Clinical Respiratory Journal最新文献

{"title":"Breastfeeding Duration and Airway Inflammation in Children With Asthma Living in a Polluted Megacity","authors":"Víctor González-Uribe,&nbsp;Zaira Selene Mojica-González,&nbsp;Jimena Prieto-Gómez,&nbsp;Ricardo Martinez-Tenopala,&nbsp;Tamara Hernández-Hernández,&nbsp;María Julia Rendón-Salazar,&nbsp;Luis Ángel Hernández-Zárate","doi":"10.1111/crj.70172","DOIUrl":"10.1111/crj.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Children with asthma living in highly polluted megacities are at increased risk of poor asthma control and airway inflammation. Breastfeeding has immunomodulatory effects, but its potential to buffer pollution-related inflammation remains understudied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate whether breastfeeding duration is associated with asthma control and airway eosinophilic inflammation (FeNO), and whether it modifies the impact of urban air pollution in children with asthma living in Mexico City.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a multicenter retrospective study (2022–2025) including children aged 6–17 years with physician-diagnosed asthma. Asthma control (ACT), airway inflammation (FeNO, NIOX VERO), breastfeeding duration (0–12 months), and borough-level pollution categories (high/medium/low) were evaluated. Multivariable logistic and linear regression models assessed associations and breastfeeding × pollution interactions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 162 children were included (mean age 10.8 years; 51.2% female). Breastfeeding ≥ 6 months was associated with better asthma control (ACT ≥ 20: OR 2.1; 95% CI 1.3–3.5) and significantly lower FeNO (β −0.24; <i>p</i> &lt; 0.01). High-pollution residence was linked to lower ACT scores and higher FeNO (both <i>p</i> &lt; 0.01). A significant interaction indicated that breastfeeding ≥ 6 months attenuated the detrimental effect of pollution on airway inflammation and asthma control (<i>p</i> for interaction &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Prolonged breastfeeding was independently associated with improved asthma control and reduced airway eosinophilic inflammation, partially mitigating the respiratory burden of chronic pollution exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Implications</h3>\u0000 \u0000 <p>Breastfeeding may serve as an accessible, low-cost protective strategy for children with asthma living in polluted urban environments, supporting its integration into respiratory health policies and early-life preventive care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: PCV-VG Combined Individualized PEEP Determination in One-Lung Ventilated Patients With PEEP Step Change Direction: A Randomized Controlled Trial","authors":"","doi":"10.1111/crj.70170","DOIUrl":"10.1111/crj.70170","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN</b>: G. Li, S. Ma, Q. Shu, Z. Fang, Z. Yan, and B. Si, “PCV-VG Combined Individualized PEEP Determination in One-Lung Ventilated Patients with PEEP Step Change Direction: A Randomized Controlled Trial,” <i>The Clinical Respiratory Journal</i> 18, no. 71 (2024): e13696, https://doi.org/10.1111/crj.13696.</p><p>This Expression of Concern is for the above article, published online on 18 September 2023 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between journal Editor-in-Chief, Yuanlin Song; and John Wiley &amp; Sons Ltd. A third party reported concerns that the ethical approval for the clinical trial described in the article appeared to have been issued in 2023 whereas the research was conducted between August 21, 2021 to August 20, 2022. Furthermore, the article does not provide information regarding any registration of the study in a clinical trials registry.</p><p>The authors responded to an inquiry by the publisher and stated that the trial had been approved prior to the start date, but that the original ethical approval letter had been lost. The authors noted that they had appealed to their university’s ethics committee and received a new approval (No. 2023–003-1) and they shared a copy of this letter dated May 19, 2023. The authors did not confirm if the trial was registered in a clinical trials registry. Representatives from the authors’ institution did not respond to inquiries requesting confirmation of the original ethical approval.</p><p>The Expression of Concern has been agreed to because the ethical approval information provided by the authors is dated after the study’s provided start and end dates, and also because there is no evidence that it was registered in a clinical trials registry. As such, Wiley and the journal are not able to verify if the study conformed to ethics guidelines. The authors were informed about the Expression of Concern.