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Hematology-Oncology Clinics of North America最新文献

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Immunotherapy in Chronic Lymphocytic Leukemia. 慢性淋巴细胞白血病的免疫治疗。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-07-08 DOI: 10.1016/j.hoc.2025.05.010
Brian Sworder, Tanya Siddiqi
{"title":"Immunotherapy in Chronic Lymphocytic Leukemia.","authors":"Brian Sworder, Tanya Siddiqi","doi":"10.1016/j.hoc.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.05.010","url":null,"abstract":"<p><p>Immune-based therapies have redefined treatment strategies for a number of lymphomas including chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). This review highlights the evolution and efficacy of immune-based therapies in CLL/SLL, especially the novel monoclonal antibodies, bispecific antibodies, and chimeric antigen receptor T-cell therapy.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontline Treatment of Chronic Lymphocytic Leukemia with Continuous Bruton's Tyrosine Kinase Inhibitors: A Comprehensive Overview. 连续布鲁顿酪氨酸激酶抑制剂治疗慢性淋巴细胞白血病的一线：全面概述。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-07-07 DOI: 10.1016/j.hoc.2025.05.006
Seema Ali Bhat, Jennifer A Woyach
{"title":"Frontline Treatment of Chronic Lymphocytic Leukemia with Continuous Bruton's Tyrosine Kinase Inhibitors: A Comprehensive Overview.","authors":"Seema Ali Bhat, Jennifer A Woyach","doi":"10.1016/j.hoc.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.05.006","url":null,"abstract":"<p><p>Continuous treatment with Bruton's tyrosine kinase (BTK) inhibitors is well established for chronic lymphocytic leukemia in the frontline setting. Long-term data shows near-normal life expectancy for patients who are treated with ibrutinib. Second-generation BTK inhibitors have improved tolerability compared to ibrutinib and continue to show long-term durable remissions. Time-limited treatments with venetoclax combined with obinutuzumab or a BTK inhibitor demonstrate durable disease control as well. However, achieving superior and sustained long-term outcomes compared to continuous BTK inhibitor treatment remains challenging, particularly in high-risk genomic subgroups.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Understanding of Richter Transformation. 李氏变换认识的新进展。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-07-07 DOI: 10.1016/j.hoc.2025.05.011
Philip A Thompson, Erin M Parry
{"title":"Advances in the Understanding of Richter Transformation.","authors":"Philip A Thompson, Erin M Parry","doi":"10.1016/j.hoc.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.05.011","url":null,"abstract":"<p><p>Despite advances in the management of chronic lymphocytic leukemia (CLL), the transformation of CLL to an aggressive lymphoma, known as Richter transformation (RT), remains associated with dismal outcomes. Recent scientific studies deepen our understanding of the genetics and biology underlying RT. In parallel, a new era of clinical investigation is focused on improving outcomes for patients with RT, leading to the exponential increase of RT-focused trials and integration of novel targeted and immunotherapy approaches. We provide an updated biologic and clinical understanding of diffuse large B-cell lymphoma-type RT and discuss promising new therapeutic avenues for improving clinical outcomes in RT.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Chronic Lymphocytic Leukemia Epigenome: A Powerful and Stable Framework for Understanding Biological and Clinical Heterogeneity. 慢性淋巴细胞白血病表观基因组：理解生物学和临床异质性的一个强大而稳定的框架。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-07-07 DOI: 10.1016/j.hoc.2025.05.005
Antonio Perez-Castro, Lynne V Abruzzo, Christopher C Oakes
{"title":"The Chronic Lymphocytic Leukemia Epigenome: A Powerful and Stable Framework for Understanding Biological and Clinical Heterogeneity.","authors":"Antonio Perez-Castro, Lynne V Abruzzo, Christopher C Oakes","doi":"10.1016/j.hoc.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.05.005","url":null,"abstract":"<p><p>This review explores how epigenetic information, and in particular DNA methylation-based \"epitypes,\" enhances our understanding of chronic lymphocytic leukemia (CLL) biology and prognosis. Epitypes correlate with B-cell maturation stages and outperform traditional biomarkers like immunoglobulin heavy chain variable region mutation status in predicting outcomes. The stability and specificity of CLL epigenetic patterns offer insights into disease history, risk stratification, and treatment response, even amid evolving therapeutic landscape. Emerging epigenetic signatures, including proliferative indices, further refine patient classification and outcome prediction, underscoring the potential clinical utility of integrating epigenetic data in CLL management.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcomas 肉瘤
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-30 DOI: 10.1016/S0889-8588(25)00068-1
Suzanne George (Editor), Alberto s. Pappo (Editors)
{"title":"Sarcomas","authors":"Suzanne George (Editor),&nbsp;Alberto s. Pappo (Editors)","doi":"10.1016/S0889-8588(25)00068-1","DOIUrl":"10.1016/S0889-8588(25)00068-1","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 4","pages":"Page i"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune Cytopenias in Chronic Lymphocytic Leukemia. 慢性淋巴细胞白血病的自身免疫性细胞减少。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-30 DOI: 10.1016/j.hoc.2025.05.002
Candida Vitale, Andrea Ferrario, Giulia Zamprogna, Marta Coscia
{"title":"Autoimmune Cytopenias in Chronic Lymphocytic Leukemia.","authors":"Candida Vitale, Andrea Ferrario, Giulia Zamprogna, Marta Coscia","doi":"10.1016/j.hoc.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.05.002","url":null,"abstract":"<p><p>Autoimmune phenomena, particularly autoimmune cytopenias (AIC), are common complications in patients with chronic lymphocytic leukemia (CLL), arising from the interplay of predisposing genetic and immunologic conditions and extrinsic triggering factors, such as infections and drugs. In this article, we provide insights into the pathogenesis of CLL-associated AIC, discuss diagnostic criteria and treatment recommendations, and present the most recent data on the impact of targeted agents on the management of AIC.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forthcoming Issues 即将到来的问题
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-30 DOI: 10.1016/S0889-8588(25)00072-3
{"title":"Forthcoming Issues","authors":"","doi":"10.1016/S0889-8588(25)00072-3","DOIUrl":"10.1016/S0889-8588(25)00072-3","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 4","pages":"Page xi"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-30 DOI: 10.1016/S0889-8588(25)00069-3
{"title":"Copyright","authors":"","doi":"10.1016/S0889-8588(25)00069-3","DOIUrl":"10.1016/S0889-8588(25)00069-3","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 4","pages":"Page ii"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors 贡献者
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-30 DOI: 10.1016/S0889-8588(25)00070-X
{"title":"Contributors","authors":"","doi":"10.1016/S0889-8588(25)00070-X","DOIUrl":"10.1016/S0889-8588(25)00070-X","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 4","pages":"Pages iii-v"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evolving Landscape of Sarcomas 肉瘤的发展前景。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-06 DOI: 10.1016/j.hoc.2025.04.021
Suzanne George MD, Alberto S. Pappo MD
{"title":"The Evolving Landscape of Sarcomas","authors":"Suzanne George MD,&nbsp;Alberto S. Pappo MD","doi":"10.1016/j.hoc.2025.04.021","DOIUrl":"10.1016/j.hoc.2025.04.021","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 4","pages":"Pages xiii-xiv"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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