Current Opinion in Hematology最新文献_第3页

Tissue factor pathway inhibitor - cofactor-dependent regulation of the initiation of coagulation. 组织因子通路抑制剂--依赖于辅因子的凝血启动调控。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-08-27 DOI: 10.1097/moh.0000000000000838

Josefin Ahnström,Anastasis Petri,James Tb Crawley

{"title":"Tissue factor pathway inhibitor - cofactor-dependent regulation of the initiation of coagulation.","authors":"Josefin Ahnström,Anastasis Petri,James Tb Crawley","doi":"10.1097/moh.0000000000000838","DOIUrl":"https://doi.org/10.1097/moh.0000000000000838","url":null,"abstract":"PURPOSE OF REVIEWIn humans, tissue factor pathway inhibitor (TFPI) exists in two alternatively spliced isoforms, TFPIα and TFPIβ. TFPIα consists of three Kunitz domains (K1, K2 and K3) and a highly basic C-terminal tail. K1 inhibits the tissue factor-activated factor VII complex, K2 specifically inhibits activated factor X, K3 is essential for interaction with its cofactor, protein S, and the basic C-terminus is binds factor V-short (FV-short) with high affinity. TFPIβ consists of K1 and K2 that is glycosylphosphatidylinositol anchored directly to cell surfaces. This review explores the structure/function of TFPI and its cofactors (protein S and FV-short), and the relative contributions that different TFPI isoforms may play in haemostatic control.RECENT FINDINGSRecent data have underscored the importance of TFPIα function and its reliance on its cofactors, protein S and FV-short, in influencing haemostatic control as well as bleeding and thrombotic risk.SUMMARYTFPIα is likely the most important pool of TFPI in modifying the risk of thrombosis and bleeding. TFPIα forms a trimolecular complex with FV-short and protein S in plasma. FV-short expression levels control the circulating levels of TFPIα, whereas protein S exerts essential cofactor mediated augmentation of it anticoagulant function.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of hematopoiesis in bone repair: an update. 造血在骨修复中的作用：最新进展。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-01 DOI: 10.1097/MOH.0000000000000821

Elise C Jeffery

{"title":"The role of hematopoiesis in bone repair: an update.","authors":"Elise C Jeffery","doi":"10.1097/MOH.0000000000000821","DOIUrl":"10.1097/MOH.0000000000000821","url":null,"abstract":"Purpose of review: The repair of bone after injury requires the participation of many different immune cell populations, which are derived from the hematopoietic lineage. The field of osteoimmunology, or the study of the interactions between bone and the immune system, is a growing field with emerging impact on both the basic science and clinical aspects of fracture healing.Recent findings: Despite previous focus on the innate immune system in fracture healing, recent studies have revealed an important role for the adaptive immune system in bone repair. The composition of adaptive and innate immune cell populations present at the fracture site is significantly altered during aging and diet-induced obesity, which may contribute to delayed healing. Recent data also suggest a complicated relationship between fracture repair and systemic inflammation, raising the possibility that immune populations from distant sites such as the gut can impact the bone repair process.Summary: These findings have important implications for the treatment of fracture patients with antibiotics or anti-inflammatory drugs. Furthermore, the effects of systemic inflammation on fracture repair in the contexts of aging or obesity should be carefully interpreted, as they may not be uniformly detrimental.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid mediators in neutrophil biology: inflammation, resolution and beyond. 中性粒细胞生物学中的脂质介质：炎症、消解和超越。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1097/MOH.0000000000000822

Anita Ghodsi, Andres Hidalgo, Stephania Libreros

{"title":"Lipid mediators in neutrophil biology: inflammation, resolution and beyond.","authors":"Anita Ghodsi, Andres Hidalgo, Stephania Libreros","doi":"10.1097/MOH.0000000000000822","DOIUrl":"10.1097/MOH.0000000000000822","url":null,"abstract":"Purpose of review: Acute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a pivotal role in eradicating infectious pathogens, orchestrating the initiation and resolution of acute inflammation, and maintaining physiological functions. The resolution of inflammation is a highly orchestrated biochemical process, partially modulated by a novel class of endogenous lipid mediators known as specialized pro-resolving mediators (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR).Recent findings: This review focuses on recent advances in understanding the multifaceted functions of SPMs, detailing their roles in expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, orchestrating bone marrow deployment, also enhances neutrophil phagocytosis and tissue repair mechanisms under both physiological and pathological conditions. We also focus on the novel role of SPMs in regulating bone marrow neutrophil functions, differentiation, and highlight open questions about SPMs' functions in neutrophil heterogeneity.Summary: SPMs play a pivotal role in mitigating excessive neutrophil infiltration and hyperactivity within pathological milieus, notably in conditions such as sepsis, cardiovascular disease, ischemic events, and cancer. This significant function highlights SPMs as promising therapeutic agents in the management of both acute and chronic inflammatory disorders.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-30 DOI: 10.1097/MOH.0000000000000823

