclusion, olfactory neuroblastoma with PD-1 expression had more aggressive clinicopathological features and worse prognosis. PD-1 may potentially predict the outcome of olfactory neuroblastoma patients.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 2","pages":"47-53"},"PeriodicalIF":1.1,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Neuropathology 2-2023. 临床神经病理学2-2023。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-03-01 DOI: 10.5414/NPP42045

Christian Mawrin

引用次数: 0

Neuropathological features of adult-onset neuronal intranuclear inclusion disease with fluid-attenuated inversion recovery high-intensity signals in the cerebellar paravermal area from an early stage: A case report. 成人发病的神经元核内包涵病伴液体衰减反转的神经病理学特征:早期在小脑皮层旁区恢复高强度信号1例报告。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-03-01 DOI: 10.5414/NP301499

Taku Homma, Utako Nagaoka, Yasuhiro Nakata, Jun Sone, Asuka Funai, Aki Murayama, Cisato Tamai, Takashi Komori, Kazushi Takahashi

引用次数: 0

Pediatric brain tumors: Origins, epidemiology, and classification - The 2022 Brain Tumor Epidemiology Consortium meeting report. 小儿脑肿瘤：起源、流行病学和分类 - 2022 年脑肿瘤流行病学联合会会议报告。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-03-01 DOI: 10.5414/NP301520

Kimberly J Johnson, Luc Bauchet, Stephen S Francis, Johannes A Hainfellner, Carol Kruchko, Ching C Lau, Quinn T Ostrom, Michael E Scheurer, Yan Yuan

引用次数: 0

Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. 两例原发性免疫缺陷患者巨细胞病毒脑炎和麻疹包涵体脑炎尸检的不寻常组织病理学特征。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-01-01 DOI: 10.5414/NP301476

Ankur Jindal, Deepti Suri, Kirti Gupta, Ashwani Kumar, Vignesh Pandiarajan, Rakesh Kumar Pilania, Sandesh Guleria, Amit Rawat, Sameer Vyas, Anmol Bhatia, Surjit Singh, Bishan Dass Radotra

{"title":"Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency.","authors":"Ankur Jindal, Deepti Suri, Kirti Gupta, Ashwani Kumar, Vignesh Pandiarajan, Rakesh Kumar Pilania, Sandesh Guleria, Amit Rawat, Sameer Vyas, Anmol Bhatia, Surjit Singh, Bishan Dass Radotra","doi":"10.5414/NP301476","DOIUrl":"https://doi.org/10.5414/NP301476","url":null,"abstract":"Purpose: To describe the neuropathological findings in two patients with primary immunodeficiency who had fatal viral encephalitis.Materials and methods: Severe combined immunodeficiency (SCID) was confirmed in case 1 by genetic testing, while case 2 had features suggestive of combined immunodeficiency; however, whole exome sequencing showed no pathogenic variants. Autopsies were performed in both cases after an informed consent. A detailed sampling of the brain including extracranial organs was conducted. Immunohistochemistry and electron microscopy was also performed to confirm the presence of viruses.Results: Besides evidence of cystic encephalomalacia observed in both cases, the brain in case 1 revealed cytomegalovirus (CMV) ventriculoencephalitis accompanied by an exuberant gemistocytic response in the entire white matter. Nuclei of gemistocytes were loaded with several CMV nuclear inclusions, which was confirmed by immunohistochemistry. Case 2 demonstrated features of measles inclusion body encephalitis with several viral inclusions within neurons and astrocytes. Rare giant cells were also seen. Measles virus was confirmed on immunohistochemistry and electron microscopy. Plausibly, there was paucity of microglial nodules in both cases. Superadded bacterial pneumonia with diffuse alveolar damage was also seen in both cases.Conclusion: These cases add to the spectrum of unusual histological features of viral encephalitis seen in patients with underlying primary immunodeficiency diseases.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 1","pages":"15-25"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colloid cyst with hyphal-like structures: A rarity that mimics actinomycosis of athe third ventricle. 具有菌丝样结构的胶体囊肿:罕见的类似第三脑室放线菌病的囊肿。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-01-01 DOI: 10.5414/NP301456

Dirar Aldabek, Martina Deckert, Christian Mawrin, Jan-Peter Warnke

引用次数: 0

Clinical Raman spectroscopy of brain tumors from an interdisciplinary perspective. 从跨学科的角度看脑肿瘤的临床拉曼光谱。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-01-01 DOI: 10.5414/NP301522

Roberta Galli, Tareq A Juratli, Ortrud Uckermann

引用次数: 0

Recurrent high-grade astroblastoma with MN1-BEND2 fusion in spinal cord and literature review. 脊髓复发性高级别星形母细胞瘤伴MN1-BEND2融合并文献复习。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-01-01 DOI: 10.5414/NP301497

Dongjin Sun, Jing Liu, Liling Xiao, Hong Guan

{"title":"Recurrent high-grade astroblastoma with MN1-BEND2 fusion in spinal cord and literature review.","authors":"Dongjin Sun, Jing Liu, Liling Xiao, Hong Guan","doi":"10.5414/NP301497","DOIUrl":"https://doi.org/10.5414/NP301497","url":null,"abstract":"Astroblastoma is an uncommon tumor of the central nervous system. It is variable in morphology, but the astroblastic pseudorosettes and vascular hyalinization are the most important features. Most astroblastomas occur in the cerebral hemisphere. We report a recurrent high-grade astroblastoma with MN1-BEND2 fusion in the spinal cord. Two lesions were found in the T5-7 level and T12-L1 level, and they were well defined in images. Rhabdoid and signet-ring-like cells were observed. It may be classified as a high-grade tumor due to cellularity, high mitotic count, and pleomorphism. The tumor cells were diffusely positive for GFAP, Olig-2, and S-100 protein. We found the MN1 arrangement and the loss of chromosome 1p by FISH, and further validated the BEN domain containing 2 genes (BEND2), which is the fusion partner of meningioma 1 gene (MN1), by next-generation sequencing (NGS) and Sanger sequencing. The MN1 mutation is crucial in the diagnosis and prognosis of rare astroblastoma. The spinal cord astroblastoma may have a high recurrence rate because of the residual lesion at the unique location and higher grade; the connection with the gene mutation is unclear. Regular follow-up is necessary. Further study and more cases are needed to establish evidence for diagnosis, prognosis, and treatment of astroblastoma with molecular characteristics.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":"42 1","pages":"30-39"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10751587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Neuropathology 1-2023. 临床神经病理学1-2023。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-01-01 DOI: 10.5414/NPP42001

Christian Mawrin

引用次数: 0

Argyrophilic grain disease pathology in a patient under 70 years of age: A brief case report and literature review. 70岁以下嗜银性谷粒病病理:一个简单的病例报告和文献复习。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2022-11-01 DOI: 10.5414/NP301484

Sumit Das

引用次数: 0