Platelet Fc gamma RIIA: time to go beyond the unknown.

IF 3.1 3区医学 Q2 HEMATOLOGY

Current Opinion in Hematology Pub Date : 2025-07-08 DOI:10.1097/MOH.0000000000000881

Izabella Andrianova, Rattanawan Thubthed, Frederik Denorme

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引用次数: 0

Abstract

Purpose of review: Increasing evidence has shown that immune and thrombotic pathways cooperate to ensure efficient immune and hemostatic functions. Due to their involvement in various cardiovascular and inflammatory conditions, this interplay has gained significant interest, leading to many important discoveries. However, difference between mice and humans have limited the translatability of some of these findings. One key receptor involved in immuno-thrombosis but lacking in mice is the Fc gamma receptor IIA (FcγRIIA).

Recent findings: Innovative in-vitro and in-vivo models for anti-PF4 immune disorders have greatly impacted our understanding of the role of FcγRIIA in these disorders and has revealed novel therapeutic strategies with great translational potential. Epideminological studies have hinted at a role for FcγRIIA in cardiovascular diseases; however, conclusive mechanistic studies are currently lacking.

Summary: Humanized transgenic FcγRIIA mice have greatly advanced our understanding of the role of FcγRIIA in anti-PF4 immune disorders, immune thrombocytopenia and lupus; however, they have only rarely been used in models of thrombo-inflammation. To improve translation from bench to bedside, inclusion of FcγRIIA transgenic mouse models is encouraged.

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血小板Fc γ RIIA：时间超越未知。

综述目的：越来越多的证据表明，免疫和血栓形成途径共同确保有效的免疫和止血功能。由于它们参与各种心血管和炎症疾病，这种相互作用引起了极大的兴趣，导致了许多重要的发现。然而，小鼠和人类之间的差异限制了这些发现的可翻译性。一种参与免疫血栓形成但在小鼠中缺乏的关键受体是Fcγ受体IIA （Fcγ riia）。最新发现：创新的抗pf4免疫疾病的体外和体内模型极大地影响了我们对FcγRIIA在这些疾病中的作用的理解，并揭示了具有巨大转化潜力的新治疗策略。流行病学研究提示fc - γ - riia在心血管疾病中的作用；然而，目前尚无结论性的机制研究。摘要：人源化转基因fc - γ - riia小鼠极大地促进了我们对fc - γ - riia在抗pf4免疫疾病、免疫性血小板减少症和狼疮中的作用的认识；然而，它们很少用于血栓炎症模型。为了提高从实验室到临床的转化，鼓励纳入FcγRIIA转基因小鼠模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Hematology 医学-血液学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.