Current Opinion in Hematology最新文献

Antithymocyte globulin and posttransplant cyclophosphamide in graft vs. host disease prophylaxis: comparison or combination. 抗胸腺细胞球蛋白和移植后环磷酰胺在移植物与宿主疾病预防中的作用：比较或联合应用。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-08 DOI: 10.1097/MOH.0000000000000882

Francisco Barriga

{"title":"Antithymocyte globulin and posttransplant cyclophosphamide in graft vs. host disease prophylaxis: comparison or combination.","authors":"Francisco Barriga","doi":"10.1097/MOH.0000000000000882","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000882","url":null,"abstract":"Purpose of review: Antithymocyte globulin (ATG) and posttransplant cyclophosphamide (PTCy) play essential roles in graft-vs.-host disease (GvHD) prophylaxis. ATG is considered the standard of care for matched related and unrelated donor (MRD/MUD) transplantation, while PTCy is the preferred approach for T cell-replete haploidentical transplantation. In recent years, PTCy has gained popularity in the MRD/MUD setting, prompting the publication of several large retrospective studies comparing the efficacy of ATG and PTCy, either as standalone regimens or in combination. This review aims to critically analyze the findings of these studies and provide context for the ongoing debate regarding the optimal prophylactic approach.Recent findings: Large retrospective studies have compared ATG and PTCy in adult MRD/MUD recipients, yielding mixed results. These studies share several limitations, including their retrospective design, variability in ATG dosing and scheduling, and the inclusion of patients who underwent transplantation during different time periods. Additionally, the combination of PTCy and ATG in haploidentical transplantation has demonstrated potential in reducing GvHD incidence.Summary: The optimal regimen for GvHD prophylaxis remains undefined. PTCy has been widely adopted for MRD/MUD transplantation, and its combination with ATG is being actively explored in the haploidentical setting. However, the current body of evidence is largely based on retrospective studies, underscoring the need for well designed prospective trials to clarify the comparative benefits of these strategies.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet Fc gamma RIIA: time to go beyond the unknown. 血小板Fc γ RIIA：时间超越未知。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-08 DOI: 10.1097/MOH.0000000000000881

Izabella Andrianova, Rattanawan Thubthed, Frederik Denorme

{"title":"Platelet Fc gamma RIIA: time to go beyond the unknown.","authors":"Izabella Andrianova, Rattanawan Thubthed, Frederik Denorme","doi":"10.1097/MOH.0000000000000881","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000881","url":null,"abstract":"Purpose of review: Increasing evidence has shown that immune and thrombotic pathways cooperate to ensure efficient immune and hemostatic functions. Due to their involvement in various cardiovascular and inflammatory conditions, this interplay has gained significant interest, leading to many important discoveries. However, difference between mice and humans have limited the translatability of some of these findings. One key receptor involved in immuno-thrombosis but lacking in mice is the Fc gamma receptor IIA (FcγRIIA).Recent findings: Innovative in-vitro and in-vivo models for anti-PF4 immune disorders have greatly impacted our understanding of the role of FcγRIIA in these disorders and has revealed novel therapeutic strategies with great translational potential. Epideminological studies have hinted at a role for FcγRIIA in cardiovascular diseases; however, conclusive mechanistic studies are currently lacking.Summary: Humanized transgenic FcγRIIA mice have greatly advanced our understanding of the role of FcγRIIA in anti-PF4 immune disorders, immune thrombocytopenia and lupus; however, they have only rarely been used in models of thrombo-inflammation. To improve translation from bench to bedside, inclusion of FcγRIIA transgenic mouse models is encouraged.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemostatic abnormalities in acute promyelocytic leukemia: clinical implications and mechanisms. 急性早幼粒细胞白血病的止血异常：临床意义和机制。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-08 DOI: 10.1097/MOH.0000000000000880

