Current Opinion in Hematology最新文献

筛选
英文 中文
Immune response to platelet transfusions. 对血小板输注的免疫反应。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-15 DOI: 10.1097/MOH.0000000000000888
Rachael P Jackman, Kimberly A Thomas
{"title":"Immune response to platelet transfusions.","authors":"Rachael P Jackman, Kimberly A Thomas","doi":"10.1097/MOH.0000000000000888","DOIUrl":"10.1097/MOH.0000000000000888","url":null,"abstract":"<p><strong>Purpose of review: </strong>Platelet transfusion can have a significant immunological impact, exposing the recipient to alloantigens on the surface of platelets and contaminating leukocytes, a dynamic range of soluble immune mediators, and donor platelets that can directly and indirectly contribute to the inflammatory profile of the recipient. Here, we will review recent developments in our understanding of the mechanisms regulating the immune response to platelet transfusion.</p><p><strong>Recent findings: </strong>Using animal models, much has been learned about the mechanisms regulating the alloimmune response to platelet transfusion and how this response is shaped by the underlying health of the recipient. There is also a growing appreciation of the active role platelets play in immunity and their impact on the recipient immune system and transfusion outcomes, and how these immunological profiles are shaped by product collection, processing, and storage practices.</p><p><strong>Summary: </strong>While platelet transfusion carries significant benefit to a wide range of patients, it carries risk of alloimmunization and other immune-mediated adverse reactions. Further characterization of the mechanisms regulating these outcomes can lead to new interventions to prevent alloimmunization and help to identify which platelet products are best suited to different patient populations.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput genotyping tools for red blood cell antigens. 红细胞抗原的高通量基因分型工具。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-15 DOI: 10.1097/MOH.0000000000000890
Yan Zheng, Ti-Cheng Chang
{"title":"High-throughput genotyping tools for red blood cell antigens.","authors":"Yan Zheng, Ti-Cheng Chang","doi":"10.1097/MOH.0000000000000890","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000890","url":null,"abstract":"<p><strong>Purpose of review: </strong>Red blood cell (RBC) antigens arise from genetic variations. RBC genotyping has been increasingly used to assist serological typing, solve serological discrepancies, guide antigen matching, and tackle RBC antigens with complex genetics, such as Rh blood group. This review will discuss common applications of RBC genotyping in patient care, genotyping methods, and computational algorithms for automated and high-throughput RBC genotyping.</p><p><strong>Recent findings: </strong>Single-nucleotide polymorphisms (SNPs) are the most common polymorphisms of genes encoding RBC antigens. High-throughput platforms focusing on identifying SNPs and small insertions and deletions (indels), such as SNP arrays and high-density SNP arrays, have been developed and/or implemented for RBC genotyping in clinical settings. Whereas SNP arrays target common variants, DNA sequencing provides more comprehensive information on RBC antigens and can identify rare and new SNPs/indels and various structural variations. Computational algorithms that address the tremendous quantities of data and bioinformatics challenges generated by DNA sequencing have been developed, enabling automated and high-throughput genotyping.</p><p><strong>Summary: </strong>With the advances in microarray and sequencing technologies and bioinformatics, RBC genotyping may become a new gold standard for RBC antigen identification and can provide critical insights for research on RBC antigens.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared host, distinct invaders: metabolomic footprints of plasmodium and babesia in host red cells. 共享宿主,不同的入侵者:疟原虫和巴贝虫在宿主红细胞中的代谢组学足迹。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-15 DOI: 10.1097/MOH.0000000000000891
Divya Beri, Marilis Rodriguez, Cheryl A Lobo
{"title":"Shared host, distinct invaders: metabolomic footprints of plasmodium and babesia in host red cells.","authors":"Divya Beri, Marilis Rodriguez, Cheryl A Lobo","doi":"10.1097/MOH.0000000000000891","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000891","url":null,"abstract":"<p><strong>Purpose of review: </strong>Malaria and babesiosis are important transfusion-transmitted diseases, therefore, it is important to report novel insights into the complex interactions the causative parasites share with their common host RBCs. Metabolomics is an important tool that can be used to reveal an in-depth analysis of parasite infections in the context of the host. Similarities and differences in the biochemical fingerprints between malaria and babesia infected RBCs are reviewed with potential reasons for these differences and implications for the host.