Clinical Respiratory Journal最新文献

{"title":"Development of a Nomogram Model to Predict Mortality in ANCA-Associated Vasculitis Patients With Pulmonary Involvement","authors":"Qifang Guo,&nbsp;Yijia Shao,&nbsp;Le Yu,&nbsp;Xiuling Zhang,&nbsp;Jingjing Shang,&nbsp;Xueqin Feng,&nbsp;Wei Zhou,&nbsp;Xinwang Duan","doi":"10.1111/crj.70067","DOIUrl":"https://doi.org/10.1111/crj.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Risk assessment and prognosis prediction are crucial for patients with pulmonary involvement in antineutrophil cytoplasimc antibody associated vasculitis (AAV). This study was conducted to create and internally validate a prognostic model for mortality of pulmonary involvement in patients with AAV that provides individualized risk assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cohort of 150 patients diagnosed with AAV at the Second Affiliated Hospital of Nanchang University Hospital between January 2013 and July 2022 was included, using data obtained from the Chinese Rheumatism Data Center (CRDC). The model was developed using Cox proportional hazards regression and the least absolute shrinkage and selection operator. To validate the model, assessments were conducted for discrimination, calibration, and through decision curve analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean survival time of lung involvement AAV patients was 57.0 ± 4.1 months. In the final predictive model for death, four clinical variables were included: age at baseline, history of tumors, baseline hemoglobin level, and the level of the percentage of forced vital capacity to the normal predicted value. One-, two-, and three-year AAV patients with pulmonary involvement mortality probability-predictive nomogram were established. Internal validation of the model was conducted, yielding Harrell's concordance index (0.884), a Brier score of 0.088, and a calibration curve indicating satisfactory performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We constructed a risk model utilizing easily accessible clinical risk factors, which could accurately forecast the future mortality risk associated with pulmonary involvement in AAV patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Lung Squamous Cell Carcinoma Harboring TP53 Mutation and PLPP5-FGFR1 Fusion Gene","authors":"Meng Xiao-ru,&nbsp;Shi Xiao-Xiong,&nbsp;Gao Qian,&nbsp;Qu Ya-jing,&nbsp;Huo Li-li,&nbsp;Gao Yan-Yan,&nbsp;Xu Peng-peng,&nbsp;Ma Guan-nan,&nbsp;Ren Gui-bing","doi":"10.1111/crj.70074","DOIUrl":"https://doi.org/10.1111/crj.70074","url":null,"abstract":"<p>Lung squamous cell carcinoma (LUSC) is one of the most common subtype of lung cancer and is associated with the poor prognoses. The fibroblast growth factor receptor (FGFR) family is known to be activated through fusions with various partners across multiple cancer types, including nonsmall cell lung cancer (NSCLC). FGFR inhibitors are currently undergoing clinical evaluation for the treatment of tumors harboring these fusions. While FGFR1 amplification has been well-documented in numerous NSCLC datasets, the characterization of specific FGFR fusion variants remains limited. In this study, we identified a novel PLPP5-FGFR1 fusion in a 65-year-old male patient with lung squamous cell carcinoma through targeted RNA sequencing. The fusion junction was located between exon 1 of PLPP5 and exon 5 of FGFR1, and the result was validated by Sanger sequencing. To our knowledge, this is the first reported case of a PLPP5-FGFR1 fusion coexisting with a TP53 mutation in LUSC. These findings broaden the spectrum of potential translocation partners in FGFR1 fusions, and the clinical implications of this novel fusion on treatment outcomes and prognosis warrant further investigation and long-term follow-up.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Physical Exercises in Asthma: An Umbrella Review of Systematic Review and Meta-Analysis","authors":"Fuchun Huang,&nbsp;Shuang Yang,&nbsp;Mingxuan Ma,&nbsp;Jialin Zhang,&nbsp;Hua Liu","doi":"10.1111/crj.70075","DOIUrl":"https://doi.org/10.1111/crj.