李氏变换认识的新进展。

IF 2.7 3区医学 Q2 HEMATOLOGY

Hematology-Oncology Clinics of North America Pub Date : 2025-07-07 DOI:10.1016/j.hoc.2025.05.011

Philip A Thompson, Erin M Parry

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引用次数: 0

摘要

尽管慢性淋巴细胞白血病（CLL）的治疗取得了进展，但CLL向侵袭性淋巴瘤的转化，即Richter转化（RT），仍然与令人沮丧的结果相关。最近的科学研究加深了我们对RT的遗传学和生物学基础的理解。与此同时，临床研究的新时代侧重于改善RT患者的预后，导致以RT为重点的试验呈指数级增长，并整合了新的靶向和免疫治疗方法。我们提供了弥漫性大b细胞淋巴瘤型放射治疗的最新生物学和临床认识，并讨论了改善放射治疗临床结果的有希望的新治疗途径。

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Advances in the Understanding of Richter Transformation.

Despite advances in the management of chronic lymphocytic leukemia (CLL), the transformation of CLL to an aggressive lymphoma, known as Richter transformation (RT), remains associated with dismal outcomes. Recent scientific studies deepen our understanding of the genetics and biology underlying RT. In parallel, a new era of clinical investigation is focused on improving outcomes for patients with RT, leading to the exponential increase of RT-focused trials and integration of novel targeted and immunotherapy approaches. We provide an updated biologic and clinical understanding of diffuse large B-cell lymphoma-type RT and discuss promising new therapeutic avenues for improving clinical outcomes in RT.

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来源期刊

Hematology-Oncology Clinics of North America 医学-血液学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.