</p><p><strong>Recent findings: </strong>Recent results from Babesia-infected RBCs offer an opportunity to develop comparative models of pathogenesis for both infections. Perturbation in the levels of key biomolecules including sugars, amino-acids and lipids, along with redox homeostasis, and heme utilization, are hallmarks of both diseases. Key similarities include enhanced glycolytic rate in both infected RBCs together with lipid scavenging from RBC membranes. Differences relate to hemoglobin breakdown and the use of resultant amino acids for propagation.</p><p><strong>Summary: </strong>Altered metabolic profiles reflect the unique lifecycles of Plasmodium and Babesia, pointing to how they carve out a niche for successful proliferation. A comprehensive understanding of the metabolic similarities and differences between the two parasites will aid in identifying new biomarkers as well as specific, effective targeted therapies.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in chimeric antigen receptor-T therapies to target tumor resistance in B-cell malignancies. 嵌合抗原受体- t疗法靶向b细胞恶性肿瘤耐药的研究进展。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-15 DOI: 10.1097/MOH.0000000000000892
Nassim Salem, Mohamad Hamieh
{"title":"Advances in chimeric antigen receptor-T therapies to target tumor resistance in B-cell malignancies.","authors":"Nassim Salem, Mohamad Hamieh","doi":"10.1097/MOH.0000000000000892","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000892","url":null,"abstract":"<p><strong>Purpose of review: </strong>Chimeric Antigen Receptor T cell (CAR-T) has transformed B-cell malignancies treatment, with seven FDA-approved therapies to date. Despite remarkable success, a substantial fraction of patients relapse, primarily due to limited CAR-T persistence or tumor escape driven by target-antigen loss. Here, we highlight preclinical and clinical advances in programming T cells to address these challenges and are poised to drive next-generation CAR-T development.</p><p><strong>Recent findings: </strong>Building on FDA-approved CAR designs, innovations in tailoring CAR signaling, cytokine armoring, and multiantigen targeting are paving the way toward more effective and safer treatments. Satisfyingly, these new approaches have demonstrated feasibility, safety, and promising clinical activity, including in patients relapsing after prior CAR treatment. In parallel, CARs with enhanced sensitivity to low-antigen tumors are advancing from preclinical to clinical development. These innovations aiming to enhance T cell persistence and counter tumor escape are defining the next wave of CAR therapies.</p><p><strong>Summary: </strong>Here, we outline key advances in CAR-T programming to improve persistence, broaden antigen targeting, and enhance efficacy in B-cell malignancies. While challenges such as toxicities or identifying optimal and standardized approaches across trials remain to be addressed, these approaches provide a foundation for translating innovations into effective and potentially curative CAR immunotherapies.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antithymocyte globulin and posttransplant cyclophosphamide in graft vs. host disease prophylaxis: comparison or combination. 抗胸腺细胞球蛋白和移植后环磷酰胺在移植物与宿主疾病预防中的作用:比较或联合应用。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-08 DOI: 10.1097/MOH.0000000000000882
Francisco Barriga
{"title":"Antithymocyte globulin and posttransplant cyclophosphamide in graft vs. host disease prophylaxis: comparison or combination.","authors":"Francisco Barriga","doi":"10.1097/MOH.0000000000000882","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000882","url":null,"abstract":"<p><strong>Purpose of review: </strong>Antithymocyte globulin (ATG) and posttransplant cyclophosphamide (PTCy) play essential roles in graft-vs.-host disease (GvHD) prophylaxis. ATG is considered the standard of care for matched related and unrelated donor (MRD/MUD) transplantation, while PTCy is the preferred approach for T cell-replete haploidentical transplantation. In recent years, PTCy has gained popularity in the MRD/MUD setting, prompting the publication of several large retrospective studies comparing the efficacy of ATG and PTCy, either as standalone regimens or in combination. This review aims to critically analyze the findings of these studies and provide context for the ongoing debate regarding the optimal prophylactic approach.</p><p><strong>Recent findings: </strong>Large retrospective studies have compared ATG and PTCy in adult MRD/MUD recipients, yielding mixed results. These studies share several limitations, including their retrospective design, variability in ATG dosing and scheduling, and the inclusion of patients who underwent transplantation during different time periods. Additionally, the combination of PTCy and ATG in haploidentical transplantation has demonstrated potential in reducing GvHD incidence.</p><p><strong>Summary: </strong>The optimal regimen for GvHD prophylaxis remains undefined. PTCy has been widely adopted for MRD/MUD transplantation, and its combination with ATG is being actively explored in the haploidentical setting. However, the current body of evidence is largely based on retrospective studies, underscoring the need for well designed prospective trials to clarify the comparative benefits of these strategies.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The interplay between physical and mental health and its impact on outcomes for hemopoietic stem cell transplant patients. 造血干细胞移植患者身心健康的相互作用及其对预后的影响
