Zheng Zhang, Qingqin Zhang, Ping Lu, Nurul Izzah Shari, Nik Ruzyanei Nik Jaafar, Mohd Razif Mohamad Yunus, Qiyue Qiu, Fuad Ismail, Nor Faizah Ab Muin, Mohammad Farris Iman Leong Bin Abdullah
{"title":"与常规治疗相比，正念减压能缓解头颈癌患者的抑郁、焦虑和内化耻辱：来自一项随机对照试验的发现","authors":"Zheng Zhang, Qingqin Zhang, Ping Lu, Nurul Izzah Shari, Nik Ruzyanei Nik Jaafar, Mohd Razif Mohamad Yunus, Qiyue Qiu, Fuad Ismail, Nor Faizah Ab Muin, Mohammad Farris Iman Leong Bin Abdullah","doi":"10.1155/da/7499120","DOIUrl":null,"url":null,"abstract":"<p><b>Background:</b> This study aimed to: (1) compare the rates of change in the severity of depression and anxiety symptoms (primary outcomes) as well as internalized stigma and its components (shame with appearance [SWA], speech and social concerns [SSCs], sense of stigma [SS], and regret [R]; secondary outcomes) between the mindfulness-based stress reduction (MBSR) group and the treatment-as-usual (TAU) control group across three timepoints (<i>T</i><sub>0</sub> = baseline assessment, prior to intervention; <i>T</i><sub>1</sub> = postintervention, immediately after completion of intervention or at 8 weeks after commence of intervention; <i>T</i><sub>2</sub> = follow-up assessment, 12 weeks after completion of intervention), and (2) evaluate the mediating effects of reductions in internalized stigma and its components on the relationship between MBSR and the severity of depression and anxiety symptoms among head and neck cancer (HNC) patients.</p><p><b>Methods:</b> This multicenter, two-armed, parallel, and double-blind randomized controlled trial (RCT) recruited 110 HNC patients. All participants were assessed for the severity of depression and anxiety symptoms, and the degrees of internalized stigma and its components, at each timepoint.</p><p><b>Results:</b> MBSR significantly reduced the severity of depression and anxiety symptoms and degrees of internalized stigma and its components across timepoints (<i>T</i><sub>0</sub>, <i>T</i><sub>1</sub>, and <i>T</i><sub>2</sub>). In contrast, no reduction in scores was observed in the TAU group. Furthermore, internalized stigma, SWA, and SSC partially mediated the relationship between MBSR and the severity of depression and anxiety symptoms. Sensitivity analyses confirmed that the changes in the severity of depression and anxiety symptoms and degrees of internalized stigma and its components according to intention-to-treat (ITT) analysis were similar to that of per-protocol (PP) and last observation carry forward (LOCF) analyses.</p><p><b>Conclusion:</b> MBSR could be recommended as part of the treatment regimen for HNC patients.</p><p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06991309</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/7499120","citationCount":"0","resultStr":"{\"title\":\"Mindfulness-Based Stress Reduction Alleviates Depression, Anxiety, and Internalized Stigma Compared With Treatment-as-Usual Among Head and Neck Cancer Patients: Findings From a Randomized Controlled Trial\",\"authors\":\"Zheng Zhang, Qingqin Zhang, Ping Lu, Nurul Izzah Shari, Nik Ruzyanei Nik Jaafar, Mohd Razif Mohamad Yunus, Qiyue Qiu, Fuad Ismail, Nor Faizah Ab Muin, Mohammad Farris Iman Leong Bin Abdullah\",\"doi\":\"10.1155/da/7499120\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Background:</b> This study aimed to: (1) compare the rates of change in the severity of depression and anxiety symptoms (primary outcomes) as well as internalized stigma and its components (shame with appearance [SWA], speech and social concerns [SSCs], sense of stigma [SS], and regret [R]; secondary outcomes) between the mindfulness-based stress reduction (MBSR) group and the treatment-as-usual (TAU) control group across three timepoints (<i>T</i><sub>0</sub> = baseline assessment, prior to intervention; <i>T</i><sub>1</sub> = postintervention, immediately after completion of intervention or at 8 weeks after commence of intervention; <i>T</i><sub>2</sub> = follow-up assessment, 12 weeks after completion of intervention), and (2) evaluate the mediating effects of reductions in internalized stigma and its components on the relationship between MBSR and the severity of depression and anxiety symptoms among head and neck cancer (HNC) patients.</p><p><b>Methods:</b> This multicenter, two-armed, parallel, and double-blind randomized controlled trial (RCT) recruited 110 HNC patients. All participants were assessed for the severity of depression and anxiety symptoms, and the degrees of internalized stigma and its components, at each timepoint.</p><p><b>Results:</b> MBSR significantly reduced the severity of depression and anxiety symptoms and degrees of internalized stigma and its components across timepoints (<i>T</i><sub>0</sub>, <i>T</i><sub>1</sub>, and <i>T</i><sub>2</sub>). In contrast, no reduction in scores was observed in the TAU group. Furthermore, internalized stigma, SWA, and SSC partially mediated the relationship between MBSR and the severity of depression and anxiety symptoms. 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Mindfulness-Based Stress Reduction Alleviates Depression, Anxiety, and Internalized Stigma Compared With Treatment-as-Usual Among Head and Neck Cancer Patients: Findings From a Randomized Controlled Trial
Background: This study aimed to: (1) compare the rates of change in the severity of depression and anxiety symptoms (primary outcomes) as well as internalized stigma and its components (shame with appearance [SWA], speech and social concerns [SSCs], sense of stigma [SS], and regret [R]; secondary outcomes) between the mindfulness-based stress reduction (MBSR) group and the treatment-as-usual (TAU) control group across three timepoints (T0 = baseline assessment, prior to intervention; T1 = postintervention, immediately after completion of intervention or at 8 weeks after commence of intervention; T2 = follow-up assessment, 12 weeks after completion of intervention), and (2) evaluate the mediating effects of reductions in internalized stigma and its components on the relationship between MBSR and the severity of depression and anxiety symptoms among head and neck cancer (HNC) patients.
Methods: This multicenter, two-armed, parallel, and double-blind randomized controlled trial (RCT) recruited 110 HNC patients. All participants were assessed for the severity of depression and anxiety symptoms, and the degrees of internalized stigma and its components, at each timepoint.
Results: MBSR significantly reduced the severity of depression and anxiety symptoms and degrees of internalized stigma and its components across timepoints (T0, T1, and T2). In contrast, no reduction in scores was observed in the TAU group. Furthermore, internalized stigma, SWA, and SSC partially mediated the relationship between MBSR and the severity of depression and anxiety symptoms. Sensitivity analyses confirmed that the changes in the severity of depression and anxiety symptoms and degrees of internalized stigma and its components according to intention-to-treat (ITT) analysis were similar to that of per-protocol (PP) and last observation carry forward (LOCF) analyses.
Conclusion: MBSR could be recommended as part of the treatment regimen for HNC patients.
期刊介绍：
Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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