Clinical Respiratory Journal最新文献

{"title":"Changes in Retinal Nerve Fiber Layer Thickness in Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis","authors":"Yunpeng Xu,&nbsp;Peidong Shi,&nbsp;Xiaoying Liu,&nbsp;Ziyi Jiang,&nbsp;Yanru Chen,&nbsp;Jian Liu,&nbsp;Xunwen Lei,&nbsp;Xue Bai,&nbsp;Fanqi Wu","doi":"10.1111/crj.70065","DOIUrl":"https://doi.org/10.1111/crj.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of this study is to evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and the onset as well as progression of chronic obstructive pulmonary disease (COPD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Database searches were conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Data, VIP Database, and CBM, covering the period from each database's inception to March 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This meta-analysis included 15 studies from 2016 to 2023, comprising a total of 1455 participants (801 in the COPD group and 654 in the health group). The results showed a significant reduction in RNFL thickness across all quadrants (average, inferior, nasal, superior, and temporal) in the COPD group compared to the health group (MD: −4.46; 95%CI: −7.77 to −1.14; <i>p</i> = 0.008; MD: −8.17; 95%CI: −11.36 to −4.99; <i>p</i> &lt; 0.00001; MD: −4.69; 95%CI: −7.22 to −2.16; <i>p</i> = 0.0003; MD: −4.83; 95%CI: −8.45 to −1.21; <i>p</i> = 0.009; MD: −2.89; 95%CI: −5.35 to −0.43; <i>p</i> = 0.02). In the mild/moderate COPD group, only the inferior RNFL (MD: −2.32; 95%CI: −4.40 to −0.24; <i>p</i> = 0.03) showed a significant reduction. However, in the severe COPD group, all quadrants were significantly reduced (MD: −5.89; 95%CI: −7.40 to −4.38; <i>p</i> &lt; 0.0001; MD: −6.74; 95%CI: −10.71 to −2.77; <i>p</i> = 0.0009; MD: −4.29; 95%CI: −5.95 to −2.64; <i>p</i> &lt; 0.0001; MD: −2.34; 95%CI: −4.30 to −0.37; <i>p</i> = 0.02; MD: −4.84; 95%CI: −8.82 to −0.86; <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on current evidence, the average RNFL thickness and the thicknesses of various RNFL regions in COPD patients are significantly lower than those in healthy subjects, and these reductions are closely associated with disease severity. The inferior RNFL may be the first to show changes with the onset and progression of COPD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nomogram for Predicting Pulmonary Embolism in Silicosis Patients","authors":"Jiaqing Zhou,&nbsp;Wen Du,&nbsp;Jin Liu,&nbsp;Lijun Peng","doi":"10.1111/crj.70059","DOIUrl":"https://doi.org/10.1111/crj.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As one of the most severe occupational diseases that prevention efforts have supported for several decades, silicosis is still a public health issue that lacks a prediction model for pulmonary embolism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 162 patients confirmed to have silicosis were all involved in a training cohort to construct a nomogram with the outcome diagnosed by the CTPA using logistic regression. Univariate and LASSO analyses were used to select variables for the nomogram.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>mMRC, pectoralgia, history of VTE, active tumor, unilateral lower limb pain or edema, hormonotherapy, reduced mobility, and heart failure/respiratory failure were selected for the establishment of the nomogram for silicosis with pulmonary embolism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A novel nomogram was developed to predict pulmonary embolism in silicosis patients. The internal validation indicated that clinicians could utilize this predictive model to help decision-making and patient management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Rescue of Massive Hemoptysis Caused by Vascular-Bronchial Fistula","authors":"Xiangwu Zhang,&nbsp;Rongxian Zhou,&nbsp;Guangqiang Zhao,&nbsp;Wanling Chen,&nbsp;Yunchao Huang,&nbsp;Lianhua Ye","doi":"10.1111/crj.70064","DOIUrl":"https://doi.org/10.1111/crj.70064","url":null,"abstract":"<p>The case reported in this paper is a vascular-bronchial fistula associated with fatal massive hemoptysis. The patient was rescued successfully by experts from a multidisciplinary team. The bronchoscopy physician cleared the accumulated blood in the airway timely and maintained the airway patency, and the anesthesiologist established artificial ventilation quickly; eventually, the thoracic surgeon performed an emergency thoracotomy to control the bleeding. It reflected the significance of multidisciplinary collaborative treatment.