Current Opinion in Hematology最新文献_第3页

Heme- and iron-activated macrophages in sickle cell disease: an updated perspective. 镰状细胞病中的血红素和铁激活巨噬细胞：最新观点。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-11-01 Epub Date: 2024-07-16 DOI: 10.1097/MOH.0000000000000836

Shobana Navaneethabalakrishnan, Xiuli An, Francesca Vinchi

{"title":"Heme- and iron-activated macrophages in sickle cell disease: an updated perspective.","authors":"Shobana Navaneethabalakrishnan, Xiuli An, Francesca Vinchi","doi":"10.1097/MOH.0000000000000836","DOIUrl":"10.1097/MOH.0000000000000836","url":null,"abstract":"Purpose of review: Sickle cell disease (SCD) is a hereditary blood disorder due to a single-point mutation in the β-globin gene. The ensuing hemoglobin has the tendency to polymerize upon deoxygenation, leading to the typical sickle shape of red blood cells. While the primary pathology of sickle cell disease is a direct consequence of altered red blood cells, emerging evidence highlights the central role of macrophages in mediating hemoglobin scavenging, perpetuating oxidative stress and inflammation, and causing endothelial dysfunction and tissue remodeling.Recent findings: Recent research uncovered the impact of heme and iron overload on macrophage polarization and functions in sickle cell disease, and its implication for chronic inflammation and tissue damage in vital organs such as the liver, spleen, lungs and kidneys. By providing a thorough understanding of the dynamic interactions between macrophages and various cellular components within the sickle cell disease milieu, these studies have laid the foundation for the identification of macrophage-related cellular and molecular mechanisms potentially targetable for therapeutic purposes to attenuate sickle complications.Summary: This review provides a current update about recent discoveries on heme/iron-activated macrophages in SCD, shedding light on their critical role in disease pathophysiology. Ultimately, it proposes avenues for future research aimed at addressing the relevance of these cells for other sickle complications and at targeting them to mitigate disease morbidity and improve patient outcomes.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"275-284"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral infection after hematopoietic stem cell transplantation. 造血干细胞移植后的病毒感染。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1097/MOH.0000000000000833

Per Ljungman

{"title":"Viral infection after hematopoietic stem cell transplantation.","authors":"Per Ljungman","doi":"10.1097/MOH.0000000000000833","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000833","url":null,"abstract":"Purpose of review: Viral infections are important complications after allogeneic hematopoietic stem cell transplantation. New infections develop such as SARS-CoV-2 with the potential for severe consequences. In this review, newly published information regarding management of viral infections is discussed.Recent findings: Letermovir and maribavir are antiviral agents that have positively impacted the management of cytomegalovirus infections. These should today be included in treatment algorithms. The first antiviral cellular therapy for anti-CD20 refractory EBV-associated lymphoproliferative disease is now licensed and available. Vaccination as well as introduction of antiviral agents, mAbs and possibly the development of different viral strains have reduced mortality in COVID-19 in this patient population. Well designed studies have shown the improved immunogenicity of high-dose influenza vaccines. There is still an unmet medical need for patients infected with human metapneumovirus and parainfluenza viruses.Summary: Although improvements in patient management for several important posttransplantation viral infections have been reported, an unmet medical need still exists for other viruses occurring in this high-risk population.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"31 6","pages":"270-274"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1097/MOH.0000000000000835

Alexander H Schmidt

{"title":"Unrelated hematopoietic stem cell donor registries: present reality and future prospects.","authors":"Alexander H Schmidt","doi":"10.1097/MOH.0000000000000835","DOIUrl":"10.1097/MOH.0000000000000835","url":null,"abstract":"Purpose of review: Stem cell donor registries play an important role in providing stem cell products from unrelated donors to patients with severe blood diseases. In this review, important aspects of donor registry work, current challenges and possible future developments are discussed.Recent findings: The current growth in global unrelated stem cell donations is in line with the long-term trend, indicating that donor registries have overcome the COVID-19 pandemic. A key challenge for donor registries is the recruitment of donors from disadvantaged populations to create greater equity in access to unrelated stem cell transplantation. In addition, recruiting young donors and increasing the availability of donors who are already registered are important goals. In recent years, numerous studies have looked at the context of these themes and the development of possible solutions.Summary: The international community of donor registries, together with the World Marrow Donor Association, has helped many patients in need of a stem cell transplant over the past decades and is, therefore, a bright example of international collaboration for a good cause. It is currently addressing a number of challenges to effectively help as many patients as possible from various populations also in the future.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"251-260"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor selection in allogeneic stem cell transplantation. 异体干细胞移植中的供体选择。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-11-01 Epub Date: 2024-07-15 DOI: 10.1097/MOH.0000000000000831

