Clinical Respiratory Journal最新文献

{"title":"Causal Relationships Between Immune Cell Traits, Plasma Metabolites, and Asthma: A Two-Step, Two-Sample Mendelian Randomization Study","authors":"Zhuozheng Hu,&nbsp;Peihao Xu,&nbsp;Jiajun Wu,&nbsp;Weijun Zhou,&nbsp;Yajie Zhou,&nbsp;Lei Xie,&nbsp;Wenxiong Zhang,&nbsp;Yong Cheng","doi":"10.1111/crj.70097","DOIUrl":"https://doi.org/10.1111/crj.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Considerable evidence suggests a strong link between immune cell traits (ICTs) and asthma development via plasma metabolites (PMs), but the causality between ICTs and asthma is still unclear, mainly due to issues like selection bias. Our research was designed to investigate the causality between ICTs, PMs, and asthma and to provide a clearer explanation of these relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilizing the GWAS database, this study employed a two-step, two-sample Mendelian randomization (MR) approach and the inverse variance weighted (IVW) method to investigate the causality between ICTs and asthma, as well as between PMs and asthma. Lastly, we calculated the mediated proportion of PMs as mediators in the link between ICTs and asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Excluding heterogeneity and pleiotropy, MR analysis identified 13 ICTs (CD14 on CD33br HLA DR+ CD14dim, etc.) and asthma causality, and no reverse causality was observed. In addition, 27 PMs (androsterone sulfate levels, succinate levels, etc.) were also causally associated with asthma. Mediate MR indicated −9.81% (−1.2%, −18.4%) of the effect of CD24 on IgD+ CD38br on asthma is mediated by S-methylcysteine sulfoxide levels, with a mediated effect value (<i>p</i> = 0.006) is 0.003 (0.0004, 0.006); 21.4% (6.2%, −36.6%) of the effect of CD3 on CD28+ CD4+ on asthma is mediated by 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4) levels, with a mediated effect value (<i>p</i> = 0.025) is 0.004 (0.001, 0.007).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We identified two pathways by which ICTs can impact asthma through PMs, which might help in identifying potential targets for personalized treatment approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient With Advanced Aggressive B2 Thymoma Achieved Positive Outcomes Post CAP-Endostar Combination Therapy","authors":"Min Zhang,&nbsp;Jingjing Zhang,&nbsp;Kelei Zhao,&nbsp;Xiaohan Yuan,&nbsp;Jinghang Zhang,&nbsp;Yanting Liu,&nbsp;Ping Lu","doi":"10.1111/crj.70081","DOIUrl":"https://doi.org/10.1111/crj.70081","url":null,"abstract":"<p>This case report features a patient with an invasive thymoma. The patient presented with an anterior mediastinal mass that invaded the left brachiocephalic trunk vein, resulting in the formation of a carcinoma thrombus in the right atrium, superior vena cava, left brachiocephalic trunk vein, and left internal jugular vein (Masaoka stage IV). No indication for surgery was assessed by surgical consultation. After six cycles of chemotherapy and chest radiotherapy, the tumor size decreased from 72.43 to 24 mm, showing a significant improvement in patient efficacy. After a follow-up of 50 months, the patient remained well, without local recurrence or distal metastasis, and maintained a partial response (PR).</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECG Abnormalities and Biomarkers Enable Rapid Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism","authors":"Siqi Jiao,&nbsp;Ying Liu,&nbsp;Haoming He,&nbsp;Qing Li,&nbsp;Zhe Wang,&nbsp;Yinong Chen,&nbsp;Longyang Zhu,&nbsp;Shuwen Zheng,&nbsp;Furong Yang,&nbsp;Zhenguo Zhai,&nbsp;Yihong Sun","doi":"10.1111/crj.70060","DOIUrl":"https://doi.org/10.1111/crj.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The patients with suspected pulmonary embolism (PE) were usually screened using electrocardiogram (ECG) and blood panel of D-dimer, troponin, and blood gas analysis in the emergency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to explore a rapid risk model to predict in-hospital adverse events for normotensive PE patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with acute PE having normal blood pressure on appearance were retrospectively enrolled at China-Japan Friendship Hospital from January 2017 to February 2020. The in-hospital adverse events were defined as death and clinical deterioration during hospitalization. The risk model for in-hospital adverse events was generated by multivariate regression