Current Allergy and Asthma Reports最新文献_第5页

The Potential of Human Monoclonal IgE Antibodies to Establish Biological Potency and Stability of Allergen Extracts. 人类单克隆 IgE 抗体在确定过敏原提取物的生物效力和稳定性方面的潜力。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.1007/s11882-024-01168-4

Ronald L Rabin

引用次数: 0

Buckwheat Allergy in Asia. 亚洲的荞麦过敏症。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1007/s11882-024-01166-6

Naoki Kajita, Koichi Yoshida

引用次数: 0

The Diagnosis of Allergy to Lipid Transfer Proteins. 脂质转移蛋白过敏的诊断。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1007/s11882-024-01164-8

Bianca Olivieri, Isabel J Skypala

引用次数: 0

Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis. 口服 Janus 激酶抑制剂治疗小儿特应性皮炎

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1007/s11882-024-01167-5

Elsy M Navarrete-Rodríguez, Désirée Larenas-Linnemann, Helena Vidaurri de la Cruz, Jorge A Luna-Pech, Esther Guevara Sanginés

{"title":"Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis.","authors":"Elsy M Navarrete-Rodríguez, Désirée Larenas-Linnemann, Helena Vidaurri de la Cruz, Jorge A Luna-Pech, Esther Guevara Sanginés","doi":"10.1007/s11882-024-01167-5","DOIUrl":"10.1007/s11882-024-01167-5","url":null,"abstract":"Purpose of review: To analyze the efficacy and safety of Janus kinase inhibitors (JAKi) in the treatment of pediatric AD.Recent findings: Adolescents with moderate and severe atopic dermatitis (AD) need systemic therapies, as stated several recent practice guidelines. (JAKi) have shown their efficacy in the treatment of adult AD, however, there is a lack of information concerning efficacy and safety of their use in pediatric AD. We found that the JAKi's abrocitinib (ABRO), baricitinib (BARI), and upadacitinib (UPA), are all an effective treatment option with a very fast onset of action for adolescents with moderate-to-severe AD. BARI was not effective in children between 2 and 10 years with moderate-to-severe AD. Fortunately, major safety issues with JAKi in adolescents with AD have not been documented in the trials, so far, contrasting with the reports in adults with AD, where these events have very rarely occurred. There are some reports of herpes zoster (HZ) infection in adolescents on JAKi, but it is not a major safety concern. Acne is a relatively common AE with UPA in adolescents; however, it is responsive to standard treatment. This review will help the clinician to choose among the JAKi according to the needs and clinical features of patients with moderate and severe AD. In the following years, with the advent of new biologicals and JAKi, these therapies will fall into place in each phase of the evolution of patients with AD.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":" ","pages":"485-496"},"PeriodicalIF":5.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China. 中国的食用花粉交叉反应及其分子诊断。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1007/s11882-024-01162-w

Lan Zhao, Tingting Ma, Xiaoyan Wang, Hongtian Wang, Yi Liu, Shandong Wu, Linglin Fu, Luud Gilissen, Ronald van Ree, Xueyan Wang, Zhongshan Gao

{"title":"Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China.","authors":"Lan Zhao, Tingting Ma, Xiaoyan Wang, Hongtian Wang, Yi Liu, Shandong Wu, Linglin Fu, Luud Gilissen, Ronald van Ree, Xueyan Wang, Zhongshan Gao","doi":"10.1007/s11882-024-01162-w","DOIUrl":"10.1007/s11882-024-01162-w","url":null,"abstract":"Purpose of review: Plant-derived foods are one of the most common causative sources of food allergy in China, with a significant relationship to pollinosis. This review aims to provide a comprehensive overview of this food-pollen allergy syndrome and its molecular allergen diagnosis to better understand the cross-reactive basis.Recent findings: Food-pollen cross-reactivity has been mainly reported in Northern China, Artemisia pollen is the major related inhalant source, followed by tree pollen (Betula), while grass pollen plays a minor role. Pollen allergy is relatively low in Southern China, with allergies to grass pollen being more important than weed and tree pollens. Rosaceae fruits and legume seeds stand out as major related allergenic foods. Non-specific lipid transfer protein (nsLTP) has been found to be the most clinically relevant cross-reacting allergenic component, able to induce severe reactions. PR-10, profilin, defensin, chitinase, and gibberellin-regulated proteins are other important cross-reactive allergen molecules. Artemisia pollen can induce allergenic cross-reactions with a wide range of plant-derived foods in China, and spring tree pollens (Betula) are also important. nsLTP found in both pollen and plant-derived food is considered the most significant allergen in food pollen cross-reactivity. Component-resolved diagnosis with potential allergenic proteins is recommended to improve diagnostic accuracy and predict the potential risk of causing allergic symptoms.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":" ","pages":"497-508"},"PeriodicalIF":5.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neglected but Clinically Relevant Allergens in Korea. 韩国被忽视但与临床相关的过敏原。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI: 10.1007/s11882-024-01161-x

