Depression and Anxiety最新文献

{"title":"Cross-Lagged Panel Networks of Distinct Complex Post-Traumatic Stress Disorder Symptom Trajectories Among Young Adults With Adverse Childhood Experiences","authors":"Aiyi Liu,&nbsp;Liying Zhang,&nbsp;Mingxiao Liu,&nbsp;Wang Ziwei,&nbsp;Xinchun Wu","doi":"10.1155/da/8823021","DOIUrl":"https://doi.org/10.1155/da/8823021","url":null,"abstract":"<p><b>Background and Objectives:</b> Young adults with a history of adverse childhood experiences (ACEs) may exhibit varying trajectories of complex post-traumatic stress disorder (CPTSD) symptoms over time. Unraveling the patterns of interactions between CPTSD symptoms across distinct trajectories is crucial. This study aimed to investigate the longitudinal relationships, changes, and central symptoms in CPTSD networks over time across distinct CPTSD trajectory groups.</p><p><b>Methods:</b> This longitudinal study followed 1277 university students (47.5% male) who reported ACEs from China through three waves of surveys. ACEs were assessed at baseline, while symptoms of CPTSD were measured at all three time points. Growth mixture modeling (GMM) was used to identify CPTSD symptom trajectories, and cross-lagged panel network (CLPN) analysis estimated the longitudinal relationships among CPTSD symptoms within these trajectories.</p><p><b>Results:</b> Two distinct and consistent CPTSD symptom trajectories were identified: a high-risk group and a resistance group. In the high-risk group, “disturbed relationships” (DRs) and “negative self-concept” (NSC) emerged as the strongest predictors of other symptoms at various time points. In the resilient group, the predictive influence of DR and NSC on other symptoms was attenuated. Instead, “affective dysregulation” (AD) emerged as the central symptom, demonstrating the strong predictive associations with other symptom domains.</p><p><b>Conclusions:</b> These findings reveal directional relationships among symptoms in young adults. Symptoms related to disturbances in self-organization (DSO), identified through centrality indices, are key drivers of symptom network development in different CPTSD trajectories. Targeting these symptoms in interventions for young adults with ACEs may help prevent or reduce CPTSD progression.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/8823021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Dynamics of Social Anxiety and Depressive Symptoms: The Moderating Role of Cognitive Flexibility","authors":"Reut Zabag,&nbsp;Daniella Mouadeb,&nbsp;Shilat Haim-Nachum,&nbsp;Einat Levy-Gigi,&nbsp;Eva Gilboa-Schechtman","doi":"10.1155/da/3055803","DOIUrl":"https://doi.org/10.1155/da/3055803","url":null,"abstract":"<p>Social anxiety (SA) and depressive symptoms frequently coexist, with the onset of SA typically preceding the onset of depression. Individuals experiencing SA-depression comorbidity exhibit increased functional impairments as compared to individuals without this comorbidity. Understanding the mechanisms that underlie the coexistence of SA and depressive symptoms can deepen our theoretical understanding regarding these conditions and contribute to depression prevention efforts. Recent theories suggest that low cognitive flexibility (CF) contributes to the development of depression and may play a role in the relationship between the disorders. However, empirical prospective findings are sparse. We examined whether CF moderates the link between SA and depressive symptoms in two independent preregistered studies: cross-sectional (<i>n</i> = 379) and longitudinal (<i>n</i> = 108, 2-year). Cross-sectionally, higher CF was linked to a weaker relationship between SA and depressive symptoms. Across time, among individuals with low CF at baseline, there was a positive association between SA at baseline and depressive symptoms 2 years later. No such association was found among individuals with high CF. These findings highlight the role of CF in the development of comorbid depressive symptoms among high SA individuals. It may contribute to the clinical prevention of depression through specific psychotherapeutic techniques targeted to enhance CF among SA patients. A preprint of this MS has previously been published.