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"","doi":"10.1111/crj.70171","DOIUrl":"https://doi.org/10.1111/crj.70171","url":null,"abstract":"<p>Rapid Nasal Breathing as a Biometric Trigger: High-Accuracy Electroencephalogram-Based Authentication for Clinical Applications by Cai Chen et al., https://doi.org/10.1111/crj.70148\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Noninvasive Ventilation in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Decreased Level of Consciousness: A Retrospective Study","authors":"Irma Sofia Fabbri,&nbsp;Teresa Pagano,&nbsp;Yuri Darin,&nbsp;Andrea Portoraro,&nbsp;Angela Vajente,&nbsp;Francesco Luppi,&nbsp;Chiara Pesci,&nbsp;Benedetta Perna,&nbsp;Angelina Passaro,&nbsp;Michele Domenico Spampinato,&nbsp;Roberto De Giorgio,&nbsp;Matteo Guarino","doi":"10.1111/crj.70166","DOIUrl":"10.1111/crj.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Noninvasive ventilation (NIV) is the treatment of choice in cases of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, depressed mental status, frequently caused by AECOPD, represents a relative contraindication to NIV. This study evaluates the efficacy of NIV in patients with AECOPD with moderate to severe impairment of consciousness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this monocentric, retrospective study, we included patients admitted to the emergency department (ED) from January 2018 to December 2022 for AECOPD, altered mental status (GCS ≤ 13 and/or KMS ≥ 2) and treated with NIV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 919 patients admitted with acute respiratory failure, 228 (24.8%) met the inclusion criteria for AECOPD. Of these, 205 (90%) underwent NIV during the ED admissions without adverse events. In 48 patients (21.1%), NIV was withdrawn due to clinical improvement. Only 23 (10.1%) experienced NIV failure with worsening of hypoxemia and occurrence of hypotension, of whom 16 (7% of the total population) died in the ED. Severe neurological impairment (low GCS) was an independent predictor of mortality. Systolic and diastolic blood pressure, SpO₂, pH value and lactate levels were predictive of early mortality. COVID-19 status did not significantly affect mortality rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NIV was feasible and associated with successful outcomes in a majority of patients with AECOPD and moderate to severe neurological impairment. Specific parameters, including initial GCS, blood pressure, SpO₂, and blood gas profiles, can help predict outcomes and treatment efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMARCA4-Deficient Undifferentiated Thoracic Tumor: Clinical Features and Prognosis of a Case Series and Literature Review","authors":"Fangzhen Shan,&nbsp;Shuntao Liang,&nbsp;Youwen Zhang,&nbsp;Wei Wu,&nbsp;Guangxia Yang,&nbsp;Mei Yan,&nbsp;Xuemei Zhang,&nbsp;Yumao Miao,&nbsp;Linlin Liu,&nbsp;Jingjing Cai,&nbsp;Zhitao Shi,&nbsp;Bangdong Liu,&nbsp;Nannan Zhang","doi":"10.1111/crj.70168","DOIUrl":"10.1111/crj.70168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are rare and aggressive epithelioid neoplasms characterized by the loss of the SMARCA4 gene. These tumors are typically diagnosed at advanced stages and exhibit a dismal prognosis. Currently, there are no standardized treatment protocols or approved targeted therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We present a case series of nine patients diagnosed of thoracic SMARCA4-UT, detailing demographic, pathological, imaging, and treatment data. Moreover, a comprehensive literature review and genomic analysis of SMARCA4 mutations in lung cancer were also performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cohort comprised predominantly male smokers (mean age: 63.0 ± 9.6 years). All cases exhibited loss of BRG1 expression, with negative staining for TTF-1 and p40, while SMARCB1/INI-1 expression was preserved. Patients showed poor responses to conventional chemotherapy but demonstrated partial responsiveness to immunotherapy or targeted agents. Genomic analysis of SMARCA4 mutations in lung cancer demonstrates that SMARCA4 mutations, primarily located in the SNF2-related and helicase conserved C-terminal domains, are associated with a poorer prognosis in lung cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Immunotherapy and targeted therapies show promise in managing thoracic SMARCA4-UT, warranting further investigation. Further exploring the genetic and molecular landscape of this tumor might reveal potential therapeutic targets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12830063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Nasal Breathing as a Biometric Trigger: High-Accuracy Electroencephalogram-Based Authentication for Clinical Applications","authors":"Cai Chen,&nbsp;Xianghong Kong,&nbsp;Danyang Lv,&nbsp;Xiangwei Meng,&nbsp;Chongxuan Tian,&nbsp;Zhi Li,&nbsp;Fengxia Wu,&nbsp;Ningling Zhang,&nbsp;Dedong Ma","doi":"10.1111/crj.70148","DOIUrl":"10.1111/crj.70148","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Traditional biometric systems are vulnerable to forgery, highlighting the need for secure alternatives. Electroencephalography (EEG) offers inherent advantages in liveness detection and antispoofing but typically requires external stimuli. We propose a novel paradigm leveraging intrinsic respiratory-evoked EEG signals for identity authentication, with potential applications in clinical settings where unobtrusive monitoring is critical.