Depression and Anxiety最新文献

{"title":"Oral Esketamine Maintenance Treatment for Treatment-Resistant Depression: Clinical Outcomes During an Off-Label Treatment Program.","authors":"Sanne Y Smith-Apeldoorn, Jolien K E Veraart, Jan Spijker, Annemarie Van Der Meij, Jeanine Kamphuis, Robert A Schoevers","doi":"10.1155/da/8320239","DOIUrl":"https://doi.org/10.1155/da/8320239","url":null,"abstract":"<p><p>Ketamine and esketamine maintenance treatment show promise in maintaining initial antidepressant effects, yet further research is needed to optimize long-term outcomes. This observational study aimed to assess long-term depression symptom severity, safety, and tolerability in a cohort of patients receiving at-home oral esketamine maintenance treatment. Between June 2017 and March 2024, 221 patients with severe treatment-resistant unipolar depression were enrolled directly or trial-transferred into an off-label induction treatment program. After 6 weeks of individually titrated oral esketamine (twice a week, max 3.0 mg/kg) administered in the clinic, 93 patients continued to maintenance treatment at home (max 3.0 mg/kg twice a week). Our primary outcome was change in depression symptom severity during maintenance treatment, measured by the 17-item Hamilton Depression Rating Scale (HDRS₁₇). Mean exposure to esketamine in the maintenance phase was 20.8 months. We found no difference between the HDRS₁₇ total score at the maintenance baseline and last-observation-carried-forward (mean difference = 0.825, 95% CI = -0.759 to 2.410, <i>p</i> = 0.302). Of the 26 initial responders (≥50% decrease in HDRS₁₇ at the end of induction treatment), 23.1% met sustained response criteria throughout maintenance treatment. Of the 40 patients meeting minimal clinically important difference (MCID) criteria (≥27.1% decrease in HDRS₁₇ at the end of induction treatment), 60.0% met sustained MCID criteria throughout maintenance treatment. Eleven patients (11.8%) successfully tapered off esketamine maintenance treatment. Twelve patients (12.9%) discontinued maintenance treatment (partly) due to adverse events. These findings suggest that oral esketamine maintenance home treatment may be associated with sustained symptom stability in patients with severe treatment-resistant depression (TRD), although causal inferences cannot be drawn from this observational study. Although some potential long-term side effects require monitoring and further examination, overall, treatment was safe and well-tolerated.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"8320239"},"PeriodicalIF":2.7,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149302264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Variant Patterns of Comorbid Depression and Anxiety Across Early to Late Adolescence: The Sex-Specific Role of Emotion Regulation.","authors":"Dongyu Liu, Xiyu Wei, Luxia Jia, Bao Zhang","doi":"10.1155/da/7875846","DOIUrl":"https://doi.org/10.1155/da/7875846","url":null,"abstract":"<p><strong>Aims: </strong>Depression-anxiety comorbidity is common in adolescence, yet prevention efforts often overlook the nonlinear course of psychosocial development. This study mapped the dynamic risk of depression-anxiety comorbidity across adolescence and examined whether emotion regulation moderated these associations by grade and sex.</p><p><strong>Methods: </strong>We utilised time-varying effect modelling (TVEM) on data of youth from all primary and secondary schools in Chenzhou, China (<i>n</i> = 58,622; grades 4-12), to map the dynamic change of comorbid risk and potential moderating role of emotion regulation, with consideration of sex difference. Participants reported depressive and anxiety symptoms through the patient health questionnaire and generalised anxiety disorder questionnaire, respectively. The emotion regulation questionnaire (ERQ) measured two dimensions of emotion regulation, cognitive reappraisal and expression suppression.</p><p><strong>Results: </strong>Overall comorbid risk increased throughout adolescence. Anxiety (OR = 1.67, 95% CI [1.61, 1.74]) and depressive (OR = 1.68, 95% CI [1.50, 1.89]) symptoms had similar overall comorbid risk, while depression-related risk became stronger than anxiety-related risk in late adolescence. Sex-specific patterns revealed higher comorbid risks in females. A gradual risk progression across grades emerged in males, whereas females showed a steeper increase in depression-associated comorbidity and an anxiety-associated peak around grade 8 (OR = 1.74, 95% CI [1.69, 1.80]). The role of emotion regulation is more pronounced in females than males. Cognitive reappraisal had a protective role against anxiety-related comorbid risk (OR = 0.99, 95% CI [0.99, 0.99]) and a maladaptive role for depression-related comorbid risk (OR = 1.01, 95% CI [1.01, 1.01]). The maladaptive role of expressive suppression for anxiety-associated comorbidity peaked during middle school for females and only emerged during early adolescence for males.</p><p><strong>Interpretation: </strong>Depression-anxiety comorbidity showed distinct grade- and sex-specific risk patterns across adolescence. These findings advocate for precise interventions prioritising anxiety management during primary-to-middle school transition and depression prevention during late adolescence. Emotion regulation interventions should be tailored by sex, adolescence stage and existing symptoms.