</p>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Causes Bilateral Pleural Effusion: A Case Report","authors":"Miaojuan Zhu,&nbsp;Shuaiyu Lin,&nbsp;Yifei Chen,&nbsp;Jiong Yang,&nbsp;Hanxiang Nie","doi":"10.1111/crj.70055","DOIUrl":"https://doi.org/10.1111/crj.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tuberculous pericarditis begins with fibrinous and hemorrhagic pericarditis, followed by pericardial effusion, then pericardial hypertrophy, which may turn into subacute or chronic stage, and partly develop into pericarditis. Early diagnosis and treatment have very important clinical significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Summary</h3>\u0000 \u0000 <p>We present a case of an 82-year-old man with a known history of hypertension who was admitted for pleural effusion. CT scan of the chest showed findings of pleural effusion. An echocardiographic study during admission revealed a small amount of pericardial effusion (~1.2 cm in thickness). A whole-body positron emission tomography-computer tomography (PET-CT) scan was then performed and showed a slightly increased fluorodeoxyglucose uptake in the entire pericardium considering tuberculosis. He was started on antituberculosis (TB) medications and tolerated them well. Follow-up echocardiographic study showed no re-accumulation of pleural effusion and pericardial fluid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Transudative–exudative pleural effusion may be one of the clinical manifestations of tuberculous pericarditis. (1) Bilateral leaking pleural effusion may be the early clinical manifestation of tuberculous pericarditis; (2) PET/CT in the diagnosis and efficacy evaluation of tuberculous pericarditis is valuable; and (3) the central venous pressure may be an indicator of choice for treatment of tuberculous pericarditis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Risk Factors and Predictors of Chronic Obstructive Pulmonary Disease in Patients With Obstructive Sleep Apnea–Hypopnea Syndrome at Plateau","authors":"Yumei Geng,&nbsp;Yu Hu,&nbsp;Bin Li,&nbsp;Zhuoma Dawa,&nbsp;Fang Zhang","doi":"10.1111/crj.70053","DOIUrl":"https://doi.org/10.1111/crj.70053","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;OSAHS patients with COPD (i.e., overlap syndrome) have a significantly worse prognosis than those with OSAHS alone, and the role of plateau hypoxia in the occurrence of the disease is still unclear. This underscores the urgent need to explore the risk factors for the incidence of COPD in patients with OSAHS and to identify predictors for the occurrence of overlap syndrome at plateau.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fifty patients with OSAHS and 34 patients with overlap syndrome were enrolled in this study. Demographic, auxiliary examination, and laboratory data were collected.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All patients enrolled were obstructive sleep apnea–hypopnea syndrome. The apnea–hypopnea index (AHI), the number of hypopnea, and the oxygen desaturation index were higher in the group of patients with overlap syndrome than in the group of patients with OSAHS. The mean pulse oxygen saturation was lower than that in the group of patients with OSAHS (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The right heart structure and function indexes (PASP, right atrial transverse diameter, RVTD, BNP, TNI) in patients with overlap syndrome were worse than those in patients with OSAHS (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), and this worse cardiovascular status was positively correlated with inflammatory factors such as high-sensitivity C-reactive protein, IL-6, and PCT (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Binary logistic regression analysis indicated that PASP, smoking index, and AHI were independent risk factors for OSAHS developing into overlap syndrome. ROC curve showed that the area under the curve of the combination of the three markers for predicting overlap syndrome was 0.908 (95% CI 0.843–0.974, &lt;i&gt;p&lt;/i&gt; = 0.000), with a sensitivity of 0.882 and a specificity of 0.820. The optimal cutoff values for PASP were 42.5 mmHg, 15 for the smoking index, and 25.65 for the AHI based on the Youden index.