Francisco Barriga, Alberto Cardoso Martins Lima

{"title":"Donor selection in allogeneic stem cell transplantation.","authors":"Francisco Barriga, Alberto Cardoso Martins Lima","doi":"10.1097/MOH.0000000000000831","DOIUrl":"10.1097/MOH.0000000000000831","url":null,"abstract":"Purpose of review: Recent progress in human leukocyte antigen (HLA) characterization, increased accrual of unrelated donors and cord blood units, and a new platform for haploidentical transplantation have resulted in the widespread availability of donors for allogeneic hematopoietic stem cell transplantation.Recent findings: Advances in HLA typing have identified an increasing number of loci and alleles that are crucial for successful transplantation. Newer HLA A, B, C, DRB1, and DQB1 alleles, DPB1 mismatches, and HLA B leader sequence matching are incorporated into donor selection algorithms. Donor selection is highly relevant because of recently published conflicting studies using different donor types. These studies are largely retrospective and compare patients with different diseases and stages, conditioning regimens, graft versus host disease (GVHD) prophylaxis, and time periods. A broad consensus indicates that the best donor is an available matched sibling, followed by a matched unrelated donor, and then alternative donors such as haploidentical, mismatched unrelated, and cord blood units. This consensus is being challenged by other factors, such as donor age, patient condition, urgency of transplantation, and costs involved.Summary: In this review, we will analyze the unique characteristics of each donor type, the HLA and non HLA factors that affect donor choices, and the outstanding comparative outcome studies of different donor usage in hematologic malignancies.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"261-269"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of inflammatory lung injury and repair by metabolic signaling in endothelial cells. 内皮细胞代谢信号控制肺部炎症损伤和修复

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-10-18 DOI: 10.1097/MOH.0000000000000848

Seth Gould, Ansley Herron, Jonathan Davis, Mollie Phillips, Mrinmay Chakrabarti, Colin E Evans

{"title":"Control of inflammatory lung injury and repair by metabolic signaling in endothelial cells.","authors":"Seth Gould, Ansley Herron, Jonathan Davis, Mollie Phillips, Mrinmay Chakrabarti, Colin E Evans","doi":"10.1097/MOH.0000000000000848","DOIUrl":"https://doi.org/10.1097/MOH.0000000000000848","url":null,"abstract":"Purpose of review: Sepsis-induced inflammatory lung injury includes acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). There are currently no effective treatments for ALI/ARDS, but clinical outcomes could be improved by inhibiting lung injury and/or promoting post-sepsis vascular repair. In this review, we describe studies of endothelial cell metabolic pathways in sepsis-induced ALI/ARDS and vascular repair and identify areas of research that deserve attention in future studies. We also describe studies of metabolic interventions that aim to inhibit ALI/ARDS and/or promote post-sepsis vascular repair, including those that target endothelial cell metabolites, endothelial cell metabolic signaling pathways, and endothelial cell metabolism.Recent findings: Endothelial cells are integral to both the injury and repair phases of ALI/ARDS. During the injury phase of ALI/ARDS, lung endothelial cell survival decreases, and lung endothelial cell-to-endothelial cell (EC-EC) junctions are weakened. During the repair phase after sepsis-induced lung injury, lung endothelial cell proliferation and lung EC-EC junction reannealing occur. These crucial aspects of ALI/ARDS and post-sepsis vascular repair, that is, endothelial cell viability, growth, and junction integrity, are controlled by a myriad of metabolites and metabolic signaling pathways in endothelial cells.Summary: Metabolic signaling pathways in endothelial cells represent a novel class of putative targets for the prevention and treatment of sepsis-induced inflammatory lung injury. Therapies that target metabolic signaling in endothelial cells are currently being explored as potential treatments for sepsis-induced inflammatory lung injury.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.1097/MOH.0000000000000829

引用次数: 0

Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor degradation. 进一步了解由 plasmin 介导的 von Willebrand 因子降解的临床作用。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-03 DOI: 10.1097/MOH.0000000000000825

Hinde El Otmani, Karen Vanhoorelbeke, Claudia Tersteeg

{"title":"Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor degradation.","authors":"Hinde El Otmani, Karen Vanhoorelbeke, Claudia Tersteeg","doi":"10.1097/MOH.0000000000000825","DOIUrl":"10.1097/MOH.0000000000000825","url":null,"abstract":"Purpose of review: Von Willebrand factor (VWF) plays a pivotal role in primary hemostasis. A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13 (ADAMTS13) is primarily responsible for cleaving ultra-large VWF multimers into smaller, less adhesive forms. However, plasmin has also been shown to cleave VWF multimers. This proteolytic cleavage of VWF results in a decreased multimer size and, hence, a lower VWF activity. This review aims to present a comprehensive overview of the involvement of plasmin-mediated VWF proteolysis in (micro)thrombosis.Recent findings: Plasmin-mediated VWF proteolysis has been suggested to play a role in various pathologies involving microthrombosis in combination with an imbalance in VWF antigen levels and ADAMTS13 activity, as well as activation of the fibrinolytic system, but quantitative assays to demonstrate this were lacking. Recently, a V H H-based bioassay was developed designed specifically to quantify plasmin-cleaved VWF (cVWF). The novel ELISA assay holds significant promise for gaining further insights into the clinical relevance of plasmin-mediated VWF proteolysis in several pathologies. Furthermore, local plasmin activation at the site of microthrombosis has been shown to be a promising treatment strategy by degrading VWF-rich microthrombi.Summary: Plasmin-mediated proteolysis of VWF is observed during microthrombosis; however, it remains unclear whether it impacts disease severity. A novel ELISA method to detect cVWF will improve our understanding of the clinical role of plasmin-mediated VWF degradation.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"245-250"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histon activities in the extracellular environment: regulation and prothrombotic implications. 细胞外环境中的组蛋白活性：调节和促血栓形成的影响。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-27 DOI: 10.1097/MOH.0000000000000827

