Invasive fungal rhinosinusitis: current evidence and research opportunities.

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2024-07-19 DOI:10.1097/MOO.0000000000000993

Jenny Ji, Lauren T Roland

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引用次数: 0

Abstract

Purpose of review: To summarize the evidence surrounding diagnosis, treatment, prognosis, and surveillance of patients with acute invasive fungal sinusitis (AIFS) and discuss future research needs.

Recent findings: New risk factors for AIFS such as COVID have been identified, and a new prognostic staging system has been developed.

Summary: Most patients who develop AIFS are immunocompromised, with the majority having a history of diabetes or a hematologic malignancy. Unfortunately, there are not any highly sensitive and specific diagnostic tools. Therefore, a combination of signs and symptoms, imaging, endoscopy, biopsy, and labs should be used to diagnosis AIFS. Although surgery and systemic antifungals are known to improve outcomes, there is limited data on time to intervention, duration of antifungals, and surveillance patterns. There is also limited information on factors that can predict outcomes in AIFS patients. However, sensory/perceptual changes, prolonged neutropenia duration, and comorbidity burden may be associated with a poor prognosis.

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侵袭性真菌性鼻炎：现有证据与研究机会。

综述的目的：总结与急性侵袭性真菌性鼻窦炎（AIFS）患者的诊断、治疗、预后和监测有关的证据，并讨论未来的研究需求：摘要：大多数罹患急性侵袭性真菌性鼻窦炎的患者免疫力低下，大多数患者有糖尿病或血液系统恶性肿瘤病史。遗憾的是，目前还没有高度敏感和特异的诊断工具。因此，诊断 AIFS 时应综合使用体征和症状、影像学检查、内窥镜检查、活组织检查和实验室检查。虽然已知手术和全身性抗真菌药物可改善预后，但有关干预时间、抗真菌药物持续时间和监测模式的数据却很有限。有关 AIFS 患者预后因素的信息也很有限。然而，感觉/知觉改变、中性粒细胞减少持续时间延长以及合并症负担可能与预后不良有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Otolaryngology & Head and Neck Surgery OTORHINOLARYNGOLOGY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Otolaryngology & Head and Neck Surgery is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including maxillofacial surgery, head and neck oncology and speech therapy and rehabilitation – every issue also contains annotated references detailing the merits of the most important papers.