Current Opinion in Hematology最新文献_第5页

Developmental regulation of primitive erythropoiesis. 原始红细胞生成的发育调节。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI: 10.1097/MOH.0000000000000806

Marlies P Rossmann, James Palis

{"title":"Developmental regulation of primitive erythropoiesis.","authors":"Marlies P Rossmann, James Palis","doi":"10.1097/MOH.0000000000000806","DOIUrl":"10.1097/MOH.0000000000000806","url":null,"abstract":"Purpose of review: In this review, we present an overview of recent studies of primitive erythropoiesis, focusing on advances in deciphering its embryonic origin, defining species-specific differences in its developmental regulation, and better understanding the molecular and metabolic pathways involved in terminal differentiation.Recent findings: Single-cell transcriptomics combined with state-of-the-art lineage tracing approaches in unperturbed murine embryos have yielded new insights concerning the origin of the first (primitive) erythroid cells that arise from mesoderm-derived progenitors. Moreover, studies examining primitive erythropoiesis in rare early human embryo samples reveal an overall conservation of primitive erythroid ontogeny in mammals, albeit with some interesting differences such as localization of erythropoietin (EPO) production in the early embryo. Mechanistically, the repertoire of transcription factors that critically regulate primitive erythropoiesis has been expanded to include regulators of transcription elongation, as well as epigenetic modifiers such as the histone methyltransferase DOT1L. For the latter, noncanonical roles aside from enzymatic activity are being uncovered. Lastly, detailed surveys of the metabolic and proteomic landscape of primitive erythroid precursors reveal the activation of key metabolic pathways such as pentose phosphate pathway that are paralleled by a striking loss of mRNA translation machinery.Summary: The ability to interrogate single cells in vivo continues to yield new insights into the birth of the first essential organ system of the developing embryo. A comparison of the regulation of primitive and definitive erythropoiesis, as well as the interplay of the different layers of regulation - transcriptional, epigenetic, and metabolic - will be critical in achieving the goal of faithfully generating erythroid cells in vitro for therapeutic purposes.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"71-81"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology. 血小板 C 型凝集素样受体-2 及其配体 podoplanin 在血管生物学中的作用。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-06 DOI: 10.1097/MOH.0000000000000805

Katsue Suzuki-Inoue, Nagaharu Tsukiji

{"title":"A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology.","authors":"Katsue Suzuki-Inoue, Nagaharu Tsukiji","doi":"10.1097/MOH.0000000000000805","DOIUrl":"10.1097/MOH.0000000000000805","url":null,"abstract":"Purpose of review: Platelets are essential for hemostasis and are also vital in lymphatic and lung development and the maintenance of vascular integrity. Platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) and its endogenous ligand podoplanin (PDPN) in lymphatic endothelial cells (LECs) and other cells regulate these processes. This review aims to comprehensively summarize the roles of platelet CLEC-2 and PDPN. This review also focuses on discussing the underlying mechanisms by which platelet CLEC-2 and PDPN mediate blood/lymphatic separation.Findings: CLEC-2/PDPN-induced platelet activation in the primary lymph sacs, developmental lymphovenous junctions, neonatal mesentery, and the site of tumor lymphangiogenesis prevents blood/lymphatic vessel misconnection. Further, CLEC-2/PDPN-induced platelet activation is essential for lung development. Mice deficient in CLEC-2 or PDPN show blood-filled lymphatics, lung malformations, and cerebrovascular abnormalities. CLEC-2 deletion in steady-state adult mice did not result in blood/lymphatic vessel mixing. In adulthood, CLEC-2 maintains vascular integrity and that of high endothelial venules in lymph nodes. CLEC-2 deletion in adulthood results in hemorrhage under inflammatory conditions, and hemolymph nodes.Summary: The platelet CLEC-2/LEC PDPN interaction prevents blood/lymphatic vessel mixing at active remodeling sites of the blood/lymphatic system, but not in steady-state adult mice. This interaction also regulates vascular integrity when vascular permeability increases before and after birth.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"130-139"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of red blood cells from induced pluripotent stem cells. 用诱导多能干细胞生成红细胞。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-05-01 Epub Date: 2024-02-13 DOI: 10.1097/MOH.0000000000000810

Naomi Gunawardena, Stella T Chou

引用次数: 0

The impact of obesity-induced inflammation on clonal hematopoiesis. 肥胖引发的炎症对克隆造血的影响

