Depression and Anxiety最新文献

{"title":"Tracking the Prevalence of Depression Among Older Adults in Singapore: Results From the Second Wave of the Well-Being of Singapore Elderly Study","authors":"AshaRani P. V.,&nbsp;Edimansyah Abdin,&nbsp;Kumarasan Roystonn,&nbsp;Fiona Devi,&nbsp;Peizhi Wang,&nbsp;Saleha Shafie,&nbsp;Vathsala Sagayadevan,&nbsp;Anitha Jeyagurunathan,&nbsp;Boon Yiang Chua,&nbsp;Bernard Tan,&nbsp;Janhavi Ajit Vaingankar,&nbsp;Fengyuan Yao,&nbsp;Harish Magadi,&nbsp;Stefan Ma,&nbsp;Wai Leng Chow,&nbsp;Paul McRone,&nbsp;Martin Prince,&nbsp;Rathi Mahendran,&nbsp;Li Ling Ng,&nbsp;Siow Ann Chong,&nbsp;Mythily Subramaniam","doi":"10.1155/da/9071391","DOIUrl":"https://doi.org/10.1155/da/9071391","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Late-life depression has serious public health implications due to its impact on healthcare systems and the economy. As the prevalence of depression tends to change over time across populations, continuous disease surveillance is warranted to inform evidence-based preventive interventions. The well-being of the Singapore elderly (WiSE) is the second study in the series that looked at the prevalence and correlates of depression in a multiethnic population in Singapore.</p>\u0000 <p><b>Methods:</b> This single-phase and comprehensive cross-sectional study employed stage 1 diagnosis of geriatric mental state-automated geriatric examination for computer-assisted taxonomy (GMS-AGECAT) to capture depression and subsyndromal depression.</p>\u0000 <p><b>Results:</b> The prevalence of depression and subsyndromal depression was 4.4% and 11.9%, respectively, compared to 3.7% and 13.4% in 2013 (<i>p</i> = 0.425). Indians, those who were divorced and had below primary education had higher odds of depression (2.2, 3.6, and 4.2 times, respectively). Depression was associated with severe disability, loneliness, suicidal ideations, poor life satisfaction, health status, and social connections.</p>\u0000 <p><b>Conclusion:</b> Despite a decade of preventive efforts for the population, there has not been any decrease in the prevalence of depression. There needs to be continued efforts to strengthen prevention, detection, and access to care of those with depression. A multiprong community–based preventive strategy focusing on social as well as health factors is needed to promote social connections, reduce loneliness, and promote the overall wellbeing of the elderly.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9071391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Birth Interval With Prevalence of Depression in Postmenopausal Women","authors":"Ronghua Zuo,&nbsp;Yan Chen,&nbsp;Qiaoying Zhu,&nbsp;Yu Liu,&nbsp;Shuang Yao,&nbsp;Qinmin Bao,&nbsp;Dake Li","doi":"10.1155/da/8066072","DOIUrl":"https://doi.org/10.1155/da/8066072","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> This study aims to explore the relationship between birth interval and prevalence of depression among postmenopausal women with two deliveries in the United States.</p>\u0000 <p><b>Methods:</b> Data from the National Health and Nutrition Examination Survey (NHANES) were used, which spanned the years 2005–2018 and is publicly accessible. We utilized weighted multivariable logistic regression analysis, restricted cubic splines (RCS), and subgroup analysis to examine the relationship between the prevalence of depression in postmenopausal women with only two deliveries and the age at first birth (AFB), age at last birth (ALB), and birth interval (the difference between ALB and AFB).</p>\u0000 <p><b>Results:</b> A total of 2375 postmenopausal women with only two deliveries were included in the study, and 271 (11.4%) had depression. RCS models showed that AFB and ALB were U-shaped curves associated with the prevalence of depression. Additionally, the birth interval was roughly L-shaped curve correlated with the risk of depression.</p>\u0000 <p><b>Conclusions:</b> Both early and late childbearing, as well as short birth intervals, may contribute to mental health challenges in this demographic. These findings suggest that women with both early and late childbearing, as well as those with short birth intervals, may face a higher risk of depression during their postmenopausal years. This underscores the importance of targeted mental health screening and support for these groups.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/8066072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of 24-h Energy Intake Behavior With Depressive Symptoms: Findings From the National Health and Nutrition Examination Survey","authors":"Jiahui Yin,&nbsp;Minqing Gu,&nbsp;Yong Zhou,&nbsp;Yongjun Wang,&nbsp;Min Zhang,&nbsp;Yao Yang,&nbsp;Yiyun Cai,&nbsp;Shen He,&nbsp;Daihui Peng","doi":"10.1155/da/5544651","DOIUrl":"https://doi.org/10.1155/da/5544651","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> Appetite changes are a significant clinical feature of depression, with circadian rhythms disruption being a crucial mechanism in depression. However, the specific role of eating rhythms in depression remains unclear. This study aimed to assess the relationship between energy intake rhythmicity and depressive symptoms.