Current Opinion in Otolaryngology & Head and Neck Surgery最新文献

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Surgical management of orbital tumors. 眼眶肿瘤的外科治疗。
IF 2 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1097/MOO.0000000000001106
Alperen Vural, Metin Unlu, Izzat Mammadov
{"title":"Surgical management of orbital tumors.","authors":"Alperen Vural, Metin Unlu, Izzat Mammadov","doi":"10.1097/MOO.0000000000001106","DOIUrl":"10.1097/MOO.0000000000001106","url":null,"abstract":"<p><strong>Purpose of review: </strong>Intraorbital tumors present unique surgical challenges due to their proximity to critical neurovascular structures. This review examines current surgical approaches, emerging techniques, and outcomes in the management of these complex lesions.</p><p><strong>Recent findings: </strong>Minimally invasive endoscopic approaches have expanded treatment options, particularly for medially and inferiorly located tumors. Classification systems such as CHEER and ORBIT now guide surgical planning based on anatomic location. Integration of image guidance, three-dimensional modeling, radiomics, and early reports of robotic assistance are promising adjuncts improving preoperative assessment and surgical precision.</p><p><strong>Summary: </strong>Surgical management of intraorbital tumors has evolved significantly, with both traditional and endoscopic approaches achieving high rates of tumor control and functional preservation. A multidisciplinary approach, individualized surgical planning, and careful patient selection are essential for optimal outcomes.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"109-119"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Head and neck adnexal skin cancers. 头颈部附件皮肤癌。
IF 2 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2025-11-19 DOI: 10.1097/MOO.0000000000001097
Cecilia Molendi, Alessandra Sordi, Isabelle Dohin, Vincenzo Maione, Davide Mattavelli, Cesare Piazza
{"title":"Head and neck adnexal skin cancers.","authors":"Cecilia Molendi, Alessandra Sordi, Isabelle Dohin, Vincenzo Maione, Davide Mattavelli, Cesare Piazza","doi":"10.1097/MOO.0000000000001097","DOIUrl":"10.1097/MOO.0000000000001097","url":null,"abstract":"<p><strong>Purpose of review: </strong>Adnexal carcinomas (AC) are rare skin lesions predominantly affecting elderly individuals. These tumors are often located in the head and neck region and are influenced by factors such as sun exposure, prior radiation therapy, and immunosuppression. Understanding the pathogenesis and management of AC is crucial for improving patient outcomes.</p><p><strong>Recent findings: </strong>AC may arise de novo or from preexisting benign lesions. They may act as cutaneous markers for hereditary syndromes, highlighting the need for their early identification. Accurate diagnosis is critical, requiring adequate biopsy for proper characterization, as superficial excisions may lead to mistakes. Surgical treatment remains the primary approach, with wide (at least 1 cm) surgical margins also recommended for lesions with lower malignancy potential. Mohs surgery is particularly useful for tumors located in cosmetically sensitive areas, offering precise resection and clear margins.</p><p><strong>Summary: </strong>AC are classified into good, intermediate or poor prognosis categories based on the risk of local recurrence and distant metastasis. This classification assists in determining the need for adjuvant treatments and follow-up strategies. The proper understanding of risk factors, pathogenesis, and treatment options is essential to improve outcomes and ensure optimal management of AC.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"67-78"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surveillance after treatment for head and neck cancer. 头颈癌治疗后的监测。
IF 1.4 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI: 10.1097/MOO.0000000000001102
Petri Koivunen
{"title":"Surveillance after treatment for head and neck cancer.","authors":"Petri Koivunen","doi":"10.1097/MOO.0000000000001102","DOIUrl":"10.1097/MOO.0000000000001102","url":null,"abstract":"<p><strong>Purpose of review: </strong>Systematic follow-up protocols, often including regular imaging, are an essential component of posttreatment care for head and neck cancer, aimed at the early detection of disease relapse and mitigating treatment-related morbidity. However, there is no consensus on the optimal length of follow-up and the value of imaging in surveillance.</p><p><strong>Recent findings: </strong>Most head and neck cancer recurrences occur within 1-2 years after treatment. After 2 years, the recurrence rate decreases significantly, and after 3 years, recurrences are infrequent. Most of the recent studies suggest that prolonged scheduled follow-up programs are not necessary, as asymptomatic salvageable late recurrences are rare. Imaging surveillance for the early detection of otherwise undetected recurrences is supported by many studies, although its impact on survival remains unclear.