Current Opinion in Hematology最新文献_第7页

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.1097/MOH.0000000000000829

引用次数: 0

Protease activated receptor-4: ready to be part of the antithrombosis spectrum. 蛋白酶激活受体-4：准备好成为抗血栓形成的一部分。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.1097/MOH.0000000000000828

Izabella Andrianova, Mia Kowalczyk, Frederik Denorme

{"title":"Protease activated receptor-4: ready to be part of the antithrombosis spectrum.","authors":"Izabella Andrianova, Mia Kowalczyk, Frederik Denorme","doi":"10.1097/MOH.0000000000000828","DOIUrl":"10.1097/MOH.0000000000000828","url":null,"abstract":"Purpose of review: Cardiovascular disease is a major cause of death worldwide. Platelets play a key role in this pathological process. The serine protease thrombin is a critical regulator of platelet reactivity through protease activated receptors-1 (PAR1) and PAR4. Since targeting PAR4 comes with a low chance for bleeding, strategies blocking PAR4 function have great antithrombotic potential. Here, we reviewed the literature on platelet PAR4 with a particular focus on its role in thromboinflammation.Recent findings: Functional PAR4 variants are associated with reduced venous thrombosis risk (rs2227376) and increased risk for ischemic stroke (rs773902). Recent advances have allowed for the creation of humanized mouse lines in which human PAR4 is express instead of murine PAR4. This has led to a better understanding of the discrepancies between human and murine PAR4. It also made it possible to introduce single nucleotide polymorphisms (SNPs) in mice allowing to directly test the in vivo functional effects of a specific SNP and to develop in vivo models to study mechanistic and pharmacologic alterations induced by a SNP.Summary: PAR4 plays an important role in cardiovascular diseases including stroke, myocardial infarction and atherosclerosis. Targeting PAR4 hold great potential as a safe antithrombotic strategy.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"238-244"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet lipidomics and de novo lipogenesis: impact on health and disease. 血小板脂质组学和新脂肪生成：对健康和疾病的影响。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI: 10.1097/MOH.0000000000000820

Laurence Pirotton, Emma de Cartier d'Yves, Luc Bertrand, Christophe Beauloye, Sandrine Horman

{"title":"Platelet lipidomics and de novo lipogenesis: impact on health and disease.","authors":"Laurence Pirotton, Emma de Cartier d'Yves, Luc Bertrand, Christophe Beauloye, Sandrine Horman","doi":"10.1097/MOH.0000000000000820","DOIUrl":"10.1097/MOH.0000000000000820","url":null,"abstract":"Purpose of review: Lipids play vital roles in platelet structure, signaling, and metabolism. In addition to capturing exogenous lipids, platelets possess the capacity for de novo lipogenesis, regulated by acetyl-coA carboxylase 1 (ACC1). This review aims to cover the critical roles of platelet de novo lipogenesis and lipidome in platelet production, function, and diseases.Recent findings: Upon platelet activation, approximately 20% of the platelet lipidome undergoes significant modifications, primarily affecting arachidonic acid-containing species. Multiple studies emphasize the impact of de novo lipogenesis, with ACC1 as key player, on platelet functions. Mouse models suggest the importance of the AMPK-ACC1 axis in regulating platelet membrane arachidonic acid content, associated with TXA 2 secretion, and thrombus formation. In human platelets, ACC1 inhibition leads to reduced platelet reactivity. Remodeling of the platelet lipidome, alongside with de novo lipogenesis, is also crucial for platelet biogenesis. Disruptions in the platelet lipidome are observed in various pathological conditions, including cardiovascular and inflammatory diseases, with associations between these alterations and shifts in platelet reactivity highlighted.Summary: The platelet lipidome, partially regulated by ACC-driven de novo lipogenesis, is indispensable for platelet production and function. It is implicated in various pathological conditions involving platelets.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"217-223"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenic filtration of red blood cells in physiology, malaria and sickle cell disease. 生理学、疟疾和镰状细胞病中红细胞的脾过滤。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-08-27 DOI: 10.1097/moh.0000000000000839

