Current Problems in Cancer最新文献

{"title":"Efficacy of atezolizumab, bevacizumab, carboplatin, and paclitaxel for epidermal growth factor receptor mutation-positive advanced non-small cell lung cancer after tyrosine kinase inhibitor failure","authors":"Yoh Yamaguchi ,&nbsp;Yuki Shinno ,&nbsp;Ken Masuda ,&nbsp;Ryo Ariyasu ,&nbsp;Kaname Nosaki ,&nbsp;Taiki Hakozaki ,&nbsp;Takaaki Tokito ,&nbsp;Shogo Nomura ,&nbsp;Makoto Nishio ,&nbsp;Koichi Goto ,&nbsp;Yukio Hosomi ,&nbsp;Koichi Azuma ,&nbsp;Yuichiro Ohe","doi":"10.1016/j.currproblcancer.2025.101200","DOIUrl":"10.1016/j.currproblcancer.2025.101200","url":null,"abstract":"<div><h3>Background</h3><div>Non-small cell lung cancer (NSCLC) with driver mutations, notably epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase, shows reduced sensitivity to immune checkpoint inhibitors. A subgroup analysis of the IMpower150 data on patients resistant to EGFR tyrosine kinase inhibitors (EGFR-TKI) before enrollment demonstrated prolonged progression-free survival (PFS) with atezolizumab, bevacizumab, carboplatin, and paclitaxel (ABCP) over bevacizumab, carboplatin, and paclitaxel. However, due to the exploratory nature and small sample size, the efficacy of ABCP post-EGFR-TKI failure is still debated. We evaluated ABCP therapy against other platinum-based regimens without immune checkpoint inhibitors in terms of effectiveness and toxicity.</div></div><div><h3>Methods</h3><div>Data from patients with advanced or recurrent NSCLC harboring EGFR-sensitizing mutations treated with platinum-based chemotherapy or ABCP at five Japanese hospitals were retrospectively analyzed. Propensity score matching compared efficacy outcomes, including overall response rate (ORR), PFS, and OS.</div></div><div><h3>Results</h3><div>Of 183 EGFR mutation carriers, 33 underwent ABCP therapy, while 150 received platinum-based chemotherapy. Following propensity score matching, 32 and 74 patients were analyzed. In the ABCP group, median PFS and OS were 6.8 and 16.7 months compared to 5.8 and 25.7 months with platinum-based chemotherapy, showing no significant differences in PFS (<em>p =</em> 0.46) and OS (<em>p =</em> 0.85). In liver metastases, ABCP yielded a median PFS of 9.9 versus 6.1 months and an ORR of 62.5 % versus 35.7 % relative to platinum-based chemotherapy, without statistical significance (PFS <em>p</em> = 0.16; ORR <em>p =</em> 0.70).</div></div><div><h3>Conclusion</h3><div>Compared with platinum-based chemotherapy, ABCP did not improve effectiveness in patients with EGFR-mutated NSCLC after EGFR-TKI failure.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"56 ","pages":"Article 101200"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of triplet versus doublet regimens in patients with multiple myeloma: A systematic review and meta-analysis","authors":"Zilu Meng ,&nbsp;Hanxue Zheng ,&nbsp;Yanhong Li ,&nbsp;Jun Bai ,&nbsp;Liansheng Zhang ,&nbsp;Lijuan Li","doi":"10.1016/j.currproblcancer.2025.101202","DOIUrl":"10.1016/j.currproblcancer.2025.101202","url":null,"abstract":"<div><h3>Background</h3><div>The efficacy and safety of various therapies for multiple myeloma (MM) remain a subject of ongoing debate, with inconsistent findings. This meta-analysis aimed to compare the efficacy and safety of triplet versus doublet regimens in the management of MM. This study followed the guidelines delineated in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 statement, with our protocol duly registered in PROSPERO (CRD42024527903).</div></div><div><h3>Methods</h3><div>An exhaustive literature search was performed across four databases, PubMed, EMBASE, Web of Science, and Cochrane Library, from their commencement to March 5, 2024. Data on overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), adverse events (AEs), and grade ≥ 3 AEs were synthesized using either random-effects or fixed-effects models.