Depression and Anxiety最新文献

{"title":"Magnitude and Associated Factors of Depressive Symptoms Among Adult Patients With Cirrhosis: An Experience From a Resource-Limited Setting","authors":"Gashahun Mekonnen Dissassa,&nbsp;Geda Lelisa Kube,&nbsp;Henok Fisseha,&nbsp;Eyoel Berhan Mekonnen,&nbsp;Dirbe Jebesa Dinka,&nbsp;Amare Hailu Ashine,&nbsp;Tamirat Godebo Woyimo","doi":"10.1155/da/6847420","DOIUrl":"10.1155/da/6847420","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Depression is a common comorbidity in cirrhosis, yet its burden and determinants are poorly characterized in sub-Saharan Africa. This study aimed to determine the magnitude and factors associated with depression among adult patients with cirrhosis at a tertiary hospital in Ethiopia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a hospital-based cross-sectional study, 134 adult patients with cirrhosis were consecutively recruited from a hepatology clinic in Addis Ababa. Depressive symptoms were assessed using the patient health questionnaire-9 (PHQ-9), with a score ≥10 indicating clinically significant depressive symptoms. Sociodemographic and clinical data, including cirrhosis etiology, disease stage, MELD score, and social support (3-item Oslo social support scale [OSS-3]), were collected via interview and chart review. Multivariable logistic regression was used to identify factors independently associated with clinically significant depressive symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve of 134 participants (9.0%; 95% CI: 5.3%–15.1%) had clinically significant depressive symptoms based on a PHQ-9 score ≥10. In adjusted analyses, longer illness duration (adjusted odds ratio [AOR] = 1.48, 95% CI: 1.12–1.96), decompensated cirrhosis was associated with approximately nine-fold higher odds of clinically significant depressive symptoms compared with compensated cirrhosis, and a higher MELD score (AOR = 1.58, 95% CI: 1.21–2.06) were significantly associated with increased odds of depression. The absence of comorbid chronic illness was also independently associated with lower depression odds (AOR = 0.14, 95% CI: 0.03–0.72, <i>p</i> = 0.018). Conversely, moderate (AOR = 0.18, 95% CI: 0.04–0.79) and strong (AOR = 0.04, 95% CI: 0.01–0.64) social support were associated with lower odds of clinically significant depressive symptoms, although the cross-sectional design precludes conclusions about causality and reverse causation (i.e., depressed individuals may underreport social support) cannot be excluded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Clinically significant depressive symptoms were identified in 9.0% of adults with cirrhosis. More advanced liver disease and poorer social support were associated with depressive symptoms. These findings underscore the critical need for integrated mental health screening and psychosocial interventions within routine cirrhosis care in resource-limited settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profiles of Psychological Distress and Suicidal Ideation Among Nursing Students: A Cross-Sectional Study of Associated Factors","authors":"Anshi Wang,&nbsp;Jingjing Wan,&nbsp;Qin Yang,&nbsp;Lijun Zhu,&nbsp;Liying Wen,&nbsp;Weiwei Chang,&nbsp;Yu Zhu,&nbsp;Yan Chen,&nbsp;Yuelong Jin,&nbsp;Yingshui Yao","doi":"10.1155/da/9138758","DOIUrl":"10.1155/da/9138758","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psychological distress and suicidal ideation frequently co-occur among nursing students, but their heterogeneity is often overlooked.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To identify latent profiles of nursing students based on psychological distress and suicidal ideation dimensions, and to explore factors associated with profile membership.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional survey of 1461 Chinese nursing students was conducted. Latent profile analysis (LPA) was applied to psychological distress and suicidal ideation dimensions to identify profiles, and multinomial logistic regression was used to examine factors associated with profile membership.