Depression and Anxiety最新文献

{"title":"Individual Participant Data Meta-Analysis Identifies Risk Factors for Acute and Persistent Posttraumatic Stress Disorder and Depression Symptoms Following Trauma.","authors":"Andrew Ratanatharathorn, Richard A Bryant, Ronald C Kessler, Katherine M Keyes, Yutaka Matsuoka, Miranda Olff, Renato Polimanti, Andrew G Rundle, Karestan C Koenen, Arieh Y Shalev","doi":"10.1155/da/9859948","DOIUrl":"https://doi.org/10.1155/da/9859948","url":null,"abstract":"<p><strong>Background: </strong>Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are common sequelae to trauma. Identifying individuals at risk for persistent symptomology allows for targeted interventions.</p><p><strong>Methods: </strong>We conducted an individual participant data meta-analysis (IPD-MA) by pooling data from five prospective emergency room and critical care unit studies (<i>N</i> participants = 2571) to examine risk factors for PTSD and MDD. We derived harmonized measures of PTSD and MDD in the acute period (0-60 days) following a traumatic event and in the follow-up persistent period (122-456 days). Multinomial logistic regression was used to estimate associations between seven risk factors for acute and persistent MDD and PTSD. Logistic models examined the association between acute symptoms and persistence of PTSD and MDD.</p><p><strong>Results: </strong>Female sex (odds ratio [OR] range: 1.48-2.14) was associated with increased risk for acute and persistent MDD and PTSD while individuals who experienced an accident versus an assault or other traumatic event as the index trauma were at reduced risk (OR range: 0.39-0.66). Acute MDD symptom severity was associated with persistent PTSD (OR: 1.17; 95% CI: 1.08, 1.27) and remained significant after inclusion of acute PTSD symptom severity (OR: 1.14; 95% CI: 1.01, 1.29). In an analysis of PTSD symptom clusters, reexperiencing symptoms (OR: 1.18; 95% CI: 1.02, 1.36) and MDD symptom severity were associated with persistent PTSD. In models of persistent MDD, acute PTSD symptom severity was associated with persistence (OR: 1.15; 95% CI: 1.03, 1.28), but neither overall symptom severity nor cluster symptom severities were associated with persistence after inclusion of acute MDD symptom severity (OR: 1.13; 95% CI: 1.00, 1.26).</p><p><strong>Conclusion: </strong>Early symptoms of MDD and reexperiencing were associated with the persistence of psychopathology indicating that depressive rumination may play a role in the maintenance of MDD and PTSD.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"9859948"},"PeriodicalIF":3.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postnatal Common Mental Disorders and Their Predictors in Northwest Ethiopia: A Community-Based Cohort Study.","authors":"Helina Abebe Kurbi, Solomon Mekonnen Abebe, Netsanet Worku Mengistu, Alemayehu Teklu Toni, Tadesse Awoke Ayele","doi":"10.1155/da/2781884","DOIUrl":"https://doi.org/10.1155/da/2781884","url":null,"abstract":"<p><strong>Background: </strong>Postnatal common mental disorders (PCMDs) are the most common complications after childbirth and are associated with many adverse effects on infant growth and development. Undiagnosed and untreated PCMDs significantly affect the health and lives of the mother, their children, and families. Although PCMDs are a significant public health concern, evidence from Ethiopia is limited. This study aimed to assess PCMDs and their predictors among postnatal women in the Dabat HDSS, Northwestern Ethiopia.</p><p><strong>Methods: </strong>A community-based cohort study involved 872 pregnant women, who were evaluated for common mental disorders during their second and third trimesters and again two to 8 weeks postpartum. Women with a self-reporting questionnaire-20 (SRQ-20) score of ≥6 were considered to have common mental disorders. A modified Poisson regression model was used to identify the independent predictors of pCMDs.</p><p><strong>Results: </strong>The prevalence and incidence of pCMDs were 16.05% (95% CI: 13.67, 18.74) and 14.02% (95% CI: 11.64, 16.79), respectively, with 3.83% of women exhibiting perinatal CMD during the study period. PCMDs are independently predicted by experiencing labor complications (IRR = 2.43, 95% CI: 1.69, 3.47), preterm birth (IRR = 1.72, 95% CI: 1.26, 2.35), antenatal CMD (IRR = 1.89, 95% CI: 1.37, 2.61), and a history of CMD before pregnancy (IRR = 2.29, 95% CI: 1.32, 3.98).</p><p><strong>Conclusion: </strong>The observed incidence and prevalence of PCMDs in Ethiopia were lower than in previous studies. Common mental disorders before and during pregnancy, preterm birth, and the presence of labor complications increase the risk of pCMDs. Early detection and treatment of mental disorders before and during pregnancy, along with interventions to reduce preterm birth and labor complications, could decrease the incidence of postnatal mental disorders.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"2781884"},"PeriodicalIF":3.