Saangyoung E Lee, Margaret T Dillon, Kevin D Brown
{"title":"Anatomy-based fitting for cochlear implant recipients.","authors":"Saangyoung E Lee, Margaret T Dillon, Kevin D Brown","doi":"10.1097/MOO.0000000000001146","DOIUrl":"10.1097/MOO.0000000000001146","url":null,"abstract":"<p><strong>Purpose of review: </strong>Frequency-to-place mismatch is the discrepancy between the frequency information delivered by a cochlear implant electrode and the natural cochlear place frequency location that is stimulated. Frequency-to-place mismatch has been shown to negatively influence cochlear implant outcomes. Anatomy-based fitting (ABF) aligns filter frequencies with cochlear frequency place to minimize or eliminate frequency-to-place mismatches. This article reviews the current evidence on variability in electrode array placement, influence of frequency-to-place mismatches on cochlear implant recipient outcomes, and effectiveness of ABF procedures.</p><p><strong>Recent findings: </strong>Most ABF procedures identify the angular insertion depth of the electrode contacts using imaging, calculate the cochlear place frequency, and then adjust filter frequencies for each electrode contact to match the cochlear place frequencies. While the specific approach varies across ABF procedures, studies generally report improvements in speech recognition in noise, music perception, user satisfaction, and/or sound quality as compared to default maps. What remains unclear are the long-term outcomes between default and ABF procedures, if there is a preferred frequency-to-place function when determining cochlear place, and whether there is an optimal ABF procedure for cochlear implant and electric-acoustic stimulation device users.</p><p><strong>Summary: </strong>Early evidence of cochlear implant recipients listening with ABF maps demonstrates better results compared to maps with default settings.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"321-325"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan M Bernstein, Margaret M Coffey, Simon H Wood
{"title":"Flap selection for circumferential pharyngeal reconstruction.","authors":"Jonathan M Bernstein, Margaret M Coffey, Simon H Wood","doi":"10.1097/MOO.0000000000001140","DOIUrl":"10.1097/MOO.0000000000001140","url":null,"abstract":"<p><strong>Purpose of review: </strong>Six systematic reviews and meta-analyses (2019-2025) have compared reconstructive options for circumferential pharyngeal defects following total laryngopharyngectomy. This narrative review synthesises their findings, examines where they conflict and why their conclusions diverge, and weighs factors that fall below systematic-review level but affect flap selection.</p><p><strong>Recent findings: </strong>Free jejunal flap (FJF) demonstrates the lowest fistula rate (8-11%); in the largest network meta-analysis (1357 patients), FJF had a 93% probability of ranking first for fistula avoidance. Tubed anterolateral thigh (ALT) showed non-significant trends toward lower flap failure and 30-day mortality. Differences in fistula rates between FJF and ALT vary with analytical method. Stricture rates overlap (FJF 11-20%, ALT 13-19%) and should not drive flap choice. Adjuvant radiation therapy is associated with a near five-fold increase in FJF stricture; this concern recedes in salvage cases. The U-shaped pectoralis major flap had the lowest stricture rate in the network meta-analysis.</p><p><strong>Summary: </strong>Flap selection requires balancing fistula risk against perioperative mortality and donor-site morbidity, modified by defect extent, thigh adiposity, anticipated radiation therapy, and institutional experience. No randomised trials exist. Progress will require prospective comparative data and regionalisation.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"362-368"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances towards biological hearing restoration by genetic reprogramming.","authors":"Melissa M McGovern, Andrew K Groves","doi":"10.1097/MOO.0000000000001148","DOIUrl":"10.1097/MOO.0000000000001148","url":null,"abstract":"<p><strong>Purpose of review: </strong>Advances in genetic reprogramming and groundbreaking first-in-human gene therapy trials have generated significant momentum for treating sensorineural hearing loss. This review evaluates the expanding potential of biological approaches for hearing restoration.</p><p><strong>Recent findings: </strong>The mammalian organ of Corti possesses limited natural regenerative capacity. Recent studies are attempting to restore hearing by genetically reprogramming supporting cells into hair cells. While merely modulating cell signaling pathways in the inner ear is currently insufficient to regenerate hair cells, expressing hair cell-specific specific transcription factors can partially activate hair cell identity. However, current attempts at reprogramming are only partially successful, yielding only immature and nonfunctional \"hair cell-like cells.