Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study

IF 2.3 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2025-06-13 DOI:10.1111/crj.70087

Yu Shi, Shuang Chen, Zhaokai Zhou, Mengke Huang, Yue Li, Xiaogang Jing

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引用次数: 0

Abstract

Background

The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF.

Methods

This research evaluated the causal relationship between serum metabolites and IPF utilizing two-sample Mendelian randomization (MR) analysis. IVW served as the main method of analysis; concurrently, MR-Egger, weighted median, and MR-PRESSO acted as supplementary analyses. Sensitivity analyses were performed with Cochran's Q test, MR-Egger's intercept test, and leave-one-out method of analysis. All statistical analyses were accomplished in R software.

Results

Our results showed that 23 metabolites have a causal connection with IPF. Following sensitivity analysis, 2 robust and 12 potential causal association pairs were identified among the known metabolites. These 14 causal pairs concerned six metabolites.

Conclusion

This study presents a novel perspective on potential mechanisms involved in IPF with important significance for screening, prevention, and treatment.

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遗传决定的人类血清代谢物水平对特发性肺纤维化风险的因果影响：孟德尔随机研究

背景：特发性肺纤维化（IPF）的发病率逐年上升；然而，潜在的生物学机制尚未完全阐明。本研究的目的是揭示循环代谢物对IPF的病因学作用。方法采用双样本孟德尔随机化（MR）分析，评价血清代谢物与IPF之间的因果关系。IVW为主要分析方法；同时，MR-Egger、加权中位数和MR-PRESSO作为补充分析。采用Cochran’s Q检验、MR-Egger’s截距检验和留一分析法进行敏感性分析。所有统计分析均在R软件中完成。结果23种代谢物与IPF有因果关系。通过敏感性分析，在已知的代谢物中鉴定出2对强大的和12对潜在的因果关联。这14对因果关系涉及6种代谢物。结论本研究为IPF的潜在机制提供了新的视角，对IPF的筛查、预防和治疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)