</p>\u0000 <p><b>Methods:</b> A total of 34,974 noninstitutionalized individuals were recruited from the National Health and Nutrition Examination Survey. To investigate the relationship between 24-h energy intake and depressive symptoms, covariate-adjusted sample-weighted regressions were employed. The study analyzed various aspects of energy intake rhythmicity, including the proportion of energy intake from non-meals and meal times, as well as the proportion of energy intake across meals and various time periods (morning, midday, afternoon, evening, night, and overnight).</p>\u0000 <p><b>Results:</b> A high proportion of energy intake from non-meals (adjusted odds ratio [OR] = 1.11, 95% confidence interval [CI]: 1.08–1.15) was associated with higher depressive symptoms. The proportion of breakfast energy intake in total daily energy intake was nonlinearly associated with depressive symptoms. In participants with a breakfast energy intake below 20%, the prevalence of depressive symptoms decreased by 15% (adjusted OR = 0.85, 95% CI: 0.75–0.96) per each 10% increment in the proportion of breakfast energy intake. A U-shaped relationship was identified between the timing of the day’s last energy intake and depressive symptoms, with the lowest prevalence occurring at 7:48 PM (before 7:48 PM: adjusted [OR = 0.96, 95% CI: 0.94–0.98]; after 7:48 PM: adjusted [OR = 1.11, 95% CI: 1.03–1.20]).</p>\u0000 <p><b>Conclusions:</b> Among adults in the United States, the proportion of energy consumed from non-meals was associated with higher depressive symptoms. Adequate energy intake at breakfast and moderate end-times of energy intake were linked to reduced depressive symptoms. These results may contribute to designing of future studies on dietary rhythm interventions for managing depression.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5544651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend of Antenatal Depression and Its Risk Factors Among Pregnant Women in China From 2016 to 2021: A Repeated Cross-Sectional Study Under Multiple Fertility Policy Adjustments and Economic Development","authors":"Chi Zhou,&nbsp;Fang Tan,&nbsp;Xu Li,&nbsp;Jingchun Chen,&nbsp;Qunfang Huang,&nbsp;Xiaoling Lin,&nbsp;Falin Zhao,&nbsp;Qi Yuan","doi":"10.1155/da/6823160","DOIUrl":"https://doi.org/10.1155/da/6823160","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The objective of the current study was to evaluate the trend and risk factors of antenatal depression (AD) among Chinese women in the third trimester of pregnancy, taking into account the impact of multiple fertility policy adjustments and economic development in China.</p>\u0000 <p><b>Method:</b> A repeated cross-sectional study design was used. A total of 3404 pregnant women at 30–42 weeks’ gestation were recruited from the two largest maternity hospitals in Zhejiang Province, China, between 2016 and 2021.</p>\u0000 <p><b>Results:</b> The prevalence of AD among women in their third trimester of pregnancy had significantly increased from 31.8% to 60.6% (<i>p</i>  &lt; 0.001) from 2016 to 2021. Pregnant women aged between 18 and 24 years reported the highest prevalence of AD. Those aged between 25 and 34 years (odds ratio [OR], 0.788; 95% confidence interval [CI]: 0.630–0.985), with a better self-reported health status (OR, 0.929; 95% CI: 0.922–0.936) and higher perceived social support (OR, 0.948; 95% CI: 0.940–0.955), reported a lower prevalence of AD. Pregnant women who were housewives (OR, 1.399; 95% CI: 1.078–1.817), had an introverted personality (OR, 1.324; 95% CI: 1.119–1.568), and had experienced an unplanned pregnancy (OR, 1.303; 95% CI: 1.098–1.547) reported a higher prevalence of AD.</p>\u0000 <p><b>Conclusions:</b> The significant increase in the prevalence of AD from 2016 to 2021 has caused concern in society. To improve the aforementioned situation, it is imperative to implement further initiatives to address the challenges faced by pregnant women, especially those who are housewives, have introverted personalities, and have experienced unplanned pregnancies.