Depression and Anxiety最新文献

{"title":"The Immediate Impact of App-Based Psychotherapeutic Exercises on Anxiety: An RCT","authors":"Julia Fabienne Sandkühler,&nbsp;Fabian Kahl,&nbsp;Magda Zena Sadurska,&nbsp;Peter Brietbart,&nbsp;Spencer Greenberg,&nbsp;Jan Brauner","doi":"10.1155/da/5586831","DOIUrl":"https://doi.org/10.1155/da/5586831","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Despite the growing integrative trend in psychotherapy, few studies have examined the potential for immediate anxiety relief of many different psychotherapeutic exercises side by side under the same conditions. This information might be important to enhance engagement and self-efficacy, stop negative feedback loops, and prevent avoidant or destructive behavior during crises. Technology-based psychotherapeutic exercises are of particular interest because they are accessible and scalable.</p>\u0000 <p><b>Methods:</b> This parallel, double-blind, randomized trial (<i>N</i> = 1092) compared 12 psychotherapeutic exercises of the Mind Ease app against a reading control and a measurement-only control. Efficacy was measured with a custom scale validated against the state subscale of the State–Trait Anxiety Inventory.</p>\u0000 <p><b>Results:</b> Each of the 12 exercises significantly reduced anxiety more than controls (<i>p</i> = 0.018 to &lt;0.001, η²<i> </i>_<i>p</i> = 0.06 to 0.37, <i>d</i> = 0.5 to 1.5, d [95% CI] for all exercises together vs. reading control = 0.8 [0.6; 1.0], and vs. measurement-only control = 0.8 [0.6; 1.0]). Exercises employing cognitive restructuring had effect sizes <i>d</i> [95% CI] of 0.5 [0.2; 0.8], 0.7 [0.3; 1.0], and 0.9 [0.6; 1.2], diaphragmatic breathing of 0.6 [0.3; 0.9], gratitude practice of 0.8 [0.5; 1.1], positive expressive writing of 1.1 [0.7; 1.4], progressive muscle relaxation of 1.3 [0.9; 1.6], guided imagery of 1.3 [1.0; 1.6], and mindfulness of 0.9 [0.6; 1.2], 1.0 [0.7; 1.3], 1.2 [0.9; 1.5], and 1.5 [1.2; 1.9]. Twenty-eight comparisons between exercises (42%) had <i>p</i>  &lt; 0.05, nine met the Bonferroni-adjusted threshold of <i>p</i>  &lt; 0.0008.</p>\u0000 <p><b>Conclusions:</b> The 12 psychotherapeutic exercises proved effective at immediately mitigating anxiety. Differences between exercises were substantial even within categories. Mindfulness tended to have a larger effect than cognitive restructuring.</p>\u0000 <p><b>Trial Registration</b>: ClinicalTrials.gov identifier: NCT05850975</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5586831","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest–Activity Rhythm Patterns and Their Associations With Depression and Obesity: A Study Using Actigraphy and Human–Smartphone Interactions","authors":"I-Ming Chen,&nbsp;Chen Lin,&nbsp;Guan-Jie She,&nbsp;Hsiang-Chih Chang,&nbsp;Hai-Hua Chuang,&nbsp;Tien-Yu Chen,&nbsp;Yu-Hsuan Lin","doi":"10.1155/da/2617282","DOIUrl":"https://doi.org/10.1155/da/2617282","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> This study aimed to empirically derive subgroups based on both actigraphy- and app-measured rest–activity rhythm (RAR) patterns and investigate the relationship between these profiles and health outcomes, including depression and obesity.</p>\u0000 <p><b>Methods:</b> We developed a mobile app, Rhythm, to record human–smartphone interactions and calculate RAR patterns alongside standard actigraphy in 135 participants (mean age: 43.8 ± 12.3 years, 64% women) with and without major depressive disorder and/or obesity. Wrist actigraphy and Rhythm app recorded activity data for at least 4 weeks, totaling 3978 person-days. Person-centered clustering was conducted to identify subgroups based on RAR characteristics, and their associations with clinical outcomes were evaluated using multivariable regression models.</p>\u0000 <p><b>Results:</b> Three distinct groups with different RAR patterns were identified based on acrophase, interdaily stability (IS), and intradaily variability (IV), measured by actigraphy and human–smartphone interactions, respectively. The “earlier” group exhibited earlier acrophase both by actigraphy and the app and had lower depressive symptom severity than the other two groups. The “later” group showed a later acrophase and a lower body mass index (BMI) compared to the “earlier” group. The “irregular” group, characterized by higher IV, lower IS, and desynchronized actigraphy- and app-measured acrophase, was associated with higher levels of depressive symptom severity and BMI.</p>\u0000 <p><b>Conclusions:</b> Our study highlights the usefulness of human–smartphone interaction patterns in providing a comprehensive understanding of individuals’ circadian rhythms beyond standard actigraphy measurements. Identifying distinct RAR profiles based on both actigraphy and app measurements contributes to a better understanding of the associations between circadian disruptions and mental and physical health outcomes.