Impact of Enolase in Allergic Disease.

IF 5.4 2区医学 Q1 ALLERGY

Current Allergy and Asthma Reports Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI:10.1007/s11882-024-01170-w

Martha Beatriz Morales-Amparano, Maria G Teran, José Ángel Huerta-Ocampo, Luis M Teran

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Abstract

Purpose of review: There is growing evidence that enolase is involved in allergy. This manuscript reviews the impact of enolase in allergic disease and describes several sources of this allergen including molds, plants, animals, and pollens, among others. IgE epitopes are carefully analyzed as they may account for cross-reactivity.

Recent findings: Enolase has been previously associated to food allergy and contact dermatitis. However, other groups and we have identified recently novel enolases derived from diverse pollens in patients suffering asthma and allergic rhinitis. Exposure to outdoor enolases may cause respiratory disease. Enolase has been identified across various species and its amino acid sequence is highly conserved among different sources of this allergen. The demonstration that enolase is involved in many allergic diseases including respiratory allergies, is of clinic relevance. Thus, the development of novel molecular-based diagnostic and therapeutic strategies may pave the way for improved diagnosis and therapeutics.

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烯醇化酶对过敏性疾病的影响

审查目的：越来越多的证据表明，烯醇化酶与过敏有关。本手稿回顾了烯醇化酶在过敏性疾病中的影响，并介绍了这种过敏原的几种来源，包括霉菌、植物、动物和花粉等。文中仔细分析了 IgE 表位，因为它们可能会导致交叉反应：烯醇化酶以前与食物过敏和接触性皮炎有关。然而，其他研究小组和我们最近在哮喘和过敏性鼻炎患者身上发现了源自各种花粉的新型烯醇化酶。暴露于室外的烯醇化酶可能会导致呼吸系统疾病。烯醇化酶已在不同物种中被发现，其氨基酸序列在这种过敏原的不同来源中高度保守。证明烯醇化酶与包括呼吸道过敏在内的多种过敏性疾病有关，具有临床意义。因此，开发基于分子的新型诊断和治疗策略可能会为改进诊断和治疗铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Allergy and Asthma Reports 医学-过敏

CiteScore

11.20

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma. We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.