Clinical Neuropathology最新文献_第4页

Rare and rapidly growing benign neoplasm arising in skull: Melanotic neuroectodermal tumor of infancy: A case report. 颅内发生的罕见且生长迅速的良性肿瘤：婴儿期黑色素神经外胚层肿瘤：病例报告。

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-01-01 DOI: 10.5414/NP301637

Krutika Patel, Kishor Managoli, Radhika Mhatre

引用次数: 0

Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism. SMART 综合征与局灶性神经元巨球症的组织学和神经影像学比较。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2024-01-01 DOI: 10.5414/NP301589

Ahmed Gilani, Bette K Kleinschmidt-DeMasters

{"title":"Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism.","authors":"Ahmed Gilani, Bette K Kleinschmidt-DeMasters","doi":"10.5414/NP301589","DOIUrl":"10.5414/NP301589","url":null,"abstract":"Two of the rarest radiation-induced adverse effects are focal neuronal gigantism (FNG) and SMART syndrome (stroke-like migraine attacks after radiation therapy). Both conditions develop years, and sometimes decades, after receipt of therapeutic radiation to the brain. To date, there are only 3 previously reported cases of FNG, all of which describe cortical thickening, enlarged \"hypertrophic\" neurons, and neuronal cytological changes. No detailed studies exist of histological features of SMART or the comparison between FNG and SMART. In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entire resection specimen. The absence of pathognomonic histologic alterations in SMART cases suggests underlying vascular dysregulation. Despite differing histology, some overlap may exist in neuroimaging features. Molecular assessment conducted in 2 cases of FNG was negative for significant alterations including in the MAPK pathway.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"10-22"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report. 环境对儿童和成人脑肿瘤的影响:2023年脑肿瘤流行病学联合会会议报告

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2024-01-01 DOI: 10.5414/NP301590

Kimberly J Johnson, Luc Bauchet, Roberta McKean-Cowdin, Carol Kruchko, Ching C Lau, Quinn T Ostrom, Michael E Scheurer, John Villano, Yan Yuan

引用次数: 0

Clinical Neuropathology 5-2024 Clinical Neuropathology 6-2024. 临床神经病理学5-2024

IF 0.8 4区医学

Clinical Neuropathology Pub Date : 2024-01-01 DOI: 10.5414/NPP43137

Christian Mawrin

引用次数: 0

Polypathology-associated neurodegeneration after remote head injury. 远端头部损伤后与息肉病相关的神经退行性变。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-11-01 DOI: 10.5414/NP301576

Declan Brennan, Conor Delaney, Michael Farrell, Matthew Campbell, Colin P Doherty

{"title":"Polypathology-associated neurodegeneration after remote head injury.","authors":"Declan Brennan, Conor Delaney, Michael Farrell, Matthew Campbell, Colin P Doherty","doi":"10.5414/NP301576","DOIUrl":"10.5414/NP301576","url":null,"abstract":"Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. TBI ranges from mild to severe and is a recognized risk factor for later neurodegenerative conditions including chronic traumatic encephalopathy (CTE), Alzheimer disease (AD) and Parkinson disease (PD). The development of CTE is typically associated with repetitive exposure to mild TBI (mTBI), while a single moderate-to-severe TBI is considered a risk factor for AD and PD. Polypathology is common, and the lines between these conditions post TBI can be somewhat blurred. The mechanisms through which TBI leads to future neurodegeneration are not well understood. Heterogeneity and distance from the injury or injuries and individual genetic and environmental factors make clinical studies difficult. We present the case of an 82-year-old man who died 4 years after developing a phenotypically mixed dementia with neuropsychiatric features and parkinsonism. He had a remote history of a severe TBI 40 years prior, following a road traffic accident which caused a large right frontal injury, requiring neurosurgical intervention. Post-mortem neuropathological examination demonstrated abnormal phosphorylated-Tau (p-Tau), beta-amyloid plaques (Aβ) and α-synuclein deposition. Spatial immunohistochemical analysis demonstrated increased perivascular accumulation of p-Tau with blood-brain barrier (BBB) disruption at the site of injury, which decreased with distance from the injury site. The appearances are suggestive of initial vascular disruption with persisting BBB disruption as a driver of the pathology.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"201-211"},"PeriodicalIF":1.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pick's disease presenting with corticobasal syndrome: A case report and clinicopathological review. 皮克氏病伴皮质基底综合征：一例报告和临床病理复习。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-11-01 DOI: 10.5414/NP301544