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three latent profiles emerged: C1: Low distress–low suicidal ideation (60.4%), C2: moderate distress–moderate suicidal ideation (30.8%), and C3: high distress–high suicidal ideation (8.8%). Multinomial regression revealed factors associated with C2/C3 vs. C1, including poor sleep quality, internet overuse/addiction, and moderate self-efficacy. Factors associated with lower likelihood of C2 vs. C1 included good academic performance, moderate/high self-esteem, and moderate/high time management skills. Factors associated with higher likelihood of C3 vs. C1 included higher body mass index (BMI), undergraduate institution enrollment, morning/neutral chronotypes, whereas exercise ≥1 time/week and a good parental relationship were associated with lower likelihood of C3 vs. C1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Nursing students exhibit three profiles, with 8.8% belonging to C3. Profile-informed screening and preventive strategies considering factors associated with profile membership (sleep quality, internet addiction, exercise frequency, time management, self-esteem, and self-efficacy) and contextual stressors (institution type, BMI, and parental relationship) may inform future screening approaches for students exhibiting elevated psychological distress and suicidal ideation patterns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Development of a Peer Willingness Scale for Depression and Analysis of Associated Factors Among Chinese College Students: A Cross-Sectional Study","authors":"Yating Fu,&nbsp;Danfeng Wang,&nbsp;Leyi Xu,&nbsp;Yue Yu,&nbsp;Jianliang Zou,&nbsp;Zhipeng Liu,&nbsp;Xiaoyu Zhang","doi":"10.1155/da/3448143","DOIUrl":"https://doi.org/10.1155/da/3448143","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>While peer support can alleviate depressive symptoms of college students, peers’ willingness to intervene and factors associated with this willingness remain understudied. This study aims to (1) develop and validate a Bystander Intervention Willingness for Depression (BIWD) scale for Chinese college students and (2) identify key sociodemographic and sociopsychological correlates of willingness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted from May to June 2024. A 13-item BIWD scale based on the Bystander Intervention Model was assessed using exploratory (<i>n</i> = 217) and confirmatory (<i>n</i> = 1008) factor analyses. Linear regression models examined associations between BIWD scores and sociodemographic factors, social perceptions, and mental health indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The BIWD scale comprised four dimensions: depression-related cognition, intervention responsibility, bystander effect resistance, and self-efficacy. Older age, higher socioeconomic status, stronger personal anti-stigma attitude, greater interpersonal closeness, and stronger social support were associated with higher BIWD scores. Students with depressive or anxiety symptoms showed higher depression-related cognition, but lower intervention responsibility, self-efficacy, and higher susceptibility to bystander effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings support the BIWD scale as a useful tool for assessing peer intervention willingness. Initiatives to reduce personal stigma, family functioning enhancement, and targeted self-efficacy training, especially for students experiencing mental health symptoms, may strengthen peer-based support for depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/3448143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Metacognitive Therapy on OCD Severity and Beliefs: A Three-Wave Multisite RCT With Panel Mediation Analysis","authors":"Saeed Anwar,&nbsp;Romana Younas,&nbsp;Wejdan Deebani,&nbsp;Jiang Yingjie","doi":"10.1155/da/5060244","DOIUrl":"https://doi.org/10.1155/da/5060244","url":null,"abstract":"<p>Obsessive–compulsive disorder (OCD) is a chronic and disabling condition, and although exposure and response prevention (ERP) is the first-line psychological treatment, many patients decline it, drop out, or retain residual symptoms. According to Wells’ metacognitive model, OCD is maintained less by intrusive thoughts themselves than by metacognitive beliefs about the significance, danger, and control of thoughts, which metacognitive therapy (MCT) targets directly. However, individual MCT has been evaluated almost exclusively in high-income Western settings, and whether metacognitive belief change temporally precedes symptom improvement remains untested. This multisite, assessor-blinded randomized controlled trial (RCT) addressed both gaps in Pakistani outpatient services. Seventy-six adults with OCD were randomized to 12 weekly sessions