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As a disease-modifying strategy, physical exercise has been demonstrated to significantly improve quality of life, exercise capacity, and lung function in individuals with asthma. However, the quality and robustness of this evidence has not been thoroughly examined in many large-scale investigations. In order to assess the evidence addressing the effects of physical exercise in patients with asthma, we therefore carried out an umbrella review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search of the PubMed, Web of Science, and Cochrane databases for systematic reviews and meta-analyses of the effects of physical activity on asthma was conducted up to December 31, 2022. The study was registered in Prospero (CRD42023382921). For every qualified systematic review and meta-analysis, we extracted information on the main characteristics and general findings. The GRADE tool was utilized to quantify the strength of the evidence, and the AMSTAR2 score was employed to evaluate the methodological quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1254 articles were searched, and 42 independent results were identified as eligible in the 11 articles that were included. Of the 42 unique outcomes, two were rated as high, two as medium, and the rest as low or very low. Physical exercise is beneficial for improving QoL, exercise capacity, and lung function in patients with asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>According to our research, physical activity benefits QoL of patients with asthma, exercise tolerance, and lung function. In the future, further evidence from superior prospective studies will be required because the quality of the available evidence is now insufficient.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comment on ‘Screening for Obstructive Sleep Apnea Before Coronary Angiography’","authors":"Baris Demirkol,&nbsp;Celal Satici","doi":"10.1111/crj.70077","DOIUrl":"https://doi.org/10.1111/crj.70077","url":null,"abstract":"<p>Obstructive sleep apnea (OSA) is closely associated with cardiovascular diseases, and its impact on coronary heart disease (CHD) has been increasingly investigated [<span>1, 2</span>]. The pathophysiological mechanisms of OSA, such as recurrent nocturnal hypoxemia and increased sympathetic nervous system activation, can lead to endothelial dysfunction and early atherosclerotic changes, thereby heightening the risk of CHD [<span>2-4</span>]. Additionally, OSA shares common characteristics with other major cardiovascular risk factors, including hypertension, obesity, and metabolic syndrome, further underscoring the strong relationship between these conditions [<span>5, 6</span>]. Therefore, effective screening and management of OSA may play a significant role in the prevention and treatment of CHD.</p><p>We have reviewed with great interest the study by Guo Pei et al., titled “Screening for Obstructive Sleep Apnea Before Coronary Angiography,” which highlights the importance of OSA screening prior to coronary angiography [<span>7</span>]. While this valuable study contributes to the literature, we believe it could yield more impactful results with some refinements.</p><p>First, since the primary focus of the study is the importance of OSA screening, selecting OSA rather than CHD as the primary endpoint might be more appropriate. This adjustment could better align the study with its focus on assessing the clinical implications of OSA and provide a more coherent framework for its objectives. Presenting and comparing the characteristics of OSA (+) and OSA (−) groups, along with conducting a multivariable analysis of these data, could also enhance the clarity and interpretability of the findings. Logistic regression analyses based on these groups could more effectively evaluate the independent predictors of OSA detection.</p><p>The current multivariable analysis model includes parameters with high collinearity (e.g., total cholesterol, LDL, HDL), which may adversely affect the model's accuracy and result in multicollinearity issues. Evaluating the model's fit using measures such as the Hosmer–Lemeshow test and considering alternative models could help better elucidate the independent effects of each parameter.</p><p>Lastly, performing a receiver operating characteristic (ROC) analysis to clarify the relationship between OSA screening and Gensini scores could provide a more precise determination of a cut-off value with high sensitivity for OSA. This additional analysis would facilitate a more practical interpretation of the results and enhance the study's clinical applicability.