慢性淋巴细胞白血病表观基因组：理解生物学和临床异质性的一个强大而稳定的框架。

IF 2.7 3区医学 Q2 HEMATOLOGY

Hematology-Oncology Clinics of North America Pub Date : 2025-07-07 DOI:10.1016/j.hoc.2025.05.005

Antonio Perez-Castro, Lynne V Abruzzo, Christopher C Oakes

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引用次数: 0

摘要

这篇综述探讨了表观遗传信息，特别是基于DNA甲基化的“表型”，如何增强我们对慢性淋巴细胞白血病（CLL）生物学和预后的理解。表型与b细胞成熟阶段相关，在预测预后方面优于免疫球蛋白重链可变区突变状态等传统生物标志物。CLL表观遗传模式的稳定性和特异性提供了对疾病史、风险分层和治疗反应的见解，甚至在不断变化的治疗环境中也是如此。新出现的表观遗传特征，包括增殖指数，进一步完善了患者分类和预后预测，强调了将表观遗传数据整合到CLL管理中的潜在临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Chronic Lymphocytic Leukemia Epigenome: A Powerful and Stable Framework for Understanding Biological and Clinical Heterogeneity.

This review explores how epigenetic information, and in particular DNA methylation-based "epitypes," enhances our understanding of chronic lymphocytic leukemia (CLL) biology and prognosis. Epitypes correlate with B-cell maturation stages and outperform traditional biomarkers like immunoglobulin heavy chain variable region mutation status in predicting outcomes. The stability and specificity of CLL epigenetic patterns offer insights into disease history, risk stratification, and treatment response, even amid evolving therapeutic landscape. Emerging epigenetic signatures, including proliferative indices, further refine patient classification and outcome prediction, underscoring the potential clinical utility of integrating epigenetic data in CLL management.

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来源期刊

Hematology-Oncology Clinics of North America 医学-血液学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.