of individual MCT (<i>n</i> = 38) or documented treatment as usual (TAU; <i>n</i> = 38) and assessed at baseline, post-treatment, and 6-month follow-up; outcomes were analyzed with intention-to-treat (ITT) mixed-effects models and an exploratory three-wave panel mediation model. MCT produced greater reductions in clinician-rated Yale-Brown Obsessive-Compulsive Scale severity than TAU, <i>F</i>(1.81, 134) = 11.30, <i>p</i> &lt; 0.001, with mean differences of −4.00 at post-treatment and −6.92 at follow-up (both <i>p</i> &lt; 0.001) and more frequent treatment response. MCT also reduced Metacognitions Questionnaire-30 belief domains, with gains maintained at follow-up. However, the prespecified lagged indirect effect through post-treatment beliefs was not supported (<i>β</i> = −0.01). Findings extend the evidence for MCT to a non-Western clinical context and suggest that broad metacognitive belief domains behave as markers of clinical state rather than proximal mechanisms, underscoring the need for temporally fine-grained mechanism research.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5060244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Fronto-Cingulate Connectivity During Social Competition and Cooperation in Adolescents With Major Depressive Disorder: An fNIRS Hyperscanning Study","authors":"Yangliuqing He,&nbsp;Yiming Wang,&nbsp;Shuo Jiang,&nbsp;Fenrong Liang","doi":"10.1155/da/8894844","DOIUrl":"10.1155/da/8894844","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Major depressive disorder (MDD) in adolescence is characterized by high prevalence (24.3% in China) and social dysfunction, particularly in competitive and cooperative behaviors. This study used fNIRS hyperscanning to explore cortical connectivity alterations during parent–adolescent interactions in adolescent MDD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-three MDD adolescents (DD) and 29 healthy controls (HCs) completed competitive/cooperative maze tasks with parents under 52-channel fNIRS. Wavelet coherence analyzed functional connectivity (FC) in prefrontal/motor regions, which provides undirected connectivity estimates. Group × task effects were tested via GLMM and FDR correction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>(1) Competition: DD exhibited hyperconnectivity in emotion regulation circuits between right opercular inferior frontal gyrus and left triangular inferior frontal gyrus (rIFGoperc and lIFGtriang, <i>p</i> = 0.047) but hypoconnectivity in executive networks between left dorsal superior frontal gyrus and left precentral gyrus (lSFGdor and lPreCG, <i>p</i> = 0.040). (2) Cooperation: DD showed enhanced motor–cognitive integration between right supplementary motor area and right middle frontal gyrus (rSMA and rMFG, <i>p</i> = 0.036) but impaired socioemotional processing between right triangular inferior frontal gyrus and left dorsal superior frontal gyrus (rIFGtriang and lSFGdor, <i>p</i> = 0.033). Task modulation: Within DD, cooperation preferentially engaged emotional resonance networks between right inferior orbital frontal gyrus and right medial superior frontal gyrus (rORBinf and rSFGmed, <i>p</i> = 0.031) while competition was associated with enhanced coupling in self-monitoring circuits between left dorsal superior frontal gyrus and right opercular inferior frontal gyrus (lSFGdor and rIFGoperc, <i>p</i> = 0.047).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Adolescent MDD involves context-dependent neural deficits in social cognition, suggesting targets for neuromodulatory interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Proteomic Landscape of Multidimensional Sleep Health and Its Association With Depression Risk Under Genetic Susceptibility","authors":"Feng Chen,&nbsp;Yanggang Hong,&nbsp;Yue Zhu,&nbsp;Yukai Wang,&nbsp;Qi Chen,&nbsp;Jiajun Li,&nbsp;Yangguang Lu,&nbsp;Haoxiong Guan,&nbsp;Huixiang Sheng,&nbsp;Ruijie Xie,&nbsp;Fan Ye","doi":"10.1155/da/9191032","DOIUrl":"https://doi.org/10.1155/da/9191032","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Multidimensional sleep health, encompassing duration, snoring, chronotype, insomnia symptoms, and daytime sleepiness, is associated with various chronic diseases. However, its relationship with depression risk, especially the underlying molecular mechanisms across different levels of genetic susceptibility, remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective cohort study, we analyzed data from 36,852 UK Biobank participants, integrating multidimensional sleep scores, plasma proteomic data covering 2,911 proteins, and polygenic risk scores (PRS) for depression. Sleep-related proteins were identified via elastic net regression, and their associations with incident depression were assessed using Cox proportional hazards models. Mediation and interaction analyses were conducted to explore the role of proteomic features and their effect modification by genetic risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy-three plasma proteins were selected by elastic net as sleep-related proteomic features, mainly involving immune regulation, neural signaling, metabolic homeostasis, and extracellular matrix remodeling. The proteomic score derived from these features was positively correlated with sleep health (<i>r</i> = 0.234, <i>p</i> &lt; 1<i>×</i>10⁻¹⁰⁰). Healthy sleepers had a lower risk of depression (HR = 0.553, 95% CI: 0.454–0.674, <i>p</i> &lt; 0.001), as did those with higher proteomic scores (HR = 0.660, 95% CI: 0.566–0.770, <i>p</i> &lt; 0.001). Mediation analysis suggested that the proteomic signature statistically accounted for a modest proportion of the observed association between sleep health and incident depression. A significant additive interaction was observed between unhealthy sleep and high genetic risk (RERI = 0.280, 95% CI: 0.022–0.538).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study characterizes the plasma proteomic profile of multidimensional sleep health and identifies sleep-associated proteomic signatures related to incident depression across levels of genetic susceptibility. These findings highlight potential biological pathways for further investigation and require independent replication and causal validation before clinical interpretation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9191032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Trauma, Recent Stressors, and Risk of Depression Relapse in Late-Life Depression","authors":"David C. Steffens,&nbsp;Rong Wu,&nbsp;Julian D. Ford","doi":"10.1155/da/1455337","DOIUrl":"10.1155/da/1455337","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recent stressors have been linked to poor outcomes of late-life depression (LLD), including relapse. Emerging evidence has linked adverse childhood experiences (ACEs) to the occurrence of LLD. We sought to examine the relationships between recent exposure to stressful life events and ACEs with relapse following remission among older adult.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this cohort study, depressed older adults (age ≥65) were provided standard antidepressant medications by a study psychiatrist. Each participant provided responses to the ACEs Questionnaire and to a list of questions regarding stressors in the past 12 months. We defined remission as Montgomery–Asberg Depression Rating Scale (MADRS) score &lt;8 and relapse worsening with a MADRS score ≥15. We conducted both logistic regression analyses of relapse over 3 years and a time-to-relapse survival analysis. To assess moderation by ACE items on the association of stress and relapse, we included them in Cox proportional hazard (PH) models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 143 depressed elders, 98 achieved remission within 2 years, and 55 of them experienced a relapse. Exposure to emotional neglect in childhood and stressors later in life were each associated with relapse of LLD, and a history of childhood neglect moderated the relationship between recent stressor exposure and relapse. In bivariate analyses, ACE item 4 (emotional neglect), ACE item 9 (family mental illness), and the combination of both (ACE4 + ACE9) were significantly related to relapse. In subsequent logistic regression models controlling for age, sex, race, education, and baseline MADRS score, the dichotomous and continuous variables combining ACE items 4 and 9 were significantly associated with relapse. In analyses using time-to-relapse as the outcome, emotional neglect was associated with a shorter time to relapse. The number of recent negative stressors was also associated with relapse, and emotional maltreatment moderated that relationship in an unexpected way.