</p><p>Baris Demirkol and Celal Satici contributed to the study's design and implementation, the evaluation and analysis of the results, and the drafting of the manuscript.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruxolitinib for Emergency Treatment of COVID-19–Associated Cytokine Storm: Findings From an Expanded Access Study","authors":"Jeffrey Weinstein,&nbsp;Nikhil Jagan,&nbsp;Shawnta Lorthridge-Jackson,&nbsp;J. E. Hamer-Maansson,&nbsp;Peg Squier","doi":"10.1111/crj.70050","DOIUrl":"https://doi.org/10.1111/crj.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This expanded access program (EAP) provided ruxolitinib (oral, selective Janus kinase [JAK]1/JAK2 inhibitor) for emergency treatment of COVID-19–associated cytokine storm in patients eligible for hospitalization (NCT04355793).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients received ruxolitinib 5 mg twice daily (preferred regimen when tolerated) or once daily for ≤ 14 days, or until determination of no clinical benefit was made. Outcomes were clinical status, physician-assessed clinical benefit, and serious adverse event (SAE) incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 312 patients, 45.5% achieved ≥ 1-point clinical status improvement. Physician-assessed clinical benefit was reported in 42.6% of evaluable patients. SAEs occurred in 42.9%, with 2.6% experiencing an SAE suspected to be ruxolitinib related.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, some hospitalized patients with COVID-19–associated cytokine storm who received ruxolitinib experienced clinical status improvement; ruxolitinib was well tolerated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT04355793</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landscape of T Cells in Tuberculous Pleural Effusion","authors":"Lihui Zou,&nbsp;Jing Chen,&nbsp;Li Xie,&nbsp;Lili Zhang,&nbsp;Li Wan,&nbsp;Weimin Li,&nbsp;Hongtao Xu","doi":"10.1111/crj.70066","DOIUrl":"https://doi.org/10.1111/crj.70066","url":null,"abstract":"<p>The distribution and the function of T lymphocyte subsets in pleural effusion (PE) and peripheral blood (PB) in tuberculous pleural effusion (TPE) patients remain unclear. In this study, we aimed to explore the expression patterns, regulatory mechanisms, and functions of T lymphocyte subsets in TPE patients, especially the distribution of T lymphocyte subsets at the single cell level. The CD3⁺ T cells were isolated from PE and PB of four TPE patients for single-cell RNA sequencing (scRNA-seq) to screen T cell subsets. T-SNE projection, Gene Set Variation Analysis (GSVA), and pseudotime analysis were performed to analyze the composition, molecular and functional properties, and developmental trajectories of T cell subsets. Finally, ELISA was carried out to identify the cytokines secreted by PE and PB. We found that CD4⁺CD8⁻ T lymphocytes (Th1, Th2, and FOXP3⁺ Treg cells) were preferentially enriched in PE. The proportion of exhausted CD4⁻CD8⁺ cells in PE was higher than that in PB, while the proportion of initial and effector CD4⁻CD8⁺ cells was quite the reverse. We also found a large number of unexpected double positive (DP) cells in PE and PB, among which the proportion of CD4⁺CD8⁺-C10-CCL3 cells was the most different between PE and PB. Meanwhile, CD4⁺CD8⁺-C10-CCL3 was the group with the largest number of interactions with other groups. CD4⁻CD8⁻ cells were mainly found in PE and may be involved in the immunomodulatory effect of PE. Furthermore, the concentrations of cytokines secreted by Th1, Th2, and Treg in PE were higher than those in PB. Our study is helpful to understand the distribution pattern and dynamic changes of T cells in PE and PB of TPE patients and further understand that the functional status and regulation of T cells will be crucial for the successful development of TPE immunotherapy.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological Features and Potential Biomarkers of Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis","authors":"Shuai Shao,&nbsp;Siyu Cao,&nbsp;Yusha Chen,&nbsp;Zhijin Zhang,&nbsp;Tong Zhaohui","doi":"10.1111/crj.70072","DOIUrl":"https://doi.org/10.1111/crj.70072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aims to summarize the similarities and differences in immune cell characteristics, and potential therapeutic targets between systemic sclerosis-associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included SSc-ILD and SSc-nonILD patients who were admitted to Beijing Chaoyang Hospital between April 4th, 2013, to June 30th, 2023. Publicly available datasets, including peripheral blood monocular cell (pbmc) single-cell data, SSc, SSc-ILD pbmc transcriptome data, and SSc-ILD, IPF lung tissue transcriptome data were analyzed. Statistical analyses were conducted using the SPSS and R software, employing standard statistical methods and bioinformatics packages such as Seurat, DESeq2, enrichR, and CellChat.