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Current Opinion in Hematology最新文献

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Generation of red blood cells from induced pluripotent stem cells. 用诱导多能干细胞生成红细胞。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-13 DOI: 10.1097/MOH.0000000000000810
Naomi Gunawardena, Stella T Chou
{"title":"Generation of red blood cells from induced pluripotent stem cells.","authors":"Naomi Gunawardena, Stella T Chou","doi":"10.1097/MOH.0000000000000810","DOIUrl":"10.1097/MOH.0000000000000810","url":null,"abstract":"<p><strong>Purpose of review: </strong>Human induced pluripotent stem cells (iPSCs) are an attractive source to generate in-vitro-derived blood for use as transfusable and reagent red cells. We review recent advancements in the field and the remaining limitations for clinical use.</p><p><strong>Recent findings: </strong>For iPSC-derived red blood cell (RBC) generation, recent work has optimized culture conditions to omit feeder cells, enhance red cell maturation, and produce cells that mimic fetal or adult-type RBCs. Genome editing provides novel strategies to improve cell yield and create designer RBCs with customized antigen phenotypes.</p><p><strong>Summary: </strong>Current protocols support red cell production that mimics embryonic and fetal hematopoiesis and cell yield sufficient for diagnostic RBC reagents. Ongoing challenges to generate RBCs for transfusion include recapitulating definitive erythropoiesis to produce functional adult-type cells, increasing scalability of culture conditions, and optimizing high-density manufacturing capacity.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"115-121"},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of obesity-induced inflammation on clonal hematopoiesis. 肥胖引发的炎症对克隆造血的影响
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-22 DOI: 10.1097/moh.0000000000000819
Santhosh Kumar Pasupuleti, Reuben Kapur
{"title":"The impact of obesity-induced inflammation on clonal hematopoiesis.","authors":"Santhosh Kumar Pasupuleti, Reuben Kapur","doi":"10.1097/moh.0000000000000819","DOIUrl":"https://doi.org/10.1097/moh.0000000000000819","url":null,"abstract":"This review meticulously delves into existing literature and recent findings to elucidate the intricate link between obesity and clonal hematopoiesis of indeterminate potential (CHIP) associated clonal hematopoiesis. It aims to enhance our comprehension of this multifaceted association, offering insights into potential avenues for future research and therapeutic interventions.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"222 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics of hematopoietic stem cell aging. 造血干细胞衰老的表观遗传学。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-15 DOI: 10.1097/moh.0000000000000818
Takako Yokomizo, Motohiko Oshima, Atsushi Iwama
{"title":"Epigenetics of hematopoietic stem cell aging.","authors":"Takako Yokomizo, Motohiko Oshima, Atsushi Iwama","doi":"10.1097/moh.0000000000000818","DOIUrl":"https://doi.org/10.1097/moh.0000000000000818","url":null,"abstract":"The development of new antiaging medicines is of great interest to the current elderly and aging population. Aging of the hematopoietic system is attributed to the aging of hematopoietic stem cells (HSCs), and epigenetic alterations are the key effectors driving HSC aging. Understanding the epigenetics of HSC aging holds promise of providing new insights for combating HSC aging and age-related hematological malignancies.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"3 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fulfilled promise and unmet potential of umbilical cord blood. 脐带血已实现的承诺和尚未发挥的潜力。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-05 DOI: 10.1097/moh.0000000000000817
James Ropa, Wouter Van't Hof
{"title":"The fulfilled promise and unmet potential of umbilical cord blood.","authors":"James Ropa, Wouter Van't Hof","doi":"10.1097/moh.0000000000000817","DOIUrl":"https://doi.org/10.1097/moh.0000000000000817","url":null,"abstract":"Here, we review classic and emerging uses of umbilical cord blood and highlight strategies to improve its utility, focusing on selection of the appropriate units and cell types for the intended applications.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"58 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription factor regulation of ribosomal RNA in hematopoiesis. 核糖体 RNA 在造血过程中的转录因子调控。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-03 DOI: 10.1097/moh.0000000000000816
Vikram R Paralkar
{"title":"Transcription factor regulation of ribosomal RNA in hematopoiesis.","authors":"Vikram R Paralkar","doi":"10.1097/moh.0000000000000816","DOIUrl":"https://doi.org/10.1097/moh.0000000000000816","url":null,"abstract":"Ribosomal RNAs (rRNAs) are transcribed within nucleoli from rDNA repeats by RNA Polymerase I (Pol I). There is variation in rRNA transcription rates across the hematopoietic tree, and leukemic blast cells have prominent nucleoli, indicating abundant ribosome biogenesis. The mechanisms underlying these variations are poorly understood. The purpose of this review is to summarize findings of rDNA binding and Pol I regulation by hematopoietic transcription factors.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in acute myeloid leukemia treatments and outcomes. 急性髓性白血病治疗和预后的差异。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2023-12-07 DOI: 10.1097/MOH.0000000000000797
Ann-Kathrin Eisfeld
