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5-Aminolevulinic Acid-mediated Photodynamic Therapy for Glioblastoma: A Systematic Review of Intracavitary and Interstitial Approaches with an Illustrative Case. 5-氨基乙酰丙酸介导的胶质母细胞瘤的光动力治疗：对腔内和间质途径的系统回顾，并有一个说明性病例。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-10-01 DOI: 10.1016/j.hoc.2026.09.001
Jheremy S Reyes, Alexandros Bouras, Sakibul Huq, Jhair A Colan, Stephanie Casillo, Constantinos G Hadjipanayis
{"title":"5-Aminolevulinic Acid-mediated Photodynamic Therapy for Glioblastoma: A Systematic Review of Intracavitary and Interstitial Approaches with an Illustrative Case.","authors":"Jheremy S Reyes, Alexandros Bouras, Sakibul Huq, Jhair A Colan, Stephanie Casillo, Constantinos G Hadjipanayis","doi":"10.1016/j.hoc.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.09.001","url":null,"abstract":"<p><p>This article systematically reviews the clinical literature on 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) for glioblastoma, focusing on intracavitary and interstitial treatment approaches. Across 12 studies involving 621 patients, the authors found that PDT appears technically feasible, biologically rational, and potentially beneficial as a locoregional adjunct, with acceptable overall safety. However, the evidence base is still limited by heterogeneous designs, inconsistent outcome reporting, and small cohorts. The review concludes that 5-ALA-mediated PDT is promising, but larger prospective and standardized studies are needed to define its role in contemporary glioblastoma care.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Platform Trials for the Treatment of Newly Diagnosed and Recurrent Glioblastoma. 新诊断和复发性胶质母细胞瘤治疗的新平台试验。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-10-01 DOI: 10.1016/j.hoc.2026.09.004
Deveney Franklin, Dominique M O Higgins
{"title":"Emerging Platform Trials for the Treatment of Newly Diagnosed and Recurrent Glioblastoma.","authors":"Deveney Franklin, Dominique M O Higgins","doi":"10.1016/j.hoc.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.09.004","url":null,"abstract":"<p><p>Glioblastoma (GBM) remains highly morbid despite maximal safe resection, radiotherapy, and chemotherapy, prompting the expansion of clinical investigation. This review examines 4 emerging therapeutic strategies for newly diagnosed and recurrent GBM that address major biological barriers to treatment: tumor immunosuppressive microenvironment, antigen heterogeneity, and the blood-brain barrier. In a subset of patients, early clinical studies demonstrate promise; however, more evidence is necessary prior to its incorporation into the mainstay therapeutic landscape.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser Interstitial Thermal Therapy: Next Steps. 激光间质热疗法：下一步。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-09-30 DOI: 10.1016/j.hoc.2026.08.004
Vratko Himic, Emma R Sass, Anshul Ratnaparkhi, Manuela Aramburu Berckemeyer, Ashish H Shah
{"title":"Laser Interstitial Thermal Therapy: Next Steps.","authors":"Vratko Himic, Emma R Sass, Anshul Ratnaparkhi, Manuela Aramburu Berckemeyer, Ashish H Shah","doi":"10.1016/j.hoc.2026.08.004","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.08.004","url":null,"abstract":"<p><p>Laser interstitial thermal therapy (LITT) has emerged as a minimally invasive, MRI-guided modality for the treatment of intracranial gliomas, metastatic disease, and treatment-resistant epilepsy, particularly in patients with limited conventional options. Clinical outcomes have been shown to tightly couple to the extent of ablation achieved, highlighting the importance of patient selection and procedural precision. LITT also has potential for inclusion in combinatorial strategies with established (as well as emerging) therapies, due to its ability to transiently disrupt and open the blood-brain barrier and induce changes in the tumor microenvironment, potentially enhancing systemic and immunotherapeutic efficacy.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chimeric Antigen Receptor T Cell Therapy for Glioblastoma: Clinical Advances and Emerging Strategies. 嵌合抗原受体T细胞治疗胶质母细胞瘤：临床进展和新兴策略。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-09-30 DOI: 10.1016/j.hoc.2026.08.001
Eric P Grewal, Rishab Ramapriyan, William T Curry, Bryan D Choi
{"title":"Chimeric Antigen Receptor T Cell Therapy for Glioblastoma: Clinical Advances and Emerging Strategies.","authors":"Eric P Grewal, Rishab Ramapriyan, William T Curry, Bryan D Choi","doi":"10.1016/j.hoc.2026.08.001","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.08.001","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR) T cell therapy is a promising investigational modality for glioblastoma (GBM), but durable disease control has been limited by antigen heterogeneity, adaptive resistance, and an immunosuppressive tumor microenvironment. Early phase I studies targeting IL-13Rα2, HER2, EGFRvIII, EphA2, B7-H3, and GD2 established proof-of-concept for CAR T cell therapy in recurrent GBM and provided important clinical insights regarding feasibility, safety, and resistance mechanisms. More recent approaches, including multi-antigen targeting and locoregional delivery, aim to address these limitations, and ongoing trials evaluating new antigens and engineered platforms may further expand the clinical potential of CAR T cells in GBM.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal Growth Factor Receptor and Tyrosine Kinase Inhibitors: Current and Emerging Strategies in Glioblastoma. 表皮生长因子受体和酪氨酸激酶抑制剂：胶质母细胞瘤的当前和新兴策略。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-09-29 DOI: 10.1016/j.hoc.2026.08.006
Manlin Shao, Kristin Huntoon