Kyoung Yong Jeong, Jung-Won Park

{"title":"Neglected but Clinically Relevant Allergens in Korea.","authors":"Kyoung Yong Jeong, Jung-Won Park","doi":"10.1007/s11882-024-01161-x","DOIUrl":"10.1007/s11882-024-01161-x","url":null,"abstract":"Purpose of review: Allergy diagnostics and immunotherapeutics in Asia heavily rely on imported products from Western countries, raising concerns about the accuracy and efficacy of these products for the management of Asian allergy patients.Recent findings: Recent advancements in allergen research have led to the identification and characterization of novel allergens from indigenous Korean species. While some allergens share homology with well-known allergens, others lack counterparts in imported allergen extracts. Classifying regional allergens in Asia into three categories based on their cross-reactivity with imported allergens offers valuable insights. Highly cross-reactive allergens, such as oak allergens Que m 1 from Quercus mongolica and Que ac 1 from Q. acutissima, can be effectively substituted with the imported allergens. Allergens with partial cross-reactivity, like the Asian needle ant allergen Pac c 3 (Antigen 5), permit limited diagnostic value by the currently available products. Unique allergens, including the Japanese hop allergen Hum j 6 (pectin methylesterase inhibitor) and the silkworm pupa allergen Bomb m 4 (30 kDa hemolymph lipoprotein) lack alternatives in the available product list. Greater attention is needed, particularly for species listed as ecologically invasive in Western regions. Additionally, allergens from domestic fruits and vegetables causing pollen food allergy syndrome require characterization for the development of improved diagnostics.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":" ","pages":"519-526"},"PeriodicalIF":5.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond. 豆类过敏原豌豆、鹰嘴豆、扁豆、羽扇豆及更多。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1007/s11882-024-01165-7

Marua Abu Risha, Eva-Maria Rick, Melanie Plum, Uta Jappe

{"title":"Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond.","authors":"Marua Abu Risha, Eva-Maria Rick, Melanie Plum, Uta Jappe","doi":"10.1007/s11882-024-01165-7","DOIUrl":"10.1007/s11882-024-01165-7","url":null,"abstract":"Purpose of the review: In the last decade, an increasing trend towards a supposedly healthier vegan diet could be observed. However, recently, more cases of allergic reactions to plants and plant-based products such as meat-substitution products, which are often prepared with legumes, were reported. Here, we provide the current knowledge on legume allergen sources and the respective single allergens. We answer the question of which legumes beside the well-known food allergen sources peanut and soybean should be considered for diagnostic and therapeutic measures.Recent findings: These \"non-priority\" legumes, including beans, pea, lentils, chickpea, lupine, cowpea, pigeon pea, and fenugreek, are potentially new important allergen sources, causing mild-to-severe allergic reactions. Severe reactions have been described particularly for peas and lupine. An interesting aspect is the connection between anaphylactic reactions and exercise (food-dependent exercise-induced anaphylaxis), which has only recently been highlighted for legumes such as soybean, lentils and chickpea. Most allergic reactions derive from IgE cross-reactions to homologous proteins, for example between peanut and lupine, which is of particular importance for peanut-allergic individuals ignorant to these cross-reactions. From our findings we conclude that there is a need for large-scale studies that are geographically distinctive because most studies are case reports, and geographic differences of allergic diseases towards these legumes have already been discovered for well-known \"Big 9\" allergen sources such as peanut and soybean. Furthermore, the review illustrates the need for a better molecular diagnostic for these emerging non-priority allergen sources to evaluate IgE cross-reactivities to known allergens and identify true allergic reactions.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":" ","pages":"527-548"},"PeriodicalIF":5.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into chronic inducible urticaria. 对慢性诱发性荨麻疹的新认识。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-08-01 Epub Date: 2024-07-19 DOI: 10.1007/s11882-024-01160-y