引用次数: 0

Pas de deux: the coordinated coupling of erythroid differentiation with the cell cycle. 双人舞：红细胞分化与细胞周期的协调耦合。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-16 DOI: 10.1097/MOH.0000000000000811

Merav Socolovsky

{"title":"Pas de deux: the coordinated coupling of erythroid differentiation with the cell cycle.","authors":"Merav Socolovsky","doi":"10.1097/MOH.0000000000000811","DOIUrl":"10.1097/MOH.0000000000000811","url":null,"abstract":"Purpose of review: Recent work reveals that cell cycle duration and structure are remodeled in lock-step with distinct stages of erythroid differentiation. These cell cycle features have regulatory roles in differentiation, beyond the generic function of increasing cell number.Recent findings: Developmental progression through the early erythroid progenitor stage (known as colony-forming-erythroid, or 'CFU-e') is characterized by gradual shortening of G1 phase of the cycle. This process culminates in a key transcriptional switch to erythroid terminal differentiation (ETD) that is synchronized with, and dependent on, S phase progression. Further, the CFU-e/ETD switch takes place during an unusually short S phase, part of an exceptionally short cell cycle that is characterized by globally fast replication fork speeds. Cell cycle and S phase speed can alter developmental events during erythroid differentiation, through pathways that are targeted by glucocorticoid and erythropoietin signaling during the erythroid stress response.Summary: There is close inter-dependence between cell cycle structure and duration, S phase and replication fork speeds, and erythroid differentiation stage. Further, modulation of cell cycle structure and speed cycle impacts developmental progression and cell fate decisions during erythroid differentiation. These pathways may offer novel mechanistic insights and potential therapeutic targets.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematopoietic stem cell collection for sickle cell disease gene therapy. 用于镰状细胞病基因治疗的造血干细胞采集。

IF 3.1 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-09 DOI: 10.1097/MOH.0000000000000807

Alexis Leonard, Mitchell J Weiss

{"title":"Hematopoietic stem cell collection for sickle cell disease gene therapy.","authors":"Alexis Leonard, Mitchell J Weiss","doi":"10.1097/MOH.0000000000000807","DOIUrl":"10.1097/MOH.0000000000000807","url":null,"abstract":"Purpose of review: Gene therapy for sickle cell disease (SCD) is advancing rapidly, with two transformative products recently approved by the US Food and Drug Administration and numerous others under study. All current gene therapy protocols require ex vivo modification of autologous hematopoietic stem cells (HSCs). However, several SCD-related problems impair HSC collection, including a stressed and damaged bone marrow, potential cytotoxicity by the major therapeutic drug hydroxyurea, and inability to use granulocyte colony stimulating factor, which can precipitate severe vaso-occlusive events.Recent findings: Peripheral blood mobilization of HSCs using the CXCR4 antagonist plerixafor followed by apheresis collection was recently shown to be safe and effective for most SCD patients and is the current strategy for mobilizing HSCs. However, exceptionally large numbers of HSCs are required to manufacture an adequate cellular product, responses to plerixafor are variable, and most patients require multiple mobilization cycles, increasing the risk for adverse events. For some, gene therapy is prohibited by the failure to obtain adequate numbers of HSCs.Summary: Here we review the current knowledge on HSC collection from individuals with SCD and potential improvements that may enhance the safety, efficacy, and availability of gene therapy for this disorder.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

microRNAs and thrombo-inflammation: relationship in sight. microRNAs与血栓-炎症：关系就在眼前。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-01-24 DOI: 10.1097/MOH.0000000000000803

Sonia Águila, Rocío González-Conejero, Constantino Martínez

引用次数: 0

Macrocytic anemias. 巨红细胞性贫血

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-07 DOI: 10.1097/MOH.0000000000000804