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/6823160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Naturalistic Prospective Study of the Prognostic Impact of EPHX2 in Major Depressive Disorder: Impulsivity may be an Important Factor","authors":"Shuqiong Zheng,&nbsp;Jia Guo,&nbsp;Rongxin Zheng,&nbsp;Yujia Ji,&nbsp;Quan Zhong,&nbsp;Honglei Yin","doi":"10.1155/da/8124403","DOIUrl":"https://doi.org/10.1155/da/8124403","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Major depressive disorder (MDD) is a leading cause of disability worldwide. The pathophysiology of MDD remains unclear, which limits the development of treatments for MDD. Recently, epoxide hydrolase 2 (EPHX2) has been found to be associated with MDD. Our previous study revealed an association between EPHX2 expression and suicide. However, the effect of EPHX2 on the prognosis of MDD and suicide remains unclear. Previous studies have found that impulsivity at baseline can be a significant predictor of clinical improvement in patients with MDD. Therefore, we inferred that EPHX2 could be associated with the treatment effect of MDD, and impulsivity could mediate the effect of EPHX2 on the treatment effect of MDD.</p>\u0000 <p><b>Methods:</b> This naturalistic prospective study included 117 participants with MDD, who were assessed, using clinical questionnaires, cognitive function, and treatment information, at baseline, 2 weeks, and 1, 2, and 3 months. A linear mixed-effects model was used to investigate longitudinal changes in the severity of symptoms, risk of suicide, and cognitive function.</p>\u0000 <p><b>Results:</b> The interactive effects of impulsivity and EPHX2 polymorphisms on the risk of suicide (measured by the Columbia-Suicide Severity Rating Scale) were significantly different for rs11288636, rs68012435, and rs11288636. The interactive effects between polymorphisms and time on depression severity (measured by the Hamilton Depression Scale-24) were significantly different and including after adjustment for the total impulsivity score.</p>\u0000 <p><b>Conclusions:</b> This study suggests that EPHX2 polymorphisms are associated with the prognosis of MDD, and impulsivity could be a critical factor for the change in suicide risk among different EPHX2 genotypes.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05575713</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/8124403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive–Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions","authors":"Kai Härpfer,&nbsp;Hannes Per Carsten,&nbsp;Franziska Magdalena Kausche,&nbsp;Anja Riesel","doi":"10.1155/da/9505414","DOIUrl":"https://doi.org/10.1155/da/9505414","url":null,"abstract":"<div>\u0000 <p>In this preregistered study, we investigated the relationship between neural correlates of performance monitoring and disorders of the anxiety and obsessive–compulsive spectrum. Specifically, we aimed at understanding the role of disorder category, clinical status, family risk, and the transdiagnostic symptom dimensions of anxious apprehension and anxious arousal. To this end, we measured event-related potentials (ERPs) of performance monitoring (i.e., error-related negativity, ERN, and correct-response negativity, CRN) in a large sample of 156 participants, including groups of patients with obsessive–compulsive disorder, social anxiety disorder, and specific phobia, as well as a naturalistic control group. Contrary to our initial expectations, we did not observe significant differences in ERPs among the clinical groups, nor in comparison to the naturalistic control group. However, after creating a more strictly defined healthy control group, we found larger ERN amplitudes in the specific phobia compared with the healthy control group. In addition, when comparing participants with and without a lifetime clinical diagnosis of any internalizing disorder, regardless of their main diagnosis, as well as when comparing those with or without a family risk for internalizing psychopathology, we observed larger amplitudes for both ERN and CRN. Subsequently, we combined data from this study and a previously published subclinical study to examine the role of transdiagnostic symptom dimensions (i.e., anxious apprehension and anxious arousal) across a wider severity spectrum. In this joint sample of 246 participants, gender emerged as a moderator of the link between anxious apprehension and enhanced performance monitoring. Specifically, women with increasing anxious apprehension exhibited elevated ERN and CRN amplitudes. In conclusion, our study challenges the notion of a disorder-specific link to performance monitoring. Instead, our findings suggest that enhanced performance monitoring is associated with a higher propensity for anxious apprehension and acts as a broad risk marker for internalizing psychopathology, reflecting vulnerability beyond diagnostic borders within the anxiety- and obsessive–compulsive spectrum.