Gwen M Keulen, Joram Huckriede, Kanin Wichapong, Gerry A F Nicolaes

{"title":"Histon activities in the extracellular environment: regulation and prothrombotic implications.","authors":"Gwen M Keulen, Joram Huckriede, Kanin Wichapong, Gerry A F Nicolaes","doi":"10.1097/MOH.0000000000000827","DOIUrl":"10.1097/MOH.0000000000000827","url":null,"abstract":"Purpose of review: Thromboembolic complications are a major contributor to global mortality. The relationship between inflammation and coagulation pathways has become an emerging research topic where the role of the innate immune response, and specifically neutrophils in \"immunothrombosis\" are receiving much attention. This review aims to dissect the intricate interplay between histones (from neutrophils or cellular damage) and the haemostatic pathway, and to explore mechanisms that may counteract the potentially procoagulant effects of those histones that have escaped their nuclear localization.Recent findings: Extracellular histones exert procoagulant effects via endothelial damage, platelet activation, and direct interaction with coagulation proteins. Neutralization of histone activities can be achieved by complexation with physiological molecules, through pharmacological compounds, or via proteolytic degradation. Details of neutralization of extracellular histones are still being studied.Summary: Leveraging the understanding of extracellular histone neutralization will pave the way for development of novel pharmacological interventions to treat and prevent complications, including thromboembolism, in patients in whom extracellular histones contribute to their overall clinical status.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":"31 5","pages":"230-237"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shedding light on GPIbα shedding. 揭示 GPIbα 的脱落。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-09 DOI: 10.1097/MOH.0000000000000826

Caitlin Debaene, Hendrik B Feys, Katrijn R Six

{"title":"Shedding light on GPIbα shedding.","authors":"Caitlin Debaene, Hendrik B Feys, Katrijn R Six","doi":"10.1097/MOH.0000000000000826","DOIUrl":"10.1097/MOH.0000000000000826","url":null,"abstract":"Purpose of review: Ectodomain shedding has been investigated since the late 1980s. The abundant and platelet specific GPIbα receptor is cleaved by ADAM17 resulting in the release of its ectodomain called glycocalicin. This review will address the role of glycocalicin as an end-stage marker of platelet turnover and storage lesion and will consider a potential function as effector in processes beyond hemostasis.Recent findings: Glycocalicin has been described as a marker for platelet senescence, turnover and storage lesion but is not routinely used in a clinical setting because its diagnostic value is nondiscriminatory. Inhibition of glycocalicin shedding improves posttransfusion recovery but little is known (yet) about potential hemostatic improvements. In physiological settings, GPIbα shedding is restricted to the intracellular GPIbα receptor subpopulation suggesting a role for shedding or glycocalicin beyond hemostasis.Summary: So far, all evidence represents glycocalicin as an end-stage biomarker of platelet senescence and a potential trigger for platelet clearance. The extensive list of interaction partners of GPIbα in fields beyond hemostasis opens new possibilities to investigate specific effector functions of glycocalicin.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"224-229"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protease activated receptor-4: ready to be part of the antithrombosis spectrum. 蛋白酶激活受体-4：准备好成为抗血栓形成的一部分。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.1097/MOH.0000000000000828

Izabella Andrianova, Mia Kowalczyk, Frederik Denorme

{"title":"Protease activated receptor-4: ready to be part of the antithrombosis spectrum.","authors":"Izabella Andrianova, Mia Kowalczyk, Frederik Denorme","doi":"10.1097/MOH.0000000000000828","DOIUrl":"10.1097/MOH.0000000000000828","url":null,"abstract":"Purpose of review: Cardiovascular disease is a major cause of death worldwide. Platelets play a key role in this pathological process. The serine protease thrombin is a critical regulator of platelet reactivity through protease activated receptors-1 (PAR1) and PAR4. Since targeting PAR4 comes with a low chance for bleeding, strategies blocking PAR4 function have great antithrombotic potential. Here, we reviewed the literature on platelet PAR4 with a particular focus on its role in thromboinflammation.Recent findings: Functional PAR4 variants are associated with reduced venous thrombosis risk (rs2227376) and increased risk for ischemic stroke (rs773902). Recent advances have allowed for the creation of humanized mouse lines in which human PAR4 is express instead of murine PAR4. This has led to a better understanding of the discrepancies between human and murine PAR4. It also made it possible to introduce single nucleotide polymorphisms (SNPs) in mice allowing to directly test the in vivo functional effects of a specific SNP and to develop in vivo models to study mechanistic and pharmacologic alterations induced by a SNP.Summary: PAR4 plays an important role in cardiovascular diseases including stroke, myocardial infarction and atherosclerosis. Targeting PAR4 hold great potential as a safe antithrombotic strategy.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"238-244"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0