Hypertrophy of the inferior olivary nucleus in corticobasal degeneration: A neuropathological study.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2024-05-01 DOI:10.5414/NP301616

Daisuke Tahara, Nao Tahara, Akio Akagi, Yuichi Riku, Jun Sone, Hiroaki Miyahara, Atsushi Nagai, Mari Yoshida, Yasushi Iwasaki

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引用次数: 0

Abstract

Aims: Corticobasal degeneration (CBD) is a rare neurodegenerative disorder. The status of the inferior olivary nucleus (ION) in CBD has been inadequately investigated. In this study, we conducted a pathological investigation of the ION in CBD.

Materials and methods: We reviewed the data of Japanese patients with pathologically confirmed CBD who underwent consecutive autopsies between 1985 and 2020 at our institute. We retrospectively examined clinical data from medical records and clinicopathological conferences and semi-quantitatively assessed the ION, central tegmental tract, superior cerebellar peduncle, and dentate nucleus.

Results: Of the 32 patients included, 14 (43.8%) had hypertrophy of the ION (HION), of whom 6 showed laterality. In the 14 HION cases, with or without laterality, except in 1 unevaluable case, atrophy/myelin pallor of the central tegmental tract was observed on the same side as the hypertrophy. Ten patients with HION, with or without laterality, had atrophy/myelin pallor of the superior cerebellar peduncle on the contralateral side to the hypertrophy.

Conclusion: The ION presents with hypertrophic changes in CBD. The lesion is a primary degeneration in CBD and is related to the degeneration of the Guillain-Mollaret triangle. This finding contributes to the elucidation of the specific pathological characteristics of CBD.

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皮质基底层变性的下橄榄核肥大：神经病理学研究

目的：皮质基底层变性（CBD）是一种罕见的神经退行性疾病。下橄榄核（ION）在CBD中的地位尚未得到充分研究。在本研究中，我们对 CBD 中的 ION 进行了病理学调查：我们回顾了 1985 年至 2020 年期间在我院接受连续尸检并经病理证实患有 CBD 的日本患者的数据。我们回顾性地检查了病历和临床病理会议中的临床数据，并对 ION、中央被盖束、小脑上梗和齿状核进行了半定量评估：在纳入的 32 例患者中，14 例（43.8%）患有 ION 肥大（HION），其中 6 例表现为侧位。在这14例HION患者中，无论有无侧位，除了1例无法确诊的病例外，均在肥大的同一侧观察到中央被盖束萎缩/髓鞘苍白。10例HION患者，无论有无侧位，在肥大的对侧均有小脑上梗萎缩/髓鞘苍白：结论：ION表现为CBD的肥大性改变。病变是CBD的原发性变性，与Guillain-Mollaret三角的变性有关。这一发现有助于阐明 CBD 的具体病理特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.