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/3055803","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Primary Psychological Healthcare Policy to Address the Risk of Depression in Underprivileged Children and Adolescents, in the Entire Lower-Middle-Economic-Status City of China: An Observational, Multicenter, and Single-Arm Cohort Study","authors":"Wei Li,&nbsp;Xue-rong Liu,&nbsp;Qianyu Zhang,&nbsp;Lei Xia,&nbsp;Yanyan Li,&nbsp;Xiaobing Tian,&nbsp;Jie Gong,&nbsp;Jidong Ren,&nbsp;Chang Shen,&nbsp;Yi Wu,&nbsp;Ji Chen,&nbsp;Chuan-Peng Hu,&nbsp;Jing-Xuan Zhang,&nbsp;Ting Xu,&nbsp;Yuanyuan Hu,&nbsp;Bowen Hu,&nbsp;Ni Yan,&nbsp;Tingyong Feng,&nbsp;Zhengzhi Feng,&nbsp;Zhiyi Chen","doi":"10.1155/da/5572365","DOIUrl":"https://doi.org/10.1155/da/5572365","url":null,"abstract":"<p><b>Background:</b> Given the historically high incidence of depressive disorders among children/adolescents, efforts to implement universally accessible primary psychological health care policies have been undertaken globally. However, the practical implementation and its association with depression risk reduction remain uncertain, particularly for underprivileged children/adolescents who are underrepresented in the current system.</p><p><b>Methods:</b> A large-scale cohort of underprivileged children/adolescent population aged 6–18 was enrolled (<i>n</i> = 290,239). Subgroups with specific underprivileged conditions were identified, including de facto unattended children/adolescents (dfUCA), orphans, and children/adolescents facing especially difficult circumstances, “left-behind” and “single-parent” children/adolescents. A subgroup of matched typically developing individuals was also included. These subgroups underwent longitudinal assessments for the incidence of identifying depression on Oct 30, 2022 (baseline, before implementing primary psychological health care policy), May 21, 2023 (half year follow-up), and Oct 29, 2023 (1-year follow-up), respectively.</p><p><b>Results:</b> At baseline, nearly twice as high incidence of depression was found in the underprivileged group (13.9%, 95% confidence interval [CI]: 13.7–14.1) as in the control group (7.5%, 7.2–7.7). After the implementation of the primary psychological policy, at the half year follow-up, a notable decrease in the incidence of depression was observed in both the underprivileged group (5.8%, relative risk reduction (RRR) = 51.6%, 51.5–51.7, <i>p</i> &lt; 0.001) and the typically developing group (4.0%, RRR = 34.5%, 27.9–41.0, <i>p</i> &lt; 0.001), particularly among orphan girls aged 12–18. The observed changes in depression incidence across all underprivileged populations were statistically noninferior compared to the typically developing group (all <i>p</i> &lt; 0.001). At the 1-year follow-up, the observed benefits were consistent across all subgroups when compared to baseline. The average expenditure per child/adolescent was $1.6 in implementing such a health care policy.</p><p><b>Conclusions:</b> Implementing the primary psychological health care policy is associated with a reduction in the citywide risk of depression among underprivileged children/adolescents in low–middle-income areas.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5572365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-Based Stress Reduction Alleviates Depression, Anxiety, and Internalized Stigma Compared With Treatment-as-Usual Among Head and Neck Cancer Patients: Findings From a Randomized Controlled Trial","authors":"Zheng Zhang,&nbsp;Qingqin Zhang,&nbsp;Ping Lu,&nbsp;Nurul Izzah Shari,&nbsp;Nik Ruzyanei Nik Jaafar,&nbsp;Mohd Razif Mohamad Yunus,&nbsp;Qiyue Qiu,&nbsp;Fuad Ismail,&nbsp;Nor Faizah Ab Muin,&nbsp;Mohammad Farris Iman Leong Bin Abdullah","doi":"10.1155/da/7499120","DOIUrl":"https://doi.org/10.1155/da/7499120","url":null,"abstract":"<p><b>Background:</b> This study aimed to: (1) compare the rates of change in the severity of depression and anxiety symptoms (primary outcomes) as well as internalized stigma and its components (shame with appearance [SWA], speech and social concerns [SSCs], sense of stigma [SS], and regret [R]; secondary outcomes) between the mindfulness-based stress reduction (MBSR) group and the treatment-as-usual (TAU) control group across three timepoints (<i>T</i>₀ = baseline assessment, prior to intervention; <i>T</i>₁ = postintervention, immediately after completion of intervention or at 8 weeks after commence of intervention; <i>T</i>₂ = follow-up assessment, 12 weeks after completion of intervention), and (2) evaluate the mediating effects of reductions in internalized stigma and its components on the relationship between MBSR and the severity of depression and anxiety symptoms among head and neck cancer (HNC) patients.