Melba Muñoz, Lea Alice Kiefer, Manuel P Pereira, Mojca Bizjak, Marcus Maurer

{"title":"New insights into chronic inducible urticaria.","authors":"Melba Muñoz, Lea Alice Kiefer, Manuel P Pereira, Mojca Bizjak, Marcus Maurer","doi":"10.1007/s11882-024-01160-y","DOIUrl":"10.1007/s11882-024-01160-y","url":null,"abstract":"Purpose of review: Chronic inducible urticaria (CIndU) is a group of long-persisting and challenging to manage diseases, characterized by recurrent wheals and angioedema induced by definite triggers. In this review, we address recent findings on CIndU pathogenesis, diagnosis as well as its treatment, and we discuss novel potential targets that may lead to the development of more effective therapies for CIndU patients.Recent advances: Meaningful advances in the understanding of its pathogenesis have been reported in the last decades. Novel CIndU-specific patient-reported outcome measures enable a closer and better evaluation of patients. CIndU is a hard-to-treat disease that highly impairs quality of life (QoL) of affected patients. Provocation tests allow to diagnose CIndU subtypes. The only licensed and recommended treatment for CIndU are second generation non-sedating H1-antihistamines, which lack efficacy in many cases. Omalizumab off-label use has been assessed in all types of CIndU with overall good outcomes. Promising emerging therapies currently assessed in chronic spontaneous urticaria are paving the path for novel treatments for CIndU.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":" ","pages":"457-469"},"PeriodicalIF":5.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Symptoms of Systemic Sclerosis for the Allergist-Immunologist. 过敏反应学家--免疫学家系统性硬化症症状管理》（Managing Symptoms of Systemic Sclerosis for the Allergist-Immunologist.

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-08-01 Epub Date: 2024-06-21 DOI: 10.1007/s11882-024-01155-9

Mehreen Elahee, Robyn T Domsic

引用次数: 0

The Role of the Microbiome in Allergy, Asthma, and Occupational Lung Disease. 微生物组在过敏、哮喘和职业性肺病中的作用。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2024-08-01 Epub Date: 2024-06-21 DOI: 10.1007/s11882-024-01156-8

Ashley Peer, Derrick R Samuelson

{"title":"The Role of the Microbiome in Allergy, Asthma, and Occupational Lung Disease.","authors":"Ashley Peer, Derrick R Samuelson","doi":"10.1007/s11882-024-01156-8","DOIUrl":"10.1007/s11882-024-01156-8","url":null,"abstract":"Purpose of review: The human commensal microbiota is now widely accepted as a key regulator of human health and disease. The composition of the mucosal associated microbiota has been shown to play a critical role in the lung health. The role of the mucosal microbiota in the development and severity of allergy, asthma, and occupational lung disease is only beginning to take shape. However, advances in our understanding of these links have tremendous potential to led to new clinical interventions to reduce allergy, asthma, and occupational lung disease morbidity.Recent findings: We review recent work describing the relationship and role of the commensal microbiota in the development of allergy, asthma, and occupational lung disease. Our review primarily focuses on occupational exposures and the effects of the microbiome, both in composition and function. Data generated from these studies may lead to the development of interventions targeted at establishing and maintaining a healthy microbiota. We also highlight the role of environmental exposures and the effects on the commensal microbial community and their potential association with occupational lung disease. This review explores the current research describing the role of the human microbiome in the regulation of pulmonary health and disease, with a specific focus on the role of the mucosal microbiota in the development of allergy, asthma, and occupational lung disease.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":" ","pages":"415-423"},"PeriodicalIF":5.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0