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Transdiagnostic Role of Emotion Regulation Difficulties and Repetitive Negative Thinking in Depression, Anxiety, and Their Comorbidity.","authors":"Eva Herzog, Sebastian Wolf, Thomas Studnitz, Anna Katharina Frei, Britta Seiffer, Jana Welkerling, Johanna-Marie Zeibig, Gorden Sudeck, Celina L Müller, Mia Maria Günak, Tristan T Nakagawa, Thomas Ehring, Leonie Sundmacher, Stefan Peters, Anna Lena Flagmeier, Lena Zwanzleitner, Ander Ramos-Murguialday, Keisuke Takano, Barbara Cludius","doi":"10.1155/da/9949037","DOIUrl":"https://doi.org/10.1155/da/9949037","url":null,"abstract":"<p><p>This study investigated emotion regulation (ER) difficulties and repetitive negative thinking (RNT) in individuals with depression, anxiety disorders, or both, compared to nonclinical controls. We aimed to determine which aspects of ER difficulties and RNT are transdiagnostic or specific to one of the disorders, and whether the presence of comorbidities is associated with greater ER difficulties and higher levels of RNT. A total of <i>N</i> = 731 participants, including <i>n</i> = 354 individuals with depression, anxiety disorders, or both (mixed group), and <i>n</i> = 377 nonclinical controls, completed the Difficulties in Emotion Regulation Scale (DERS) and the Perseverative Thinking Questionnaire (PTQ). Parametric and nonparametric analyses were conducted to assess group differences and comorbidity effects. The depression and anxiety disorders groups exhibited significantly greater ER difficulties and higher levels of RNT than nonclinical controls. The mixed group showed more pronounced difficulties in certain aspects of ER (nonacceptance of emotional responses, difficulties engaging in goal-directed behavior, impulse control difficulties, and limited access to ER strategies) and higher levels of RNT compared to the single-diagnosis groups. No significant differences were found in emotional awareness and clarity across clinical groups. Evidence regarding the relationship between the number of comorbid diagnoses and the severity of the difficulties was less clear. This suggests that specific disorders may have a more significant impact than comorbidity alone. Our findings highlight the transdiagnostic role of ER difficulties and RNT in depression and anxiety disorders and suggest that they may be a promising target for transdiagnostic interventions. Future research should further explore the nuanced ways in which ER difficulties and RNT vary across different mental disorders.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"9949037"},"PeriodicalIF":3.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Cortex Entropy Derived From Resting-State fNIRS for Brain Age Prediction in Major Depressive Disorder.","authors":"Shanling Ji, Yang Tian, Xinyu Lin, Xia Liu, Hao Yu","doi":"10.1155/da/4616978","DOIUrl":"https://doi.org/10.1155/da/4616978","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the potential of frontal brain entropy (BEN) metrics derived from resting-state functional near-infrared spectroscopy (rs-fNIRS) as neurophysiological biomarkers for predicting brain age in patients with major depressive disorder (MDD).</p><p><strong>Methods: </strong>Rs-fNIRS data (26 channels) were acquired from the frontal cortex of 49 healthy controls (HCs) and 35 MDD patients. Time-series signals for oxyhemoglobin (HbO), deoxyhemoglobin (HbR), and total hemoglobin (HbT) were extracted. Static BEN was computed as permutation entropy (PE) using the full time series for each channel, while dynamic BEN was derived by calculating PE within consecutive time windows. Support vector regression (SVR) was applied to predict brain age in the HC group using static and dynamic BEN features. The optimal model was then used to predict brain age in the MDD group. Finally, receiver operating characteristic (ROC) curve analysis was conducted to evaluate the discriminative capacity of BEN and brain age metrics for distinguishing MDD from HC.</p><p><strong>Results: </strong>In HC, the strongest brain age prediction was achieved by dynamic BEN derived from HbR signals (<i>r</i> = -0.62, <i>p</i> < 0.001), while in MDD, the best performance was obtained using dynamic BEN from HbO signals (<i>r</i> = -0.78, <i>p</i> < 0.001). MDD patients exhibited a significantly elevated brain age gap (BAG) compared with HC across all entropy-based features (all <i>p</i> < 0.001). Moreover, both group-discriminative BEN and brain age metrics derived from static and dynamic BEN achieved outstanding diagnostic performance, with several combinations reaching an area under the ROC curve of 1.00 in distinguishing MDD from HC.</p><p><strong>Conclusions: </strong>Frontal BEN derived from rs-fNIRS represents a potential neurophysiological biomarker of accelerated brain aging in patients with MDD. Furthermore, brain age estimated from cerebrovascular hemodynamic complexity demonstrates high discriminative ability for identifying MDD. Collectively, these findings suggest that frontal neurovascular complexity metrics may serve as both diagnostic markers for MDD and quantitative indicators of pathological aging progression.