</div></div><div><h3>Results</h3><div>This analysis considered 29 studies, which cover approximately 11,230 MM patients in total. Triplet regimens were found to yield better PFS and OS for MM patients as compared to the doublet regimens. Although the incidence of serious AEs was higher under the triplet regimens, with pooled RRs of grade ≥ 3 AEs reaching 1.13. Besides, subgroup analysis demonstrated that patients with relapsed/refractory multiple myeloma (RRMM) tended to have better PFS and OS under triple therapy, in contrast to newly diagnosed multiple myeloma (NDMM) and older adults, who experienced little to no significant impact.</div></div><div><h3>Conclusions</h3><div>Triplet regimens demonstrate superior PFS and OS compared to doublet regimens in MM patients, but also have a higher likelihood of causing AEs of grade 3 or 4.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"56 ","pages":"Article 101202"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond CTS5 score: A novel nomogram predicting long-term prognosis in patients with hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer","authors":"Mingqi Zhang ,&nbsp;Jing Yu ,&nbsp;Liang Qin ,&nbsp;Jiayi Wu","doi":"10.1016/j.currproblcancer.2025.101201","DOIUrl":"10.1016/j.currproblcancer.2025.101201","url":null,"abstract":"<div><h3>Background</h3><div>HR+/HER2+ breast cancer are exposed to high late-recurrence risk. CTS5 is widely used in predicting late recurrence of HR+/HER2- patients. This study aims to explore the application of CTS5 in HR+/HER2+ patients and develop a novel model with greater predictive efficacy.</div></div><div><h3>Methods</h3><div>We collect 26605 HR+/HER2+ breast cancer patients diagnosed between 2010 and 2019 from SEER database. The main survival outcome was breast cancer-specific survival (BCSS) after 5 years of diagnosis. CTS5 score was calculated. Survival analysis was performed. Cox regression identified significant clinicopathological parameters, which were used to construct a nomogram.</div></div><div><h3>Results</h3><div>Patients were stratified into CTS5 low- (<em>n</em> = 10,217, 38.4%), intermediate- (<em>n</em> = 9,257, 34.8%) and high-risk (<em>n</em> = 7,131, 26.8%) groups. Patients in CTS5 high-risk subgroup were more likely to be older at diagnosis, postmenopausal and have tumors with higher TN stage and grades (all <em>p</em> &lt; 0.001). High-risk patients showed worse BCSS compared with intermediate- and low-risk patients (cumulative hazard: BCSS, 7.4%, 3.2% and 1.7%, <em>p</em> &lt; 0.001). Cox regression suggested age, TN stage, chemotherapy and radiotherapy were BCSS associated (all <em>p</em> &lt; 0.001) while grade wasn't. A nomogram based on age, tumor size and lymph nodes was constructed. The AUC values of the ROC curves for 6, 8, and 10-year BCSS were 0.687, 0.698, and 0.700. The nomogram demonstrated a significantly higher likelihood ratio statistic compared to CTS5 (518.9 vs. 483.8, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>We confirmed the prognostic value of CTS5 in HR+/HER2+ breast cancer and developed a new nomogram with superior predictive performance for long-term prognosis compared to CTS5.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"56 ","pages":"Article 101201"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0147-0272(25)00019-4","DOIUrl":"10.1016/S0147-0272(25)00019-4","url":null,"abstract":"","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"55 ","pages":"Article 101192"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S0147-0272(25)00015-7","DOIUrl":"10.1016/S0147-0272(25)00015-7","url":null,"abstract":"","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"55 ","pages":"Article 101188"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the clinical efficacy of neoadjuvant intravesical Mitomycin C in naïve non-muscle invasive urinary bladder cancer: A systematic review and meta-analysis","authors":"Anuja Thakur ,&nbsp;Lalit Kumar ,&nbsp;Sakshi Agarwal ,&nbsp;Rachana Tripathy ,&nbsp;Yashasvi Singh ,&nbsp;Sameer Trivedi ,&nbsp;Ujwal Kumar","doi":"10.1016/j.currproblcancer.2025.101198","DOIUrl":"10.1016/j.currproblcancer.2025.101198","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Naïve non-muscle invasive bladder cancer (NMIBC) is commonly treated with transurethral resection (TURBT), but recurrence and progression remain concerns.