Current Opinion in Hematology最新文献_第3页

Cryogenic electron microscopy and coagulation factors. 低温电子显微镜和凝血因子。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-09-01 Epub Date: 2026-05-15 DOI: 10.1097/MOH.0000000000000933

Bassem M Mohammed, Nicola Pozzi, Enrico Di Cera

{"title":"Cryogenic electron microscopy and coagulation factors.","authors":"Bassem M Mohammed, Nicola Pozzi, Enrico Di Cera","doi":"10.1097/MOH.0000000000000933","DOIUrl":"10.1097/MOH.0000000000000933","url":null,"abstract":"Purpose of review: Cryogenic electron microscopy (cryo-EM) resolves the structures of proteins and their complexes under near-native conditions that are often inaccessible to other structural techniques. Cryo-EM has recently contributed significant advances in basic knowledge to the field of coagulation. New paradigms regarding individual domain role in protein-protein interactions have emerged, casting the main reactions of the coagulation cascade in a much-needed structural context. This review focuses on recent advances in the study of coagulation factors using cryo-EM.Recent findings: Cryo-EM structures have defined the architecture of Factor V/Va free and bound to their biological partners, revealing that protease domains dominate protein-protein interactions while auxiliary domains act as scaffolds. Breakthroughs in mapping autoantibody epitopes for prothrombin and Factor VIII have elucidated pathogenic mechanisms in antiphospholipid syndrome and hemophilia. Furthermore, cryo-EM is accelerating biotherapeutic design, evidenced by recent structures of Factor XIIa, prothrombin and engineered Factor VIII.Summary: Cryo-EM, often, enables the resolution of discrete macromolecular conformations using minimal quantities of full-length proteins. These structural insights enable the rational design of next-generation therapeutics and targeted diagnostics guided by near physiological forms, marking a new era in coagulation research. Future integration with HDX-MS, smFRET, and cryo-electron tomography (cryo-ET) will resolve these molecular machineries in situ on the surface of activated platelets and vascular beds.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"189-195"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional relationship between metabolic and thrombotic disease mechanisms. 代谢与血栓性疾病机制的双向关系。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-09-01 Epub Date: 2026-06-09 DOI: 10.1097/MOH.0000000000000929

Angelica T Jameson, Woosuk S Hur

{"title":"Bidirectional relationship between metabolic and thrombotic disease mechanisms.","authors":"Angelica T Jameson, Woosuk S Hur","doi":"10.1097/MOH.0000000000000929","DOIUrl":"10.1097/MOH.0000000000000929","url":null,"abstract":"Purpose of review: Metabolic diseases, including obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and diabetes, are associated with increased thrombotic risks. Conversely, components of the hemostatic system influence the development of metabolic pathologies, suggesting a bidirectional relationship between metabolic and thrombotic diseases. This review provides an update on recent advances in the mechanisms by which metabolic pathologies drive thrombosis and how hemostatic system components modulate metabolic diseases.Recent findings: Novel insights into fibrinolytic changes as a driver of thrombosis, improved thrombotic risk prediction models, synergistic thrombotic effect with other prothrombotic conditions in metabolic pathologies as well as the impact of weight loss therapies on metabolic dysfunction-associated thrombosis are discussed. Furthermore, recent updates on the roles of urokinase plasminogen activator and factor XIIIA (FXIIIA) in metabolic pathology development are highlighted.Summary: Metabolic pathologies suppress fibrinolytic activity and are largely driven by elevated plasminogen activator inhibitor 1 (PAI-1) levels. Development of novel strategies targeting PAI-1 to attenuate thrombotic risks are in progress. Weight loss following bariatric surgery is associated with reduced thrombotic risk, though the impact of glucagon-like peptide 1 receptor agonist on obesity-associated cardiovascular disease risk remains unclear. Conversely, new insights identify urokinase and FXIIIA as promoters of metabolic dysfunction, particularly MASLD.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"183-188"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YY1 in hematopoietic stem cells: epigenetic regulation, chromatin architecture, and aging. YY1在造血干细胞中的作用：表观遗传调控、染色质结构和衰老。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-05-18 DOI: 10.1097/MOH.0000000000000925