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"4616978"},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directional Asymmetry Without Timescale Dependence: Longitudinal Associations Between Procrastination and Depressive Symptoms.","authors":"Rong Zhang, Huaxian Tan, Lin Wang, Shunmin Zhang","doi":"10.1155/da/3056943","DOIUrl":"https://doi.org/10.1155/da/3056943","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal research has examined procrastination-emotion dynamics across diverse temporal intervals, yet it remains unclear whether findings obtained at different timescales reflect distinct underlying mechanisms. Guided by an emotion-regulation account, the present study tested the hypotheses that negative emotions predicted subsequent procrastination more strongly at shorter intervals, whereas procrastination predicted increases in depressive symptoms over longer intervals.</p><p><strong>Methods: </strong>To test whether the procrastination-depressive symptoms coupling varied across temporal scales, we integrated three longitudinal datasets (i.e., daily, 1-month, and half-yearly intervals) and compared models in which within-person lagged effects (i.e., from depressive symptoms to procrastination and the reverse path) were allowed to vary versus constrained to be invariant across timescales. Directional paths were then reported based on the better-fitting model.</p><p><strong>Results: </strong>Model comparisons favored the timescale-invariant model over the timescale-variant model for both directional paths. Across multiple temporal scales, the timescale-invariant model showed negligible effects of depressive symptoms on subsequent procrastination, while procrastination predicted increases in depressive symptoms.</p><p><strong>Conclusion: </strong>Contrary to timescale-dependent expectations, no evidence for temporally distinct mechanisms was observed within the examined intervals. Instead, the findings reveal a modest directional asymmetry across timescales, suggesting that procrastination may have consistent but small effects on subsequent increases in depressive symptoms rather than forming a reciprocal feedback loop.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"3056943"},"PeriodicalIF":3.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Patterns and Predictive Factors of Childhood Depressive Disorders Across Asia.","authors":"Kexin Zhang, Chengxia Kan, Yujie Ma, Zhenghui Tian, Fang Han, Xiaodong Sun","doi":"10.1155/da/5544502","DOIUrl":"https://doi.org/10.1155/da/5544502","url":null,"abstract":"<p><strong>Background: </strong>Childhood depressive disorders represent a growing mental health concern, yet region-specific evidence in Asia remains limited. Asia hosts more than half of the global child population and has experienced rapid social and environmental changes that may heighten psychosocial stress. This study assessed the burden, temporal trends, geographic variation, and determinants of childhood depressive disorders across Asia from 1990 to 2023.</p><p><strong>Methods: </strong>Data for children aged 0-14 years were obtained from the Global Burden of Disease (GBD) 2023 study. Incidence and disability-adjusted life years (DALYs) were analyzed by age, sex, region, and country. Joinpoint regression quantified annual and long-term temporal trends. Bullying victimization was evaluated as a behavioral risk factor. Extreme Gradient Boosting (XGBoost) models with Shapley Additive Explanations (SHAP), which show how each variable influences model predictions, were used to identify the major predictors of incidence and DALYs.</p><p><strong>Results: </strong>In 2023, South Asia showed the highest incidence rate (1099 per 100,000) and DALYs rate (119 per 100,000). Across all regions, children aged 10-14 years and girls had the greatest incidence and DALYs rates. India, China, and Pakistan contributed the largest absolute numbers of cases and DALYs, while Mauritius, Bangladesh, and Pakistan recorded the highest rates. Pakistan demonstrated the steepest long-term increases in both incidence and DALYs. Bullying-attributable DALYs increased across all regions, with the largest growth in South and Southeast Asia. SHAP analyses identified age, sex, calendar year, and population size as the strongest predictors, with older children and girls showing markedly higher predicted burdens.</p><p><strong>Conclusion: </strong>Childhood depressive disorders have increased steadily across Asia over the past three decades, with clear demographic and geographic disparities. These findings highlight the urgency of early detection, school-based mental health programs, antibullying interventions, and gender-responsive services. Strengthening child mental health systems in Asia is critical for improving developmental outcomes.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"5544502"},"PeriodicalIF":3.