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1097/MOH.0000000000000874
Jennifer Martynowicz, Sarah Gutch, Maegan Capitano
{"title":"The interplay between physical and mental health and its impact on outcomes for hemopoietic stem cell transplant patients.","authors":"Jennifer Martynowicz, Sarah Gutch, Maegan Capitano","doi":"10.1097/MOH.0000000000000874","DOIUrl":"10.1097/MOH.0000000000000874","url":null,"abstract":"<p><strong>Purpose of review: </strong>The incidence of mental health conditions within hematopoietic stem cell transplant (HSCT) patients is high and has profound impacts on quality of life after transplant. Mental health is an underexplored and underutilized outcome in this patient population.</p><p><strong>Recent findings: </strong>Standard mental health interventions in this patient population have shown limited results. Multiple factors including acuity of systemic illness, proinflammatory states, heterogeneous patient populations, and use of specific therapeutics could impact results. This presents the opportunity to identify new areas of improvement, such as focusing on leukocyte recovery, exogenous steroid use, and cytokine response to inform new bedside interventions.</p><p><strong>Summary: </strong>Overall, interventions incorporating the biological mechanisms of mental health are underutilized in the HSCT patient population and offer a novel approach to improving morbidity, mortality and quality of life.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"187-192"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal hematopoiesis of indeterminate potential: recent developments and perspectives. 潜力不确定的克隆造血:最新进展和前景。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-03-10 DOI: 10.1097/MOH.0000000000000870
Meiqi Guo, Yuan Li, Baobing Zhao
{"title":"Clonal hematopoiesis of indeterminate potential: recent developments and perspectives.","authors":"Meiqi Guo, Yuan Li, Baobing Zhao","doi":"10.1097/MOH.0000000000000870","DOIUrl":"10.1097/MOH.0000000000000870","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review encompasses the recently published information on clonal hematopoiesis of indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in the research of CHIP risk factors and related diseases, with the purpose of offering new insights to treat both hematologic and nonhematologic disorders.</p><p><strong>Recent findings: </strong>The majority of studies have shown that CHIP is a common biological condition associated with aging and the incidence of clonal hematopoiesis increases with age. The pathophysiology of blood diseases is projected to be significantly influenced by CHIP. Nevertheless, increasing studies have expanded the application of CHIP to cover nonhematologic diseases such as cardiovascular, renal, liver, and pulmonary diseases. Furthermore, with the fast advancement of genetic testing technology and preventive medicine, the involvement of CHIP in a variety of disorders shows promise as an essential target for preventing disease onset and progression.</p><p><strong>Summary: </strong>CHIP is linked to a variety of illnesses and has a significant influence on an individual's health outlook. Thus, identifying and managing CHIP is critical for improving the clinical results of the individuals concerned.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"193-198"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signaling mechanisms and cis -regulatory control of Samd14 in erythroid regeneration. Samd14在红系再生中的信号机制和顺式调控。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI: 10.1097/MOH.0000000000000873
Kyle J Hewitt, Pooja Roy, Meg A Schaefer
{"title":"Signaling mechanisms and cis -regulatory control of Samd14 in erythroid regeneration.","authors":"Kyle J Hewitt, Pooja Roy, Meg A Schaefer","doi":"10.1097/MOH.0000000000000873","DOIUrl":"10.1097/MOH.0000000000000873","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review evaluates the known mechanisms of regulating erythroid regeneration via the sterile alpha motif protein-14 ( Samd14 ) enhancer, Samd14's role in stem cell factor/Kit and erythropoietin (Epo) signaling, possible SAMD14 functions beyond erythropoiesis, and extrapolation to other anemia-response pathways.