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-04-22 DOI: 10.1097/moh.0000000000000819

Santhosh Kumar Pasupuleti, Reuben Kapur

引用次数: 0

Epigenetics of hematopoietic stem cell aging. 造血干细胞衰老的表观遗传学。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-04-15 DOI: 10.1097/moh.0000000000000818

Takako Yokomizo, Motohiko Oshima, Atsushi Iwama

引用次数: 0

The fulfilled promise and unmet potential of umbilical cord blood. 脐带血已实现的承诺和尚未发挥的潜力。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-04-05 DOI: 10.1097/moh.0000000000000817

James Ropa, Wouter Van't Hof

引用次数: 0

Transcription factor regulation of ribosomal RNA in hematopoiesis. 核糖体 RNA 在造血过程中的转录因子调控。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-04-03 DOI: 10.1097/moh.0000000000000816

Vikram R Paralkar

引用次数: 0

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2023-12-15 DOI: 10.1097/MOH.0000000000000798

Tal Bacharach, Nathali Kaushansky, Liran I Shlush

{"title":"Age-related micro-environmental changes as drivers of clonal hematopoiesis.","authors":"Tal Bacharach, Nathali Kaushansky, Liran I Shlush","doi":"10.1097/MOH.0000000000000798","DOIUrl":"10.1097/MOH.0000000000000798","url":null,"abstract":"Purpose of review: Both aging and reduced diversity at the hematopoietic stem cells (HSCs) level are ubiquitous. What remains unclear is why some individuals develop clonal hematopoiesis (CH), and why does CH due to specific mutations occur in specific individuals. Much like aging, reduced diversity of HSCs is a complex phenotype shaped by numerous factors (germline & environment). The purpose of the current review is to discuss the role of two other age-related ubiquitous processes that might contribute to the dynamics and characteristics of losing HSC diversity and the evolution of CH. These processes have not been reviewed in depth so far and include the accumulation of fatty bone marrow (FBM), and the decline in sex hormones.Recent findings: Interestingly, sex hormone decline can directly shape HSC function, but also reshape the delicate balance of BM supporting cells, with a shift towards FBM. FBM accumulation can shape the clonal expansion of preleukemic mutations, particularly DNMT3A mutations, through IL-6 mediation. DNMT3A mutations are one of the only preleukemic mutations which is more prevalent in women, and especially in women with early menopause, demonstrating an association between age-related hormone decline and CH evolution, the mechanisms of which are yet to be discovered.Summary: Aging is a multifactorial phenotype and the same is true for the aging of the blood system. While many factors which can shape CH have been discussed, we shed more light on FBM and sex hormone decline. Much more is missing: how and should we even try to prevent these phenomena? Why do they occur? and how they are connected to other age-related blood factors?","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"53-57"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI: 10.1097/MOH.0000000000000801

引用次数: 0

Disparities in acute myeloid leukemia treatments and outcomes. 急性髓性白血病治疗和预后的差异。

IF 3.2 3区医学

Current Opinion in Hematology Pub Date : 2024-03-01 Epub Date: 2023-12-07 DOI: 10.1097/MOH.0000000000000797

Ann-Kathrin Eisfeld

{"title":"Disparities in acute myeloid leukemia treatments and outcomes.","authors":"Ann-Kathrin Eisfeld","doi":"10.1097/MOH.0000000000000797","DOIUrl":"10.1097/MOH.0000000000000797","url":null,"abstract":"Purpose of review: This review aims to summarize different contributors to survival disparities in acute myeloid leukemia (AML) patients. The focus is set on African-American (hereafter referred to as Black) patients, with separate consideration of self-reported race and ancestry. It aims to also highlight the interconnectivity of the different features that impact on despair survival.Recent findings: The main themes in the literature covered in this article include the impact of social deprivation, clinical trial enrollment and biobanking, structural racism and ancestry-associated differences in genetic features on survival outcomes.Summary: An increasing number of studies have not only shown persistent survival disparities between Black and non-Hispanic White AML patients, but uncovered a multitude of contributors that have additive adverse effects on patient outcomes. In addition to potentially modifiable features, such as socioeconomic factors and trial enrollment odds that require urgent interventions, there is emerging data on differences in disease biology with respect to genetic ancestry, including frequencies of known AML-driver mutations and their associated prognostic impact.","PeriodicalId":55196,"journal":{"name":"Current Opinion in Hematology","volume":" ","pages":"58-63"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0