Yohei Hisada, Radhika Gangaraju

{"title":"Hemostatic abnormalities in acute promyelocytic leukemia: clinical implications and mechanisms.","authors":"Yohei Hisada, Radhika Gangaraju","doi":"10.1097/MOH.0000000000000880","DOIUrl":"10.1097/MOH.0000000000000880","url":null,"abstract":"Purpose of review: Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. The long-term prognosis for APL is generally more favorable than for other types of acute leukemia due to the use of differentiation therapies. However, early hemorrhagic death remains a significant clinical challenge in APL patients.Recent findings: Real-world studies reveal that the rate of early hemorrhagic death remains high (10-30%) in APL patients in the era of differentiation therapy. APL patients have systemic hemostatic changes including activation of coagulation followed by consumption of coagulation factors, hyperfibrinolysis, and severe thrombocytopenia. Our study found that tissue factor contributes to a bleeding phenotype in mouse models of APL. In-vitro studies suggest that there may be direct or indirect interaction between APL cells and brain endothelial cells.Summary: Predictors of hemorrhagic death in APL are only partially understood. The associations between bleeding and hyperfibrinolysis or thrombocytopenia in APL need to be determined. The interaction between APL cells and brain endothelial cells need to be determined in vivo.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances on the genetic basis of red cell membrane disorders. 红细胞膜疾病的遗传基础研究进展。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-07 DOI: 10.1097/MOH.0000000000000883

Mary Risinger, Wenying Zhang, Theodosia A Kalfa

{"title":"Advances on the genetic basis of red cell membrane disorders.","authors":"Mary Risinger, Wenying Zhang, Theodosia A Kalfa","doi":"10.1097/MOH.0000000000000883","DOIUrl":"10.1097/MOH.0000000000000883","url":null,"abstract":"Purpose of review: The development and widespread use of genetic testing for diagnosis of red blood cell (RBC) membrane disorders and other hereditary hemolytic anemias (HHA) have expanded our understanding of these diseases and revealed additional complexities. We describe here such complexities and make suggestions regarding genotypic/phenotypic evaluation with the goal of early diagnosis of patients with HHA before inappropriate treatment or complications occur.Recent findings: Widespread use of clinical genetic diagnosis in patients, for more than a decade now, has revealed the heterogeneity of RBC membranopathies, even when caused by different variants in the same gene, and sometimes due to the same genetic variant, likely because of genetic modifiers or mutations in other genes encoding for RBC membrane proteins, enzymes, or globins. Many under-recognized diseases are now more easily diagnosed.Summary: Despite complexities in the genetic evaluation of RBC membranopathies, the future holds great promise for timely and accurate diagnosis. Correlation and documentation of genotypic and phenotypic data from affected individuals and family members will allow for improved detection and interpretation of genetic results. The use of such testing in newborns and children with HHA can optimize treatment decisions and explore possibilities for novel targeted or genetic therapies.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between physical and mental health and its impact on outcomes for hemopoietic stem cell transplant patients. 造血干细胞移植患者身心健康的相互作用及其对预后的影响

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1097/MOH.0000000000000874

Jennifer Martynowicz, Sarah Gutch, Maegan Capitano

引用次数: 0

Clonal hematopoiesis of indeterminate potential: recent developments and perspectives. 潜力不确定的克隆造血：最新进展和前景。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-03-10 DOI: 10.1097/MOH.0000000000000870