</p><p><strong>Recent findings: </strong>Samd14 expression is controlled by an anemia-activated E-box-GATA transcriptional enhancer required for erythroid regeneration, and the Samd14 protein is needed for acute anemia recovery. Samd14 interacts with actin capping proteins to elevate Kit signaling via MAPK and PI3K/Akt pathways in stress erythroid precursors and promotes Epo signaling at later stages. Whereas canonical cellular stress transcriptional mechanisms are involved in anemia (e.g. hypoxia-inducible HSF1, Nrf2, ATF4, and others), enhancers with sequence and molecular features resembling the Samd14 S14E cis -element - occupied by GATA1 and TAL1 - regulate anemia-activated proteins. Relative to physiological replacement of red blood cells, unique signaling cues are involved in erythroid regeneration at multiple stages.</p><p><strong>Summary: </strong>Anemia-activated proteins coordinate an acute increase in red blood cell production from erythroid progenitors to regenerate lost cells and restore homeostasis. The Samd14 locus provides an exemplary examination of cell signaling - through both stem cell factor/Kit and Epo as well as transcriptional mechanisms involved in erythroid regeneration.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"206-212"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenosine signaling in promoting the balance between erythropoiesis and myelopoiesis. 腺苷信号在促进红细胞生成和骨髓生成平衡中的作用。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-23 DOI: 10.1097/MOH.0000000000000872
Mahmoud Mikdar, Marion Serra, Slim Azouzi
{"title":"Adenosine signaling in promoting the balance between erythropoiesis and myelopoiesis.","authors":"Mahmoud Mikdar, Marion Serra, Slim Azouzi","doi":"10.1097/MOH.0000000000000872","DOIUrl":"10.1097/MOH.0000000000000872","url":null,"abstract":"<p><strong>Purpose of review: </strong>Adenosine signaling is emerging as a key regulator of hematopoietic lineage commitment, influencing both erythropoiesis and myelopoiesis. This review explores the distinct roles of adenosine receptors in balancing these processes, particularly under stress conditions. Since adenosine extracellular levels are increased in multiple hematological disorders, including sickle cell disease, deciphering the mechanisms downstream of adenosine receptor activation is crucial to understand the pathophysiology of these conditions.</p><p><strong>Recent findings: </strong>Extracellular adenosine levels in the bone marrow microenvironment are tightly regulated by CD39/CD73 activity and ENT1 uptake. Recent studies have shown that ENT1-mediated adenosine transport is crucial for adenosine intracellular metabolism and normal erythropoiesis, while increased extracellular adenosine levels impact hematopoietic differentiation through adenosine receptor activation. . High dose of exogenous adenosine inhibits erythroid proliferation by inducing G1 arrest and p53-mediated apoptosis. Furthermore, A 2B and A 3 receptor signaling inhibits erythroid differentiation, while adenosine signaling through A 3 also favors granulopoiesis.</p><p><strong>Summary: </strong>Collectively, these findings highlight adenosine signaling as a critical and multifaceted regulator of hematopoietic balance, offering novel insights into its therapeutic potential for managing disorders characterized by ineffective erythropoiesis and aberrant myelopoiesis.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"199-205"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct megakaryopoiesis. 直接megakaryopoiesis。
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/MOH.0000000000000871
Hans-Willem Snoeck
{"title":"Direct megakaryopoiesis.","authors":"Hans-Willem Snoeck","doi":"10.1097/MOH.0000000000000871","DOIUrl":"10.1097/MOH.0000000000000871","url":null,"abstract":"<p><strong>Purpose of review: </strong>Megakaryocytes are large, polyploid cells that produce platelets and originate from hematopoietic stem cells (HSCs) in the bone marrow. While in the classical paradigm, megakaryocytes are generated in a stepwise fashion through increasingly committed progenitor stages, studies using in-vivo barcoding, transplantation, and in-vitro culture have suggested that, in addition, a more direct pathway existed. The relevance of this direct pathway and its functional and phenotypic characteristics were unclear, however.</p><p><strong>Recent findings: </strong>Recent publications using fate-mapping and single-cell transplantation now unequivocally demonstrate the existence of a direct megakaryocyte differentiation pathway, provide molecular characterization, and indicate distinct roles and regulation of both pathways. The direct pathway originates from a separate subset of 'top' HSCs, is enhanced by hematopoietic stress, inflammation and aging, bypasses multipotential progenitors, may be more active in myeloproliferative neoplasms, and generates phenotypically distinct megakaryocyte progenitors and more reactive platelets.</p><p><strong>Summary: </strong>Novel insights into the direct megakaryocyte differentiation pathway provide a deeper understanding of HSC biology, hematological recovery after myeloablation, and aging of the hematopoietic system, and suggest that this pathway may contribute to the increase in thrombotic incidents with age and in myeloproliferative neoplasms.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"213-220"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信