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Circulating endothelial cells in pathophysiology. 病理生理学中的循环内皮细胞
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-15 DOI: 10.1097/MOH.0000000000000814
Victor Emmanuel Brett, Francoise Dignat George, Chloe James
{"title":"Circulating endothelial cells in pathophysiology.","authors":"Victor Emmanuel Brett, Francoise Dignat George, Chloe James","doi":"10.1097/MOH.0000000000000814","DOIUrl":"10.1097/MOH.0000000000000814","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to synthesize recent insights into the roles and importance of circulating endothelial cells (CECs) as indicators of the severity, progression, and prognosis of vascular-related diseases.</p><p><strong>Recent findings: </strong>Recent studies have identified elevated counts of CECs in pathological conditions, notably inflammatory or cardiovascular diseases such as acute myocardial infarction and heart failure, underscoring their potential as sensitive indicators of disease. Furthermore, the rise in CEC levels in cancer patients, particularly with disease advancement, points to their role in cancer-associated angiogenesis and response to treatment.</p><p><strong>Summary: </strong>This review underscores the evolving significance of CECs as markers for evaluating the gravity and advancement of diseases with vascular injury, including cardiovascular diseases, cancer, inflammatory conditions, and thromboembolic events. These last years, efforts made to standardize flow cytometry detection of CEC and the development of highly sensitive techniques to isolate, quantify or phenotype rare cells open promising avenues for clinical application. This may yield extensive knowledge regarding the mechanisms by which endothelial cells contribute to a variety of vascular-related disorders and their clinical value as emerging biomarkers.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signaling networks guiding erythropoiesis. 引导红细胞生成的信号网络。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-07 DOI: 10.1097/MOH.0000000000000808
Shilpa Kuttikrishnan, Kirti S Prabhu, Abdul Q Khan, Shahab Uddin
{"title":"Signaling networks guiding erythropoiesis.","authors":"Shilpa Kuttikrishnan, Kirti S Prabhu, Abdul Q Khan, Shahab Uddin","doi":"10.1097/MOH.0000000000000808","DOIUrl":"10.1097/MOH.0000000000000808","url":null,"abstract":"<p><strong>Purpose of review: </strong>Cytokine-mediated signaling pathways, including JAK/STAT, PI3K/AKT, and Ras/MAPK pathways, play an important role in the process of erythropoiesis. These pathways are involved in the survival, proliferation, and differentiation function of erythropoiesis.</p><p><strong>Recent findings: </strong>The JAK/STAT pathway controls erythroid progenitor differentiation, proliferation, and survival. The PI3K/AKT signaling cascade facilitates erythroid progenitor survival, proliferation, and final differentiation. During erythroid maturation, MAPK, triggered by EPO, suppresses myeloid genes, while PI3K is essential for differentiation. Pro-inflammatory cytokines activate signaling pathways that can alter erythropoiesis like EPOR-triggered signaling, including survival, differentiation, and proliferation.</p><p><strong>Summary: </strong>A comprehensive understanding of signaling networks is crucial for the formulation of treatment approaches for hematologic disorders. Further investigation is required to fully understand the mechanisms and interactions of these signaling pathways in erythropoiesis.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139713468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental regulation of primitive erythropoiesis. 原始红细胞生成的发育调节。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI: 10.1097/MOH.0000000000000806
Marlies P Rossmann, James Palis
{"title":"Developmental regulation of primitive erythropoiesis.","authors":"Marlies P Rossmann, James Palis","doi":"10.1097/MOH.0000000000000806","DOIUrl":"10.1097/MOH.0000000000000806","url":null,"abstract":"<p><strong>Purpose of review: </strong>In this review, we present an overview of recent studies of primitive erythropoiesis, focusing on advances in deciphering its embryonic origin, defining species-specific differences in its developmental regulation, and better understanding the molecular and metabolic pathways involved in terminal differentiation.