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9505414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms of Depression and Anxiety After COVID-19 Despite Systematic Telemedical Care: Results From the Prospective COVID-SMART Study","authors":"Aenne S. von Falkenhausen,&nbsp;Antonia Gail,&nbsp;Scott Geipel,&nbsp;Clemens Scherer,&nbsp;Sven Stockhausen,&nbsp;Lauren E. Sams,&nbsp;Finn Becker,&nbsp;Steffen Massberg,&nbsp;Stefan Kääb,&nbsp;Moritz F. Sinner","doi":"10.1155/da/9989990","DOIUrl":"https://doi.org/10.1155/da/9989990","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Long-COVID has attracted increased attention with rising numbers of affected patients and high individual symptom burden. Prior studies have described its prevalence, course of disease, and severity. Yet, the influence of intensive care, including telemedical support for patients at risk for a severe course of the initial COVID-19 disease, on the occurrence of Long-COVID and its associated symptoms is studied to a lesser extent.</p>\u0000 <p><b>Methods:</b> Here, we report the long-term results of the COVID-SMART study, which randomized at-risk COVID-19 patients to either smartwatch-based monitoring with telemedical support or standard care. We investigate Long-COVID symptoms, including symptoms of depression and anxiety after 12 months.</p>\u0000 <p><b>Findings:</b> Between October 2020 and May 2022, we enrolled 607 patients in the COVID-SMART study. Complete 12-month follow-up was available for 573 patients, with 288 patients randomized to the intervention group and 285 to the control group. Overall, 234 participants (40.8%) reported COVID-related symptoms, with a high prevalence of symptoms of depression (209 participants, 36.5%) and anxiety (232 participants, 40.5%). However, telemedical support did not reduce these symptoms at follow-up. Multivariable regression analysis identified sex, active smoking, and pre-existing asthma as significant predictors of both outcomes.</p>\u0000 <p><b>Interpretation:</b> COVID-SMART is the first prospective, randomized clinical trial to systematically assess the impact of telemedical care on the development of Long-COVID associated risk of depression and anxiety. We identify in part modifiable risk factors for these outcomes. However, telemedical support does not appear to be beneficial in reducing symptoms of anxiety and depression and should hence be focused to the acute infection phase.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT04471636</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9989990","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Elevated Depression Levels and Life’s Essential 8 on Cardiovascular Health With Predicted Machine Learning Models and Interpretations: Evidence From NHANES 2007–2018","authors":"Zhixing Wu,&nbsp;Pengyuan Xu,&nbsp;Yali Zhai,&nbsp;Jinli Mahe,&nbsp;Kai Guo,&nbsp;Wuraola Olawole,&nbsp;Jiahao Zhu,&nbsp;Jin Han,&nbsp;Guannan Bai,&nbsp;Lin Zhang","doi":"10.1155/da/8865176","DOIUrl":"https://doi.org/10.1155/da/8865176","url":null,"abstract":"<div>\u0000 <p><b>Background and Objective:</b> The association between depression severity and cardiovascular health (CVH) represented by Life’s Essential 8 (LE8) was analyzed, with a novel focus on ranked levels and different ages. Machine learning (ML) algorithms were also selected aimed at providing predictions to suggest practical recommendations for public awareness and clinical treatment.</p>\u0000 <p><b>Methods:</b> We included 21,279 eligible participants from the National Health and Nutrition Examination Survey (NHANES) 2007–2018. Weighted ordinal logistic regression (LR) was utilized with further sensitivity and dose–response analysis, and ML algorithms were analyzed with SHapley Additive exPlanations (SHAP) applied to make interpretable results and visualization.</p>\u0000 <p><b>Results:</b> Our studies demonstrated an inverse relationship between LE8 and elevated depressive levels, with robustness confirmed through subgroup and interaction analysis. Age-specific findings revealed middle-aged and older adults (aged 40–60 and over 60) which showed higher depresion severity, highlighting the need for greater awareness and targeted interventions. Eight ML algorithms were selected to provide predictive results, and further SHAP would become ideal supplement to increase model interpretability.</p>\u0000 <p><b>Conclusions:</b> Our studies demonstrated a negative association between LE8 and elevated depressive levels and provided a suite of ML predictive models, which would generate recommendations toward clinical implications and subjective interventions.