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"7875846"},"PeriodicalIF":2.7,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149302238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Brain Structure to Stress Response: COVID-Specific Anxiety Links Pre-Pandemic Gray Matter Volume to Changes in Life Satisfaction.","authors":"Zhuqing Feng, Graham J Kemp, Song Wang","doi":"10.1155/da/7767487","DOIUrl":"https://doi.org/10.1155/da/7767487","url":null,"abstract":"<p><p>The COVID-19 pandemic severely threatened mental well-being, potentially impacting individual life satisfaction (LS); thus, this study sought to identify pre-pandemic brain structural markers associated with subsequent LS changes and explore the role of COVID-specific anxiety in this relationship. We utilized structural magnetic resonance imaging (MRI) and behavioral data (including the LS scale) collected before the pandemic (T1) from 115 general university students, followed up 1 year after the outbreak (T2) for LS and COVID-anxiety measures. Employing whole-brain voxel-based morphometry (VBM) and confirmatory prediction analyses, we identified brain regions where pre-pandemic gray matter volume (GMV) correlated with subsequent LS changes (ΔLS from T1 to T2), followed by mediation analysis to assess the indirect effect of COVID-anxiety. While group-level ΔLS was stable, individual variability showed a significant negative correlation with pre-pandemic GMV in the pregenual anterior cingulate cortex (pgACC) and left superior temporal gyrus (STG), and a positive correlation with GMV in right precuneus. Furthermore, COVID-anxiety correlated with ΔLS, and mediation analysis revealed a significant negative indirect effect of COVID-anxiety on the link between pgACC GMV and ΔLS, such that greater pre-pandemic pgACC GMV was associated with higher COVID-specific anxiety, which in turn was associated with a decrease in LS. This mediation effect was partial, as the direct path from pgACC GMV to ΔLS remained significant. Crucially, these results were independent of socioeconomic status, stressful life events, and general mental health. Overall, our study indicates that pre-pandemic brain structure can prospectively predict individual LS changes during the pandemic, and this relationship was mediated by COVID-specific anxiety. These findings shed light on the neuroanatomical basis of LS and could have implications for targeted interventions during public health crises and similar challenges.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"7767487"},"PeriodicalIF":2.7,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149302206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eHealth Literacy and Depressive Symptoms Among Adults Aged 50 Years and Older in China: A National Cross-Sectional Study.","authors":"Qin Zhou, Shengpeng Guo, Rize Jing","doi":"10.1155/da/3142110","DOIUrl":"https://doi.org/10.1155/da/3142110","url":null,"abstract":"<p><strong>Objective: </strong>Despite existing research confirming that eHealth literacy promotes healthy lifestyles and subjective well-being among adults aged 50 years and older, its connection to depressive symptoms remains unclear. This cross-sectional study explored the association between eHealth literacy and depressive symptoms among adults aged 50 years and older, and investigated potential mechanisms and moderating effects of the association.</p><p><strong>Methods: </strong>Data were obtained from the China Digital Divide and Digital Inclusion Survey (CDDDIS), which provided a nationally representative sample of 4284 participants aged 50 years and older. Ordinary least squares (OLS) regression was employed to analyze the associations between eHealth literacy and depressive symptoms, adjusting for relevant sociodemographic and health-related covariates. Bootstrap-based mediation analysis was conducted to evaluate indirect pathways embedded within the correlation network. Income-stratified analyses were performed to explore differences in the association across income groups.</p><p><strong>Results: </strong>The results revealed that higher eHealth literacy was significantly correlated with fewer depressive symptoms (<i>β</i> = -0.029, 95% CI = [-0.052, -0.006], <i>p</i> = 0.012). Bootstrapped mediation analysis revealed that physical activity and perceived stress served as significant indirect pathways mediating the association in this correlational analysis, whereas the indirect pathway via online healthcare services utilization was not statistically significant. Income-stratified analysis showed that the negative association between eHealth literacy and depressive symptoms was statistically significant among middle- and high-income participants, whereas no significant association was observed for low-income participants.</p><p><strong>Conclusions: </strong>eHealth literacy constitutes a critical resource for promoting healthy aging and mitigating aging-related stressors among adults aged 50 years and older. These correlational patterns suggest potential utility for targeted eHealth interventions aimed at reducing depressive symptoms in aging populations.