造血干细胞衰老的表观遗传学。

IF 3.1 3区医学 Q2 HEMATOLOGY

Current Opinion in Hematology Pub Date : 2024-04-15 DOI:10.1097/moh.0000000000000818

Takako Yokomizo, Motohiko Oshima, Atsushi Iwama

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引用次数: 0

摘要

开发新的抗衰老药物对当前的老年人和老龄化人口具有重大意义。造血系统的衰老归因于造血干细胞（HSCs）的衰老，而表观遗传学改变是驱动造血干细胞衰老的关键效应因子。了解造血干细胞衰老的表观遗传学有望为抗击造血干细胞衰老和与年龄相关的血液恶性肿瘤提供新的见解。

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Epigenetics of hematopoietic stem cell aging.

The development of new antiaging medicines is of great interest to the current elderly and aging population. Aging of the hematopoietic system is attributed to the aging of hematopoietic stem cells (HSCs), and epigenetic alterations are the key effectors driving HSC aging. Understanding the epigenetics of HSC aging holds promise of providing new insights for combating HSC aging and age-related hematological malignancies.

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来源期刊

Current Opinion in Hematology 医学-血液学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.