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/8865176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real-Time fMRI Neurofeedback","authors":"Jiahe Zhang,&nbsp;Emma Tusuzian,&nbsp;Francesca Morfini,&nbsp;Clemens C. C. Bauer,&nbsp;Lena Stone,&nbsp;Angelina Awad,&nbsp;Ann K. Shinn,&nbsp;Margaret A. Niznikiewicz,&nbsp;Susan Whitfield-Gabrieli","doi":"10.1155/da/2848929","DOIUrl":"https://doi.org/10.1155/da/2848929","url":null,"abstract":"<div>\u0000 <p>Auditory hallucinations (AHs) are debilitating and often treatment-resistant symptoms of schizophrenia (SZ). Real-time functional magnetic resonance imaging (fMRI) neurofeedback (NFB) is emerging as a flexible brain circuit-based tool for targeting AH via self-modulation of brain activity. A better understanding of what baseline characteristics predict NFB success will enhance its clinical utility. Previous work suggests that AH symptomology implicates measures across multiple modalities, including T1 structural MRI (sMRI), diffusion-weighted MRI (dMRI), and resting-state fMRI (rsfMRI). Specifically, AH severity and treatment response are associated with thinner superior temporal gyrus (STG), thinner dorsolateral prefrontal cortex (DLPFC), reduced white matter integrity in tracts connecting brain regions implicated in SZ symptomatology, increased within-default mode network (DMN) connectivity, and reduced DMN–DLPFC anticorrelation. In this study, we tested the individual and combined contributions of multimodal brain features for the prediction of AH change after NFB in adults (<i>N</i> = 25, 36.1 ± 10.0 years, 24% females) with SZ spectrum disorders (SZ or schizoaffective disorder) and frequent medication-resistant AH. Participants underwent a baseline MRI scan (including sMRI, dMRI, and rsfMRI) and were randomly assigned to receive NFB from their STG (<i>n</i> = 12, real condition) or NFB from their motor cortex (MC) (<i>n</i> = 13, sham condition). NFB success was operationalized as the improvement in AH severity after NFB. We found that higher baseline AH severity, greater STG thickness, decreased dorsal cingulum integrity, increased within-DMN resting-state functional connectivity, and increased DMN–DLPFC anticorrelation were each individually correlated with reduction in AH severity. However, in a combined regression model, DMN–DLPFC connectivity emerged as the only independent variable that explained the unique variance in AH change. These results suggest that a specific rsfMRI measure, namely DMN–DLPFC connectivity, may be a promising predictor of NFB success in reducing AH and support the precision medicine approach.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03504579</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/2848929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immediate Impact of App-Based Psychotherapeutic Exercises on Anxiety: An RCT","authors":"Julia Fabienne Sandkühler,&nbsp;Fabian Kahl,&nbsp;Magda Zena Sadurska,&nbsp;Peter Brietbart,&nbsp;Spencer Greenberg,&nbsp;Jan Brauner","doi":"10.1155/da/5586831","DOIUrl":"https://doi.org/10.1155/da/5586831","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Despite the growing integrative trend in psychotherapy, few studies have examined the potential for immediate anxiety relief of many different psychotherapeutic exercises side by side under the same conditions. This information might be important to enhance engagement and self-efficacy, stop negative feedback loops, and prevent avoidant or destructive behavior during crises. Technology-based psychotherapeutic exercises are of particular interest because they are accessible and scalable.</p>\u0000 <p><b>Methods:</b> This parallel, double-blind, randomized trial (<i>N</i> = 1092) compared 12 psychotherapeutic exercises of the Mind Ease app against a reading control and a measurement-only control. Efficacy was measured with a custom scale validated against the state subscale of the State–Trait Anxiety Inventory.</p>\u0000 <p><b>Results:</b> Each of the 12 exercises significantly reduced anxiety more than controls (<i>p</i> = 0.018 to &lt;0.001, η²<i> </i>_<i>p</i> = 0.06 to 0.37, <i>d</i> = 0.5 to 1.5, d [95% CI] for all exercises together vs. reading control = 0.8 [0.6; 1.0], and vs. measurement-only control = 0.8 [0.6; 1.0]). Exercises employing cognitive restructuring had effect sizes <i>d</i> [95% CI] of 0.5 [0.2; 0.8], 0.7 [0.3; 1.0], and 0.9 [0.6; 1.2], diaphragmatic breathing of 0.6 [0.3; 0.9], gratitude practice of 0.8 [0.5; 1.1], positive expressive writing of 1.1 [0.7; 1.4], progressive muscle relaxation of 1.3 [0.9; 1.6], guided imagery of 1.3 [1.0; 1.6], and mindfulness of 0.9 [0.6; 1.2], 1.0 [0.7; 1.3], 1.2 [0.9; 1.5], and 1.5 [1.2; 1.9]. Twenty-eight comparisons between exercises (42%) had <i>p</i>  &lt; 0.05, nine met the Bonferroni-adjusted threshold of <i>p</i>  &lt; 0.0008.</p>\u0000 <p><b>Conclusions:</b> The 12 psychotherapeutic exercises proved effective at immediately mitigating anxiety. Differences between exercises were substantial even within categories. Mindfulness tended to have a larger effect than cognitive restructuring.</p>\u0000 <p><b>Trial Registration</b>: ClinicalTrials.gov identifier: NCT05850975</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/5586831","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}