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional Associations of 24-h Movement Behaviors With Depressive and Anxiety Symptoms in Middle-Aged Adults.","authors":"Clarence Tan, Maisa Niemelä, Marjo Seppänen, Anna-Maiju Leinonen, Vahid Farrahi","doi":"10.1155/da/6881070","DOIUrl":"https://doi.org/10.1155/da/6881070","url":null,"abstract":"<p><strong>Background: </strong>Physical activity could reduce the risk of depression and anxiety. A 24-h day includes time spent sleeping, in sedentary behavior (SB), or engaging in physical activities. However, the joint and combined associations of these 24-h movement behaviors with depressive and anxiety symptoms remain unclear.</p><p><strong>Aim: </strong>To investigate the compositional associations of 24-h movement behaviors with depressive and anxiety symptoms in a population-based sample of middle-aged adults.</p><p><strong>Methods: </strong>The study population (<i>N</i> = 4490) comprised of participants from the Northern Finland Birth Cohort 1966 (NFBC1966). Over 14 consecutive days, movement behaviors-SB, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA)-were recorded using a hip-worn accelerometer and were combined with self-reported sleep duration to obtain the 24-h time-use composition. Three different screening tools-Beck Depression Inventory-II (BDI-II), Generalized Anxiety Disorder-7 (GAD-7), and Hopkins Symptom Checklist-25 (HSCL-25)-were utilized to assess the severity of depressive and anxiety symptoms. Compositional linear regression and time reallocation analysis were performed to examine the associations of 24-h movement behaviors with depressive and anxiety symptoms.</p><p><strong>Results: </strong>Compositional 24-h movement behaviors were significantly associated with depressive and anxiety symptoms. Higher MVPA relative to other components of 24-h movement behaviors was associated with significantly lower depressive and anxiety symptoms. A 30-min reallocation of time from SB to MVPA was associated with 9.0% (95% confidence interval [CI]: 6.3%, 11.6%) lower depressive symptoms and 4.5% (95% CI: 2.1%, 6.9%) lower anxiety symptoms assessed with BDI-II and GAD-7 tools, respectively. Similar patterns of associations were observed in the time reallocation analysis when depressive and anxiety symptoms were assessed with the HSCL-25 screening tool.</p><p><strong>Conclusion: </strong>Each component of 24-h movement behaviors was associated with depressive and anxiety symptoms. Among the component parts of 24-h movement behaviors, MVPA was most strongly associated with lower depressive and anxiety symptoms, whereas LPA only showed marginal favorable benefits.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"6881070"},"PeriodicalIF":3.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Psychotropic Polypharmacy and Associated Factors in Antidepressant-Treated Patients With Depressive Disorder: A Population-Based Cohort Study Using Real World Data.","authors":"Diego Infante-Ventura, Benjamín Rodríguez-Díaz, Miguel Ángel García-Bello, Cristina Válcarcel-Nazco, Francisco Estupiñán-Romero, Francisco Javier Acosta Artiles, Beatriz González de León, Isabel Hurtado-Navarro, Tasmania Del Pino-Sedeño","doi":"10.1155/da/6076326","DOIUrl":"https://doi.org/10.1155/da/6076326","url":null,"abstract":"<p><strong>Introduction: </strong>Psychotropic polypharmacy typically refers to the prescription of more than one psychotropic medication to a patient. While polypharmacy can sometimes be clinically justified, it is widely recognized that multiple drug use and exposure can be problematic. The aim of this article is to analyze polypharmacy experienced by patients with depressive disorders, estimating its incidence during the first year after diagnosis and exploring the sociodemographic, clinical, and health-related lifestyle factors related to psychotropic polypharmacy.</p><p><strong>Methods: </strong>A retrospective population-based cohort study was conducted among adults (aged 18 and over) within the Canary Islands Health Service. The study analyzed routine health record data from patients diagnosed with depressive disorders who received antidepressant treatment between 2013 and 2022. Psychotropic polypharmacy refers to the concurrent use of two or more psychotropic medications by the same patient. To explore the relationship with sociodemographic, clinical, and lifestyle characteristics, multivariate logistic regression analyses were conducted.</p><p><strong>Results: </strong>The study included a total of 39,800 participants, with a polypharmacy incidence of 86.28%. Most patients (48.10%) received three or more medications (<i>N</i> = 19,145). Factors associated with polypharmacy included the 45-64 age group (OR: 1.21), previous depressive episodes (OR: 1.15), number of comorbidities (OR: 1.11), and male gender (OR: 0.83).</p><p><strong>Conclusion: </strong>The results highlight the complexity of psychotropic polypharmacy, especially in patients with previous episodes and comorbidities. While the use of multiple medications may be necessary, it is critical to periodically review treatments to ensure their safety, especially in vulnerable populations. New prescription trends suggest a shift toward more rational approaches, although further research is required to support clinical guidelines.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"6076326"},"PeriodicalIF":3.