</div><div>This meta-analysis, the first we have conducted on this topic, compared recurrence and progression rates between patients treated with neoadjuvant Mitomycin C (MMC) and the control group (TURBT alone).</div></div><div><h3>Methods</h3><div>Relevant articles were identified and appraised through a structured literature assessment. Databases searched included PubMed, Medline, Scopus, and Science Direct. Duplicate publications, book sections, conference papers, encyclopedias, case reports, magazine articles, presentations, theses, protocols, systematic reviews, and meta-analyses were excluded. Heterogeneity was assessed using the I².</div></div><div><h3>Key findings and limitations</h3><div>The meta-analysis evaluated recurrence rates, progression rates, and adverse events. No heterogeneity was observed (I²=0 %). The pooled odd ratio (OR) for recurrence was 2.554 (95 % CI: 1.637-3.986), indicating a significant decrease in recurrence for the MMC group (<em>P</em> &lt; 0.001). For progression rates, the overall pooled OR was 1.508 (95 % CI: 0.832-2.734), suggesting that the MMC group showed a lower progression rate. However, this difference was not statistically significant (<em>P</em> = 0.176).Adverse events varied, with the MMC group showing fewer cases of hematuria (8.4 % vs. 34 %) but more irritative bladder symptoms.</div></div><div><h3>Conclusions and Clinical Implications</h3><div>The meta-analysis suggests lower recurrence and progression rates in the neoadjuvant MMC group compared to the control group. Both groups experienced a comparable range of adverse events, suggesting that both treatment approaches exhibit a similar safety profile. Larger and more randomized controlled trials (RCT) are needed to confirm MMC's effectiveness in NIMBC treatment and establish its role in clinical practice.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"55 ","pages":"Article 101198"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcomes of pediatric extracranial malignant germ cell tumors: A decade of experience from a single institution in Southern Vietnam","authors":"An Thi Thanh Dao ,&nbsp;Nhi Thuy To ,&nbsp;Chau Hoan Nguyen ,&nbsp;Khai Dinh Truong ,&nbsp;Tuan Diep Tran ,&nbsp;Soh Shui Yen ,&nbsp;Amos Loh Hong Pheng ,&nbsp;Michelle Hermiston ,&nbsp;Phi Duong Nguyen","doi":"10.1016/j.currproblcancer.2025.101197","DOIUrl":"10.1016/j.currproblcancer.2025.101197","url":null,"abstract":"<div><h3>Background</h3><div>Extracranial malignant germ cell tumors (GCTs) generally exhibit favorable outcomes with contemporary therapeutic approaches. However, the outcomes of pediatric GCTs in Vietnam remain unclear. This study aims to evaluate the clinical features, treatment modalities, and prognostic factors associated with survival outcomes in children with GCTs treated at Children's Hospital Number 2 (CH2) in Ho Chi Minh City, Vietnam.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study involving pediatric patients with GCTs treated at CH2 between January 1, 2011, and July 30, 2019. Data were extracted from medical records and entered into REDCap for analysis using SPSS version 20.0 (IBM Corporation, Armonk, NY). Descriptive statistics were reported as mean ± standard deviation, unless otherwise specified. Overall survival (OS) and event-free survival (EFS) rates were estimated using the Kaplan-Meier method, and the log-rank test was employed to assess the significance of potential prognostic factors.