Yinghua Wang, Xuan Pan

{"title":"YY1 in hematopoietic stem cells: epigenetic regulation, chromatin architecture, and aging.","authors":"Yinghua Wang, Xuan Pan","doi":"10.1097/MOH.0000000000000925","DOIUrl":"10.1097/MOH.0000000000000925","url":null,"abstract":"Purpose of review: Yin Yang 1 (YY1) is a multifunctional transcription factor (TF) with established roles in lymphocyte development. More recently, its functions as a Polycomb group (PcG) protein and chromatin structural regulator in the hematopoietic system have gained increasing attention. This mini-review summarizes emerging insights into the epigenetic and architectural roles of YY1 in fetal and adult hematopoietic stem cells (HSCs), extending beyond its classical transcriptional activity. We also discuss how altered YY1 function contributes to HSC aging and hematopoietic decline.Recent findings: Recent studies show that YY1 is essential for maintaining HSC quiescence, self-renewal, and engraftment during both fetal and adult hematopoiesis. Mechanistically, YY1 regulates hematopoiesis through PcG-dependent pathways and by shaping higher-order chromatin organization. It mediates long-range chromatin interactions, cooperates with cohesin and CTCF to organize three-dimensional genome architecture, and coordinates transcriptional and metabolic programs critical for stem cell maintenance. Notably, age-associated reductions in YY1 activity are linked to functional impairment of HSCs, implicating YY1 in hematopoietic aging.Summary: YY1 acts as a TF, chromatin organizer, and PcG protein in hematopoiesis. Defining its roles in normal and aging HSCs may reveal mechanisms of hematopoietic decline and inform strategies to preserve blood system function.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"129-136"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G protein-coupled receptor-mediated platelet thrombus formation. G蛋白偶联受体介导的血小板血栓形成。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-05-14 DOI: 10.1097/MOH.0000000000000931

Xuefei Zhao, Peisong Ma

{"title":"G protein-coupled receptor-mediated platelet thrombus formation.","authors":"Xuefei Zhao, Peisong Ma","doi":"10.1097/MOH.0000000000000931","DOIUrl":"10.1097/MOH.0000000000000931","url":null,"abstract":"Purpose of review: Platelet G protein-coupled receptor (GPCR) signaling plays a central role in platelet activation and thrombus formation; however, much of our current understanding of GPCR regulation is derived from isolated platelets and single-receptor knockout mouse models, and it does not fully capture vascular bed-specific regulation in vivo . This review highlights recent advances in GPCR regulatory mechanisms, including GPCR kinases (GRKs) and biased signaling, and discusses the challenges posed by interspecies differences in modeling and interpreting human thrombin/PAR signaling.Recent findings: Recent work reveals distinct roles of platelets in arterial thrombosis versus venous thromboembolism, platelet heterogeneity within developing thrombi, and the emergence of procoagulant platelets as a functional link between coagulation and thromboinflammation. Together, these findings indicate that platelet GPCR signaling should be reconsidered in the context of vascular bed-specific cues, platelet-immune cell crosstalk, and the spatial organization of growing thrombi, highlighting its dynamic and context-dependent nature.Summary: Spatiotemporal regulation of platelet GPCR signaling provides a conceptual framework to better understand context-dependent platelet function in hemostasis and thrombosis and may inform the development of more selective antithrombotic strategies, including approaches that target specific GPCR downstream effectors or signaling bias while preserving physiological hemostasis.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"165-171"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-05-28 DOI: 10.1097/MOH.0000000000000927

引用次数: 0

From bud to stem: dynamics of hematopoietic stem cells that drive homing and mobilization. 从芽到干：造血干细胞驱动归巢和动员的动力学。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-04-10 DOI: 10.1097/MOH.0000000000000922