\"</p><p><strong>Summary: </strong>To develop viable gene therapies, future research must identify the molecular mechanisms that maintain supporting cell identity in the mature cochlea. Targeting and suppressing these gene networks in addition to activating hair cell gene networks is essential to improve the complete transition of supporting cells into functional hair cells, paving the way for translating these regenerative strategies into effective clinical treatments.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"303-307"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam Omari, Andreas Frithioff, Steven Arild Wuyts Andersen
{"title":"Advances in patient-specific 3D-printed models in temporal bone surgery.","authors":"Adam Omari, Andreas Frithioff, Steven Arild Wuyts Andersen","doi":"10.1097/MOO.0000000000001143","DOIUrl":"10.1097/MOO.0000000000001143","url":null,"abstract":"<p><strong>Purpose of review: </strong>Temporal bone surgery requires high precision drilling near critical anatomical structures. Traditional planning relies on expertise and the mental reconstruction of 2D imaging, which is cognitively demanding and might lead to errors. This review provides an overview on the steps required to generate accurate models and the current state of patient-specific 3D-printed models as tools for preoperative rehearsal, intraoperative navigation, and patient communication.</p><p><strong>Recent findings: </strong>Advances in high-resolution imaging, segmentation routines and 3D-printers have streamlined the creation of patient-specific replicas of the temporal bone. Reports demonstrate that physical rehearsal on these models could aid determining surgical corridors, safely navigate aberrant anatomy, and refine approaches for accessing complex pathology. In the operating room, these models can serve as 3D references, potentially reducing the cognitive load associated with interpreting traditional 2D imaging data. 3D-printed models might improve patient comprehension and shared decision-making by translating abstract data into a tangible format despite limited reports in temporal bone surgery.</p><p><strong>Summary: </strong>Patient-specific models show immense promise for enhancing surgical precision and safety, but the current literature is limited by a lack of high-level evidence and standardized reporting. Future research must transition from feasibility studies to rigorous clinical validation before these models are introduced into clinical standard of care.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"342-348"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A translational framework for early-phase inner-ear gene therapy: clinical trial design, regulatory strategy, and ethical considerations.","authors":"Emma C Dunn, Spencer H Short, Ravi N Samy","doi":"10.1097/MOO.0000000000001155","DOIUrl":"10.1097/MOO.0000000000001155","url":null,"abstract":"<p><strong>Purpose of review: </strong>Hereditary hearing loss has historically been approached as a diagnostic category rather than a therapeutically modifiable disease. Recent advances in molecular genetics, cochlear gene delivery, and first-in-human clinical trials are changing that. This review summarizes contemporary progress in the genetics of hearing loss, with emphasis on emerging gene-based therapies, clinical trial design, regulatory and ethical considerations, and practical implications for otolaryngologists as biologic treatment enters clinical practice.</p><p><strong>Recent findings: </strong>Early clinical trials targeting OTOF -related DFNB9 deafness have demonstrated satisfactory safety profiles and meaningful auditory recovery, establishing the first proof-of-concept for cochlear gene therapy in humans, culminating in the April 2026 FDA approval of Otarmeni. Genetic diagnoses are increasingly informing prognosis, cochlear implant counseling, and therapeutic candidacy. Preclinical research continues to expand toward recessive, dominant, and syndromic hearing loss using gene replacement, antisense, RNA interference, and genome-editing strategies. Substantial challenges remain, including heterogeneous outcome measures, uncertain long-term efficacy, regulatory complexity, and inequitable global access.</p><p><strong>Summary: </strong>The genetics of hearing loss is transitioning from a diagnostic modality to an interventional one. Widespread clinical impact will require advances in vector engineering, equitable implementation, multidisciplinary counseling, and integration with established rehabilitation pathways. For otolaryngologists, genetic literacy is becoming essential to contemporary hearing care.