</p><p><b>Methods:</b> This multicenter, two-armed, parallel, and double-blind randomized controlled trial (RCT) recruited 110 HNC patients. All participants were assessed for the severity of depression and anxiety symptoms, and the degrees of internalized stigma and its components, at each timepoint.</p><p><b>Results:</b> MBSR significantly reduced the severity of depression and anxiety symptoms and degrees of internalized stigma and its components across timepoints (<i>T</i>₀, <i>T</i>₁, and <i>T</i>₂). In contrast, no reduction in scores was observed in the TAU group. Furthermore, internalized stigma, SWA, and SSC partially mediated the relationship between MBSR and the severity of depression and anxiety symptoms. Sensitivity analyses confirmed that the changes in the severity of depression and anxiety symptoms and degrees of internalized stigma and its components according to intention-to-treat (ITT) analysis were similar to that of per-protocol (PP) and last observation carry forward (LOCF) analyses.</p><p><b>Conclusion:</b> MBSR could be recommended as part of the treatment regimen for HNC patients.</p><p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06991309</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/7499120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin–Beck Disease","authors":"Ye Liu,&nbsp;Yan Wen,&nbsp;Zhengjun Yang,&nbsp;Ruixue Zhou,&nbsp;Jingni Hui,&nbsp;Cheng Li,&nbsp;Gangyao Xu,&nbsp;Chan Liu,&nbsp;Huan Liu,&nbsp;Bolun Cheng,&nbsp;Yumeng Jia,&nbsp;Xianni Guo,&nbsp;Feng Zhang","doi":"10.1155/da/8722395","DOIUrl":"https://doi.org/10.1155/da/8722395","url":null,"abstract":"<p><b>Background:</b> Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has been conducted in KBD patients.</p><p><b>Methods:</b> We conducted a field investigation in KBD areas in Northwest China. Questionnaires were designed and used to assess demographic characteristics, clinical characteristics, and medical comorbidities. Patient Health Questionnaire-9 (PHQ-9) was included for the prevalence of depression. Finally, 440 subjects were clinically diagnosed and recruited. Depression was diagnosed when PHQ-9 ≥ 5 and classified into mild (5–9), moderate (10–14), and severe (≥ 15) groups. Logistic regression was also used to identify potential associated factors among KBD patients.</p><p><b>Results:</b> Depression was present in 53.2% of patients in our KBD samples. Among them, 27.5% had mild depression, 18.4% had moderate depression, and 7.3% had severe depression. Being male (odds ratio [OR]: 0.296, 95% confidence interval [CI]: 0.180–0.486, <i>p</i> &lt; 0.001) was an independent protective factor for depression, while the presence of comorbid chronic diseases (OR: 4.701, 95% CI: 2.292–9.640, <i>p</i> &lt; 0.001), and a higher visual analog scale (VAS) pain level (OR: 5.275, 95% CI: 1.326–20.978, <i>p</i> = 0.018) were independent risk factors for depression in KBD patients.</p><p><b>Conclusion:</b> This study is the first to investigate the prevalence of depression and associated factors among Chinese KBD patients, suggesting the significance of an early intervention for their mental issues.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/8722395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interaction Among Depressive Symptoms, Pain, and Frailty in Middle-Aged and Older Adults: A Longitudinal Cross-Lagged Panel Analysis","authors":"Tian-Ming Song,&nbsp;Xue Chen,&nbsp;Xue-He Chen,&nbsp;Si-Jia Tan,&nbsp;Chen-Huan Song,&nbsp;Lin Fan,&nbsp;Jia-Yi Li,&nbsp;Hong-Li Li","doi":"10.1155/da/5566680","DOIUrl":"https://doi.org/10.1155/da/5566680","url":null,"abstract":"<p><b>Background:</b> Depressive symptoms, pain, and frailty interactions in middle-aged and older adults do have longitudinal research support, yet the currently available evidence remains insufficient for a comprehensive understanding. This study aimed to examine their interrelationships and underlying mechanisms.