Meiqi Guo, Yuan Li, Baobing Zhao

{"title":"Clonal hematopoiesis of indeterminate potential: recent developments and perspectives.","authors":"Meiqi Guo, Yuan Li, Baobing Zhao","doi":"10.1097/MOH.0000000000000870","DOIUrl":"10.1097/MOH.0000000000000870","url":null,"abstract":"Purpose of review: This review encompasses the recently published information on clonal hematopoiesis of indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in the research of CHIP risk factors and related diseases, with the purpose of offering new insights to treat both hematologic and nonhematologic disorders.Recent findings: The majority of studies have shown that CHIP is a common biological condition associated with aging and the incidence of clonal hematopoiesis increases with age. The pathophysiology of blood diseases is projected to be significantly influenced by CHIP. Nevertheless, increasing studies have expanded the application of CHIP to cover nonhematologic diseases such as cardiovascular, renal, liver, and pulmonary diseases. Furthermore, with the fast advancement of genetic testing technology and preventive medicine, the involvement of CHIP in a variety of disorders shows promise as an essential target for preventing disease onset and progression.Summary: CHIP is linked to a variety of illnesses and has a significant influence on an individual's health outlook. Thus, identifying and managing CHIP is critical for improving the clinical results of the individuals concerned.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"193-198"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signaling mechanisms and cis -regulatory control of Samd14 in erythroid regeneration. Samd14在红系再生中的信号机制和顺式调控。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI: 10.1097/MOH.0000000000000873

Kyle J Hewitt, Pooja Roy, Meg A Schaefer

{"title":"Signaling mechanisms and cis -regulatory control of Samd14 in erythroid regeneration.","authors":"Kyle J Hewitt, Pooja Roy, Meg A Schaefer","doi":"10.1097/MOH.0000000000000873","DOIUrl":"10.1097/MOH.0000000000000873","url":null,"abstract":"Purpose of review: This review evaluates the known mechanisms of regulating erythroid regeneration via the sterile alpha motif protein-14 ( Samd14 ) enhancer, Samd14's role in stem cell factor/Kit and erythropoietin (Epo) signaling, possible SAMD14 functions beyond erythropoiesis, and extrapolation to other anemia-response pathways.Recent findings: Samd14 expression is controlled by an anemia-activated E-box-GATA transcriptional enhancer required for erythroid regeneration, and the Samd14 protein is needed for acute anemia recovery. Samd14 interacts with actin capping proteins to elevate Kit signaling via MAPK and PI3K/Akt pathways in stress erythroid precursors and promotes Epo signaling at later stages. Whereas canonical cellular stress transcriptional mechanisms are involved in anemia (e.g. hypoxia-inducible HSF1, Nrf2, ATF4, and others), enhancers with sequence and molecular features resembling the Samd14 S14E cis -element - occupied by GATA1 and TAL1 - regulate anemia-activated proteins. Relative to physiological replacement of red blood cells, unique signaling cues are involved in erythroid regeneration at multiple stages.Summary: Anemia-activated proteins coordinate an acute increase in red blood cell production from erythroid progenitors to regenerate lost cells and restore homeostasis. The Samd14 locus provides an exemplary examination of cell signaling - through both stem cell factor/Kit and Epo as well as transcriptional mechanisms involved in erythroid regeneration.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"206-212"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenosine signaling in promoting the balance between erythropoiesis and myelopoiesis. 腺苷信号在促进红细胞生成和骨髓生成平衡中的作用。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-23 DOI: 10.1097/MOH.0000000000000872

Mahmoud Mikdar, Marion Serra, Slim Azouzi

{"title":"Adenosine signaling in promoting the balance between erythropoiesis and myelopoiesis.","authors":"Mahmoud Mikdar, Marion Serra, Slim Azouzi","doi":"10.1097/MOH.0000000000000872","DOIUrl":"10.1097/MOH.0000000000000872","url":null,"abstract":"Purpose of review: Adenosine signaling is emerging as a key regulator of hematopoietic lineage commitment, influencing both erythropoiesis and myelopoiesis. This review explores the distinct roles of adenosine receptors in balancing these processes, particularly under stress conditions. Since adenosine extracellular levels are increased in multiple hematological disorders, including sickle cell disease, deciphering the mechanisms downstream of adenosine receptor activation is crucial to understand the pathophysiology of these conditions.Recent findings: Extracellular adenosine levels in the bone marrow microenvironment are tightly regulated by CD39/CD73 activity and ENT1 uptake. Recent studies have shown that ENT1-mediated adenosine transport is crucial for adenosine intracellular metabolism and normal erythropoiesis, while increased extracellular adenosine levels impact hematopoietic differentiation through adenosine receptor activation. . High dose of exogenous adenosine inhibits erythroid proliferation by inducing G1 arrest and p53-mediated apoptosis. Furthermore, A 2B and A 3 receptor signaling inhibits erythroid differentiation, while adenosine signaling through A 3 also favors granulopoiesis.Summary: Collectively, these findings highlight adenosine signaling as a critical and multifaceted regulator of hematopoietic balance, offering novel insights into its therapeutic potential for managing disorders characterized by ineffective erythropoiesis and aberrant myelopoiesis.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"199-205"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct megakaryopoiesis. 直接megakaryopoiesis。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/MOH.0000000000000871