</div></div><div><h3>Results</h3><div>A total of 69 patients with a median age of 25 months were included in the study. Of these, 48 (69.9 %) had gonadal tumors, and 21 (30.4 %) had extragonadal tumors. The median alpha-fetoprotein (AFP) level at diagnosis was 2,589 kU/L, with 26 (37.7 %) patients presenting with AFP levels exceeding 10,000 kU/L. All patients underwent surgical resection followed by platinum-based chemotherapy (carboplatin in 92.8 % and cisplatin in 7.2 %). The incidence of grade 3-4 toxicities (neutropenia, febrile neutropenia, and thrombocytopenia) varied between 3.5 % and 19.4 % per chemotherapy cycle. The mean follow-up duration was 53.3 months, with a relapse rate of 5.8 % and an abandonment rate of 11.6 %. The 5-year OS and EFS rates were 92.5 % and 91 %, respectively. EFS was significantly higher in patients with gonadal tumors compared to those with extragonadal tumors (95.7 % vs 84.4 %, <em>p</em> = 0.035). Additionally, OS was significantly better in patients with stage I-II tumors compared to those with stage III-IV (100 % vs 86.2 %, <em>p</em> = 0.03), in patients with AFP levels &lt;10,000 kU/L compared to those with AFP &gt;10,000 kU/L (97.6 % vs 84 %, <em>p</em> = 0.041), and in patients who did not abandon treatment (94.9 % vs 77 %, <em>p</em> = 0.044).</div></div><div><h3>Conclusions</h3><div>The outcomes of pediatric extracranial malignant germ cell tumors in this cohort were excellent, with relatively low early treatment-related toxicity. Reducing treatment abandonment and identifying high-risk patients for intensified therapy may further improve survival outcomes in this setting.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"55 ","pages":"Article 101197"},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal age at first birth and uterine cancer risk: A comprehensive analysis using NHANES data (2003–2018)","authors":"Shelby Marozoff ,&nbsp;Mohammad Ehsanul Karim ,&nbsp;Michael Asamoah-Boaheng ,&nbsp;Trevor J.B. Dummer","doi":"10.1016/j.currproblcancer.2025.101184","DOIUrl":"10.1016/j.currproblcancer.2025.101184","url":null,"abstract":"<div><h3>Background</h3><div>Several reproductive factors, including parity and age at menarche, have been identified as risk factors for uterine cancers. However, the association between maternal age at first birth and uterine cancer remains conflicting.</div></div><div><h3>Methods</h3><div>This cross-sectional study included females aged 20 years and older with at least one live birth across eight National Health and Nutrition Examination Survey (NHANES) cycles (2003–2018). We used design-adjusted logistic regression, with multiple imputation for missing data, to explore the association of age at first birth and uterine cancer. As a sensitivity analysis, the sample was restricted to post-menopausal females; logistic regression analyses were repeated.</div></div><div><h3>Results</h3><div>Among 7095 participants, 104 had uterine cancer. The adjusted odds ratio (aOR) for uterine cancer for participants with a first live birth at ≥25 years was 0.66 (95 % confidence interval (CI): 0.33–1.35) compared to those with a first birth at &lt;20 years. For participants with a first birth between 20–24 years, the aOR was 0.93 (95 % CI: 0.51–1.69). Multiple imputation and sensitivity analyses yielded similar non-significant results.</div></div><div><h3>Conclusion</h3><div>Our findings suggest no statistically significant association between maternal age at first live birth and uterine cancer, aligning with existing literature. Further research is needed to explore other reproductive factors and their role in uterine cancer risk.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"55 ","pages":"Article 101184"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thallium-201 single photon emission computed tomography for the differentiation of malignant versus non-malignant intracranial space-occupying lesions in developing countries","authors":"Mark Willy L. Mondia ,&nbsp;Anisah Hayaminnah D. Alonto ,&nbsp;Nicole Girlyn T. Pang ,&nbsp;Francis Manuel L. Resma ,&nbsp;Al Joseph R. Molina ,&nbsp;John Kenneth V. Gacula ,&nbsp;Arnel E. Pauco ,&nbsp;Annabell E. Chua ,&nbsp;Julette Marie F. Batara","doi":"10.1016/j.currproblcancer.2024.101160","DOIUrl":"10.1016/j.currproblcancer.2024.101160","url":null,"abstract":"<div><h3>Background</h3><div>Thallium-201 single-photon emission computed tomography (TI-SPECT) imaging has been used historically to distinguish malignant cerebral neoplasms from infectious etiologies.