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Hematology-Oncology Clinics of North America最新文献

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The Evolving Landscape of Sarcomas. 肉瘤的发展前景。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-06-05 DOI: 10.1016/j.hoc.2025.04.021
Suzane George, Alberto S Pappo
{"title":"The Evolving Landscape of Sarcomas.","authors":"Suzane George, Alberto S Pappo","doi":"10.1016/j.hoc.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.04.021","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liposarcoma: Novel Approaches to Systemic Therapy and Multidisciplinary Care. 脂肪肉瘤：系统治疗和多学科护理的新方法。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-24 DOI: 10.1016/j.hoc.2025.04.010
Emily Jonczak, Jonathan Trent, Christina Roland, Elise Nassif Haddad
{"title":"Liposarcoma: Novel Approaches to Systemic Therapy and Multidisciplinary Care.","authors":"Emily Jonczak, Jonathan Trent, Christina Roland, Elise Nassif Haddad","doi":"10.1016/j.hoc.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.04.010","url":null,"abstract":"<p><p>Retroperitoneal well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are rare tumors presenting as bulky abdominal tumors requiring multidisciplinary management in high-volume centers. Surgery is the mainstay of treatment through complete en bloc resection with the goal of achieving macroscopically complete resection, with a single specimen encompassing the tumor and involved contiguous organs. Preoperative radiation therapy is not standard of care and the role of preoperative chemotherapy is under investigation. If the tumor is not resectable or metastatic, the preferred treatment is doxorubicin-based chemotherapy in the case of DDLPS, whereas WDLPS are generally thought of as chemo-resistant.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leiomyosarcoma Therapeutic Approaches and Future Directions. 平滑肌肉瘤的治疗方法及未来发展方向。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI: 10.1016/j.hoc.2025.04.007
Candace L Haddox, David J Papke, César Serrano
{"title":"Leiomyosarcoma Therapeutic Approaches and Future Directions.","authors":"Candace L Haddox, David J Papke, César Serrano","doi":"10.1016/j.hoc.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.04.007","url":null,"abstract":"<p><p>Leiomyosarcomas (LMS) are mesenchymal malignancies with smooth muscle differentiation that most commonly arise in the uterus, retroperitoneum, and extremity. Clinical course is variable, and management differs by site of origin. Recently completed and ongoing clinical trials are optimizing LMS management, and multidisciplinary care by an expert team is essential to navigate the nuances and provide optimal care. Advances in molecular characterization have improved diagnosis and identification of novel prognostic factors and systemic therapies. This article provides an overview of LMS presentation, diagnosis, molecular features, and clinical management, and highlights advancements in LMS biology and treatment.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Role of Blood-based Biomarkers in Sarcomas. 血液生物标志物在肉瘤中的新作用。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI: 10.1016/j.hoc.2025.04.002
David S Shulman, Brian D Crompton
{"title":"Emerging Role of Blood-based Biomarkers in Sarcomas.","authors":"David S Shulman, Brian D Crompton","doi":"10.1016/j.hoc.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.04.002","url":null,"abstract":"<p><p>We assess the emerging role of liquid biopsies, particularly circulating tumor DNA (ctDNA), in sarcoma management. Preliminary studies suggest that ctDNA has multiple potential applications including, early detection in patients with cancer predisposition syndromes, diagnosis, prognostication, therapy selection, and monitoring treatment response. Among patients with gastrointestinal stromal tumors, studies have demonstrated the capacity for identification of clinically relevant resistance mutations. In other sarcoma subtypes such as Ewing sarcoma and osteosarcoma, early findings indicate that ctDNA levels might correlate with tumor burden and outcomes, potentially aiding in risk stratification. Clinical utility has not been established for these applications.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI: 10.1016/S0889-8588(25)00032-2
{"title":"Copyright","authors":"","doi":"10.1016/S0889-8588(25)00032-2","DOIUrl":"10.1016/S0889-8588(25)00032-2","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 3","pages":"Page ii"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forthcoming Issues 即将到来的问题
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI: 10.1016/S0889-8588(25)00035-8
{"title":"Forthcoming Issues","authors":"","doi":"10.1016/S0889-8588(25)00035-8","DOIUrl":"10.1016/S0889-8588(25)00035-8","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 3","pages":"Page x"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors 贡献者
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI: 10.1016/S0889-8588(25)00033-4
{"title":"Contributors","authors":"","doi":"10.1016/S0889-8588(25)00033-4","DOIUrl":"10.1016/S0889-8588(25)00033-4","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 3","pages":"Pages iii-v"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemophagocytic Syndromes Hemophagocytic综合症
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-22 DOI: 10.1016/S0889-8588(25)00031-0
Nancy Berliner (Editor), Barbara A. Degar (Editors)
{"title":"Hemophagocytic Syndromes","authors":"Nancy Berliner (Editor),&nbsp;Barbara A. Degar (Editors)","doi":"10.1016/S0889-8588(25)00031-0","DOIUrl":"10.1016/S0889-8588(25)00031-0","url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":"39 3","pages":"Page i"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local Control in Soft Tissue Sarcomas. 软组织肉瘤的局部控制。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-14 DOI: 10.1016/j.hoc.2025.04.011
Elizabeth H Baldini, Alessandro Gronchi
{"title":"Local Control in Soft Tissue Sarcomas.","authors":"Elizabeth H Baldini, Alessandro Gronchi","doi":"10.1016/j.hoc.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.04.011","url":null,"abstract":"<p><p>Soft tissue sarcoma is a rare heterogeneous group of tumors made up of over 100 histologic types and subtypes. Expert pathology review is crucial to confirm the correct diagnosis prior to treatment. Multidisciplinary discussion and management at an expert center is strongly recommended given the many nuances of treatment. Wide resection +/- preoperative radiotherapy is recommended in most extremity and trunk wall STS patients, while a minority may also require perioperative medical therapy. Macroscopic complete resection remains the standard of care for retroperitoneal sarcoma patients, with preoperative radiotherapy recommended in selected histologic types.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Is It Important to Sequence Sarcomas and Other Mesenchymal Neoplasms? A Practical Guide to Molecular Testing. 何时对肉瘤和其他间质肿瘤进行测序是重要的？分子测试实用指南。
IF 2.5 3区 医学
Hematology-Oncology Clinics of North America Pub Date : 2025-05-14 DOI: 10.1016/j.hoc.2025.04.001
Maria Del Carmen Rodriguez Pena, David J Papke
{"title":"When Is It Important to Sequence Sarcomas and Other Mesenchymal Neoplasms? A Practical Guide to Molecular Testing.","authors":"Maria Del Carmen Rodriguez Pena, David J Papke","doi":"10.1016/j.hoc.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.hoc.2025.04.001","url":null,"abstract":"<p><p>The increasingly widespread availability of next-generation sequencing has led to its incorporation as a diagnostic tool in pathology and a modality for identifying targetable alterations. However, sequencing is still a somewhat expensive and time-consuming. Here, we discuss tumor types for which (1) molecular testing is not generally indicated, (2) surrogate immunohistochemical markers have rendered molecular testing unnecessary, or (3) sequencing is important for diagnostic and therapeutic purposes. We also provide a practical framework to assist in decision-making for molecular testing of both classified and unclassified mesenchymal neoplasms, reflecting our practice in a tertiary sarcoma referral center.</p>","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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