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 ","pages":"3142110"},"PeriodicalIF":2.7,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149302231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and Coping Strategies in Caregivers of Children With Epidermal Differentiation Disorders: A Case-Control Study","authors":"Magdalena Fryze,&nbsp;Aldona Pietrzak,&nbsp;Radoslaw Mlak,&nbsp;Bartłomiej Wawrzycki,&nbsp;Katarzyna Wertheim-Tysarowska,&nbsp;Fauve C. A. P. van Veen,&nbsp;Antoni H. Gostynski","doi":"10.1155/da/1126242","DOIUrl":"https://doi.org/10.1155/da/1126242","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Epidermal differentiation disorders (EDDs) are rare, chronic skin diseases with significant psychosocial impact on patients and families. Their daily management requires complex care, placing caregivers at risk of stress and anxiety. Few studies have systematically examined anxiety and coping strategies in this group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare anxiety levels and coping styles between caregivers of children with syndromic or nonsyndromic EDD and caregivers of healthy children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this cross-sectional case-control study, 39 caregivers of children with EDD and 39 matched controls were recruited from a dermatology clinic. Anxiety was assessed with the State-Trait Anxiety Inventory (STAI) and coping styles with the Coping Inventory for Stressful Situations (CISS). Sociodemographic and clinical data were collected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Caregivers of children with EDDs reported significantly higher trait anxiety than controls (79.5% vs. 53.8%; <i>p</i> = 0.017). Task-oriented coping (TOC) was less frequent among EDD caregivers, with more than half showing low TOC compared with less than one-third of controls (56.4% vs. 28.6%; <i>p</i> = 0.019). High avoidance-oriented coping (AOC) was observed more often in controls (21.4% vs. 5.6%; <i>p</i> = 0.044). Anxiety was greater among caregivers of boys than girls (95.7% vs. 56.2%; <i>p</i> = 0.003). Avoidant coping was associated with greater child symptom severity, including pruritus and redness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Caregivers of children with EDD experience high anxiety and rely less on adaptive coping strategies. These findings emphasize the need for early, family-centered psychosocial interventions to support caregiver well-being and improve outcomes for affected children.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/1126242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Depressive Symptoms From Cross-Sectional and Longitudinal Data Using XGBoost–SHAP and Cross-Lagged Model","authors":"Jing Jie,&nbsp;Ming Yin,&nbsp;Jiayue Zeng,&nbsp;Songlin Yang","doi":"10.1155/da/4401725","DOIUrl":"https://doi.org/10.1155/da/4401725","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;University students face significant academic, social, and career-planning challenges. Under such stressors, deficient emotion regulation may increase vulnerability to depressive states, in which persistent symptoms could progress to clinical depression. This study investigates key risk and protective factors for depressive symptoms among university students, including negative life events, neuroticism, and social support. A longitudinal framework was further employed to assess changes in depressive symptoms before and after the COVID-19 pandemic, with the goal of informing early identification and intervention strategies.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The dataset included 18 024 valid responses from baseline assessments. Follow-up assessments conducted 1 year later included 6129 participants. The extreme gradient boosting (XGBoost) model with SHapley Additive exPlanations (SHAP) was used to quantify the relative importance of specific factors (e.g., negative life events and social support) on depressive symptoms, while a cross-lagged panel model examined longitudinal directional associations between these factors and depressive symptoms.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The prevalence of depressive symptoms was 15.2% among the student sample. Significant correlations were observed between symptom severity and adverse family relationships, childhood trauma, prior suicide attempts, and psychiatric history. Neuroticism and negative life events showed significant positive associations with depressive symptoms, while subjective support and support utilization demonstrated negative associations with symptom severity. Longitudinal analysis revealed an increase in both symptom severity and depression detection rates following the COVID-19 pandemic. The cross-lagged panel model identified neuroticism as a significant positive longitudinal predictor of depressive symptoms, whereas subjective support showed a significant negative longitudinal association with subsequent depressive symptoms.