核糖体 RNA 在造血过程中的转录因子调控。

IF 3.1 3区医学 Q2 HEMATOLOGY

Current Opinion in Hematology Pub Date : 2024-04-03 DOI:10.1097/moh.0000000000000816

Vikram R Paralkar

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引用次数: 0

摘要

核糖体 RNA（rRNA）在核小体内由 RNA 聚合酶 I（Pol I）从 rDNA 重复序列转录而来。在整个造血树中，rRNA 的转录率存在差异，而白血病爆炸细胞具有突出的核小体，这表明核糖体的生物生成非常丰富。人们对这些变化的机制知之甚少。本综述旨在总结造血转录因子对 rDNA 结合和 Pol I 调控的研究结果。

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Transcription factor regulation of ribosomal RNA in hematopoiesis.

Ribosomal RNAs (rRNAs) are transcribed within nucleoli from rDNA repeats by RNA Polymerase I (Pol I). There is variation in rRNA transcription rates across the hematopoietic tree, and leukemic blast cells have prominent nucleoli, indicating abundant ribosome biogenesis. The mechanisms underlying these variations are poorly understood. The purpose of this review is to summarize findings of rDNA binding and Pol I regulation by hematopoietic transcription factors.

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来源期刊

Current Opinion in Hematology 医学-血液学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.