Mark J Koury, Daniel J Hausrath

{"title":"Macrocytic anemias.","authors":"Mark J Koury, Daniel J Hausrath","doi":"10.1097/MOH.0000000000000804","DOIUrl":"10.1097/MOH.0000000000000804","url":null,"abstract":"Purpose of review: Over the last century, the diseases associated with macrocytic anemia have been changing with more patients currently having hematological diseases including malignancies and myelodysplastic syndrome. The intracellular mechanisms underlying the development of anemia with macrocytosis can help in understanding normal erythropoiesis. Adaptations to these diseases involving erythroid progenitor and precursor cells lead to production of fewer but larger red blood cells, and understanding these mechanisms can provide information for possible treatments.Recent findings: Both inherited and acquired bone marrow diseases involving primarily impaired or delayed erythroid cell division or secondary adaptions to basic erythroid cellular deficits that results in prolonged cell division frequently present with macrocytic anemia.Summary of findings: In marrow failure diseases, large accumulations of iron and heme in early stages of erythroid differentiation make cells in those stages especially susceptible to death, but the erythroid cells that can survive the early stages of terminal differentiation yield fewer but larger erythrocytes that are recognized clinically as macrocytic anemia. Other disorders that limit deoxynucleosides required for DNA synthesis affect a broader range of erythropoietic cells, but they also lead to macrocytic anemia. The source of macrocytosis in other diseases remains uncertain.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular microphysiological systems. 血管微生理系统

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-01-18 DOI: 10.1097/MOH.0000000000000802

Sarah E Shelton

{"title":"Vascular microphysiological systems.","authors":"Sarah E Shelton","doi":"10.1097/MOH.0000000000000802","DOIUrl":"10.1097/MOH.0000000000000802","url":null,"abstract":"Purpose of review: This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works.Recent findings: Vascular MPS are increasing in complexity and ability to replicate tissue. Many labs use vascular MPS to study transport phenomena such as analyzing endothelial barrier function. Beyond vascular permeability, these models are also being used for pharmacological studies, including drug distribution and toxicity modeling. In part, these studies are made possible due to exciting advances in organ-specific models. Inflammatory processes have also been modeled by incorporating immune cells, with the ability to explore both cell migration and function. Finally, as methods for generating vascular MPS flourish, many researchers have turned their attention to incorporating flow to more closely recapitulate in vivo conditions.Summary: These models represent many different types of tissue and disease states. Some devices have relatively simple geometry and few cell types, while others use complex, multicompartmental microfluidics and integrate several cell types and origins. These 3D models enable us to observe model evolution in real time and perform a plethora of functional assays not possible using traditional cell culture methods.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Venous thromboembolism: diagnostic advances and unaddressed challenges in management. 静脉血栓栓塞症：诊断方面的进步和管理方面尚未解决的难题。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-12 DOI: 10.1097/MOH.0000000000000809

Rick Mathews, Monica T Hinds, Khanh P Nguyen

{"title":"Venous thromboembolism: diagnostic advances and unaddressed challenges in management.","authors":"Rick Mathews, Monica T Hinds, Khanh P Nguyen","doi":"10.1097/MOH.0000000000000809","DOIUrl":"10.1097/MOH.0000000000000809","url":null,"abstract":"Purpose of review: This review summarizes recent advances in developing targeted diagnostics for venous thromboembolism (VTE) and unaddressed knowledge gaps in patient management. Without addressing these critical data needs, the morbidity in VTE patients will persist.Recent findings: Recent studies investigating plasma protein profiles in VTE patients have identified key diagnostic targets to address the currently unmet need for low-cost, confirmatory, point-of-care VTE diagnostics. These studies and a growing body of evidence from animal model studies have revealed the importance of inflammatory and vascular pathology in driving VTE, which are currently unaddressed targets for VTE therapy. To enhance the translation of preclinical animal studies, clinical quantification of thrombus burden and comparative component analyses between modeled VTE and clinical VTE are necessary.Summary: Lead candidates from protein profiling of VTE patients' plasma offer a promising outlook in developing low cost, confirmatory, point-of-care testing for VTE. Additionally, addressing the critical knowledge gap of quantitatively measuring clinical thrombi will allow for an array of benefits in VTE management and informing the translatability of experimental therapeutics.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0