analysis. The discrimination ability of the model was compared with PESI, Bova, and FAST risk score, and evaluated by the receiver operating characteristic curve (ROC), net reclassification improvement (NRI), and integrated discrimination improvement index (IDI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 213 patients, 35 (16.4%) experienced in-hospital adverse events,y including 15 deaths. The average age was 69 ± 19 years, and 118 (44.6%) were females. Multiple logistic regression analysis showed that independent risk factors associated with in-hospital adverse events were low QRS voltage in ECG (OR: 5.321; 95% CI: 1.608–7.310), positive age-adjusted D-dimer (OR: 2.061; 95% CI: 0.622–6.836), positive troponin (OR: 3.504; 95% CI: 1.744–8.259), and PaO₂/FiO₂ &lt; 300 (OR: 3.268; 95% CI: 0.978–5.260). The ROC analysis showed that the AUC of the new model (0.847, 95% CI: 0.786–0.901) was better than the PESI score (0.628, 95% CI: 0.509–0.769), the Bova score (0.701, 95% CI: 0.594–0.808), and the FAST score (0.775 95% CI: 0.690–0.859).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ECG abnormalities and biomarkers on admission may provide a rapid and effective approach to identify patients with poor prognoses during hospitalization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Circular RNA NFIX Functions as an Oncogene in Non-Small Cell Lung Cancer by Modulating the miR-214-3p/TRIAP1 Axis”","authors":"","doi":"10.1111/crj.70096","DOIUrl":"https://doi.org/10.1111/crj.70096","url":null,"abstract":"<p>\u0000 <span>G. Liu</span>, <span>H. Shi</span>, <span>H. Zheng</span>, <span>W. Kong</span>, <span>X. Cheng</span>, <span>L. Deng</span>, “ <span>Circular RNA NFIX Functions as an Oncogene in Non-Small Cell Lung Cancer by Modulating the miR-214-3p/TRIAP1 Axis</span>,” <i>Clinical Respiratory Journal</i> <span>18</span>, no. <span>8</span> (<span>2024</span>). https://doi.org/10.1111/crj.13801.\u0000 </p><p>Figures 4 and 7 are incorrect. Below are the correct figures.</p><p>FIGURE 4 | Effect of circRNA NFIX interference in NSCLC by targeting miRNA-214-3p. A549 cells were transfected with control-siRNA, circRNA NFIX-siRNA, circRNA NFIX-siRNA + inhibitor control, or circRNA NFIX-siRNA + miR-214-3p inhibitor for 48 h. (A) Cell proliferation was counted by MTT assay. (B and C) The apoptosis ratio of cancer cells was detected by flow cytometry. (D and E) The level of cleaved-caspase3 was detected by western blot assay, and cleaved-caspase3/caspase3 ratio was calculated. ** indicates <i>p</i> &lt; 0.01 versus control-siRNA, ## indicates <i>p</i> &lt; 0.01 circRNA NFIX-siRNA + inhibitor control. Data are exhibited as average ± SD of triple single experiments.</p><p>FIGURE 7 | Overexpression of miRNA-214-3p suppressed cell growth and promoted cell apoptosis via TRIAP1 in NSCLC cells. A549 cells were transfected with mimic control, miRNA-214-3p mimic, miRNA-214-3p mimic + control-plasmid, or miRNA-214-3p mimic + TRIAP1-plasmid for 48 h. (A) Cell proliferation was counted by MTT assay. (B and C) The apoptosis of A549 cells was analyzed by flow cytometry. (D and E) The level of cleaved-caspase3 was detected by western blot assay, and the ratio of cleaved-caspase3/caspase3 was determined. ** indicates <i>p</i> &lt; 0.01 versus mimic control, ## indicates <i>p</i> &lt; 0.01 versus miR-214-3p mimic + control-plasmid. Data are exhibited as average ± SD of triple single experiments.</p><p>We apologize for these errors.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Soluble Urokinase Plasminogen Activator Receptor (suPAR) as Predictive Tool in Hospitalised Patients With Community-Acquired Pneumonia (CAP)","authors":"Lisa Hessels,&nbsp;Ruud Duijkers,&nbsp;Marianne Schoorl,&nbsp;Lotte Terpstra,&nbsp;Willemien Thijs,&nbsp;Wim Boersma","doi":"10.1111/crj.70089","DOIUrl":"https://doi.org/10.1111/crj.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker elevated in severely ill patients, but its prognostic value in community-acquired pneumonia (CAP) remains unclear. This study aimed to evaluate suPAR's prognostic role for CAP severity compared to other biomarkers and severity scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 204 hospitalised CAP patients were enrolled. C-reactive protein (CRP), procalcitonin (PCT), suPAR, CURB-65 and Pneumonia Severity Index (PSI) scores were measured at admission, and patients were followed for 365 days. The primary outcome was the relationship between suPAR levels and CAP severity based on IDSA/ATS guidelines. Secondary outcomes included time to clinical stability (TTCS), length of stay (LOS) and mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 204 patients, 174 (85%) had non-severe and 30 (15%) had severe CAP. SuPAR levels were not associated with severe CAP (OR 1.03, 95% CI 0.88–1.21; AUC 0.53). Unlike the PSI and CURB-65 scores, suPAR did not correlate with TTCS (HR PSI 0.80, HR CURB-65 0.86), though all three markers were correlated to LOS (AUC suPAR 0.61). Only suPAR was significantly associated with 30-day mortality (HR 1.51, AUC 0.68).