Farnaz Razmkhah, Stephanie N Hurwitz

{"title":"From bud to stem: dynamics of hematopoietic stem cells that drive homing and mobilization.","authors":"Farnaz Razmkhah, Stephanie N Hurwitz","doi":"10.1097/MOH.0000000000000922","DOIUrl":"10.1097/MOH.0000000000000922","url":null,"abstract":"Purpose of review: Hematopoietic stem and progenitor cells (HSPCs) ensure lifelong hematopoiesis through their unique ability to self-renew and differentiate into all blood cell lineages. Their localization within bone marrow niches and the ability to traffic between hematopoietic and peripheral tissues during development and adult life are governed by complex signaling networks involving adhesion molecules, chemokines, metabolic cues, and niche-derived factors.Recent findings: This review explores the molecular and cellular mechanisms that regulate HSPC homing, retention, and mobilization during development, homeostasis, and therapeutic transplantation. In particular, we focus on intrinsic, dynamic properties of HSPCs that guide developmental transitions in trafficking behavior from fetal to adult niches, physiological egress under steady-state conditions, and dictate outcomes of forced mobilization and bone marrow homing during therapeutic collection and transplantation.Summary: These findings highlight HSPC trafficking as a highly regulated and adaptable process integrating intrinsic stem cell states with extrinsic niche cues. Understanding these mechanisms provides a conceptual framework for improving strategies to enhance HSPC mobilization, homing, and engraftment toward optimizing hematopoietic stem cell therapies.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"143-151"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging in the bone marrow: when hematopoiesis gets clonal. 骨髓老化：当造血获得克隆时。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-05-03 DOI: 10.1097/MOH.0000000000000928

Dawn M E Bowdish, Candice Quin

{"title":"Aging in the bone marrow: when hematopoiesis gets clonal.","authors":"Dawn M E Bowdish, Candice Quin","doi":"10.1097/MOH.0000000000000928","DOIUrl":"10.1097/MOH.0000000000000928","url":null,"abstract":"Purpose of review: It has been known that the cytokine TNF (tumor necrosis factor alpha) influences hematopoiesis for decades. We now know that increases in TNF in the aging microenvironment favor the persistence and expansion of myeloid progenitors, especially those that contain mutations associated with clonal hematopoiesis of indeterminate potential (CHIP). Herein, we will examine both seminal and recent studies that have advanced our understanding of how TNF shapes hematopoietic development during aging and influences clonal dynamics in CHIP.Recent findings: Elevated levels of TNF contribute to engraftment and expansion of CHIP-mutant clones; however, there are subtle differences between the specific CHIP mutations. Sex differences in levels of TNF may contribute to differences in the frequency and types of CHIP mutations found in males and females. Anti-TNF inhibitors reduce the frequency of CHIP mutation containing clones in multiple inflammatory diseases.Summary: The elevated levels of TNF that occur with both age and chronic inflammatory conditions contribute to both myeloid skewing and CHIP. Anti-TNF drugs reduce problematic changes in myeloid hematopoiesis. Anti-TNF drugs are not an effective strategy to treat CHIP and more research is needed as to whether other anti-inflammatory strategies, including diet and exercise, are also effective.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"137-142"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress granules and RNA modifications in blood development and erythroid regeneration. 应激颗粒和RNA修饰在血液发育和红细胞再生中的作用。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-05-15 DOI: 10.1097/MOH.0000000000000930