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/2617282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Brain Functional Connectivity and Peripheral Transcriptomic Profiles in Major Depressive Disorder With Childhood Maltreatment","authors":"Min Wang,&nbsp;Jinxue Wei,&nbsp;Yushun Yan,&nbsp;Yue Du,&nbsp;Huanhuan Fan,&nbsp;Yikai Dou,&nbsp;Liansheng Zhao,&nbsp;Rongjun Ni,&nbsp;Xiao Yang,&nbsp;Xiaohong Ma","doi":"10.1155/da/6059502","DOIUrl":"https://doi.org/10.1155/da/6059502","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Childhood maltreatment (CM) is a significant risk factor for major depressive disorder (MDD), yet the underlying biological mechanisms remain unclear. This study aimed to investigate brain functional networks and peripheral transcriptomics in patients with MDD who have a history of CM.</p>\u0000 <p><b>Methods:</b> Functional imaging data were collected and network-based statistics were used to identify differences in functional networks among MDD patients with CM (MDD_CM, <i>n</i> = 78), MDD patients without CM (MDD_nCM, <i>n</i> = 61), and healthy controls (HC, <i>n</i> = 126). Additionally, blood transcriptional data were clustered into co-expression modules, and module differential connectivity analysis was utilized to assess variations in gene co-expression network modules among the groups.</p>\u0000 <p><b>Results:</b> The results revealed a significant difference in an inferior occipital gyrus-centered functional network among the three groups. Furthermore, eight gene co-expression modules differed among the groups and were enriched in multiple branches related to immune responses or metabolic processes. Notably, a module enriched in type I interferon-related signaling pathways demonstrated a significant correlation with the disrupted network in the MDD_nCM group. Moreover, multiple immune-related gene modules were found to be significantly correlated with sleep disturbances in MDD_CM patients.</p>\u0000 <p><b>Conclusions:</b> Dysregulation of an inferior occipital gyrus-centered functional network and immune-related transcriptomic alterations significantly associate with the pathophysiology of MDD_CM.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/6059502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Distress in Childbearing Persons During the COVID-19 Pandemic: A Multi-Trajectory Study of Anger, Anxiety, and Depression","authors":"Christine Ou,&nbsp;Guanyu Chen,&nbsp;Gerald F. Giesbrecht,&nbsp;Elizabeth Keys,&nbsp;Catherine Lebel,&nbsp;Lianne Tomfohr-Madsen","doi":"10.1155/da/6663877","DOIUrl":"https://doi.org/10.1155/da/6663877","url":null,"abstract":"<div>\u0000 <p>Psychological distress can manifest as depression, anxiety, and anger in the perinatal period. These conditions are often comorbid yet studied in isolation. A full understanding of perinatal psychopathology requires the spectrum of common psychological distress to be studied concurrently to better understand interconnected symptoms. A transdiagnostic approach provides valuable insights into how symptoms interact and cumulatively affect mental health, which can inform more effective screening and treatment strategies. This, in turn, can improve outcomes for birthing parents experiencing psychological distress. We undertook group-based multi-trajectory modeling (GBMTM) to uncover the patterns of affective disorders (anger, anxiety, and depression) over three-time points (pregnancy, 3-, and 12-months postpartum (mPP)) in a large longitudinal cohort of persons who gave birth during the COVID-19 pandemic (<i>n</i> = 2145). We identified five trajectory groups: high-stable (11.3%), postpartum-increase (16.0%), postpartum-decrease (21.5%), low-stable (37.9%), and minimal stable (13.2%) symptoms of anger, anxiety, and depression. Multinomial regression revealed that lower levels of sleep disturbance, less financial hardship, and lower intolerance of uncertainty predicted postpartum decreases in psychological distress compared with the high stable group. Higher levels of sleep disturbance, greater financial hardship, lower level of social support, and greater intolerance of uncertainty predicted postpartum increases in psychological distress compared with the low-stable and minimal-stable groups. Screening for psychological distress symptoms (i.e., anger, anxiety, and depression), paired with access to evidence-based management for those who screen positive, is warranted during the first postpartum year to reduce the harmful effects of unmanaged distress on families.