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study identifies neuroticism as an important longitudinal risk indicator for depressive symptoms and subjective support as a protective indicator, while negative life events showed significant cross-sectional associations with symptom severity. The findings demonstrate how integrating longitudinal designs with interpretable machine learning elucidates complex mental health dynamics in student populations, providing an evidence-based framework for targeted intervent","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/4401725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Possible to Establish Thresholds for Depressive Symptom Severity Associated With Cognitive Impairments in Bipolar Disorders? Findings From the FACE-BD Cohort","authors":"Nathan Vidal,&nbsp;Eric Brunet-Gouet,&nbsp;Alexandre Billard,&nbsp;Solène Frileux,&nbsp;Raoul Belzeaux,&nbsp;Anamaria Bogdan,&nbsp;Philippe Courtet,&nbsp;Thierry D’Amato,&nbsp;Caroline Dubertret,&nbsp;Bruno Etain,&nbsp;Emmanuel Haffen,&nbsp;Dominique Januel,&nbsp;Marion Leboyer,&nbsp;Antoine Lefrere,&nbsp;Pierre-Michel Llorca,&nbsp;Emeline Marlinge,&nbsp;Katia M’Bailara,&nbsp;Emilie Olié,&nbsp;Mircea Polosan,&nbsp;Raymund Schwan,&nbsp;Michel Walter,&nbsp;The FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders) group,&nbsp;Christine Passerieux,&nbsp;Paul Roux","doi":"10.1155/da/9918396","DOIUrl":"https://doi.org/10.1155/da/9918396","url":null,"abstract":"<p>Individuals with bipolar disorders (BDs) with depressive symptoms exhibit poorer cognitive performance and are often excluded from procognitive interventions and cognitive research. Threshold values on depression severity scales, based on cutoffs defining depressive episodes, have traditionally been used to exclude patients suspected of having depression-associated cognitive impairment. Identifying a threshold value for depression-associated cognitive impairment on these scales could help guide patient selection and treatment. We assessed neuropsychological performance in outpatients with BD with varying levels of depressive symptom severity measured by the Montgomery–Åsberg Depression Rating Scale (MADRS). The sample was divided based on the total MADRS score or subscores in MADRS theoretical domains. We then compared average cognitive performance between groups while adjusting for relevant covariates to determine a MADRS score above which cognition is significantly impaired. We included 2532 individuals with BD. The composite cognitive score was significantly lower in individuals with a MADRS score ≥ 12 than in those with a score ≤ 1 but did not differ from that of individuals with scores between 2 and 11. Symptoms of detachment and sadness were more strongly associated with cognitive impairment than other symptoms. Individuals with type I BD with MADRS detachment subscores higher than 4 and individuals with type II BD with nonzero sadness subscores had significant cognitive impairment compared to individuals with lower subscores. Excluding individuals with BD whose cognition may be affected by depressive symptoms would require omitting those with MADRS detachment subscores higher than 4 or nonzero sadness subscores. Our findings question the existence of a total depression severity threshold for cognitive impairment, as specific depressive symptoms seem more strongly associated with cognitive impairment than total symptom severity.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9918396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Heart Failure With Preserved Ejection Fraction: An Inflammatory Perspective","authors":"Hongfan Chen,&nbsp;Nan Zhang,&nbsp;Yufan Feng,&nbsp;Mengxing Tao,&nbsp;Chi Geng","doi":"10.1155/da/7169650","DOIUrl":"https://doi.org/10.1155/da/7169650","url":null,"abstract":"<p>Depression is a common comorbidity in patients with heart failure with preserved ejection fraction (HFpEF), suggesting potential epidemiological and pathophysiological connections between these two age-related chronic diseases. Extensive clinical evidence demonstrates that depression is closely associated with both the incidence and prognosis of HFpEF. It is currently believed that depression may contribute to the pathogenesis of HFpEF through various interconnected mechanisms, including intestinal dysfunction, endothelial dysfunction, disturbances in fat and energy metabolism, autonomic nervous system dysfunction, hypothalamic–pituitary–adrenal (HPA) axis imbalance, and sex differences. Both conditions often share common comorbidities and genetic predispositions. Notably, inflammation is implicated in all these mechanisms and processes, playing a key role at different stages and facilitating the interaction between the two diseases during their onset and progression. However, the connections between depression and HFpEF have not yet been systematically and thoroughly elucidated. This review aims to comprehensively summarize the associations between depression and HFpEF, focusing particularly on elucidating their interplay in pathogenesis from an inflammation perspective, with special emphasis on the adverse effects of depression on the development of HFpEF. Additionally, we evaluate the management approaches for patients with comorbid depression and HFpEF, which include both pharmacological and nonpharmacological treatments, highlighting that personalized and integrated interventions may offer significant benefits. The review underscores the importance of increased attention and early identification of patients with comorbid depression and HFpEF and is expected to provide valuable insights and guidance for the clinical management of this significant patient population.