</p><p><b>Methods:</b> This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), which includes four assessments for depressive symptoms, pain, and frailty over 7 years. We included 4961 participants aged 45 years and older in our analysis. We employed cross-lagged panel models (CLPMs) and random intercept CLPMs (RI-CLPMs) to analyze the bidirectional temporal relationships at the between-person and within-person levels.</p><p><b>Results:</b> Cross-lagged panel analysis revealed bidirectional associations between depressive symptoms and pain. A reciprocal predictive relationship was also identified between frailty and pain. After controlling individual differences with the RI-CLPM, depressive symptoms continued to positively predict pain during subsequent periods. However, the predictive effect of pain on subsequent depressive symptoms turned nonsignificant. Although a cross-lagged relationship remained between pain and frailty, it showed a declining trend.</p><p><b>Limitations:</b> While engagement in depressive symptoms, pain, and frailty was assessed via questionnaire, long measurement intervals may not capture short-term fluctuations in the state of each variable.</p><p><b>Conclusions:</b> This study differentiated within- and between-individual effects, uncovering distinct lagged effects of pain, depression, and frailty across levels. It underscored the importance of jointly assessing these conditions and integrating within- and between-individual differences to formulate and execute targeted interventions.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5566680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Underlying Mechanisms of Comorbid Anxiety and Depression Among Young Women: Evidence From Brain Structure and Hormone","authors":"Yao Meng,&nbsp;Zhuoling Li,&nbsp;Lulu Hou,&nbsp;Yan Ji","doi":"10.1155/da/9917994","DOIUrl":"https://doi.org/10.1155/da/9917994","url":null,"abstract":"<p><b>Aim:</b> Youth is a time of a significant rise in depressive symptoms, particularly impacted by anxiety in females. However, the identification of the transition from anxiety to depression in young women remains ambiguous. This study collects data on brain structure and hormone levels in young women, intending to investigate the neurophysiological differences among women with anxiety disorders and comorbid anxiety and depression (CAD).</p><p><b>Methods:</b> 53 young women were divided into three groups, namely an anxiety group, a CAD group, and a control group, aiming to explore the differences in brain structure and ovarian hormone levels.</p><p><b>Results:</b> The CAD group exhibited significantly reduced gray matter volume (GMV) in the right superior frontal gyrus (SFG; 0.38 ± 0.05) and right middle occipital gyrus (MOG; 0.37 ± 0.04) compared to the anxiety (SFG: 0.41 ± 0.04; MOG: 0.41 ± 0.04) and control groups (SFG: 0.45 ± 0.04; MOG: 0.44 ± 0.03; all <i>p</i>  &lt; 0.001). Cortical thickness in the right SFG was also significantly lower in the CAD group (2.81 ± 0.24) than in the anxiety (3.08 ± 0.21) and control groups (3.11 ± 0.19; <i>p</i>  &lt; 0.001). Progesterone was negatively correlated with GMV in the right MOG (<i>r</i> = −0.48, <i>p</i> = 0.042) and SFG (<i>r</i> = −0.53, <i>p</i> = 0.020) only in the CAD group. Further, no significant associations were observed between estradiol levels and brain structure, nor between anxiety/depression scores and hormone or brain data (all <i>p</i>  &gt; 0.070).</p><p><b>Conclusions:</b> The change of brain structure in the SFG and MOG may be one of the mechanisms underlying the progression of symptoms from anxiety to CAD, which may also be related to the increase in progesterone, indicating the exacerbation of emotional disorders in young women.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9917994","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of TMEM106B as a Shared Potential Drug Target for Depression and Stroke Through Comprehensive Genetic Analyses","authors":"Wenqiang Zhang,&nbsp;Lingli Qiu,&nbsp;Yunjie Liu,&nbsp;Yutong Wang,&nbsp;Mingshuang Tang,&nbsp;Lin Chen,&nbsp;Ben Zhang,&nbsp;Xia Jiang","doi":"10.1155/da/5250758","DOIUrl":"https://doi.org/10.1155/da/5250758","url":null,"abstract":"<p><b>Background:</b> The coexistence of depression and stroke has long been observed; however, their intrinsic link has not been fully understood. We aimed to inform the importance of depression intervention as a primary prevention of stroke by investigating shared genetic etiology and causal relationship underlying depression and stroke.