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/6663877","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Structure–Function Coupling in Major Depressive Disorder Patients With and Without Anhedonia","authors":"Qingli Mu,&nbsp;Congchong Wu,&nbsp;Yue Chen,&nbsp;Yuwei Xu,&nbsp;Kejing Zhang,&nbsp;Ce Zhu,&nbsp;Shaohua Hu,&nbsp;Manli Huang,&nbsp;Peng Zhang,&nbsp;Dong Cui,&nbsp;Shaojia Lu","doi":"10.1155/da/1925158","DOIUrl":"https://doi.org/10.1155/da/1925158","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> As a core symptom of major depressive disorder (MDD), previous magnetic resonance studies have demonstrated that MDD with anhedonia may exhibit distinctive brain structural and functional alterations. Nevertheless, the impact of anhedonia on synchronized alterations in the structure and function of brain regions in MDD remains uncertain.</p>\u0000 <p><b>Methods:</b> A total of 92 individuals were enrolled in the study, including 29 MDD patients with anhedonia, 33 MDD patients without anhedonia, and 30 healthy controls (HCs). All subjects underwent structural and resting-state functional magnetic resonance imaging (MRI) scans. The structure–function coupling of cortical and subcortical regions was constructed by using the obtained structural and functional data to quantify the distributional similarity of gray matter volume (GMV) and amplitude of low-frequency fluctuations (ALFFs). Analysis of covariance (ANCOVA) was used to compare differences in structure–function coupling among the three groups. Partial correlation analyses were conducted to identify relationships between structure–function coupling and clinical features. Finally, receiver operating characteristic (ROC) curve and support vector machine (SVM) analysis were employed to verify the capacity to distinguish between MDD with anhedonia and MDD without anhedonia, MDD with anhedonia and HCs, and MDD without anhedonia and HCs.</p>\u0000 <p><b>Results:</b> The ANCOVA revealed significant differences in structure-function coupling among three groups in the bilateral precentral gyrus (PrG), right insular gyrus (INS), right cingulate gyrus (CG), right thalamus (Tha), left superior temporal gyrus (STG), and left middle temporal gyrus (MTG). Compared to HCs, both MDD groups showed reduced coupling in the right INS, bilateral PrG, while increased coupling in the right CG. Additionally, MDD with anhedonia showed reduced coupling in the right Tha, right PrG, and left MTG, while increased coupling in the left STG, compared to the other two groups. Furthermore, ROC analyses indicated that structure-function coupling in the right PrG, right CG, and left MTG exhibited the greatest capacity to distinguish between the following groups: MDD with anhedonia from HCs, MDD without anhedonia from HCs, and MDD with anhedonia from MDD without anhedonia. The combined metrics demonstrated greater diagnostic value in two-by-two comparisons.</p>\u0000 <p><b>Conclusion:</b> The present findings highlight that altered structure–function synchrony in the frontal, temporal lobes, and Tha may be implicated in the development of symptoms of anhedonia in MDD patients. Altered structure–function coupling in the aforementioned brain regions may serve as a novel neuroimaging biomarker for MDD with anhedonia.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/1925158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding Patterns and Postpartum Depressive Symptoms: The Mediating Role of Parenting Self-Efficacy","authors":"Yi Zhu,&nbsp;Yuhang Xie,&nbsp;Xiaoxu Yin,&nbsp;Yanhong Gong","doi":"10.1155/da/2748707","DOIUrl":"https://doi.org/10.1155/da/2748707","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> The mechanisms underlying the association between breastfeeding and postpartum depressive symptoms remain unclear. In this study, we analyzed the relationship between maternal feeding patterns and postpartum depressive symptoms and investigated the mediating role of parenting self-efficacy (PSE).</p>\u0000 <p><b>Methods:</b> A prospective longitudinal survey of 708 mothers was conducted from September 2018 to August 2020. Structural equation modeling was used to examine the relationship between feeding patterns and postpartum depressive symptoms and the effect of PSE.</p>\u0000 <p><b>Results:</b> Breastfeeding mothers experienced milder depressive symptoms and higher PSE than women who did not breastfeed. The structural equation modeling results showed a direct effect of feeding patterns on postpartum depressive symptoms and an indirect effect of postpartum depressive symptoms through PSE.</p>\u0000 <p><b>Conclusions:</b> Feeding patterns affected postpartum depression through PSE, which enhanced the favorable effects of breastfeeding in preventing postpartum depression and protecting maternal mental health. Future measures aimed at optimizing PSE will not only help prevent postpartum depression but also contribute to further promoting the psychological health and resilience of breastfeeding women.