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/7169650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HADS-Assessed Anxiety/Depression Status and Ocular Outcomes in Vision-Threatening Diabetic Retinopathy: A Multicenter Retrospective Cohort Study","authors":"Bo Li,&nbsp;Yujin Jiang,&nbsp;Chenxin Li,&nbsp;Yikeng Huang,&nbsp;Shuzhi Zhao,&nbsp;Chuandi Zhou,&nbsp;Zhi Zheng,&nbsp;Xiaofeng Zhang","doi":"10.1155/da/6998782","DOIUrl":"https://doi.org/10.1155/da/6998782","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Vision-threatening diabetic retinopathy (VTDR) poses significant blindness risks and the study aimed to identify the impact of psychological factors on its ocular outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study enrolled 782 VTDR patients from three ophthalmological centers (2018–2021). DR severity was graded using ETDRS criteria. Primary outcomes included tractional retinal detachment (TRD) involving the fovea, neovascular glaucoma (NVG), final best-corrected visual acuity (BCVA) &lt;0.3, and recurrent vitreous hemorrhage (VH). Anxiety and depression were assessed via the hospital anxiety and depression scale (HADS). Univariable and multivariable logistic regression evaluated the associations between HADS scores and ocular outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After a median follow-up of 24.8 months, depressive symptoms (HADS-D ≥8) were associated with higher rates of BCVA &lt;0.3 (67.8% vs. 57.2%, <i>p</i> = 0.033) and NVG (13.6% vs. 6.9%, <i>p</i> = 0.020). Recurrent VH was more frequent in patients with anxiety (21.0% vs. 10.6%, <i>p</i> = 0.031) or depression (20.3% vs. 10.7%, <i>p</i> = 0.045). Multivariable logistic analysis revealed that each 1-point increase in HADS-D score significantly increased adjusted odds of TRD (aOR = 1.06, 95% CI: 1.01−1.11), BCVA &lt;0.3 (aOR = 1.07, 95% CI: 1.02−1.11), recurrent VH (aOR = 1.09, 95% CI: 1.02−1.17), and NVG (aOR = 1.10, 95% CI: 1.03−1.17; all <i>p</i> &lt; 0.05). There was a consistent positive gradient between HADS severity and adverse outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Depressive symptoms are independently associated with worse ocular prognoses in VTDR patients. Systematic psychological screening and intervention is essential to mitigate vision deterioration risk in this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/6998782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Inhibitory Control Across Subclinical Depression and Major Depressive Disorder: Evidence From Stroop Tasks and Diffusion Modeling","authors":"Qingying Ye,&nbsp;Yi-shuo Qiao,&nbsp;Jia-jia Jin,&nbsp;Si-yu Zhang,&nbsp;Yun-da Li,&nbsp;Wen-jie Dou,&nbsp;Kai Jin,&nbsp;Ke Ni,&nbsp;Zhong Yang,&nbsp;Bao-ming Li,&nbsp;Xin-lu Cai","doi":"10.1155/da/5711923","DOIUrl":"https://doi.org/10.1155/da/5711923","url":null,"abstract":"<p>Inhibitory control deficits are central to cognitive dysfunction in major depressive disorder (MDD), yet how such deficits vary across subclinical depression and MDD remains unclear. Childhood trauma may further contribute to variability in inhibitory control. This study examined behavioral and computational markers of inhibitory control across nonemotional and emotional contexts in healthy, subclinical depression, and MDD groups and explored associations with childhood trauma. Thirty individuals with subclinical depression, 33 patients with MDD, and 36 healthy controls (HCs) completed three Stroop tasks (color-word, emotion, and face-word), during which reaction times (RTs) were recorded. Latent cognitive parameters were estimated using the drift diffusion model (DDM) and diffusion model for conflict tasks (DMCs). Associations between these indicators and childhood trauma were examined. Patients with MDD showed significantly longer RTs than subclinical individuals in emotion and face-word Stroop tasks. Computational modeling revealed prolonged nondecision time in MDD, relative to subclinical depression (color-word Stroop task) and HCs (emotion Stroop task). In the subclinical group, greater childhood trauma was associated with faster RTs in incongruent face-word trials and shorter nondecision time in the color-word Stroop task. Our findings support a possible inverted U-shaped pattern of inhibitory control across depressive severity, with enhanced performance in subclinical depression but poorer performance in MDD. Enhanced inhibitory control in subclinical depression may reflect compensatory adaptation linked to early adversity. These findings provide novel insights into stage-related differences of inhibitory control in depression.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2026 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5711923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}