{"title":"Disparities in acute myeloid leukemia treatments and outcomes.","authors":"Ann-Kathrin Eisfeld","doi":"10.1097/MOH.0000000000000797","DOIUrl":"10.1097/MOH.0000000000000797","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to summarize different contributors to survival disparities in acute myeloid leukemia (AML) patients. The focus is set on African-American (hereafter referred to as Black) patients, with separate consideration of self-reported race and ancestry. It aims to also highlight the interconnectivity of the different features that impact on despair survival.</p><p><strong>Recent findings: </strong>The main themes in the literature covered in this article include the impact of social deprivation, clinical trial enrollment and biobanking, structural racism and ancestry-associated differences in genetic features on survival outcomes.</p><p><strong>Summary: </strong>An increasing number of studies have not only shown persistent survival disparities between Black and non-Hispanic White AML patients, but uncovered a multitude of contributors that have additive adverse effects on patient outcomes. In addition to potentially modifiable features, such as socioeconomic factors and trial enrollment odds that require urgent interventions, there is emerging data on differences in disease biology with respect to genetic ancestry, including frequencies of known AML-driver mutations and their associated prognostic impact.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"58-63"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-related micro-environmental changes as drivers of clonal hematopoiesis. 与年龄相关的微环境变化是克隆造血的驱动因素。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2023-12-15 DOI: 10.1097/MOH.0000000000000798
Tal Bacharach, Nathali Kaushansky, Liran I Shlush
{"title":"Age-related micro-environmental changes as drivers of clonal hematopoiesis.","authors":"Tal Bacharach, Nathali Kaushansky, Liran I Shlush","doi":"10.1097/MOH.0000000000000798","DOIUrl":"10.1097/MOH.0000000000000798","url":null,"abstract":"<p><strong>Purpose of review: </strong>Both aging and reduced diversity at the hematopoietic stem cells (HSCs) level are ubiquitous. What remains unclear is why some individuals develop clonal hematopoiesis (CH), and why does CH due to specific mutations occur in specific individuals. Much like aging, reduced diversity of HSCs is a complex phenotype shaped by numerous factors (germline & environment). The purpose of the current review is to discuss the role of two other age-related ubiquitous processes that might contribute to the dynamics and characteristics of losing HSC diversity and the evolution of CH. These processes have not been reviewed in depth so far and include the accumulation of fatty bone marrow (FBM), and the decline in sex hormones.</p><p><strong>Recent findings: </strong>Interestingly, sex hormone decline can directly shape HSC function, but also reshape the delicate balance of BM supporting cells, with a shift towards FBM. FBM accumulation can shape the clonal expansion of preleukemic mutations, particularly DNMT3A mutations, through IL-6 mediation. DNMT3A mutations are one of the only preleukemic mutations which is more prevalent in women, and especially in women with early menopause, demonstrating an association between age-related hormone decline and CH evolution, the mechanisms of which are yet to be discovered.</p><p><strong>Summary: </strong>Aging is a multifactorial phenotype and the same is true for the aging of the blood system. While many factors which can shape CH have been discussed, we shed more light on FBM and sex hormone decline. Much more is missing: how and should we even try to prevent these phenomena? Why do they occur? and how they are connected to other age-related blood factors?</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"53-57"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial introduction. 编辑介绍。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI: 10.1097/MOH.0000000000000801
{"title":"Editorial introduction.","authors":"","doi":"10.1097/MOH.0000000000000801","DOIUrl":"10.1097/MOH.0000000000000801","url":null,"abstract":"","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"31 2","pages":"v"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric acute myeloid leukemia - novel approaches. 儿童急性髓性白血病-新方法。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2023-11-20 DOI: 10.1097/MOH.0000000000000795
Seth E Karol, Gwenaelle Gueguen
{"title":"Pediatric acute myeloid leukemia - novel approaches.","authors":"Seth E Karol, Gwenaelle Gueguen","doi":"10.1097/MOH.0000000000000795","DOIUrl":"10.1097/MOH.0000000000000795","url":null,"abstract":"<p><strong>Purpose of review: </strong>Despite higher remission and survival rates than observed in adults, children with acute myeloid leukemia (AML) still suffer unacceptably high rates of treatment failure and late toxicities. Ongoing work aims to improve these long-term outcomes through improvements in the utilization of current therapies, the incorporation of novel chemotherapy agents, and improved use of current or novel cellular and immunotherapeutic approaches. In this review, we highlight recent advances and contextualize them within this evolving landscape.</p><p><strong>Recent findings: </strong>Novel agents such as the B-cell lymphoma 2 inhibitor venetoclax and the menin inhibitors have shown promising results with implications for large portions of the pediatric AML population. Older agents are being used in novel combinations (e.g. gemtuzumab ozogamicin) or are expanding into pediatrics after longer use in adults (e.g. Fms-like tyrosine kinase 3 inhibitors). Finally, immunotherapeutic approaches offer new options for patients with high-risk or relapsed disease.</p><p><strong>Summary: </strong>Recent findings have altered the landscape of pediatric AML therapy with exciting immediate and long-term implications. Ongoing studies may soon define this as standard as well. After many years in which few new therapies have become available for children with AML, recent and upcoming advances may soon dramatically alter the therapeutic landscape.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"47-52"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138048852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Opinion in Hematology. 血液学的最新观点。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI: 10.1097/MOH.0000000000000799
Stephanie Halene
{"title":"Current Opinion in Hematology.","authors":"Stephanie Halene","doi":"10.1097/MOH.0000000000000799","DOIUrl":"10.1097/MOH.0000000000000799","url":null,"abstract":"","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"31 2","pages":"39"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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