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/2748707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Identification and Management of Subthreshold Depression and Anxiety in Primary Care for People With Long-Term Conditions","authors":"Patrick Cabasag,&nbsp;Frederick Sundram,&nbsp;Amy Chan,&nbsp;Kebede Beyene,&nbsp;Lauren Shepherd,&nbsp;Jeff Harrison","doi":"10.1155/da/9497509","DOIUrl":"https://doi.org/10.1155/da/9497509","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Subthreshold depression (sDep) and anxiety (sAnx) are common conditions and are associated with significant suffering, impaired functioning, increased healthcare utilisation and economic costs. Furthermore, they are risk factors for crossing the clinical threshold and developing mental health disorders. Subthreshold conditions are associated with long-term conditions (LTCs). This scoping review aimed to explore the identification and management of sDep and sAnx in primary care for patients with LTCs.</p>\u0000 <p><b>Methods:</b> We conducted a scoping review, following the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis. Medline, PsycInfo, CINAHL and International Pharmaceutical Abstracts were searched for articles prior to September 2023. We included studies written in English that were conducted among the adult population. All studies that aimed to identify and manage sDep and anxiety in patients with LTC in primary care have been included.</p>\u0000 <p><b>Results:</b> Thirty-three articles were included in this scoping review, of which seven studies incorporated an intervention component for sDep and sAnx in patients with LTCs. A variety of definitions and screening tools were used to identify sDep and sAnx. Problem-solving therapy (PST) and behavioural activation (BA) were the most common intervention components and showed promising results.</p>\u0000 <p><b>Limitations:</b> We excluded studies that did not explicitly state the terms ’subthreshold’, ’subclinical’ or ’subsyndromal’ depression or anxiety which may be relevant.</p>\u0000 <p><b>Conclusion:</b> There is currently limited evidence regarding the identification and management of sDep and sAnx in patients with LTCs, warranting further research.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9497509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Determinants and Wealth-Related Inequality of Anxiety and Depression Symptoms Among Reproductive-Aged Women (15–49 Years) in Nepal: An Analysis of Nationally Representative Nepal Demographic and Health Survey Data 2022","authors":"Syed Toukir Ahmed Noor,&nbsp;Samin Yeasar,&nbsp;Sazid Siddique,&nbsp;Rajon Banik,&nbsp;Sahar Raza","doi":"10.1155/da/9942669","DOIUrl":"https://doi.org/10.1155/da/9942669","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Mental health issues, particularly anxiety and depression, among women of reproductive age, remain a significant public health concern, yet comprehensive studies addressing these issues are limited in Nepal.</p>\u0000 <p><b>Objective:</b> This study aimed to assess the prevalence, associated factors and wealth-related inequality of anxiety and depression symptoms among women aged 15–49 years in Nepal.</p>\u0000 <p><b>Methods:</b> Data from the Nepal Demographic and Health Survey (NDHS) 2022 included 7410 women. Logistic regression analysis was conducted to identify factors associated with anxiety, depression and combined symptoms. We also employed the concentration curve to assess wealth-related disparities with mental health outcomes.</p>\u0000 <p><b>Findings:</b> The prevalence of depression and anxiety symptoms was 5.4% (95% CI: 4.8% to 6.2%) and 7.5% (95% CI: 6.7% to 8.4%), respectively. Furthermore, 9.1% (95% CI: 8.2% to 10.1%) of the women experienced either condition, while 3.8% (95% CI: 3.3% to 4.4%) experienced both. Women with lower educational attainment, a higher number of children, unemployed partners, residents in rural areas and those living in Karnali province exhibited a higher prevalence of anxiety and depression symptoms. Women with limited mass media exposure were associated with a higher risk of anxiety and depression symptoms. Additionally, women with tobacco habits demonstrated a significantly higher risk of depression. Finally, wealth-related inequality was evident; women with lower socioeconomic status were more vulnerable to anxiety and depression symptoms.</p>\u0000 <p><b>Conclusions:</b> The study highlights the need for targeted interventions addressing socio-economic determinants and lifestyle factors, including tobacco use, to mitigate the burden of anxiety and depression symptoms among women in Nepal.