</p><p><b>Methods:</b> Leveraging summary statistics from the hitherto largest genome-wide association studies (GWAS) in European-ancestry individuals for depression (<i>N</i>_case/<i>N</i>_control = 294,322/741,438) and stroke (<i>N</i>_case/<i>N</i>_control = 73,652/1,234,808), we performed cross-trait linkage-disequilibrium (LD) score regression and SUPERGNOVA to quantify global and local genetic correlations, cross-trait meta-analysis to identify shared genetic loci, transcriptome-wide association study (TWAS) to detect shared tissue-specific gene expression, and Mendelian randomization (MR) analysis to make causal inference between the two conditions.</p><p><b>Results:</b> We observed a significant positive global genetic correlation between depression and stroke (rg = 0.18, <i>p</i> = 2.92 ×10⁻⁹). Partitioning the whole genome, we observed one genomic region (11q23.2) presenting a significant local genetic correlation. Cross-trait meta-analysis and TWAS identified two shared genetic loci (<i>TMEM106B</i> and <i>FES</i>) revealing potential shared biological mechanisms involving lysosome localization. MR identified a putative causal association of genetically predicted depression on stroke (odds ratio [OR] = 1.13, 95% confidence interval [CI] = 1.07−1.19, <i>p</i> = 1.12 ×10⁻⁵). A considerable proportion of this association was mediated through smoking initiation (proportion-mediated [PM] = 44.0%, 95% CI = 19.9%–68.1%, <i>p</i> = 3.42 ×10⁻⁴), hypertension (PM = 34.0%, 95% CI = 14.5%–53.5%, <i>p</i> = 6.46 ×10⁻⁴), type 2 diabetes (PM = 19.0%, 95% CI = 8.5%–29.5%, <i>p</i> = 3.78 ×10⁻⁴), and atrial fibrillation (PM = 10.9%, 95% CI = 0.7%–21.1%, <i>p</i> = 3.61 ×10⁻²), respectively. MR in the reverse direction identified a putative association of genetically predicted stroke on depression (OR = 1.05, 95% CI = 1.01−1.09, <i>p</i> = 1.73 ×10⁻²), which attenuated to nonsignificant when correcting for both correlated and uncorrelated pleiotropy (OR = 1.00, 95% CI = 0.98−1.03, <i>p</i> = 0.88). Drug target MR identified causal associations of genetically predicted <i>TMEM106B</i> level on depression (OR = 0.92, 95% CI = 0.90−0.94, <i>p</i> = 2.04 ×10⁻¹²) and stroke (OR = 0.90, 95% CI = 0.86−0.95, <i>p</i> = 3.53 ×10⁻⁵).</p><p><b>Conclusion:</b> Our work highlights a shared genetic basis and a putative causal relationship between depression and stroke, providing novel insights into the primary prevention of stroke by depression intervention.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5250758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Veteran Reports of Anxiety and Depression Before, During, and After COVID-19: Associations With Race/Ethnicity, Gender, and Traumatic Exposures","authors":"Ryan Chesnut,&nbsp;Keith R. Aronson,&nbsp;Daniel F. Perkins","doi":"10.1155/da/5572394","DOIUrl":"https://doi.org/10.1155/da/5572394","url":null,"abstract":"<p>The COVID-19 pandemic was a world-wide health emergency that resulted in individuals experiencing challenges in numerous life domains. Life domains affected included physical and mental health, finances, and social isolation. Many health and research professionals evidenced concern that veterans were more likely than civilians to experience COVID-19 related problems due to their “at-risk” health status. Veterans are at-risk for health problems due to encountering unique military experiences such as traumatic exposures, development of trauma-related mental health symptoms or disorders, combat-related injuries, and disability, exposure to toxins such as burn pits and biological agents, and living with chronic stress during their transition to civilian life. It was suggested that the disruptions and challenges the COVID-19 pandemic created could trigger mental health problems among veterans. Indeed, based on cumulative stress theory, female veterans and veterans from racial and ethnic minority groups were thought to be particularly vulnerable for experiencing