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results revealed that the CD4+/CD8+ T cell ratio of pbmc in SSc-ILD patients was significantly higher than in SSc-nonILD patients. In IPF patients, an elevated CD4+/CD8+ T cell ratio was also observed in progressive group, and Treg and mature CD4+ T cells might cause this change. JAK–STAT pathway and the cytokine–cytokine receptor interaction pathway were activated in peripheral blood T cells of IPF patients. The CD30, CD40, and FLT3 signaling pathways were found to play crucial roles in T cell interactions with other immune cells among IPF patients. SPA17 as a commonly upregulated gene among SSc, SSc-ILD, and IPF pbmc and lung, with its expression correlating positively with disease severity and lung function progression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CD4+/CD8+ T cell ratio might associate with ILD initiation and progression; Treg cells and mature CD4+ T cells play key roles of it. SPA17 might serve as a pan-ILD marker and associated with lung function progression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID-19) in Elderly Patients With COPD: A Territory-Wide Cohort Study","authors":"Wang Chun Kwok,&nbsp;Yat Fung Shea,&nbsp;James Chung Man Ho,&nbsp;David Chi Leung Lam,&nbsp;Terence Chi Chun Tam,&nbsp;Anthony Raymond Tam,&nbsp;Mary Sau Man Ip,&nbsp;Ivan Fan Ngai Hung","doi":"10.1111/crj.70070","DOIUrl":"https://doi.org/10.1111/crj.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to investigate the association between elderly patients with COPD with different blood eosinophil on admission and those without COPD and the prognosis of COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A territory-wide retrospective study was conducted to investigate the association between elderly COPD patients with different blood eosinophil on admission and the prognosis of COVID-19. Elderly patients admitted to public hospitals and community treatment facility in Hong Kong for COVID-19 from January 23, 2020, to September 31, 2021, were included in the study. Severe diseases were defined as those who develop respiratory complications, systemic complications and death.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 1925 patients included, 133 had COPD. Forty had admission blood eosinophil count ≥ 150 cells/μL, and 93 had blood eosinophil count &lt; 150 cells/μL. Patients with COPD and admission blood eosinophil count ≥ 150 cells/μL, but not those with admission blood eosinophil count &lt; 150 cells/μL, had severe COVID-19 with the development of respiratory and systemic complications. They were more likely to develop respiratory failure (OR = 5.235, 95% CI = 2.088–13.122, <i>p</i> &lt; 0.001) and require invasive mechanical ventilation (OR = 2.433, 95% CI = 1.022–5.791, <i>p</i> = 0.045) and intensive care unit admission (OR = 2.214, 95% CI = 1.004–4.881, <i>p</i> = 0.049).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Our study suggested that the blood eosinophil count on admission could have significant prognostic implications among elderly patients with COPD. Patients with COPD and admission blood eosinophil count ≥ 150 cells/μL, but not those with admission blood eosinophil count &lt; 150 cells/μL, have significantly increased risks of developing respiratory and systemic complications from COVID-19, when compared with non-COPD patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on the Implementation of Mechanical Prophylaxis Procedures for Deep Venous Thrombosis in ICU in Southwest China: A Cross-Sectional Study","authors":"Na Li,&nbsp;Zhihong Tang,&nbsp;Yongming Tian,&nbsp;Xia Li","doi":"10.1111/crj.70069","DOIUrl":"10.1111/crj.70069","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;For ICU patients at high risk of bleeding or those already bleeding, it is recommended to use mechanical prophylaxis methods such as intermittent pneumatic compression (IPC), graduated compression stockings (GCS), or a venous foot pump (VFP).