出现中风的特发性高嗜酸性粒细胞综合征。

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2024-05-01 DOI:10.5414/NP301613

Neeraj Singla, Anuj Prabhakar, Nupur Pradhan, Sreejesh Sreedharanunni, Manupdesh Singh Sachdeva, Harbir Singh Kohli, Kirti Gupta

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引用次数: 0

摘要

嗜酸性粒细胞增多综合征（HES）的特点是嗜酸性粒细胞增多并伴有器官损伤。这种疾病具有很大的临床异质性，预后变化很大。本报告描述了一例有趣的尸检病例：一位 62 岁的女士出现瘙痒和中风样症状。在彻底排除所有已知病因后，她被诊断为 "特发性 "变异型 HES。尽管采取了充分的措施，她的病情还是迅速恶化。尸检发现，她的急性脑梗死发生在多个血管区域，包括分水岭区域的梗死。此外，她的心脏显示出跨越三个阶段的嗜酸性粒细胞性心肌炎的典型病理特征。

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Idiopathic hypereosinophilic syndrome presenting with stroke.

Hypereosinophilic syndrome (HES) is characterized by eosinophilia associated with organ damage. The disorder has substantial clinical heterogeneity and a highly variable prognosis. This report describes an interesting autopsy case of a 62-year-old lady presenting with itching and stroke-like symptoms. She was diagnosed with an "idiopathic" variant of HES after a thorough exclusion of all known causes. Despite adequate measures, she deteriorated rapidly. At autopsy, acute cerebral infarcts were identified in multiple vascular territories including infarcts in watershed areas. Additionally, her heart showed classic pathological features of eosinophilic myocarditis spanning all three stages.

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.