{"title":"Epidermal Growth Factor Receptor and Tyrosine Kinase Inhibitors: Current and Emerging Strategies in Glioblastoma.","authors":"Manlin Shao, Kristin Huntoon","doi":"10.1016/j.hoc.2026.08.006","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.08.006","url":null,"abstract":"<p><p>Epidermal growth factor receptor (EGFR) is the most frequent alteration in isocitrate dehydrogenase - wild-type glioblastoma and has been considered a promising therapeutic target. Despite extensive investigation, EGFR-targeted therapies have not improved overall survival because of limited central nervous system drug delivery, tumor heterogeneity, adaptive resistance, and an evolving tumor microenvironment. This review summarizes the molecular biology of EGFR, clinical experience with EGFR-targeted therapies, mechanisms underlying therapeutic resistance, and emerging strategies that may improve future clinical outcomes.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketone-targeting Approaches in Glioma. 胶质瘤中的酮靶向方法。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-09-29 DOI: 10.1016/j.hoc.2026.08.009
Maria Ioannou, Karisa C Schreck
{"title":"Ketone-targeting Approaches in Glioma.","authors":"Maria Ioannou, Karisa C Schreck","doi":"10.1016/j.hoc.2026.08.009","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.08.009","url":null,"abstract":"<p><p>Metabolic dysregulation in gliomas creates a therapeutic vulnerability for interventions such as ketogenic metabolic therapies (KMTs). KMTs can take many forms, including fasting, ketogenic diet therapy, exogenous ketone supplementation, or a combination. Preclinical evidence suggests that these approaches can impair tumor growth, normalize the tumor microenvironment, and enhance sensitivity to cancer-directed therapies. Clinical studies highlight not only the safety of KMTs but also the challenges related to tolerability and biological effect. Here, we summarize preclinical and clinical data on ketone-targeting approaches in gliomas, as well as future directions toward improved implementation.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue-Based Trials: Windows of Opportunity in Neuro-Oncology Drug Development. 基于组织的试验：神经肿瘤药物开发的机会之窗。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-09-28 DOI: 10.1016/j.hoc.2026.08.007
Charuta G Furey, Rian Chang, An-Chi Tien, Artak Tovmasyan, Shwetal Mehta, Nader Sanai
{"title":"Tissue-Based Trials: Windows of Opportunity in Neuro-Oncology Drug Development.","authors":"Charuta G Furey, Rian Chang, An-Chi Tien, Artak Tovmasyan, Shwetal Mehta, Nader Sanai","doi":"10.1016/j.hoc.2026.08.007","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.08.007","url":null,"abstract":"<p><p>Tissue-based trials use limited exposure to investigational agents to obtain human tumor pharmacokinetic and pharmacodynamic data early in development. This approach is particularly valuable in neuro-oncology, where preclinical models are imperfect and the blood-brain barrier complicates conventional drug development. Phase 0 and related tissue-based studies directly test whether an agent reaches the tumor, engages its intended target, and elicits the expected biological effect. This chapter describes the rationale and regulatory framework for tissue-based trials, distinguishes the principal designs, and addresses their operational requirements and interpretation.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Signals in Gliomas: Mechanisms, Clinical Implications, and Future Perspectives. 神经胶质瘤中的微生物信号：机制、临床意义和未来展望。
IF 3.1 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-09-28 DOI: 10.1016/j.hoc.2026.08.002
Oscar Alcantar, Antonio Dono, Angel Bueno, Yoshua Esquenazi
{"title":"Microbial Signals in Gliomas: Mechanisms, Clinical Implications, and Future Perspectives.","authors":"Oscar Alcantar, Antonio Dono, Angel Bueno, Yoshua Esquenazi","doi":"10.1016/j.hoc.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.hoc.2026.08.002","url":null,"abstract":"<p><p>Emerging evidence suggests that the gut microbiome contributes to glioma biology through immune regulation, microbial metabolites, and modulation of the tumor microenvironment. This review summarizes current evidence linking the microbiome-gut-brain axis to glioma development, progression, and treatment response, highlighting findings from human studies, preclinical models, and recent mechanistic investigations. The review also discusses the influence of the microbiome on anticancer therapy, current limitations of the field, and future directions for microbiome-based biomarkers and therapeutic strategies. Although clinical translation remains limited, microbial signals represent a promising area of investigation in neuro-oncology.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Big Data in Pediatric Oncology 儿童肿瘤学中的大数据
IF 2.7 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-06-01 Epub Date: 2026-06-10 DOI: 10.1016/j.hoc.2026.02.004
Kirk D. Wyatt MD , Samuel L. Volchenboum MD, PhD
{"title":"Big Data in Pediatric Oncology","authors":"Kirk D. Wyatt MD ,&nbsp;Samuel L. Volchenboum MD, PhD","doi":"10.1016/j.hoc.2026.02.004","DOIUrl":"10.1016/j.hoc.2026.02.004","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"40 3","pages":"Pages 417-428"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
IF 2.7 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2026-06-01 Epub Date: 2026-06-10 DOI: 10.1016/S0889-8588(26)00031-6
{"title":"Copyright","authors":"","doi":"10.1016/S0889-8588(26)00031-6","DOIUrl":"10.1016/S0889-8588(26)00031-6","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"40 3","pages":"Page ii"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148208241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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