</p><p><strong>Summary: </strong>Recent literature emphasizes intensive follow-up programs during 1-2 years, as well as patient education for self-observation of alarming symptoms. Prolonged surveillance programs after 2-3 years may not be effective in detecting asymptomatic recurrences. While personalized surveillance based on risk factors is suggested, a lack of strict evidence hampers stratification. Imaging may be of value in detecting early asymptomatic recurrences at least up to 2 years, but disagreement exists regarding its utility in improving survival.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"83-87"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of recent advancements in oropharyngeal reconstruction for transoral robotic surgery defects: emerging techniques, functional preservation, and technological innovations. 回顾经口机器人手术缺陷口咽重建的最新进展:新兴技术、功能保存和技术创新。
IF 1.4 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI: 10.1097/MOO.0000000000001115
Annie E Arrighi-Allisan, Robert M Brody, Steven B Cannady
{"title":"Review of recent advancements in oropharyngeal reconstruction for transoral robotic surgery defects: emerging techniques, functional preservation, and technological innovations.","authors":"Annie E Arrighi-Allisan, Robert M Brody, Steven B Cannady","doi":"10.1097/MOO.0000000000001115","DOIUrl":"10.1097/MOO.0000000000001115","url":null,"abstract":"<p><strong>Purpose of review: </strong>The dynamic reconstruction of oropharyngeal defects demands tailored solutions that balance functional, aesthetic, and oncologic priorities. This review synthesizes advancements in reconstructive techniques over the last 18  months, contextualized within the evolving landscape of oropharyngeal disease, and highlights innovations that prioritize both surgical efficacy and quality of life.</p><p><strong>Recent findings: </strong>Recent studies underscore the importance of tailored, functionally focused reconstructive strategies, integrating robotic-assisted surgery and tunneled, folded, or super-thin flaps. Buccinator myomucosal and lateral arm flaps have garnered attention for their versatility and low morbidity, while platelet-rich fibrin and tissue plug modifications have shown promise in reducing common reconstructive complications such as pharyngocutaneous fistulas. Other studies have addressed the impact of prior or upcoming radiation on reconstructive approach. Many emphasize quality of life and aesthetic measures, representing a shift toward survivorship over solely objective outcomes.</p><p><strong>Summary: </strong>Modern oropharyngeal reconstruction emphasizes patient-specific and function-preserving strategies that necessitate biologic adjuncts and nuanced surgical planning. However, the lack of prospective studies, standardized outcome measures, and comparator groups underscores the need for future research to ensure broader applicability and improved reliability of these approaches.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"120-126"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: an update. 具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤:最新进展。
IF 2 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2025-11-10 DOI: 10.1097/MOO.0000000000001098
Nadia H Van Den Berg, Linda Feeley, Patrick Sheahan
{"title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: an update.","authors":"Nadia H Van Den Berg, Linda Feeley, Patrick Sheahan","doi":"10.1097/MOO.0000000000001098","DOIUrl":"10.1097/MOO.0000000000001098","url":null,"abstract":"<p><strong>Purpose of review: </strong>Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has been recognized as a diagnostic entity since 2017. It has been shown to exhibit indolent behaviour, and lobectomy alone is advocated as the treatment of choice. In this review, the diagnostic challenges including interobserver variation, the role of artificial intelligence, and the latest data on the risk of recurrence or metastasis, is evaluated.</p><p><strong>Recent findings: </strong>Diagnosis of NIFTP is reliant on examination of the entire tumour-parenchymal interface. Strict criteria are required in order to establish a diagnosis. Inter-observer variation exists even among experienced thyroid pathologists. Recent studies continue to support the nonaggressive nature of NIFTP lesions.</p><p><strong>Summary: </strong>NIFTP is considered a low risk follicular-cell derived thyroid neoplasm. Adherence to diagnostic criteria is crucial in accurately applying the diagnosis. Further long-term follow up is required in order to establish guidelines on the long term management of these patients.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"88-93"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconstructive options and issues after extensive infratemporal fossa clearance for bucco-alveolar cancer. 颞下窝广泛清除治疗颊-肺泡癌后重建的选择和问题。
IF 1.4 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1097/MOO.0000000000001108
Karthik N Rao, Radhika Kapatia, Sreeram Mp
