Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes Mellitus Among People With Mental Disorders

IF 4.7 2区医学 Q1 PSYCHIATRY

Depression and Anxiety Pub Date : 2024-12-31 DOI:10.1155/da/6651804

Jiaxuan He, Fan Liu, Peiye Xu, Ting Xu, Haiyang Yu, Baihui Wu, Hanbing Wang, Jia Chen, Kun Zhang, Junbei Zhang, Kaikai Meng, Xiaoqing Yan, Qinsi Yang, Xingxing Zhang, Da Sun, Xia Chen

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Abstract

The escalating global prevalence of type 2 diabetes mellitus (T2DM) and mental disorder (MD) including schizophrenia, bipolar disorder, major depressive disorder, and anxiety highlights the urgency for comprehensive therapeutic strategies. Aerobic exercise (AE) is a viable adjunct therapy, providing significant benefits for individuals dealing with both T2DM and MD. This review consolidates evidence on AE’s role in alleviating the physiological and psychological effects of these comorbid conditions. It delves into the pathophysiological connections between T2DM and various MD, including depression, schizophrenia, anxiety, and bipolar disorder—emphasizing their reciprocal exacerbation. Key neurophysiological mechanisms through which AE confers benefits are explored, including neuroinflammation modulation, brain structure and neuroplasticity enhancement, growth factor expression regulation, and hypothalamic–pituitary–adrenal (HPA)/microbiota–gut–brain (MGB) axis normalization. Clinical results indicate that AE significantly improves both metabolic and psychological parameters in patients with T2DM and MD, providing a substantial argument for integrating AE into comprehensive treatment plans. Future research should aim to establish detailed, personalized exercise prescriptions and explore the long-term benefits of AE in this population. This review underscores the potential of AE to complement existing therapeutic modalities and enhance the management of patients with T2DM and MD.

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有氧运动改善2型糖尿病精神障碍患者的总体预后

2型糖尿病（T2DM）和精神障碍（MD）的全球患病率不断上升，包括精神分裂症、双相情感障碍、重度抑郁症和焦虑症，这凸显了制定综合治疗策略的紧迫性。有氧运动（AE）是一种可行的辅助治疗方法，为T2DM和MD患者提供了显著的益处。这篇综述巩固了AE在减轻这些合并症的生理和心理影响方面的作用。它深入探讨了T2DM和各种MD（包括抑郁症、精神分裂症、焦虑和双相情感障碍）之间的病理生理联系，强调了它们的相互加剧。探讨了AE带来益处的关键神经生理机制，包括神经炎症调节、脑结构和神经可塑性增强、生长因子表达调节和下丘脑-垂体-肾上腺(HPA)/微生物-肠-脑（MGB）轴正常化。临床结果表明，AE可显著改善T2DM合并MD患者的代谢和心理参数，为将AE纳入综合治疗方案提供了有力依据。未来的研究应旨在建立详细的、个性化的运动处方，并探索AE在这一人群中的长期益处。这篇综述强调了AE在补充现有治疗模式和加强T2DM和MD患者管理方面的潜力。

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来源期刊

Depression and Anxiety 医学-精神病学

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

4-8 weeks

期刊介绍： Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.