Rajesh Gunage

{"title":"Stress granules and RNA modifications in blood development and erythroid regeneration.","authors":"Rajesh Gunage","doi":"10.1097/MOH.0000000000000930","DOIUrl":"10.1097/MOH.0000000000000930","url":null,"abstract":"Purpose of review: Stress granules (SGs) are RNA and protein assemblies that form rapidly in the cytoplasm in response to cellular or environmental stress. SGs, traditionally recognized as transient repressors of translation, are now understood as versatile regulatory centers that shape RNA metabolism, signaling, proteostasis, and cell fate. In this review, we collate recent findings showing SGs' role in steady-state and regenerative stress in erythropoiesis.Recent findings: Blood loss, anemia caused by ribosomal mutations, has been reported to alter the SG axis and protein translation. During regeneration stress, SGs selectively capture lineage-defining RNAs to regulate their translation during recovery phases. This process ensures that blood progenitors and differentiating cells retain essential transcripts, supporting proper fate decisions and regeneration. Pathological SG accumulation disrupts RNA metabolism and translational reprogramming, key to blood cell regeneration.Summary: SGs regulate the transcriptome to endure stress via translational control mechanisms during erythropoiesis. SG deregulation can undermine these adaptive processes. Therapies modulating SG formation, dissolving pathological SGs, or influencing RNA sorting via genetics or targeted small molecules promise new directions to restore blood health, treat anemia, and regeneration in a range of blood disorders.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"172-181"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-dependent regulation of hematopoiesis by megakaryocytes. 巨核细胞年龄依赖性造血调节。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-04-07 DOI: 10.1097/MOH.0000000000000924

Sen Zhang, Sandra Pinho

{"title":"Age-dependent regulation of hematopoiesis by megakaryocytes.","authors":"Sen Zhang, Sandra Pinho","doi":"10.1097/MOH.0000000000000924","DOIUrl":"10.1097/MOH.0000000000000924","url":null,"abstract":"Purpose of review: Recent studies have expanded the concept of the bone marrow niche beyond stromal cells to include differentiated hematopoietic progeny as direct regulators of hematopoietic stem cells (HSCs). Among these, megakaryocytes have emerged as key niche regulators of HSC function across homeostasis, stress responses, aging, and disease. This review summarizes recent advances defining how aging alters megakaryocyte-mediated regulation of hematopoiesis.Recent findings: Megakaryocytes regulate HSC quiescence, lineage output, and stress responsiveness through spatial organization within the bone marrow microenvironment and the production of niche-derived factors. Recent studies revealed that aging is associated with changes in megakaryocyte abundance, maturation state, and transcriptional and secretory programs, resulting in altered niche functions and hematopoiesis. These findings establish megakaryocytes as dynamic niche components whose regulatory roles evolve across the lifespan.Summary: Age-dependent remodeling of the megakaryocytic niche provides a conceptual framework for understanding how hematopoietic regulation is reprogrammed with aging. Targeting megakaryocyte-derived niche signals may offer new opportunities to rejuvenate hematopoiesis and improve outcomes in age-associated hematopoietic disorders.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"152-157"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving lymphopoiesis in aged bone marrow. 改善老化骨髓的淋巴系统。

IF 2.9 3区医学

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-03-18 DOI: 10.1097/MOH.0000000000000923

Anna Konturek-Ciesla, David Bryder

{"title":"Improving lymphopoiesis in aged bone marrow.","authors":"Anna Konturek-Ciesla, David Bryder","doi":"10.1097/MOH.0000000000000923","DOIUrl":"10.1097/MOH.0000000000000923","url":null,"abstract":"Purpose of review: Aging is associated with impaired B lymphopoiesis and T lymphopoiesis, contributing to immunosenescence and poor immune recovery. Although this decline can be attributed to intrinsic hematopoietic stem cell aging, growing evidence indicates that lymphoid failure reflects constraints operating across multiple levels of the hematopoietic system. This review frames age-associated lymphopoiesis decline as a systems-level problem and outlines conceptual avenues for therapeutic intervention.Recent findings: Age-associated lymphoid failure is increasingly attributed to inflammatory suppression, dominance of dysfunctional stem and progenitor states, and compromised extramedullary support. These insights provide a framework for interventions that restore immune competence by rebalancing hematopoiesis or selectively replacing compromised stem cell function.Summary: Age-associated lymphoid decline arises from coordinated constraints across the bone marrow niche, stem and progenitor composition, and extramedullary lymphoid support, rather than intrinsic stem cell exhaustion alone. Targeting these bottlenecks in a context-dependent manner offers multiple routes to improve lymphopoiesis and restore immune competence in aging.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"158-164"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0