Hans-Willem Snoeck

{"title":"Direct megakaryopoiesis.","authors":"Hans-Willem Snoeck","doi":"10.1097/MOH.0000000000000871","DOIUrl":"10.1097/MOH.0000000000000871","url":null,"abstract":"Purpose of review: Megakaryocytes are large, polyploid cells that produce platelets and originate from hematopoietic stem cells (HSCs) in the bone marrow. While in the classical paradigm, megakaryocytes are generated in a stepwise fashion through increasingly committed progenitor stages, studies using in-vivo barcoding, transplantation, and in-vitro culture have suggested that, in addition, a more direct pathway existed. The relevance of this direct pathway and its functional and phenotypic characteristics were unclear, however.Recent findings: Recent publications using fate-mapping and single-cell transplantation now unequivocally demonstrate the existence of a direct megakaryocyte differentiation pathway, provide molecular characterization, and indicate distinct roles and regulation of both pathways. The direct pathway originates from a separate subset of 'top' HSCs, is enhanced by hematopoietic stress, inflammation and aging, bypasses multipotential progenitors, may be more active in myeloproliferative neoplasms, and generates phenotypically distinct megakaryocyte progenitors and more reactive platelets.Summary: Novel insights into the direct megakaryocyte differentiation pathway provide a deeper understanding of HSC biology, hematological recovery after myeloablation, and aging of the hematopoietic system, and suggest that this pathway may contribute to the increase in thrombotic incidents with age and in myeloproliferative neoplasms.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"213-220"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelets in vascular inflammation: fire-fighters or pyromaniacs? 血小板血管炎症：消防员还是纵火狂？

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-05-13 DOI: 10.1097/MOH.0000000000000877

Yacine Boulaftali, Steffen Massberg, Leo Nicolai

{"title":"Platelets in vascular inflammation: fire-fighters or pyromaniacs?","authors":"Yacine Boulaftali, Steffen Massberg, Leo Nicolai","doi":"10.1097/MOH.0000000000000877","DOIUrl":"10.1097/MOH.0000000000000877","url":null,"abstract":"Purpose of review: In this review, we aim to highlight recent insights into the mechanisms through which platelets contribute to vascular inflammation. We will discuss how platelets interact with other cellular players in the vascular milieu, their role in shaping inflammatory responses, and the potential therapeutic implications of targeting platelet function in inflammatory vascular diseases.Recent findings: Platelets are essential components in the processes of hemostasis and thrombosis. Their role is now widely acknowledged as far more complex than merely acting as \"band-aids\" or helping to \"clog a pipe\". Platelets are now recognized as crucial mediators in inflammatory reactions, particularly in various diseases of the vasculature, where they contribute to the onset and progression of injury. Through their interactions with leukocytes, vascular cells, and by supporting the coagulation cascade, platelets are able to finely regulate the extent and intensity of vascular damage.Summary: Recent findings underscore the remarkable diversity and functionality of platelets in vascular diseases. Mechanistic studies in preclinical models reveal promising therapeutic opportunities, which require further validation before being translated into clinical practice.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"221-230"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0