Abdoulaye Sissoko,Yosra Ben Othmene,Pierre Buffet

{"title":"Splenic filtration of red blood cells in physiology, malaria and sickle cell disease.","authors":"Abdoulaye Sissoko,Yosra Ben Othmene,Pierre Buffet","doi":"10.1097/moh.0000000000000839","DOIUrl":"https://doi.org/10.1097/moh.0000000000000839","url":null,"abstract":"PURPOSE OF REVIEWThe human spleen clears the blood from circulating microorganisms and red blood cells (RBCs) displaying alterations. This review analyzes how generic mechanisms by which the spleen senses RBC, such pitting, trapping and erythrophagocytosis, impact the pathogenesis of twos major spleen-related diseases, malaria and sickle cell disease (SCD).RECENT FINDINGSScintigraphy, functional histology, comparison of circulating and splenic RBC, ex-vivo perfusion of human spleens and in-silico modeling enable relevant exploration of how the spleen retains and processes RBC in health and disease. Iterative cross-validations between medical observations, in-vitro experiments and in-silico modeling point to mechanical sensing of RBC as a central event in both conditions. Spleen congestion is a common pathogenic process explaining anemia and splenomegaly, the latter carrying a risk of severe complications such as acute splenic sequestration crisis and hypersplenism in SCD. Sickling of hemoglobin S-containing RBC may contribute but not trigger these complications.SUMMARYOngoing progress in the exploration and understanding of spleen-related complications in malaria and SCD open the way to optimized prognosis evaluation and therapeutic applications.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"50 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue factor pathway inhibitor - cofactor-dependent regulation of the initiation of coagulation. 组织因子通路抑制剂--依赖于辅因子的凝血启动调控。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-08-27 DOI: 10.1097/moh.0000000000000838

Josefin Ahnström,Anastasis Petri,James Tb Crawley

{"title":"Tissue factor pathway inhibitor - cofactor-dependent regulation of the initiation of coagulation.","authors":"Josefin Ahnström,Anastasis Petri,James Tb Crawley","doi":"10.1097/moh.0000000000000838","DOIUrl":"https://doi.org/10.1097/moh.0000000000000838","url":null,"abstract":"PURPOSE OF REVIEWIn humans, tissue factor pathway inhibitor (TFPI) exists in two alternatively spliced isoforms, TFPIα and TFPIβ. TFPIα consists of three Kunitz domains (K1, K2 and K3) and a highly basic C-terminal tail. K1 inhibits the tissue factor-activated factor VII complex, K2 specifically inhibits activated factor X, K3 is essential for interaction with its cofactor, protein S, and the basic C-terminus is binds factor V-short (FV-short) with high affinity. TFPIβ consists of K1 and K2 that is glycosylphosphatidylinositol anchored directly to cell surfaces. This review explores the structure/function of TFPI and its cofactors (protein S and FV-short), and the relative contributions that different TFPI isoforms may play in haemostatic control.RECENT FINDINGSRecent data have underscored the importance of TFPIα function and its reliance on its cofactors, protein S and FV-short, in influencing haemostatic control as well as bleeding and thrombotic risk.SUMMARYTFPIα is likely the most important pool of TFPI in modifying the risk of thrombosis and bleeding. TFPIα forms a trimolecular complex with FV-short and protein S in plasma. FV-short expression levels control the circulating levels of TFPIα, whereas protein S exerts essential cofactor mediated augmentation of it anticoagulant function.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"33 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of hematopoiesis in bone repair: an update. 造血在骨修复中的作用：最新进展。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-01 DOI: 10.1097/MOH.0000000000000821