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prognostic value of suPAR for CAP severity is low, and it does not provide additional prognostic benefit over the CURB-65 or PSI scores in predicting CAP severity. While it has moderate predictive ability for 30-day mortality, its utility for predicting LOS or TTCS is low.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT01964495</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Circulating Platelet Count as a Risk Factor for Lung Squamous Cell Carcinoma: A Retrospective Study and Mendelian Randomization Analysis","authors":"Guo-Sheng Li,&nbsp;Jun Liu,&nbsp;Yue Li,&nbsp;Chang-Qian Li,&nbsp;Dong-Sheng Lu,&nbsp;Xiang Gao,&nbsp;Guan-Qiang Yan,&nbsp;Zhan-Yu Xu,&nbsp;Hua-Fu Zhou,&nbsp;Nuo Yang","doi":"10.1111/crj.70090","DOIUrl":"https://doi.org/10.1111/crj.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The association between platelet count (PLTC) and the risk of lung squamous cell carcinoma (LUSC) remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 19 223 samples from public and internal cohorts to investigate the relationship between high PLTC and the risk of developing LUSC using the retrospective analysis and Mendelian randomization analysis (MRA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Elevated PLTC were detected in the population with lung cancer compared to healthy individuals (odds ratio [OR] = 1.41 [per 1-SD], 95% CI 1.13–1.75, <i>p</i> &lt; 0.05). Furthermore, there is a significant association between elevated PLTC and an increased risk of LUSC based on an in-house cohort (OR = 1.63 [per 1-SD], 95% CI 1.08–2.45, <i>p</i> &lt; 0.05). Individuals with high PLTC had an increased risk of developing LUSC using the inverse-variance weighting method (OR = 1.62 [per 1-SD], 95% CI 1.14–2.31, <i>p</i> &lt; 0.05), an outcome that was directionally consistent across the weighted median, MR Egger, simple mode, and weighted modes methods (OR &gt; 1.00). No pleiotropy (the MRA pleiotropy residual sum and outlier test <i>p</i> = 0.553) or heterogeneity (Cochran's <i>Q</i> statistic <i>p</i> = 0.777) was found in the MRAs. Besides PLTC, age and five other hematological parameters (e.g., red blood cell count) were identified as independent factors associated with the incidence of lung cancer or its subtype LUSC (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>High circulating PLTC may serve as a risk factor for lung squamous cell carcinoma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study","authors":"Yu Shi,&nbsp;Shuang Chen,&nbsp;Zhaokai Zhou,&nbsp;Mengke Huang,&nbsp;Yue Li,&nbsp;Xiaogang Jing","doi":"10.1111/crj.70087","DOIUrl":"https://doi.org/10.1111/crj.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This research evaluated the causal relationship between serum metabolites and IPF utilizing two-sample Mendelian randomization (MR) analysis. IVW served as the main method of analysis; concurrently, MR-Egger, weighted median, and MR-PRESSO acted as supplementary analyses. Sensitivity analyses were performed with Cochran's <i>Q</i> test, MR-Egger's intercept test, and leave-one-out method of analysis. All statistical analyses were accomplished in R software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results showed that 23 metabolites have a causal connection with IPF. Following sensitivity analysis, 2 robust and 12 potential causal association pairs were identified among the known metabolites. These 14 causal pairs concerned six metabolites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study presents a novel perspective on potential mechanisms involved in IPF with important significance for screening, prevention, and treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Treatment Approaches for Pulmonary Hypertension in Colombia: A Call to Action”","authors":"","doi":"10.1111/crj.70095","DOIUrl":"https://doi.org/10.1111/crj.70095","url":null,"abstract":"<p>\u0000 <span>G. G. Pitsiou</span>, “ <span>Treatment Approaches for Pulmonary Hypertension in Colombia: A Call to Action</span>,” <i>Clinical Respiratory Journal</i> <span>19</span>, no. <span>2</span> (<span>2025</span>), https://doi.org/10.1111/crj.70062.