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found that exposure to emotional neglect in childhood and stressors later in life both were associated with relapse of LLD, and a history of childhood neglect moderated the relationship between recent stressor exposure and relapse. These findings are consistent with, and extend, the robust research evidence base linking psychological neglect with depression in adolescence and adulthood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Disease Classification of Depression, Bipolar Disorder, and Schizophrenia Using Multiscale Spatiotemporal Network Fusion Features From fNIRS","authors":"Yajing Meng,&nbsp;Yulu Yang,&nbsp;Qing Li,&nbsp;Qian Fu,&nbsp;Mingyao Gao,&nbsp;Ling He,&nbsp;Jing Zhang,&nbsp;Changjian Qiu","doi":"10.1155/da/9921579","DOIUrl":"10.1155/da/9921579","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are highly prevalent and disabling psychiatric conditions with increasing incidence, significantly affecting individuals’ daily functioning, social relationships, and overall quality of life. Current diagnostic practices largely rely on clinical interviews and symptom-based rating scales, which are inherently subjective and time-consuming—posing major obstacles to large-scale screening.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To address this, we propose a novel multiscale spatiotemporal network fusion (MSNF) feature extraction method based on functional near–infrared spectroscopy (fNIRS) combined with the verbal fluency test (VFT). This method is designed to enable objective, efficient, and automated differentiation among multiple psychiatric disorders (MDD, BD, and SCZ), as well as between patient groups and healthy controls (HCs). Leveraging the practical advantages of fNIRS, including its portability, motion tolerance, and balanced spatiotemporal resolution, the proposed MSNF fuses temporal dynamics with graph-theoretical topology, capturing both local hemodynamic dynamics and hierarchy connectivity patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, a total of 414 participants were recruited, including individuals diagnosed with MDD, BD, SCZ, and HCs. Classification experiments using machine learning (ML) models demonstrate the proposed method’s robustness and superior diagnostic performance in binary and multiclass settings, outperforming traditional unidimensional feature approaches. Additionally, group-level functional connectivity (FC) analyses reveal distinct neurobiological signatures among psychiatric groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings underscore the translational potential of MSNF-enhanced fNIRS as a scalable neuroimaging–based biomarker tool for early psychiatric screening and differential diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial of a Digital Stepped-Care Program to Reduce Anxiety and Depressive Symptoms Among Long-Term Care Workers With Psychological Distress: The REPICAL Study","authors":"Leticia González-Spinoglio,&nbsp;Mireia Esplugues-Tormo,&nbsp;Iago Giné-Vázquez,&nbsp;Jordi Rodeiro-Boliart,&nbsp;Salvatore Aguilar-Ortiz,&nbsp;Jose Luis Ayuso-Mateos,&nbsp;Kerry R. McGreevy,&nbsp;Roberto Mediavilla,&nbsp;Rinske Roos,&nbsp;Marit Sijbrandij,&nbsp;Anke B. Witteveen,&nbsp;Josep Maria Haro,&nbsp;Mireia Felez-Nobrega","doi":"10.1155/da/5875889","DOIUrl":"10.1155/da/5875889","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Long-term care workers (LTCWs), encompassing those in long-term care facilities and home-care settings, constitute a particularly vulnerable population to psychological distress. This study aimed to evaluate the effectiveness of a digital stepped-care program, adapted from two World Health Organization (WHO) psychological interventions—Doing What Matters in Times of Stress (DWM) and Problem Management Plus (PM+)—in reducing anxiety and depressive symptoms among LTCWs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A parallel-group randomized controlled trial was conducted. Participants were LTCWs from Catalonia (Spain) experiencing psychological distress (Kessler Psychological Distress Scale, K10 ≥ 16). All participants received Psychological First Aid (PFA), and those in the intervention group subsequently received the digital stepped-care program: DWM as step 1, and if psychological distress persisted (K10 ≥ 16), PM + as step 2. The primary outcome was the between-group difference in self-reported depressive and anxiety symptoms at week 21 (2-month post-program follow-up), measured using the Patient Health Questionnaire–Anxiety