Autoimmune Cytopenias in Chronic Lymphocytic Leukemia.

IF 2.7 3区医学 Q2 HEMATOLOGY

Hematology-Oncology Clinics of North America Pub Date : 2025-06-30 DOI:10.1016/j.hoc.2025.05.002

Candida Vitale, Andrea Ferrario, Giulia Zamprogna, Marta Coscia

引用次数: 0

Abstract

Autoimmune phenomena, particularly autoimmune cytopenias (AIC), are common complications in patients with chronic lymphocytic leukemia (CLL), arising from the interplay of predisposing genetic and immunologic conditions and extrinsic triggering factors, such as infections and drugs. In this article, we provide insights into the pathogenesis of CLL-associated AIC, discuss diagnostic criteria and treatment recommendations, and present the most recent data on the impact of targeted agents on the management of AIC.

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慢性淋巴细胞白血病的自身免疫性细胞减少。

自身免疫性现象，特别是自身免疫性细胞减少症（AIC），是慢性淋巴细胞白血病（CLL）患者常见的并发症，由易感遗传和免疫条件以及外部触发因素（如感染和药物）的相互作用引起。在本文中，我们提供了cll相关AIC的发病机制，讨论了诊断标准和治疗建议，并介绍了靶向药物对AIC治疗影响的最新数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hematology-Oncology Clinics of North America 医学-血液学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.