理化特性能否改变空气过敏原的效力?第 2 部分 - 物理化学特性的影响。

IF 5.4 2区 医学 Q1 ALLERGY
Current Allergy and Asthma Reports Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI:10.1007/s11882-024-01173-7
Carla S S Teixeira, Bruno Carriço-Sá, Caterina Villa, Isabel Mafra, Joana Costa
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引用次数: 0

摘要

综述的目的:最近对食物过敏原的理化特性如何调节蛋白质的过敏性进行了全面分析,这为对航空过敏原进行类似分析提出了挑战。在首先回顾了吸入性过敏原的蛋白质家族分类(第 1 部分)之后,第二部分(第 2 部分)将探讨理化特性(丰度/生物功能、蛋白质结构/翻译后修饰的存在、配体/辅助因子/脂质结合)对吸入性蛋白质过敏性的影响:最新研究结果:对于大多数蛋白质家族而言,与生物功能相关的丰度与过敏风险的增加有关,而结构完整性的丧失以及随之而来的构象表位的破坏则与过敏性的降低密切相关。配体的结合效应完全取决于配体类型,不同的航空过敏原之间存在很大差异。有关航空过敏原理化性质的知识仍然很少,这突出表明需要使用综合方法(硅学和实验)进行研究,以生成和分析有关已知/新航空过敏原的新数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 2 - Impact of Physicochemical Properties.

Purpose of review: A holistic perspective on how physicochemical properties modulate the allergenicity of proteins has recently been performed for food allergens, launching the challenge of a similar analysis for aeroallergens. After a first review on aeroallergen classification into protein families (Part 1), this second part (Part 2) will exploit the impact of physicochemical properties (abundance/biological function, protein structure/presence of post-translational modifications, ligand/cofactor/lipid-binding) on inhalant protein allergenicity.

Recent findings: The abundance linked to biological function is correlated with increased allergenic risk for most protein families, while the loss of structural integrity with consequent destruction of conformational epitopes is well linked with decreased allergenicity. Ligand-binding effect totally depends on the ligand type being highly variable among aeroallergens. Knowledge about the physicochemical properties of aeroallergens is still scarce, which highlights the need for research using integrated approaches (in silico and experimental) to generate and analyze new data on known/new aeroallergens.

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来源期刊
CiteScore
11.20
自引率
1.80%
发文量
21
审稿时长
6-12 weeks
期刊介绍: The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma. We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.
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