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our study reveals that overlap syndrome has more frequent nighttime hypopnea and hypoxia than OSAHS alone. The cardiovascular complications of overlapping syndromes at plateau are more pronounced, possibly due to the exacerbation of the systemic inflammatory response. The combination of PASP, smoking index, and AHI can be a powerful tool for predicting and assessing the occurrence of COPD in OSAHS patients from plateau populations in China. These findings have the potential to significantly improve the management and prognosis of patients with overlap syndrome.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Patterns of Patients With Pulmonary Hypertension: A Descriptive Study in Colombia","authors":"Manuel Machado-Duque,&nbsp;Andrés Gaviria-Mendoza,&nbsp;Luis Fernando Valladales-Restrepo,&nbsp;Manuel Pacheco,&nbsp;Juan Sebastián Franco,&nbsp;María del Rosario Forero,&nbsp;Rubiela Suarez,&nbsp;Oscar Peñuela,&nbsp;Jorge E. Machado-Alba","doi":"10.1111/crj.70063","DOIUrl":"https://doi.org/10.1111/crj.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pulmonary hypertension (PH) is a chronic disease characterized by a progressive rise in pulmonary artery blood pressure. The objective was to describe the treatment patterns among ambulatory patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) in a real-world setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a longitudinal cohort follow-up study characterizing the treatment patterns of patients diagnosed with PAH or CTEPH, with secondary data from a population-based drug-dispensing database between 2022 and 2023, which includes sociodemographic, diagnosis, prescribing specialty, and treatment (drugs, persistence of use, and concomitant medications).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 1045 patients with a diagnosis of PH were identified, with mean age of 62.9 ± 18.2 years, and 72.3% of females; of which 947 (90.6%) received monotherapy, and 98 (9.4%) received combination therapy at the beginning of follow-up. The most frequently used drugs for the treatment of PH were calcium channel blockers (58.1%), followed by phosphodiesterase 5 inhibitors (41.1%), endothelin receptor antagonist (32.5%), and guanylate cyclase stimulants (9.7%). The schemes used most frequently were monotherapy with amlodipine (31.0%), sildenafil (19.2%), or nifedipine (10.0%), but the main combination were sildenafil with nifedipine (2.5%). The mean of persistence of use was 161 ± 123 days during 1 year of follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This group of patients with PH from Colombia were treated predominantly with monotherapy of calcium channel blockers and phosphodiesterase 5 inhibitors. However, current clinical practice guidelines recommend the use of combined therapy. The average persistence of the use of drugs for treatment for less than 6 months may be associated with difficulties in follow-up, adherence, effectiveness, tolerability, and access.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection","authors":"Colin J. Crooks,&nbsp;Dominick Shaw,&nbsp;Timothy R. Card,&nbsp;Iain Au-Yong,&nbsp;Yutaro Higashi,&nbsp;Elisabetta Giannotti,&nbsp;Andrew W. Fogarty","doi":"10.1111/crj.70056","DOIUrl":"https://doi.org/10.1111/crj.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chest radiographs are generally used for diagnostic purposes. They also have potential to quantify disease severity. This analysis tested the hypothesis that there was an association between chest radiograph opacification and measures of respiratory physiological status and systemic inflammation in patients with Covid-19 infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on chest radiograph opacification were compared with concurrent measures of oxygen requirements and saturation and serum C-reactive protein.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data were available from 628 individuals. The median opacification on chest radiographs was 20% (interquartile range 5–45). This was associated both SFR (oxygen saturation/supplementary oxygen) with an <i>r</i> value of −0.38 (95% confidence intervals CI: −0.45 to −31, Pearson's correlation coefficient) and CRP (+0.33; 95% CI: +0.24 to +0.41, Pearson's correlation coefficient).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Chest radiograph opacification scores are associated with both respiratory physiology status and systemic inflammation levels in patients with Covid-19 infection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Approaches for Pulmonary Hypertension in Colombia: A Call to Action","authors":"Georgia G. Pitsiou","doi":"10.1111/crj.70062","DOIUrl":"https://doi.org/10.1111/crj.70062","url":null,"abstract":"","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Insecurity Is Associated With Current Asthma, Wheeze, and Lung Function in Children and Adults","authors":"Weiliang Kong,&nbsp;Yilian Xie,&nbsp;Kunlong Xiong,&nbsp;Jingjing Hu,&nbsp;Weina Huang,&nbsp;Chao Cao","doi":"10.1111/crj.70052","DOIUrl":"https://doi.org/10.1111/crj.