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed a 64-channel EEG acquisition system with synchronized respiratory event monitoring. Thirteen healthy volunteers performed four breathing patterns: oral, nasal, slow nasal, and rapid nasal breathing. A hybrid deep learning model was designed to optimize spatial–temporal feature extraction from EEG signals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The model achieved 98.3% accuracy in identity recognition using rapid nasal breathing-evoked EEG, outperforming traditional biometric methods. Nasal breathing patterns consistently yielded higher accuracy than oral breathing, with rapid nasal breathing showing the strongest discriminative power.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Respiratory-evoked EEG signals provide a viable, noninvasive biometric identifier. The high accuracy of rapid nasal breathing opens avenues for clinical integration, such as continuous patient authentication in respiratory monitoring devices or secure access to electronic health records.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Significant Blood Pressure Reduction Through Ambulatory Blood Pressure Monitoring in Patients With Obstructive Sleep Apnea Treated With Continuous Positive Airway Pressure","authors":"Yuanni Jiao,&nbsp;Hehe Zhang,&nbsp;Hao Wu,&nbsp;Xin Xi,&nbsp;Shuang Li,&nbsp;Jiang Xie","doi":"10.1111/crj.70167","DOIUrl":"10.1111/crj.70167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) results in a modest reduction in blood pressure. This study aimed to identify parameters from 24-h ambulatory blood pressure monitoring (ABPM) that are predictive of treatment response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Treatment-naïve patients with OSA were prospectively recruited from the Centre for Sleep Medicine and Science at Beijing Anzhen Hospital between July 2023 and April 2025. All participants underwent 24-h ABPM assessments before and after 3-month CPAP therapy. Correlations between the baseline ABPM data and post-CPAP changes in blood pressure were analyzed. Multivariate analysis was used to determine whether specific baseline blood pressure cutoffs independently predicted a clinically significant reduction in blood pressure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Good CPAP adherence (median usage: 6.1 h/night and 6.0 days/week; residual apnea–hypopnea index: 1.7 events/h) was achieved among 51 recruited patients (92.2% male, median age 40.5 years). After 3 months of CPAP treatment, significant reductions were observed in nearly all blood pressure measurements. Baseline 24-h mean arterial pressure (MAP) was positively correlated with the reduction in all 24-h blood pressure measures, all nighttime blood pressure measures, and daytime MAP. Compared with patients with 24-h MAP &lt; 96 mmHg, those with baseline 24-h MAP ≥ 96 mmHg experienced relatively high absolute and relative reductions in all blood pressure measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Baseline 24-h MAP effectively predicts blood pressure reduction following CPAP therapy in patients with OSA, demonstrating the clinical value of an ABPM-guided strategy for managing patients with comorbid OSA and hypertension.</p>\u0000 \u0000 <p>Trial Registration: ChiCTR2300067728</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty as a Key Determinant of Cardiovascular Risk and Mortality in Preserved Ratio Impaired Spirometry: A Nationally Representative Study","authors":"Yue Ren,&nbsp;Yixing Wu,&nbsp;Weiping Hu,&nbsp;Li Liu,&nbsp;Hui Cai,&nbsp;Jing Zhang","doi":"10.1111/crj.70165","DOIUrl":"10.1111/crj.