\u0000 </p><p>In the References section, reference section 3 is outdated and should be updated to</p><p>3. Μ. Machado-Duque, Α. Gaviria-Mendoza, L. F. Valladales-Restrepo, et al., “Treatment Patterns of Patients With Pulmonary Hypertension: A Descriptive Study in Colombia,” <i>Clinical Respiratory Journal</i> 19, no. 2 (2025), https://doi.org/10.1111/crj.70063.</p><p>We apologize for this error.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Assessment of Tuberculosis in Patients With Chronic Mental Illness and Related Factors: A Population-Based Cohort Study in Taiwan","authors":"Li-Chen Hung,&nbsp;Pei-Tseng Kung,&nbsp;Tung-Han Tsai,&nbsp;Wen-Chen Tsai,&nbsp;Kuang-Hua Huang","doi":"10.1111/crj.70088","DOIUrl":"https://doi.org/10.1111/crj.70088","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Tuberculosis (TB) is a globally prevalent chronic infectious disease. The World Health Organization estimates that mental illnesses will become the leading cause of global disease burden in 2030. The inability to detect and provide proper treatment for TB in mental illness patients is an epidemic prevention blind spot. The objective of this study was to retrospectively compare the incidence of TB between the general public and mental illness patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used data across Taiwan from 2002 to 2013. The National Health Insurance Research Database, Registry for Catastrophic Illness Patients, Tuberculosis Database, and Household Registration Records of Taiwan were analyzed. Propensity score matching was used to reduce basic characteristic differences between mental illness patients and the general public. The conditional Cox proportional hazards model and cumulative risk curve were used to compare their risk of developing TB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>It was shown that TB incidence was 87 and 71 per 100 000 person-years in mental illness patients and the general public, respectively. The risk of developing TB in mental illness patients was 1.48 times (95% CI: 1.38–1.59) that of the general public.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Mental illness patients are a high-risk population for TB and should be listed as key subjects for TB prevention and control.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Research to Evaluate the 30 Most Common Pulmonary Embolism Drugs in the Food and Drug Administration Adverse Event Reporting System","authors":"Hang Chen,&nbsp;Yiming Shen,&nbsp;Yinyu Mu,&nbsp;Shuguang Xu,&nbsp;Shimo Shen,&nbsp;Weiyu Shen,&nbsp;Zeyang Hu,&nbsp;Hongxiang Li,&nbsp;Keyue Qiu,&nbsp;Jiaheng Zhang,&nbsp;Zhe Chen,&nbsp;Guodong Xu","doi":"10.1111/crj.70054","DOIUrl":"https://doi.org/10.1111/crj.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Backgrounds</h3>\u0000 \u0000 <p>Pulmonary embolism (PE) is a common disease and a common cause of death. However, it is currently unclear which clinically common drugs can lead to PE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected, organized, and analyzed reports from the first quarter of 2018 to the fourth quarter of 2022. We performed disproportionality analysis algorithms to calculate reporting odds ratio (ROR), which could quantify the signal values of different adverse events (AEs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We have screened a total of 3091 drugs, with AE containing “PE” and calculated the ROR signal values of the top 30 drugs reported and ranked them. TESTIM (ROR = 32.03[28.77–35.66]), BARICITINIB (ROR = 23.48[20.55–26.83]), and NUVARIANG (ROR = 19.89[17.13–23.10]) are the drugs with the strongest correlation with PE. In addition, among the 30 drugs with the strongest correlation with PE, most of which are Biologics &amp; Immunomodulators. Therefore, when using these 30 drugs, it is necessary to be alert to the possible risk of PE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In our study, we filtered 30 common drugs that could cause PE through the FAERS public database, which provides theoretical support for drug selection in the treatment of malignant tumors and IMID.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}