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This work aims to examine the implementation of mechanical prophylaxis measures for DVT in ICUs in Southwest China and provide a foundation for improving their adoption and effectiveness.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this study, a questionnaire developed by the researchers, based on existing literature, was used as the data collection tool. Following ethical approval, data were collected through self-administered questionnaires from 780 ICU nurses across 124 ICUs in Southwest China, between August and December 2022. Of these, 67.7% (84/124) were from Grade III hospitals, and 32.3% (40/124) were from Grade II hospitals. Additionally, 66.5% (519/780) of nurses had received training on DVT prophylaxis knowledge, whereas 33.5% (261/780) had not. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) software, version 21.0, with descriptive statistics and Pearson chi-square tests applied for analysis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Statistically significant differences were observed among hospitals of different grades in several aspects, including the professional management team, dynamic assessments, risk assessment records, bedside warning signs, and implement sign-in communication for high-risk patients (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Statistically significant differences were also found between nurses who had received training on DVT prevention and those who had not, in terms of excluding related contraindications, conducting monthly inspections and preventive maintenance, having a specially assigned person for management, and providing clear precautions (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). All ICUs were equipped with at least one type of mechanical prophylaxis equipment, but the proportion and duration of equipment use varied between hospitals. The top three factors hindering the implementation of mechanical prophylaxis were insufficient equipment, inadequate human resources, and failure to reset equipment in a timely manner after disuse.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Hospital grade, DVT prevention training, resource allocation for mechanical prophylaxis, and the im","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Comparison of Laboratory Methods in Diagnosing Mycobacterium tuberculosis and Nontuberculous Mycobacteria in 3012 Sputum Samples","authors":"Qian Wu,&nbsp;Yelei Zhu,&nbsp;Yu Zhang,&nbsp;Zhengwei Liu,&nbsp;Mingwu Zhang,&nbsp;Jiazhen Chen,&nbsp;Beibei Wu","doi":"10.1111/crj.70071","DOIUrl":"https://doi.org/10.1111/crj.70071","url":null,"abstract":"<p>Tuberculosis is a global public health threat as an infectious disease, and effective blocking of transmission relies on timely diagnosis. Although a number of laboratory tests are available in diagnosing <i>Mycobacterium tuberculosis</i> (MTB) and nontuberculous mycobacteria (NTM), it is still of great need to evaluate their diagnostic value in clinical samples. In this study, we evaluated five MTB diagnostic methods (including conventional sputum smear microscopy, sandwich cup sputum smear microscopy, sputum culture, Xpert-MTB/RIF, and CapitalBio TB/NTM kit detection test) in 3012 sputum specimens and compared their diagnostic performance of the single and combined tests. In the diagnosis of MTB, the Xpert-MTB/RIF had the highest sensitivity, 79.6% (0.770–0.819), among all the single diagnostic methods, and the combination of CapitalBio TB/NTM kit and culture approach significantly increased sensitivity to 88.4% (<i>p</i> &lt; 0.05). In the diagnosis of NTM, the culture method has higher sensitivity (85.7%) compared with the Capital Bio TB/NTM kit method (45.7%). In the diagnosis of mycobacteria, the CapitalBio TB/NTM kit detection test has the highest sensitivity (77.1%) and combined with conventional sputum smear and culture significantly increased the sensitivity further to 84.2%. In conclusion, Xpert-MTB/RIF is a sensitive, rapid, and reliable method for TB detection in sputum samples, and other diagnostic methods including culture are still of great clinical values for improving the sensitivity of MTB diagnosis. The sensitivity of CapitalBio TB/NTM kit in diagnosing NTM is still insufficient in clinical practice.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}