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"315-320"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tympanomastoidectomy canal wall reconstruction with mastoid obliteration.","authors":"Adam S Vesole, Ravi N Samy","doi":"10.1097/MOO.0000000000001157","DOIUrl":"10.1097/MOO.0000000000001157","url":null,"abstract":"<p><strong>Purpose of review: </strong>To describe the various techniques in performing a tympanomastoidectomy canal wall reconstruction with mastoid obliteration for surgical management of chronic otitis media and cholesteatoma, and to assess the outcomes and complications compared to the more traditional canal wall up and canal wall down surgical techniques. Additionally, the purpose of this review is to highlight the versatility and novelty of this approach in addressing other middle ear pathologies such as glomus tympanicum.</p><p><strong>Recent findings: </strong>As canal wall reconstruction (CWR) with mastoid obliteration (MO) has become more recognized, several modifications and variations in the technique have been described with good results - from how the canal wall is taken down, to what material is being used for reconstruction and obliteration, including both autologous and alloplastic materials. Indications for the use of CWR with MO have also expanded to include those with large glomus tympanicum or patients needing canal wall down (CWD) reversal.</p><p><strong>Summary: </strong>CWR with MO is a useful alternative approach to addressing middle ear pathology, particularly cholesteatoma, as it provides enhanced visualization seen with CWD while also preserving native EAC anatomy. Reconstruction can be performed with a variety of materials, each with relative advantages and disadvantages.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"296-302"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelly L Staricha, Joshua D Smith, Steven B Chinn, Kevin J Contrera, Shaum S Sridharan, Matthew E Spector
{"title":"Graduated autonomy in head and neck microvascular surgery fellowship training: oncologic and reconstructive competency, safety, and educational implications.","authors":"Kelly L Staricha, Joshua D Smith, Steven B Chinn, Kevin J Contrera, Shaum S Sridharan, Matthew E Spector","doi":"10.1097/MOO.0000000000001141","DOIUrl":"10.1097/MOO.0000000000001141","url":null,"abstract":"<p><strong>Purpose of review: </strong>Graduated autonomy is a foundational principle of surgical education, yet no standardized framework exists for how autonomy should be structured, assessed, or achieved within head and neck oncologic and microvascular reconstructive fellowship training. This review examines contemporary models of graduated autonomy and integrates recent educational literature with institutional experience to explore competency development and training consistency.</p><p><strong>Recent findings: </strong>Recent surgical education literature supports competency-based assessment and structured entrustment as central to operative autonomy progression. Supervisory trust decisions are increasingly recognized as multifactorial, incorporating technical skill, judgment, and procedural complexity rather than time-based advancement alone. In parallel, team-based operative models in head and neck oncologic and microvascular reconstructive surgery improve efficiency while maintaining oncologic and reconstructive outcomes, creating an environment conducive to progressive autonomy with consistent faculty oversight.</p><p><strong>Summary: </strong>Graduated autonomy paired with structured assessment, individualized entrustment, and team-based operative workflows supports reliable development of technical proficiency and intraoperative judgment in fellowship training. Emerging literature and institutional experience suggest competency-based autonomy models can be implemented while preserving patient outcomes. Continued refinement and standardization of these frameworks are essential for advancement of fellowship education in head and neck oncologic and microvascular reconstructive surgery.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"356-361"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The present and future of nonviral delivery-based genome editing for hereditary hearing loss.","authors":"Seung Hyun Jang, Heon Yung Gee, Jinsei Jung","doi":"10.1097/MOO.0000000000001151","DOIUrl":"10.1097/MOO.0000000000001151","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes nonviral genome-editing delivery platforms for hereditary hearing loss, focusing on lipid nanoparticles (LNPs) and engineered virus-like particles (eVLPs), and discusses their advantages over adeno-associated virus-based delivery, as well as the barriers to clinical translation.