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preserved ratio impaired spirometry (PRISm) is associated with elevated cardiovascular disease (CVD) risk and progression to COPD, but the underlying mechanisms remain unclear. Frailty is known to worsen outcomes in COPD; however, its role in PRISm has not been well defined. This study examined factors associated with cardiovascular events and mortality in PRISm and developed risk models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 8882 adults (aged 20–79 years) from NHANES 2007–2012, identifying 763 (8.6%) with PRISm (FEV₁/FVC ≥ 0.70 and FEV₁ &lt; 80% predicted). Frailty was assessed using the 23-item laboratory frailty index (FI-LAB; cut-off ≥ 0.23). The primary outcome was all-cause mortality, obtained from linked National Death Index records; the secondary outcome was major adverse cardiovascular events (MACEs: myocardial infarction, stroke, heart failure, or angina), assessed cross-sectionally. LASSO regression and multivariable logistic/Cox models were used to identify variables independently associated with the outcomes, and nomograms were constructed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PRISm participants had higher frailty prevalence (53.9% vs. 45.5%) and more MACEs (16.2% vs. 6.0%) than those with normal spirometry (both <i>p</i> &lt; 0.0001). Frailty was independently associated with prevalent MACEs (adjusted OR = 18.87, <i>p</i> &lt; 0.001) and was bidirectionally associated with PRISm (OR = 1.40, <i>p</i> &lt; 0.001). Key factors independently associated with MACEs included frailty index, age, sex, anemia, and emphysema (AUC = 0.786). Over 9.9 years, mortality was higher in frail vs. non-frail PRISm individuals (15.2% vs. 7.0%; adjusted HR = 30.66). Frailty severity demonstrated a clear mortality gradient, and a mortality nomogram integrating age and frailty achieved an AUC of 0.81.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Frailty is strongly and independently associated with cardiovascular morbidity and mortality. FI-LAB offers a practical tool for risk stratification and may help guide targeted preventive strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antineutrophil Cytoplasmic Antibodies Contribute to Airway Inflammation via Induction of Neutrophil Extracellular Traps in Children With Bronchiolitis Obliterans","authors":"Xiaowen Chen,&nbsp;Shangzhi Wu,&nbsp;Zhenwei Liu,&nbsp;Zhanhang Huang,&nbsp;Jiaxing Xu,&nbsp;Zhongji Wu,&nbsp;Hui Li,&nbsp;Hongwei Li,&nbsp;Dehui Chen","doi":"10.1111/crj.70145","DOIUrl":"10.1111/crj.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>It was found that the levels of antineutrophil cytoplasmic antibodies (ANCA) are elevated and linked to disease severity of bronchiolitis obliterans (BO) in children. This study aims to explore the mechanism of ANCA in the process of BO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Plasma from BO patients (<i>n</i> = 40) and healthy controls (<i>n</i> = 11) was analyzed for ANCA and neutrophil extracellular traps (NETs) components. Plasma IgG from ANCA-positive BO children and normal controls were used to stimulate neutrophils, measuring reactive oxygen species (ROS) and NETs production. Small airway epithelial cells (SAECs) were exposed to NETs, assessing viability by CCK8 and cytokine release by ELISA. The IgG treated neutrophils were co-cultured with SAECs, and cytokines were measured by ELISA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The levels of ANCA and NETs components including dsDNA, neutrophil elastase (NE) and myeloperoxidase (MPO) in the plasma of BO children were significantly higher than those of healthy controls. ANCA-positive IgG induced neutrophils produce ROS and NETs. The cell viability of SAECs was significantly reduced upon treatment with NETs in a concentration-dependent manner. The levels of IL-8, IL-17, TNF-<i>α</i>, and TGF-<i>β</i> secreted by SAECs treated with NETs were increased significantly, and the degree of increase was positively correlated with the concentration of NETs. The co-culture of neutrophils stimulated by ANCA IgG with SAECs significantly increased the expression of cytokines including IL-8, IL-17, TNF-<i>α</i>, and TGF-<i>β</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>NETs induced by ANCA may exacerbate airway inflammation in children with BO.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12782669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Psychogenic Cough to Somatic Cough Syndrome","authors":"Haiyang Wang,&nbsp;Tongyangzi Zhang,&nbsp;Li Yu,&nbsp;Xianghuai Xu","doi":"10.1111/crj.70152","DOIUrl":"10.1111/crj.70152","url":null,"abstract":"<p>Patients with various etiologies of chronic cough may have psychological disorders, and those with psychological disorders may also exhibit physical symptoms such as coughing. The terminology “psychogenic cough” and “somatic cough syndrome” have been used to describe chronic cough patients with underlying psychological issues, but both terms lack clear definitions and diagnostic criteria. This article provides a review of the definition changes, pathogenesis, and diagnostic and therapeutic points related to chronic cough with comorbid psychological disorders based on relevant studies of psychogenic cough and somatic cough syndrome.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}