Elise C Jeffery

{"title":"The role of hematopoiesis in bone repair: an update.","authors":"Elise C Jeffery","doi":"10.1097/MOH.0000000000000821","DOIUrl":"10.1097/MOH.0000000000000821","url":null,"abstract":"Purpose of review: The repair of bone after injury requires the participation of many different immune cell populations, which are derived from the hematopoietic lineage. The field of osteoimmunology, or the study of the interactions between bone and the immune system, is a growing field with emerging impact on both the basic science and clinical aspects of fracture healing.Recent findings: Despite previous focus on the innate immune system in fracture healing, recent studies have revealed an important role for the adaptive immune system in bone repair. The composition of adaptive and innate immune cell populations present at the fracture site is significantly altered during aging and diet-induced obesity, which may contribute to delayed healing. Recent data also suggest a complicated relationship between fracture repair and systemic inflammation, raising the possibility that immune populations from distant sites such as the gut can impact the bone repair process.Summary: These findings have important implications for the treatment of fracture patients with antibiotics or anti-inflammatory drugs. Furthermore, the effects of systemic inflammation on fracture repair in the contexts of aging or obesity should be carefully interpreted, as they may not be uniformly detrimental.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"163-167"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid mediators in neutrophil biology: inflammation, resolution and beyond. 中性粒细胞生物学中的脂质介质：炎症、消解和超越。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1097/MOH.0000000000000822

Anita Ghodsi, Andres Hidalgo, Stephania Libreros

{"title":"Lipid mediators in neutrophil biology: inflammation, resolution and beyond.","authors":"Anita Ghodsi, Andres Hidalgo, Stephania Libreros","doi":"10.1097/MOH.0000000000000822","DOIUrl":"10.1097/MOH.0000000000000822","url":null,"abstract":"Purpose of review: Acute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a pivotal role in eradicating infectious pathogens, orchestrating the initiation and resolution of acute inflammation, and maintaining physiological functions. The resolution of inflammation is a highly orchestrated biochemical process, partially modulated by a novel class of endogenous lipid mediators known as specialized pro-resolving mediators (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR).Recent findings: This review focuses on recent advances in understanding the multifaceted functions of SPMs, detailing their roles in expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, orchestrating bone marrow deployment, also enhances neutrophil phagocytosis and tissue repair mechanisms under both physiological and pathological conditions. We also focus on the novel role of SPMs in regulating bone marrow neutrophil functions, differentiation, and highlight open questions about SPMs' functions in neutrophil heterogeneity.Summary: SPMs play a pivotal role in mitigating excessive neutrophil infiltration and hyperactivity within pathological milieus, notably in conditions such as sepsis, cardiovascular disease, ischemic events, and cancer. This significant function highlights SPMs as promising therapeutic agents in the management of both acute and chronic inflammatory disorders.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"175-192"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-30 DOI: 10.1097/MOH.0000000000000823

引用次数: 0

Editorial introduction. 编辑介绍。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-30 DOI: 10.1097/MOH.0000000000000823

引用次数: 0

Hematopoietic stem cell collection for sickle cell disease gene therapy. 用于镰状细胞病基因治疗的造血干细胞采集。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-09 DOI: 10.1097/MOH.0000000000000807

Alexis Leonard, Mitchell J Weiss

{"title":"Hematopoietic stem cell collection for sickle cell disease gene therapy.","authors":"Alexis Leonard, Mitchell J Weiss","doi":"10.1097/MOH.0000000000000807","DOIUrl":"10.1097/MOH.0000000000000807","url":null,"abstract":"Purpose of review: Gene therapy for sickle cell disease (SCD) is advancing rapidly, with two transformative products recently approved by the US Food and Drug Administration and numerous others under study. All current gene therapy protocols require ex vivo modification of autologous hematopoietic stem cells (HSCs). However, several SCD-related problems impair HSC collection, including a stressed and damaged bone marrow, potential cytotoxicity by the major therapeutic drug hydroxyurea, and inability to use granulocyte colony stimulating factor, which can precipitate severe vaso-occlusive events.Recent findings: Peripheral blood mobilization of HSCs using the CXCR4 antagonist plerixafor followed by apheresis collection was recently shown to be safe and effective for most SCD patients and is the current strategy for mobilizing HSCs. However, exceptionally large numbers of HSCs are required to manufacture an adequate cellular product, responses to plerixafor are variable, and most patients require multiple mobilization cycles, increasing the risk for adverse events. For some, gene therapy is prohibited by the failure to obtain adequate numbers of HSCs.Summary: Here we review the current knowledge on HSC collection from individuals with SCD and potential improvements that may enhance the safety, efficacy, and availability of gene therapy for this disorder.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"104-114"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0