Yuanyuan Gu, Qi Zhang, Stephen H Pasternak, Lee Cyn Ang

引用次数: 0

Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas. 腺癌向胶质母细胞瘤的肿瘤间转移——肿瘤向胶质瘤转移的文献综述。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-09-01 DOI: 10.5414/NP301578

Georgi Galev, Maximillian A Weigelt, Richard A Prayson

{"title":"Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas.","authors":"Georgi Galev, Maximillian A Weigelt, Richard A Prayson","doi":"10.5414/NP301578","DOIUrl":"10.5414/NP301578","url":null,"abstract":"Tumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histologically, the lesion showed a glioblastoma, IDH-wildtype, WHO grade 4, associated with a metastatic adenocarcinoma (positive for estrogen receptor, progesterone receptor, and mammaglobin), suggesting a breast primary. The patient passed away 5 months after surgery. Involvement of glioblastoma by TTM is especially rare; only 1 case of TTM to glioblastoma is thus far reported in the English literature. The mechanism by which TTM occurs is poorly understood. TTM may be the first presentation of an occult malignancy and warrants thorough clinical, laboratory, and imaging investigation.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"190-196"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral amyloid angiopathy: Neuropathological diagnosis, link to Alzheimer's disease and impact on clinics. 脑淀粉样血管病:神经病理学诊断，与阿尔茨海默病的联系和对临床的影响。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-09-01 DOI: 10.5414/NP301564

Dietmar Rudolf Thal, Klara Gawor

{"title":"Cerebral amyloid angiopathy: Neuropathological diagnosis, link to Alzheimer's disease and impact on clinics.","authors":"Dietmar Rudolf Thal, Klara Gawor","doi":"10.5414/NP301564","DOIUrl":"10.5414/NP301564","url":null,"abstract":"Cerebral amyloid angiopathy (CAA) is the most frequent cause of lobar hemorrhages in the brains of elderly individuals. It is characterized by the deposition of amyloidogenic proteins in the vessel wall of leptomeningeal and/or intracerebral blood vessels. Different proteins can cause CAA. Most frequently, the amyloid β protein (Aβ) is found to be deposited in CAA and indicates a link to Alzheimer's disease, because Aβ is known to be deposited in amyloid plaques characteristic of Alzheimer's disease. Among other proteins that can also cause CAA, transthyretin (TTR) is the most important one because TTR amyloidosis can be successfully treated. Therefore, it is essential to diagnose TTR-related CAA even in biopsies taken in the context of cerebral hematoma evacuations if possible. The current \"Boston criteria version 2.0\" for the diagnosis of CAA highlight the importance of autopsy for the definite diagnosis of CAA and biopsies for the diagnosis of probable CAA. Here, we discuss the implications of Aβ-related and non-Aβ-related forms of CAA for their current diagnostic relevance also in the context of neurodegenerative diseases as well as the implications of the Boston criteria version 2.0 for neuropathological diagnosis.","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":" ","pages":"176-189"},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9870849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Neuropathology 5 & 6, 2023. 临床神经病理学5和62023。

IF 1.1 4区医学

Clinical Neuropathology Pub Date : 2023-09-01 DOI: 10.5414/NPP42173

Christian Mawrin

引用次数: 0

Obituary for J. Michael Schröder (1937 – 2023) J. Michael的讣告Schröder (1937 - 2023)

4区医学

Clinical Neuropathology Pub Date : 2023-09-01 DOI: 10.5414/npp42174

Joachim Weis

引用次数: 0