</p><p><strong>Recent findings: </strong>Single-cell transcriptomics combined with state-of-the-art lineage tracing approaches in unperturbed murine embryos have yielded new insights concerning the origin of the first (primitive) erythroid cells that arise from mesoderm-derived progenitors. Moreover, studies examining primitive erythropoiesis in rare early human embryo samples reveal an overall conservation of primitive erythroid ontogeny in mammals, albeit with some interesting differences such as localization of erythropoietin (EPO) production in the early embryo. Mechanistically, the repertoire of transcription factors that critically regulate primitive erythropoiesis has been expanded to include regulators of transcription elongation, as well as epigenetic modifiers such as the histone methyltransferase DOT1L. For the latter, noncanonical roles aside from enzymatic activity are being uncovered. Lastly, detailed surveys of the metabolic and proteomic landscape of primitive erythroid precursors reveal the activation of key metabolic pathways such as pentose phosphate pathway that are paralleled by a striking loss of mRNA translation machinery.</p><p><strong>Summary: </strong>The ability to interrogate single cells in vivo continues to yield new insights into the birth of the first essential organ system of the developing embryo. A comparison of the regulation of primitive and definitive erythropoiesis, as well as the interplay of the different layers of regulation - transcriptional, epigenetic, and metabolic - will be critical in achieving the goal of faithfully generating erythroid cells in vitro for therapeutic purposes.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of red blood cells from induced pluripotent stem cells. 用诱导多能干细胞生成红细胞。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-13 DOI: 10.1097/MOH.0000000000000810
Naomi Gunawardena, Stella T Chou
{"title":"Generation of red blood cells from induced pluripotent stem cells.","authors":"Naomi Gunawardena, Stella T Chou","doi":"10.1097/MOH.0000000000000810","DOIUrl":"10.1097/MOH.0000000000000810","url":null,"abstract":"<p><strong>Purpose of review: </strong>Human induced pluripotent stem cells (iPSCs) are an attractive source to generate in-vitro-derived blood for use as transfusable and reagent red cells. We review recent advancements in the field and the remaining limitations for clinical use.</p><p><strong>Recent findings: </strong>For iPSC-derived red blood cell (RBC) generation, recent work has optimized culture conditions to omit feeder cells, enhance red cell maturation, and produce cells that mimic fetal or adult-type RBCs. Genome editing provides novel strategies to improve cell yield and create designer RBCs with customized antigen phenotypes.</p><p><strong>Summary: </strong>Current protocols support red cell production that mimics embryonic and fetal hematopoiesis and cell yield sufficient for diagnostic RBC reagents. Ongoing challenges to generate RBCs for transfusion include recapitulating definitive erythropoiesis to produce functional adult-type cells, increasing scalability of culture conditions, and optimizing high-density manufacturing capacity.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology. 血小板 C 型凝集素样受体-2 及其配体 podoplanin 在血管生物学中的作用。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-06 DOI: 10.1097/MOH.0000000000000805
Katsue Suzuki-Inoue, Nagaharu Tsukiji
{"title":"A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology.","authors":"Katsue Suzuki-Inoue, Nagaharu Tsukiji","doi":"10.1097/MOH.0000000000000805","DOIUrl":"10.1097/MOH.0000000000000805","url":null,"abstract":"<p><strong>Purpose of review: </strong>Platelets are essential for hemostasis and are also vital in lymphatic and lung development and the maintenance of vascular integrity. Platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) and its endogenous ligand podoplanin (PDPN) in lymphatic endothelial cells (LECs) and other cells regulate these processes. This review aims to comprehensively summarize the roles of platelet CLEC-2 and PDPN. This review also focuses on discussing the underlying mechanisms by which platelet CLEC-2 and PDPN mediate blood/lymphatic separation.</p><p><strong>Findings: </strong>CLEC-2/PDPN-induced platelet activation in the primary lymph sacs, developmental lymphovenous junctions, neonatal mesentery, and the site of tumor lymphangiogenesis prevents blood/lymphatic vessel misconnection. Further, CLEC-2/PDPN-induced platelet activation is essential for lung development. Mice deficient in CLEC-2 or PDPN show blood-filled lymphatics, lung malformations, and cerebrovascular abnormalities. CLEC-2 deletion in steady-state adult mice did not result in blood/lymphatic vessel mixing. In adulthood, CLEC-2 maintains vascular integrity and that of high endothelial venules in lymph nodes. CLEC-2 deletion in adulthood results in hemorrhage under inflammatory conditions, and hemolymph nodes.</p><p><strong>Summary: </strong>The platelet CLEC-2/LEC PDPN interaction prevents blood/lymphatic vessel mixing at active remodeling sites of the blood/lymphatic system, but not in steady-state adult mice. This interaction also regulates vascular integrity when vascular permeability increases before and after birth.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of obesity-induced inflammation on clonal hematopoiesis. 肥胖引发的炎症对克隆造血的影响
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-22 DOI: 10.1097/moh.0000000000000819