{"title":"Reconstructive options and issues after extensive infratemporal fossa clearance for bucco-alveolar cancer.","authors":"Karthik N Rao, Radhika Kapatia, Sreeram Mp","doi":"10.1097/MOO.0000000000001108","DOIUrl":"10.1097/MOO.0000000000001108","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review addresses the timely and relevant challenge of reconstructing extensive infratemporal fossa defects following composite bucco-alveolar cancer resection. The complexity of these three-dimensional defects, involving mucosa, soft tissue, and skin, alongside the frequent need for adjuvant radiation and the proximity to dissected cervical vessels, necessitates a deliberate and robust reconstructive strategy.</p><p><strong>Recent findings: </strong>Recent literature underscores a shift towards a structured, component-based reconstructive approach. This review details the utility and specific limitations of regional pedicled and microvascular free flap options to restore critical elements: bulk, reliable lining, and durable external cover. Key technical considerations prominently discussed include managing vessel-depleted necks, utilizing vein grafts, mitigating risks associated with postchemotherapy thrombosis, and planning for salvage surgery.</p><p><strong>Summary: </strong>The reviewed evidence supports a tailored, flap-specific approach based on defect components and patient-specific risk factors. For optimal outcomes in this complex anatomical region, surgical planning must prioritize the introduction of well vascularized tissue to ensure healing, protect vital structures, and withstand adjuvant therapies, thereby reducing complications and facilitating rehabilitation.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"100-108"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent nasopharyngeal carcinoma: treatment outcomes and morbidity. 复发性鼻咽癌:治疗结果及发病率。
IF 2 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2025-12-29 DOI: 10.1097/MOO.0000000000001107
Vittorio Rampinelli, Claudia Lodovica Modesti, Alessandro Vinciguerra, Cesare Piazza
{"title":"Recurrent nasopharyngeal carcinoma: treatment outcomes and morbidity.","authors":"Vittorio Rampinelli, Claudia Lodovica Modesti, Alessandro Vinciguerra, Cesare Piazza","doi":"10.1097/MOO.0000000000001107","DOIUrl":"10.1097/MOO.0000000000001107","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review highlights current management strategies for recurrent nasopharyngeal carcinoma (NPC) and their balance between efficacy and toxicity.</p><p><strong>Recent findings: </strong>Optimal management of recurrent NPC requires individualized, multidisciplinary decisions that consider not only oncologic control but also functional outcomes and toxicity. Advances in imaging and Epstein--Barr virus DNA monitoring are improving early detection and risk stratification, helping tailor salvage approach to patient and disease factors. Recent evidences also shows that severe toxicity is not only modality-dependent but is shaped by patient and disease-related factors.</p><p><strong>Summary: </strong>Endoscopic nasopharyngectomy achieves the best outcomes in resectable cases, with higher survival and lower morbidity than re-irradiation (re-RT). Extended resections are feasible only in selected cases. Re-RT, particularly with hyperfractionated intensity-modulated RT or proton therapy, remains essential for unresectable tumors but demands careful patient selection and vigilant management of late adverse effects. Systemic therapy has uncertain benefit, while immunotherapy is mostly effective in metastatic disease. Nodal recurrence is mainly managed with neck dissection, with prognosis shaped by extranodal spread and recurrence type.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"94-99"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary management of paediatric head and neck teratomas. 儿科头颈部畸胎瘤的当代处理。
IF 1.4 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1097/MOO.0000000000001114
Jacquline Chan, Sara Badrol, Michael Kuo
{"title":"Contemporary management of paediatric head and neck teratomas.","authors":"Jacquline Chan, Sara Badrol, Michael Kuo","doi":"10.1097/MOO.0000000000001114","DOIUrl":"10.1097/MOO.0000000000001114","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarise current understanding of and highlight recent literature on the management of paediatric head and neck teratomas.</p><p><strong>Recent findings: </strong>Advances in foetal ultrasonography and MRI have enhanced early detection and anatomical characterisation, allowing for birth planning. The tracheoesophageal displacement index (TEDI) offers a predictive tool for airway risk. The EXIT (ex utero intrapartum treatment) procedure remains critical for airway control in high-risk cases, with foetal endoscopic tracheal intubation (FETI) emerging as a minimally invasive alternative. While histologically immature teratomas were previously thought to carry higher malignant potential, recent studies challenge this assumption. Complete surgical resection remains the cornerstone of treatment, with increasing use of intraoperative nerve monitoring. The role of adjuvant chemotherapy remains unclear, with limited evidence of efficacy in immature tumours.</p><p><strong>Summary: </strong>Contemporary management of paediatric head and neck teratomas prioritises early identification, airway safety, and complete resection. Innovations in foetal imaging and perinatal planning have reduced morbidity, while long-term outcomes remain favourable. Ongoing research into minimally invasive foetal interventions and tumour biology is essential to further optimise care.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"79-82"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The continuous evolution of concepts in compartmental resections for oral cavity cancer: principles, indications, and outcomes. 口腔癌隔室切除术概念的不断演变:原则、适应症和结果。