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.","authors":"Haonan Guan, Luyao Wang, Fan Dong, Wenjing Hu, Zhilin Zhang, Jinglong Wu, Yue Lu, Wei Ding, Jiehui Jiang","doi":"10.1155/da/1705507","DOIUrl":"https://doi.org/10.1155/da/1705507","url":null,"abstract":"<p><p>Patients with facial synkinesis (FS) comorbid depression may experience aggravated symptoms of perceived synkinesis and poorer recovery outcomes. Exploring imaging features associated with depressive symptoms could help us better understand disease conditions and formulate appropriate rehabilitation plans. Although abnormal activation in the middle frontal gyrus (MFG) has been reported in depression patients, whether it represents an imaging correlate of depressive symptoms in patients with FS is still unknown. Therefore, a total of 52 participants (20 normal controls [NCs], 32 patients) with both task and resting-state functional magnetic resonance imaging (rs-fMRI) data were included in this study. Comorbid depression was assessed with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V), and depressive symptom severity was measured with the Beck Depression Inventory-II (BDI-II). We investigated brain activation during motor tasks (smiling, blinking, and grinning). In addition, the seed-based functional connectivity (FC) between the MFG and other brain areas was calculated in the resting state. Additionally, we analyzed the associations between brain activity and clinical scale scores. The results revealed reduced activation in the sensorimotor and MFG during affected side movements across all tasks (voxel-level <i>p</i> < 0.05, cluster-level <i>p</i> < 0.05, Gaussian random field [GRF]-corrected). Moreover, seed-based FC between the MFG and emotion-related areas was increased (voxel-level <i>p</i> < 0.05, cluster-level <i>p</i> < 0.05, GRF-corrected), indicating impaired emotional networks in patients. Scores on the BDI-II were negatively associated with MFG activation during tasks (R = -0.318, <i>p</i> = 0.027) and positively associated with the FC of the MFG (<i>R</i> = 0.387, <i>p</i> = 0.029). Thus, the MFG activation and connectivity may represent an increased risk for elevated depressive symptoms in patients with FS, warranting further validation in future studies. <b>Trial Registration:</b> Chinese Clinical Trial Registry: ChiCTR1800014630.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"1705507"},"PeriodicalIF":3.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Voice Acoustics in Depression Assessment: Findings From Bibliometric Analysis, Literature Review, and Meta-Analysis.","authors":"Lady Catherine Cantor-Cutiva, Andrés Carrillo-González, Ahmed M Yousef, Mark Berardi, Eric J Hunter","doi":"10.1155/da/5592230","DOIUrl":"https://doi.org/10.1155/da/5592230","url":null,"abstract":"<p><strong>Background: </strong>Depression is a prevalent mental health disorder that significantly impairs psychosocial functioning and quality of life. Recent advances in health sciences and digital technologies have highlighted the potential of voice acoustic parameters as objective indicators of health status, including depression.</p><p><strong>Methods: </strong>A bibliometric analysis, systematic literature review, and meta-analysis were conducted to consolidate and critically evaluate the current evidence regarding the relationship between voice acoustic parameters and depression. The search was performed in January 2024 across seven databases, including PubMed, Web of Science, and Scopus. Studies were included if they involved participants with clinically significant depression, identified either through formal diagnostic criteria or through validated depression rating scales with established clinical thresholds and explicitly reported voice acoustic parameters. A total of 31 potential publications were identified and analyzed, and after full-text reading, 17 publications were included. Only six out of the 17 included studies reported sufficient numerical fundamental frequency (fo) data for meta-analysis; other parameters could not be synthesized quantitatively due to a lack of extractable values.</p><p><strong>Results: </strong>The bibliometric analysis suggests an evolution from studies identifying \"valid\" assessment tools towards the modeling of potential discriminatory factors. The mean difference (MD) suggests a decreased fo of 1.82 Hz among participants identified with depression compared to participants identified as the control group. However, the difference between the groups was not statistically significant (<i>Z</i> test = 0.58; <i>p</i>-value 0.56).</p><p><strong>Conclusions: </strong>Voice acoustic parameters seem to have the potential to be noninvasive, cost-effective biomarkers for measuring and monitoring depression symptomatology. Although there was a trend of decreased fo of 1.82 Hz among participants identified with depression compared to participants identified as the control group, the meta-analysis suggests a nonsignificant difference in average values.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"5592230"},"PeriodicalIF":3.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}