mental health challenges. The current study examined changes in the symptoms of depression and anxiety before, during, and after the COVID-19 pandemic among a large and diverse sample of post-9/11 veterans. As predicted, when compared to White male veterans, male and female veterans from racial and ethnic minority groups reported having higher symptom levels of anxiety and depression before, during, and after the COVID-19 pandemic. All veterans, except for females from racial and ethnic minority groups, reported experiencing increases in symptoms over time. Exposure to adverse childhood experiences (ACEs), combat exposure, and length of longest deployment were inconsistently associated with symptoms over time. The results suggest that the COVID-19 pandemic was associated with individuals experiencing increased anxious and depressive symptoms over time, although not in a wholly consistent manner. Future global health emergencies may have differential gender- and race/ethnicity-based effects on veterans; thus, veteran-serving organizations should carefully plan their responses to such crises.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5572394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Era for Depression and Anxiety: Global Perspective and Meaningful Impact","authors":"","doi":"10.1155/da/9860293","DOIUrl":"https://doi.org/10.1155/da/9860293","url":null,"abstract":"<p><i>Letter from the Editor in Chief</i></p><p>As <i>Depression and Anxiety</i> starts a new chapter, we are taking the time to reflect on where we have come from—and where we are heading. Under the previous leadership of Editor-in-Chief Murray Stein in collaboration with the Anxiety and Depression Association of America (ADAA) and Editor-in-Chief Peter P. Roy-Byrne the journal has been taking the toll of the challenges that mental health has faced in the last 10 years or so. We thank the Editors for the work they have done.</p><p>Under a new direction, the journal’s mission will be to publishing work that truly resonates with and benefits our global audience. <i>Depression and Anxiety</i> will embrace a more international and interdisciplinary approach. We want to publish high-quality research and thoughtful reviews that speak to the real-world challenges of mental health. By fostering dialog and engagement across borders and disciplines, we are building a collaborative and diverse community that recognizes the multifaceted aspect of mental health. Social, political, and environmental forces all shape our well-being in complex ways. That is why we are prioritizing work that takes an inclusive, interdisciplinary approach to the understanding and treatment of depression and anxiety. Neurobiology, epidemiology, experimental psychopathology, pharmacology, and treatment innovations for mood and anxiety disorders will all fall within the scope of the journal. Some examples of topics our journal is interested in include: environmental degradation and its impact on mental health; political conflicts and mental health; new treatments for anxiety and depression new drugs development; mental health in adolescents and young adults, including how to preserve their well-being and treat any disorders; mental health in marginalized populations, including prisoners, ethnic minorities, LGBTQ+, people with disabilities, people who live with addictions, and people who live in extremely poor conditions; how our diet and nutrition is linked to some mental health disorders. We actively welcome contributions from clinicians, researchers, and individuals around the world who can offer a novel evidence-based approach. Studies that aim to replicate prior findings, while valuable, will be referred to our open-access partner journal <i>Brain and Behavior</i>, with a guarantee of peer review, to ensure fit and relevance.</p><p>We invite academics, clinicians, policymakers, and the public with lived experience to join us. Through shared insights, innovative research, and open exchange, we believe <i>Depression and Anxiety</i> can be more than a journal—it can be a catalyst for meaningful, global change in the field of mental health.</p><p><i>Depression and Anxiety</i></p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9860293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}