IF 1.4 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI: 10.1097/MOO.0000000000001110
Claudia Montenegro, Alberto Grammatica, Cesare Piazza
{"title":"The continuous evolution of concepts in compartmental resections for oral cavity cancer: principles, indications, and outcomes.","authors":"Claudia Montenegro, Alberto Grammatica, Cesare Piazza","doi":"10.1097/MOO.0000000000001110","DOIUrl":"10.1097/MOO.0000000000001110","url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper is aimed at synthetizing the conceptual basis of compartmental surgery (CS) for tumours of the anterior (floor of mouth and oral tongue) as well as posterior (base of tongue, superior and inferior gingival-buccal sulcus extending into the masticator space and infratemporal fossa) oral cavity, its indications, and outcomes.</p><p><strong>Recent findings: </strong>In spite of numerous bioendoscopic, radiological, and surgical advancements in management of oral cancer, its oncologic surgical control continues to be hampered by a considerable risk of local recurrence rate. Use of a conventional approach based on an empirical 5 mm safe margin surrounding the lesion in its three-dimensional extension, even when associated to accurate frozen sections techniques, seems inadequate to improve the oncologic outcomes of these patients in the near future. In contrast, application of the CS concepts herein detailed seems to open new opportunities for increasing surgical radicality, while maintaining adequate functional outcomes when proper reconstructive techniques are applied.</p><p><strong>Summary: </strong>Even though further multicentric prospective studies are needed to confirm the replicability of the oncological results described by pioneers of the CS approach, as well as to quantify the functional outcomes obtained by its large-scale application, this surgical philosophy confirms its vitality, relentless diffusion, and progressive evolution in the head and neck cancer arena.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"127-135"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing endotypes in chronic rhinosinusitis: emerging research and clinical applications. 表征慢性鼻窦炎的内源性:新兴研究和临床应用。
IF 2 4区 医学
Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2026-02-01 Epub Date: 2025-12-24 DOI: 10.1097/MOO.0000000000001105
Steven Chun-Kang Liao, Brooke N Gleason, Bruce K Tan
{"title":"Characterizing endotypes in chronic rhinosinusitis: emerging research and clinical applications.","authors":"Steven Chun-Kang Liao, Brooke N Gleason, Bruce K Tan","doi":"10.1097/MOO.0000000000001105","DOIUrl":"10.1097/MOO.0000000000001105","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this study is to describe why this review is timely and relevant. Endotyping, the organization of rhinologic inflammation around immunologic precepts, has evolved from a research subject to a clinically relevant tool with the advent of targeted biologics in chronic rhinosinusitis (CRS). This review highlights recent progress but also the challenges to implementing endotype-based care into routine clinical practice.</p><p><strong>Recent findings: </strong>Describe the main themes in the literature covered by the article. Recent literature demonstrates organization of patients around multiple endotypes, most prominently Type 2, Type 1/3, pauci-inflammation, and mixed inflammatory profiles. Three principal approaches to endotyping have been widely utilized: cellular (histology-based) analysis, single-biomarker, and multibiomarkers assays. Emerging machine-learning models further enhance data-driven multibiomarkers classification. Importantly, developed endotypes demonstrate correlates with key clinical features, postoperative outcomes, and responsiveness to sinus surgery and biologic therapy.</p><p><strong>Summary: </strong>Describe the implications of the findings for clinical practice or research. Increase use of precision biologics necessitates developing well validated endotypes to better select therapy for patients. Three major approaches - histology-based, single-biomarker, and multibiomarker strategies - are commonly employed, each with distinct advantages and limitations. Moving forward, standardization of methods, development of cost-effective testing, and rigorous clinical validation remain essential steps.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"16-27"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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