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9942669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Causal Relationship Between Differential White Blood Cell Counts and Depression: A Bidirectional Two-Sample Mendelian Randomization Study","authors":"Ying Cao,&nbsp;Xuguang Li,&nbsp;Jing Gao,&nbsp;Nan Zhang,&nbsp;Guoqian Zhang,&nbsp;Shen Li","doi":"10.1155/da/3131579","DOIUrl":"https://doi.org/10.1155/da/3131579","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The link between white blood cells (WBC) and depression has been studied, but the causal relationship remains unclear. This study aimed to elucidate the potential bidirectional causal links between six specific WBC count features and depression using a two-sample Mendelian randomization (MR) analysis, leveraging summary statistics from genome-wide association studies (GWAS).</p>\u0000 <p><b>Method:</b> The dataset on depression (<i>N</i> = 406,986) was sourced from the FinnGen database, while the dataset on WBC (<i>N</i> = 563,085) was obtained from a combined dataset of Blood Cell Consortium (BCX) and UK Biobank. The MR analyses employed include inverse variance weighted (IVW), MR-Egger, weighted median, contamination mixture method (conmix), and constrained maximum likelihood-based Mendelian randomization (cML-MA). A threshold <i>p</i> &lt; 0.05 after false discovery rate (FDR) correction was set as the criterion for causality based on IVW.</p>\u0000 <p><b>Results:</b> Reverse MR analysis indicated a causal relationship where depression leads to an increase in overall WBC count (IVW beta = 0.031, <i>p</i> = 0.015, <i>p</i>_FDR = 0.044) and specifically in basophil count (IVW beta = 0.038, <i>p</i> = 0.006, <i>p</i>_FDR = 0.038), with a marginally significant impact on lymphocyte count (beta = 0.029, <i>p</i> = 0.036, <i>p</i>_FDR = 0.071). Furthermore, forward MR analysis suggested a potential role of monocyte count in decreasing depression risk (<i>p</i> = 0.028), though this association did not retain statistical significance after FDR correction.</p>\u0000 <p><b>Conclusion:</b> These findings suggest that depression may causally influence the immune system by elevating overall WBC and basophil counts, with a marginally significant increase in lymphocyte levels. Conversely, higher monocyte count might confer some protection against depression, albeit with less statistial certainty. This study provides novel insights into the complex interplay between depression and immune function.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/3131579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Pathogenic Factors of Thyroid Dysfunction in First-Episode and Drug-Naïve Major Depressive Disorder Patients With Fasting Blood Glucose Abnormalities in Early- and Late-Onset Age","authors":"Ting Wang,&nbsp;Minxuan Zhang,&nbsp;Jinjin Cao,&nbsp;Sanrong Xiao,&nbsp;Xiangyang Zhang","doi":"10.1155/da/9947375","DOIUrl":"https://doi.org/10.1155/da/9947375","url":null,"abstract":"<div>\u0000 <p><b>Aims:</b> This study aims to explore the mutual mechanisms and distinct pathogenic factors between fasting blood glucose (FBG) abnormalities and thyroid dysfunction (TD) in major depressive disorder (MDD) patients of different onset ages.</p>\u0000 <p><b>Methods:</b> One thousand seven hundred eighteen first-episode and drug-naïve (FEDN) MDD patients were selected. Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale (PANSS) positive subscale, Clinical Global Impression (CGI), FBG, and thyroid-stimulating hormone (TSH) were measured, along with other relevant biochemical indicators.</p>\u0000 <p><b>Results:</b> TD prevalence was 86.69% in early-onset MDD patients with abnormal FBG while in late-onset was 86.86%. No significant difference was found. The area under the curve (AUC) values of FBG detecting TD were all over 0.700. Depressive symptoms and lipid metabolites were significant risk factors and were more specific indicators for late-onset MDD patients with FBG abnormalities. Further binary logistic regression and receiver operating characteristic (ROC) curves revealed that depression severity, high-density lipoprotein cholesterol (HDL-C) predicted TD well in MDD patients with FBG abnormalities, making this predictive effect more significant in the late-onset group.</p>\u0000 <p><b>Conclusions:</b> Insulin resistance and lipid metabolism abnormalities based on FBG abnormalities significantly impact TD in late-onset MDD. Specificity and regular monitoring should be considered for different onset ages of MDD patients with abnormal metabolism. Further research should clarify the interactions among insulin resistance, lipid metabolism, and TD. The First Hospital of Shanxi Medical University Ethics Committee reviewed and approved this study (No. 2016-Y27).</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9947375","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}