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Food insecurity (FI) has been a global threat, as a social determinant in connection with the prevalence of diseases requiring dietary interventions, such as asthma, has been established. This study aims to examine the relationship between FI and respiratory health outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 7626 children and 17 530 adults from the 2007 to 2012 National Health and Nutritional Examination Surveys (NHANES) in the United States. Weighted multivariate regression models were used to evaluate the associations between FI and respiratory outcomes, including current asthma, wheezing, fractional exhaled nitric oxide (FeNO), and lung function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The weighted prevalence of high FI was 19.68% in children and 13.74% in adults. In adults, high FI was significantly associated with current asthma (OR: 1.41, 95% CI: 1.19–1.67) and wheezing (OR: 1.72, 95% CI: 1.48–1.99). The association with asthma was stronger in women (<i>p</i> for interaction = 0.02) and non-Hispanic Whites (<i>p</i> for interaction = 0.04), whereas wheezing showed stronger associations in non-Hispanic Whites (<i>p</i> for interaction = 0.01). High FI was linked to lower percent-predicted forced expiratory volume in 1 s (FEV₁) in children (β: −15.93%, 95% CI: −27.82%, −4.03%) and adults (β: −1.13%, 95% CI: −2.22%, −0.04%) without asthma or wheezing. Additionally, high FI was inversely associated with FeNO in adults with current asthma (β: −3.36, 95% CI: −5.54, −1.17) and wheezing (β: −4.40, 95% CI: −7.79, −1.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FI is associated with increased asthma and wheezing in adults, particularly among women and non-Hispanic Whites, and with reduced FEV1 in both adults and children without asthma and wheezing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Prognosis of Lung Cancer Patients Receiving Anlotinib Treatment: A Retrospective Cohort Study","authors":"Congyi Xie,&nbsp;Jinzhan Chen,&nbsp;Shuwen Yang,&nbsp;Feiyang Ye,&nbsp;Zhenyang Lin,&nbsp;Yijiao Xu,&nbsp;Yimin Yang,&nbsp;Lin Tong","doi":"10.1111/crj.70051","DOIUrl":"https://doi.org/10.1111/crj.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Anlotinib is widely used in the treatment of lung cancer. However, there remains a lack of predictive biomarkers to effectively gauge the response to anlotinib therapy. We conducted a retrospective study to preliminarily explore potential risk factors that might predict outcomes in lung cancer patients undergoing anlotinib treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed lung cancer patients treated with anlotinib at our hospital between 1 June 2018 and 1 June 2021. Data were gathered from electronic medical records. Demographic and clinical characteristics of patients, progression-free survival (PFS), and overall survival (OS) were described. Predictive factors related to treatment efficacy were preliminarily analyzed using Cox regression and Kaplan–Meier survival analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After adjusting for potential confounders, clinical stage IV (hazard ratio [HR] = 2.52, 95% confidence interval [CI], 1.09–5.82, <i>p</i> = 0.0311), N-terminal fragment brain natriuretic peptides (NT-pro-BNP) &gt; 300 pg/mL (HR = 2.54, 95% CI, 1.17–5.52, <i>p</i> = 0.0183), and neuron-specific enolase (NSE) &gt; 16.3 ng/mL (HR = 1.70, 95% CI, 1.03–2.81, <i>p</i> = 0.0389) were associated with shorter OS, whereas age (HR = 0.96, 95% CI, 0.94–0.99, <i>p</i> = 0.0055) was associated with a longer PFS in fully adjusted model. Kaplan–Meier analyses of cumulative risk factors (clinical stage IV, NT-pro-BNP &gt; 300 pg/mL, and NSE &gt; 16.3 ng/mL) indicated that patients with a greater number of coexisting risk factors had significantly shorter OS (<i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Clinical stage IV, NT-pro-BNP level, and NSE level were identified as independent prognostic factors for lung cancer patients undergoing anlotinib treatment. Patients with multiple high-risk factors may derive limited benefit from anlotinib.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}