</div></div><div><h3>Objectives</h3><div>Our study aims to conduct a retrospective study, review existing literature, and perform meta-analysis on the use of TI-SPECT to differentiate malignant from non-malignant nervous system lesions when other advanced imaging modalities are not available, such as in resource-limited setting.</div></div><div><h3>Methods</h3><div>A retrospective study on the use of TI-SPECT in differentiating malignant versus non-malignant nervous system lesions was conducted in two tertiary hospitals in the Philippines.</div><div>A systematic review of relevant studies regarding TI-SPECT for the central nervous system was also done. Meta-analysis was performed to generate pooled sensitivity and specificity.</div></div><div><h3>Results</h3><div>A total of 19 patients from 2 institutions were included in the analysis. Data from Philippine General Hospital showed a sensitivity of 83% (95% CI: 36%, 100%) and a specificity of 100% (95% CI: 16%, 100%), while St. Luke's Medical Center had a sensitivity of 100% (95% CI: 40%, 100%) and specificity of 100% (95% CI: 48%, 100%).</div><div>Thirty-two (32) articles were qualitatively described and 24 datasets were subjected to meta-analysis. Pooled sensitivity and specificity were 89% (95% CI: 81%-94%) and 81% (95% CI: 73%-87%), respectively with an area under the curve (AUC) for diagnostic accuracy of 92%.</div></div><div><h3>Conclusion</h3><div>TI-SPECT imaging may be a potential diagnostic tool to discriminate malignant from non-malignant nervous system lesions when advanced imaging modalities such as PET/ MRI are not available. Due to the heterogeneity of the population in the studies included in both the quantitative and qualitative analyses, further studies are needed to validate these findings.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"54 ","pages":"Article 101160"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the expression and functional landscape of key enzymes in glucose metabolism within human gynecological tumors","authors":"Wen Zhang ,&nbsp;Ying-Tong Lin ,&nbsp;Jing-Wen Jiang ,&nbsp;Yan Hu","doi":"10.1016/j.currproblcancer.2024.101155","DOIUrl":"10.1016/j.currproblcancer.2024.101155","url":null,"abstract":"<div><div>Gynecological tumors, primarily ovarian cancer (OC), cervical cancer (CC), and endometrial cancer (EC), have a significant global impact on women's health, characterized by high mortality rates. Emerging evidence underscores the pivotal role of altered glucose metabolism in the initiation and progression of these malignancies. Glucose metabolism, encompassing glycolysis, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and the pentose phosphate pathway (PPP), among others, is intricately governed by a spectrum of key enzymes. These enzymes drive metabolic reprogramming essential for tumor growth and survival, thereby influencing patient outcomes and clinical management strategies. However, the comprehensive characterization and summary of the expression profiles, regulatory networks involved, and functional roles of these glucose metabolic enzymes in human gynecological tumors remain incomplete. In this review, we systematically map the expression landscape of these critical glucose metabolic enzymes in gynecological cancers based on research utilizing clinical gynecological tumor tissues. Additionally, we summarize the specific functions of key enzymes of glucose metabolism and the pathways they regulate in gynecological tumors. This review provides profound insights into the metabolic dynamics underlying these diseases. This understanding illuminates the metabolic strategies employed by tumor cells and sets the stage for innovative therapeutic approaches targeting cancer cell glucose metabolic dependencies, thereby holding promise for enhancing patient outcomes in gynecological oncology.</div></div>","PeriodicalId":55193,"journal":{"name":"Current Problems in Cancer","volume":"54 ","pages":"Article 101155"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}