</p><p><strong>Recent findings: </strong>Recent advances have established LNPs as a clinically advanced nonviral platform, although challenges related to inner ear biodistribution, cell type specificity, endosomal escape, and immunogenicity remain to be addressed. In parallel, eVLPs have undergone substantial technical evolution, progressing from early low efficiency systems to advanced base editor- and prime editor-eVLP architectures that enhance cargo loading and editing efficiency. Extracellular vesicle-based genome editing has also emerged as an additional platform, although issues related to reproducibility, loading efficiency, and scalability remain major hurdles.</p><p><strong>Summary: </strong>Nonviral genome editing platforms expand the therapeutic toolkit for hereditary hearing loss by enabling transient delivery of genome editors with potential safety advantages. Future efforts should focus on characterizing biodistribution and immunogenicity, refining cell type-specific tropism, and establishing scalable manufacturing processes to enable successful clinical translation.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"308-314"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Costs and system-wide considerations within head and neck reconstruction: moving toward a value-based care framework.","authors":"Mitchell Mead, Pratyusha Yalamanchi","doi":"10.1097/MOO.0000000000001142","DOIUrl":"10.1097/MOO.0000000000001142","url":null,"abstract":"<p><strong>Purpose of review: </strong>Head and neck (H&N) reconstruction presents unique economic and system-wide considerations due to the resource-intensive nature of reconstructive techniques, such as free flap reconstruction and multidisciplinary perioperative care requirements. This article highlights the current cost and price drivers within H&N reconstruction. In addition, we review challenges and initiatives to address these drivers and consider a framework for value-based care (VBC) interventions in H&N reconstruction.</p><p><strong>Recent findings: </strong>H&N reconstruction cost drivers include operative time, postoperative monitoring setting, and complication management within the surgical global period. Current system-wide considerations for H&N reconstruction include operating room and specialized workforce availability, postoperative intensive care unit utilization, and streamlined perioperative care pathways such as enhanced recovery protocols. Early VBC interventions have shown promise through length of stay reduction and cost containment, however, there is significant opportunity for further aligning reimbursement with drivers of costs and outcomes for H&N reconstruction.</p><p><strong>Summary: </strong>While previous efforts have predominantly focused on cost drivers in the perioperative period, significant opportunities exist to further align cost-saving measures with better outcomes across H&N reconstruction care. A framework for VBC in H&N reconstruction supports the development of interventions to align cost and price drivers with value.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"349-355"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julien B Azimzadeh, Brian E Applegate, John S Oghalai
{"title":"Optical coherence tomography of the tympanic membrane and middle ear: clinical applications.","authors":"Julien B Azimzadeh, Brian E Applegate, John S Oghalai","doi":"10.1097/MOO.0000000000001147","DOIUrl":"10.1097/MOO.0000000000001147","url":null,"abstract":"<p><strong>Purpose of review: </strong>Optical coherence tomography (OCT) is a noninvasive optical imaging technique to image soft tissue and thin bony structures with high resolution, approaching that of histology. This review summarizes recent progress in the clinical application of OCT for tympanic membrane and middle ear disease.</p><p><strong>Recent findings: </strong>Recent reports from clinical trials show that OCT is having a meaningful impact on the diagnosis of fluid in the middle ear. In parallel with this, numerous groups are obtaining previously unattainable normative data in vivo on human middle ear structures. OCT is also starting to be used for functional assessments of the middle ear in the clinical setting by detecting sound and pressure-evoked motion.</p><p><strong>Summary: </strong>OCT allows real-time noninvasive radiation-free structural and functional imaging of the tympanic membrane and middle ear at the point of care. As artificial intelligence becomes more commonplace in medicine, it is likely that OCT will become a key technology for the otolaryngologist. The data provided by OCT can be used to train machine learning algorithms for the segmentation of ear structures, which will ultimately support the automated diagnosis of ear disease. This will also aid in objectively tracking disease progression over time. Thus, OCT presents much promise for our field by revolutionizing office-based otological diagnostics.</p>","PeriodicalId":55195,"journal":{"name":"Current Opinion in Otolaryngology & Head and Neck Surgery","volume":" ","pages":"326-332"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}