and Depression Scale (PHQ-ADS). Secondary outcomes included depressive and anxiety symptoms measured separately, post-traumatic stress disorder (PTSD) symptoms, and health-related quality of life (HR-QoL; measured using PHQ-9, 7-item Generalized Anxiety Disorder [GAD-7] scale, PCL-5, and EuroQol 5-dimensional descriptive system–5-level [EQ-5D-5L], respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between October 2022 and May 2024, 165 participants were randomized (intervention: <i>n</i> = 83; control: <i>n</i> = 82). At week 21, depressive and anxiety symptoms were significantly lower in the intervention group, with moderate to large effect sizes (mean difference = 4.2, 95% CI: 1.1–7.3; Standardized effect size [SES] = 0.8, 95% CI: 0.1–1.4). Secondary outcomes also showed significantly greater improvement in the intervention group, except for HR-QoL, for which no differences were found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides evidence supporting the effectiveness of a digital and scalable stepped-care program to support LTCWs’ mental health. These robust findings may inform occupational and public health strategies for supporting LTCWs’ experiencing psychological distress.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05526235</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Antidepressant Mechanisms and Side Effects: Network Pharmacology and Molecular Docking Study of Amitriptyline, Mirtazapine, and Escitalopram for Treating Major Depressive Disorder","authors":"Chuanjun Zhuo,&nbsp;Qiuyu Zhang,&nbsp;Haitao Song,&nbsp;Jiatong Zou,&nbsp;Ranli Li,&nbsp;Xiaoyan Ma,&nbsp;Ximing Chen,&nbsp;Yachen Li,&nbsp;Lei Yang,&nbsp;Lina Wang,&nbsp;Chao Li,&nbsp;Hongjun Tian","doi":"10.1155/da/6981320","DOIUrl":"10.1155/da/6981320","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Amitriptyline, mirtazapine, and escitalopram are effective antidepressants for treating major depressive disorder (MDD). Our study aimed to use computational biology to understand the mechanisms for the similarities and differences in efficacies and side effects of these drugs.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Potential targets for MDD and the three drugs were obtained using public databases. Venn diagrams and protein–protein interaction (PPI) networks were constructed. Drug-target-pathway (D-T-P) networks were built using Cytoscape, and core targets were filtered using CytoNCA and CytoHubba plugins. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted using the Database for Annotation, Visualization, and Integrated Discovery. Ligand compounds and receptor proteins were processed with PyMOL and AutoDock. The binding of amitriptyline, mirtazapine, and escitalopram with core targets was predicted by molecular docking using AutoDock Vina. The results were visualized using PyMOL and protein–ligand interaction profiler (PLIP).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Forty-eight overlapping targets and 66, 50, and 30 individual targets for MDD treatment were identified for amitriptyline, mirtazapine, and escitalopram, respectively. Critical pathways included “Neuroactive ligand–receptor interaction,” “Calcium signaling pathway,” and “Serotonergic synapse.” Key targets, indicating a wide range of effects on cellular activities and signaling mechanisms, included D(2) dopamine receptor (DRD2), CYP2D6, monoamine oxidase type B (MAOB), solute carrier family 6 member 3 (SLC6A3), solute carrier family 6 member 4 (SLC6A4), 5-hydroxytryptamine receptor 2C (HTR2C), and CHRNA4. MAOB had the highest binding affinity with amitriptyline, followed by SLC6A4 and DRD2. Binding stability was enhanced by salt bridges and π-stacking interactions. Mirtazapine formed strong binding affinities with HTR2C, SLC6A4, and CHRNA4 through hydrogen bonds and π-stacking interactions. Escitalopram exhibited the highest affinity for SLC6A3, followed by HTR2C.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All three drugs regulated serotonin, norepinephrine (NE), and dopamine, but target specificity, pathways, and binding patterns differed. Amitriptyline exhibited stronger antidepressant effects and broader mechanisms but a higher risk of side effects. Mirtazapine’s dual mechanism regulates broad targets with reliable efficacy and fewer side effects. Escitalopram selectively acts on serotonin-","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}