Current perspectives on Lifileucel tumor-infiltrating lymphocyte therapy: A paradigm shift in immunotherapy

IF 2.3 4区医学 Q3 ONCOLOGY

Current Problems in Cancer Pub Date : 2025-09-12 DOI:10.1016/j.currproblcancer.2025.101252

Simran Deep Kaur , Md Abubakar , Neena Bedi , Eswara Rao puppala , Deepak N Kapoor , Nitesh Kumar , Nafees Ahemad , Sirajudheen Anwar

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Abstract

Lifileucel, a tumor-infiltrating lymphocyte (TIL) therapy, provides renewed hope for individuals with advanced, treatment-resistant malignancies. This is a groundbreaking advancement in cancer immunotherapy. Revolutionizing the way the immune system fights cancer, this state-of-the-art cellular therapy takes advantage of TILs' innate capacity to target tumors. Lifileucel is an innovative medicine that is garnering attention in oncology. It has shown remarkable efficacy in clinical trials, assisting individuals unresponsive to other therapy in sustaining their responses and enhancing their survival rates. This paper provides a comprehensive overview of contemporary perspectives on Lifileucel, including its mechanism of action, clinical results, challenges and potential applicability to a broader spectrum of solid tumors. The Lifileucel concept has initiated a new epoch in personalized cancer therapy. This review offers a forward-looking perspective on the potential advancements and opportunities for establishing Lifileucel and TIL-based therapies as a cornerstone in cancer therapy.

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Lifileucel肿瘤浸润性淋巴细胞治疗的现状：免疫治疗的范式转变

Lifileucel是一种肿瘤浸润性淋巴细胞（TIL）疗法，为晚期恶性肿瘤患者提供了新的希望。这是癌症免疫疗法的突破性进展。这种最先进的细胞疗法利用了TILs靶向肿瘤的先天能力，彻底改变了免疫系统对抗癌症的方式。Lifileucel是在肿瘤学领域备受关注的创新药物。它在临床试验中显示出显著的疗效，帮助对其他治疗无反应的个体维持其反应并提高其生存率。本文全面概述了Lifileucel的当代观点，包括其作用机制、临床结果、挑战和在更广泛的实体肿瘤中的潜在适用性。Lifileucel的概念开启了个体化癌症治疗的新纪元。这篇综述为建立Lifileucel和基于til的治疗作为癌症治疗基石的潜在进展和机会提供了前瞻性的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cancer 医学-肿瘤学

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

15 days

期刊介绍： Current Problems in Cancer seeks to promote and disseminate innovative, transformative, and impactful data on patient-oriented cancer research and clinical care. Specifically, the journal''s scope is focused on reporting the results of well-designed cancer studies that influence/alter practice or identify new directions in clinical cancer research. These studies can include novel therapeutic approaches, new strategies for early diagnosis, cancer clinical trials, and supportive care, among others. Papers that focus solely on laboratory-based or basic science research are discouraged. The journal''s format also allows, on occasion, for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering articles that present dynamic material that influences the oncology field.