Santhosh Kumar Pasupuleti, Reuben Kapur
{"title":"The impact of obesity-induced inflammation on clonal hematopoiesis.","authors":"Santhosh Kumar Pasupuleti, Reuben Kapur","doi":"10.1097/moh.0000000000000819","DOIUrl":"https://doi.org/10.1097/moh.0000000000000819","url":null,"abstract":"This review meticulously delves into existing literature and recent findings to elucidate the intricate link between obesity and clonal hematopoiesis of indeterminate potential (CHIP) associated clonal hematopoiesis. It aims to enhance our comprehension of this multifaceted association, offering insights into potential avenues for future research and therapeutic interventions.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics of hematopoietic stem cell aging. 造血干细胞衰老的表观遗传学。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-15 DOI: 10.1097/moh.0000000000000818
Takako Yokomizo, Motohiko Oshima, Atsushi Iwama
{"title":"Epigenetics of hematopoietic stem cell aging.","authors":"Takako Yokomizo, Motohiko Oshima, Atsushi Iwama","doi":"10.1097/moh.0000000000000818","DOIUrl":"https://doi.org/10.1097/moh.0000000000000818","url":null,"abstract":"The development of new antiaging medicines is of great interest to the current elderly and aging population. Aging of the hematopoietic system is attributed to the aging of hematopoietic stem cells (HSCs), and epigenetic alterations are the key effectors driving HSC aging. Understanding the epigenetics of HSC aging holds promise of providing new insights for combating HSC aging and age-related hematological malignancies.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fulfilled promise and unmet potential of umbilical cord blood. 脐带血已实现的承诺和尚未发挥的潜力。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-05 DOI: 10.1097/moh.0000000000000817
James Ropa, Wouter Van't Hof
{"title":"The fulfilled promise and unmet potential of umbilical cord blood.","authors":"James Ropa, Wouter Van't Hof","doi":"10.1097/moh.0000000000000817","DOIUrl":"https://doi.org/10.1097/moh.0000000000000817","url":null,"abstract":"Here, we review classic and emerging uses of umbilical cord blood and highlight strategies to improve its utility, focusing on selection of the appropriate units and cell types for the intended applications.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription factor regulation of ribosomal RNA in hematopoiesis. 核糖体 RNA 在造血过程中的转录因子调控。
IF 3.2 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-03 DOI: 10.1097/moh.0000000000000816
Vikram R Paralkar
{"title":"Transcription factor regulation of ribosomal RNA in hematopoiesis.","authors":"Vikram R Paralkar","doi":"10.1097/moh.0000000000000816","DOIUrl":"https://doi.org/10.1097/moh.0000000000000816","url":null,"abstract":"Ribosomal RNAs (rRNAs) are transcribed within nucleoli from rDNA repeats by RNA Polymerase I (Pol I). There is variation in rRNA transcription rates across the hematopoietic tree, and leukemic blast cells have prominent nucleoli, indicating abundant ribosome biogenesis. The mechanisms underlying these variations are poorly understood. The purpose of this review is to summarize findings of rDNA binding and Pol I regulation by hematopoietic transcription factors.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Desialylation by neuraminidases in platelets, kiss of death or bittersweet? 血小板中神经氨酸酶的去酰化作用，死亡之吻还是苦乐参半？
IF 3.1 3区 医学
Current Opinion in Hematology Pub Date : 2024-04-02 DOI: 10.1097/MOH.0000000000000815
Nora Butta, Dianne E van der Wal
{"title":"Desialylation by neuraminidases in platelets, kiss of death or bittersweet?","authors":"Nora Butta, Dianne E van der Wal","doi":"10.1097/MOH.0000000000000815","DOIUrl":"10.1097/MOH.0000000000000815","url":null,"abstract":"<p><strong>Purpose of review: </strong>Loss of surface sialic acid by neuraminidases is known as 'desialylation'. Platelets are desialylated in bacterial or viral infections, during storage, senescence, various mutations, platelet auto antibodies, hemostasis and shear stress. In this review the recent literature on the different sialic acid capped glycan structures will be covered as well as platelet desialylation in inherited glycan disorders and induced by external neuraminidases.</p><p><strong>Recent findings: </strong>Neuraminidases are released from platelet intracellular stores and translocated to the platelet surface. Apart from clearance, loss of surface sialic acid by neuraminidases ('desialylation') affects platelet signaling including ligand binding and their procoagulant function. Platelets are also desialylated in infections, various mutations, presence of platelet auto antibodies.</p><p><strong>Summary: </strong>Since platelet desialylation occurs in various healthy and pathological conditions, measuring desialylation might be a new diagnostic tool.</p>","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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